HRP20010089B1 - 2-substituted-1-piperidyl benzimidazole compounds as orl1-receptor agonists - Google Patents

2-substituted-1-piperidyl benzimidazole compounds as orl1-receptor agonists

Info

Publication number
HRP20010089B1
HRP20010089B1 HR970081A HRP20010089A HRP20010089B1 HR P20010089 B1 HRP20010089 B1 HR P20010089B1 HR 970081 A HR970081 A HR 970081A HR P20010089 A HRP20010089 A HR P20010089A HR P20010089 B1 HRP20010089 B1 HR P20010089B1
Authority
HR
Croatia
Prior art keywords
orl1
piperidyl
substituted
receptor agonists
benzimidazole compounds
Prior art date
Application number
HR970081A
Other languages
English (en)
Inventor
Fumitaka Ito
Hirohide Noguchi
Kondo Hiroshi
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of HRP20010089A2 publication Critical patent/HRP20010089A2/hr
Publication of HRP20010089B1 publication Critical patent/HRP20010089B1/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00Anaesthetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/12Drugs for disorders of the metabolism for electrolyte homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/02Antidotes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56Nitrogen atoms
    • C07D211/58Nitrogen atoms attached in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Toxicology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HR970081A 1998-08-06 2001-02-02 2-substituted-1-piperidyl benzimidazole compounds as orl1-receptor agonists HRP20010089B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IBPCT/IB98/01206 1998-08-06
PCT/IB1999/001239 WO2000008013A2 (en) 1998-08-06 1999-07-05 2-substituted-1-piperidyl benzimidazole compounds as orl1-receptor agonists

Publications (2)

Publication Number Publication Date
HRP20010089A2 HRP20010089A2 (en) 2002-02-28
HRP20010089B1 true HRP20010089B1 (en) 2003-04-30

Family

ID=11004738

Family Applications (1)

Application Number Title Priority Date Filing Date
HR970081A HRP20010089B1 (en) 1998-08-06 2001-02-02 2-substituted-1-piperidyl benzimidazole compounds as orl1-receptor agonists

Country Status (44)

Country Link
US (1) US6172067B1 (sl)
EP (1) EP1102762B1 (sl)
JP (1) JP3367945B2 (sl)
CN (1) CN1317968A (sl)
AP (1) AP2001002063A0 (sl)
AR (1) AR018686A1 (sl)
AT (1) ATE227716T1 (sl)
AU (1) AU749166B2 (sl)
BG (1) BG105301A (sl)
BR (1) BR9912778A (sl)
CA (1) CA2339621C (sl)
CZ (1) CZ2001397A3 (sl)
DE (1) DE69903953T2 (sl)
DK (1) DK1102762T3 (sl)
EA (1) EA200100104A1 (sl)
EE (1) EE200100075A (sl)
ES (1) ES2185357T3 (sl)
GE (1) GEP20033000B (sl)
GT (1) GT199900125A (sl)
HK (1) HK1040188A1 (sl)
HN (1) HN1999000105A (sl)
HR (1) HRP20010089B1 (sl)
HU (1) HUP0103567A3 (sl)
ID (1) ID27212A (sl)
IL (1) IL141029A0 (sl)
IS (1) IS5812A (sl)
MA (1) MA26659A1 (sl)
NO (1) NO20010603L (sl)
NZ (1) NZ509299A (sl)
OA (1) OA11590A (sl)
PA (1) PA8477701A1 (sl)
PE (1) PE20000868A1 (sl)
PL (1) PL346211A1 (sl)
PT (1) PT1102762E (sl)
SI (1) SI1102762T1 (sl)
SK (1) SK1602001A3 (sl)
SV (1) SV1999000099A (sl)
TN (1) TNSN99142A1 (sl)
TR (1) TR200100403T2 (sl)
TW (1) TW513424B (sl)
UY (1) UY25659A1 (sl)
WO (1) WO2000008013A2 (sl)
YU (1) YU8201A (sl)
ZA (1) ZA200100900B (sl)

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SE9903544D0 (sv) 1999-10-01 1999-10-01 Astra Pharma Prod Novel compounds
ES2249237T3 (es) 2000-01-05 2006-04-01 Pfizer Inc. Compuestos de bencimidazol como antagonistas del receptor orl1.
GB2359081A (en) 2000-02-11 2001-08-15 Astrazeneca Uk Ltd Pharmaceutically active thiazolopyrimidines
GB2359078A (en) 2000-02-11 2001-08-15 Astrazeneca Uk Ltd Pharmaceutically active pyrimidine derivatives
GB2359551A (en) 2000-02-23 2001-08-29 Astrazeneca Uk Ltd Pharmaceutically active pyrimidine derivatives
GB0005642D0 (en) 2000-03-10 2000-05-03 Astrazeneca Uk Ltd Chemical compounds
SE0003828D0 (sv) 2000-10-20 2000-10-20 Astrazeneca Ab Novel compounds
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GB0104050D0 (en) 2001-02-19 2001-04-04 Astrazeneca Ab Chemical compounds
GB0107228D0 (en) 2001-03-22 2001-05-16 Astrazeneca Ab Chemical compounds
SE0101322D0 (sv) 2001-04-12 2001-04-12 Astrazeneca Ab Novel compounds
ES2312616T3 (es) 2001-04-18 2009-03-01 Euro-Celtique S.A. Compuestos de bencimidazolona.
US6867222B2 (en) 2001-04-18 2005-03-15 Euro-Celtique, S.A. Nociceptin analogs
WO2002085354A1 (en) 2001-04-18 2002-10-31 Euro-Celtique S.A. Spiroindene and spiroindane compounds
KR100855204B1 (ko) * 2001-04-18 2008-09-01 유로-셀티크 소시에떼 아노뉨 노시셉틴 유사체
ATE403429T1 (de) 2001-04-18 2008-08-15 Euro Celtique Sa Spiropyrazol-verbindungen
WO2003004034A1 (en) * 2001-07-02 2003-01-16 Omeros Corporation Method for inducing analgesia comprising administration alternatively of an opioid receptor agonist and an opioid receptor like receptor 1 agonist for and an implantable infusion pump
US20030040479A1 (en) * 2001-07-02 2003-02-27 Omeros Corporation Rotational intrathecal analgesia method and device
SE0102716D0 (sv) * 2001-08-14 2001-08-14 Astrazeneca Ab Novel compounds
SE0103818D0 (sv) * 2001-11-15 2001-11-15 Astrazeneca Ab Chemical compounds
US7812035B2 (en) * 2001-12-11 2010-10-12 Sepracor Inc. 4-substituted piperidines, and methods of use thereof
US7566728B2 (en) 2002-03-29 2009-07-28 Mitsubishi Tanabe Pharma Corporation Remedy for sleep disturbance
GB0221829D0 (en) * 2002-09-20 2002-10-30 Astrazeneca Ab Novel compound
GB0221828D0 (en) 2002-09-20 2002-10-30 Astrazeneca Ab Novel compound
DE10252665A1 (de) * 2002-11-11 2004-06-03 Grünenthal GmbH 4-Aminomethyl-1-aryl-cyclohexylamin-Derivate
DE10252666A1 (de) * 2002-11-11 2004-08-05 Grünenthal GmbH N-Piperidyl-cyclohexan-Derivate
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WO2005060947A2 (en) * 2003-12-19 2005-07-07 Sri International Agonist and antagonist ligands of the nociceptin receptor
US20080021069A1 (en) * 2004-10-08 2008-01-24 Takeda Pharmaceutical Company Limited Receptor Function Regulating Agent
WO2006074991A1 (en) 2005-01-11 2006-07-20 Neurosearch A/S Novel 2-amino benzimidazole derivatives and their use as modulators of small-conductance calcium-activated potassium channels
CA2654666A1 (en) * 2006-07-03 2008-01-10 Neurosearch A/S Pharmaceutical compositions
RS51474B (en) * 2007-01-16 2011-04-30 Purdue Pharma L.P. HETEROCYCLICALLY SUBSTITUTED PIPERIDINES AS ORL-1 LIGANDS
BRPI0815327A2 (pt) 2007-08-31 2015-12-15 Purdue Pharma Lp "compostos de piperidina do tipo quinoxalina substituída e os usos destes"
US8119661B2 (en) * 2007-09-11 2012-02-21 Astrazeneca Ab Piperidine derivatives and their use as muscarinic receptor modulators
RU2500678C2 (ru) 2008-07-21 2013-12-10 Пэдью Фарма Л.П. Замещенные хиноксалинового типа мостиковые пиперидиновые соединения и их применение
JP5795635B2 (ja) 2010-08-05 2015-10-14 アムジェン インコーポレイテッド 未分化リンパ腫キナーゼを阻害するベンゾイミダゾール化合物およびアザベンゾイミダゾール化合物
MX346043B (es) 2012-01-06 2017-03-03 Novus Int Inc Tensioactivos basados en sulfoxido.
RS57845B1 (sr) 2012-02-09 2018-12-31 Novus Int Inc Ciklični dimeri koji sadrže heteroatom
JO3300B1 (ar) 2012-06-06 2018-09-16 Novartis Ag مركبات وتركيبات لتعديل نشاط egfr
BR112015000494A2 (pt) 2012-07-12 2017-06-27 Novus Int Inc matriz e composições da camada para a proteção dos biotivos
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US9090618B2 (en) 2012-12-27 2015-07-28 Purdue Pharma L.P. Substituted benzimidazole-type piperidine compounds and uses thereof
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PT3119762T (pt) * 2014-03-20 2021-08-31 Capella Therapeutics Inc Derivados de benzimidazole como inibidores de tirosina quinase erbb para o tratamento do cancro
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ID29137A (id) 1998-07-27 2001-08-02 Schering Corp Ligan-ligan afinitas tinggi untuk reseptor nosiseptin orl-1

Also Published As

Publication number Publication date
JP3367945B2 (ja) 2003-01-20
CZ2001397A3 (cs) 2002-05-15
WO2000008013A3 (en) 2000-03-23
AU749166B2 (en) 2002-06-20
ATE227716T1 (de) 2002-11-15
AP2001002063A0 (en) 2001-03-31
DK1102762T3 (da) 2002-12-16
CA2339621A1 (en) 2000-02-17
PL346211A1 (en) 2002-01-28
CA2339621C (en) 2005-04-05
DE69903953T2 (de) 2003-03-27
SI1102762T1 (sl) 2003-04-30
PE20000868A1 (es) 2000-08-31
JP2002522431A (ja) 2002-07-23
PT1102762E (pt) 2003-02-28
OA11590A (en) 2004-08-18
ID27212A (id) 2001-03-08
SK1602001A3 (en) 2002-09-10
IS5812A (is) 2001-01-16
IL141029A0 (en) 2002-02-10
BG105301A (en) 2001-12-29
DE69903953D1 (de) 2002-12-19
HRP20010089A2 (en) 2002-02-28
ZA200100900B (en) 2002-08-28
TNSN99142A1 (fr) 2005-11-10
HUP0103567A3 (en) 2003-01-28
AU4385999A (en) 2000-02-28
PA8477701A1 (es) 2000-09-29
SV1999000099A (es) 2000-09-05
EA200100104A1 (ru) 2001-08-27
EP1102762B1 (en) 2002-11-13
UY25659A1 (es) 2000-02-23
ES2185357T3 (es) 2003-04-16
MA26659A1 (fr) 2004-12-20
GT199900125A (es) 2001-01-27
US6172067B1 (en) 2001-01-09
GEP20033000B (en) 2003-06-25
BR9912778A (pt) 2001-09-25
NZ509299A (en) 2003-05-30
HUP0103567A2 (hu) 2002-02-28
WO2000008013A2 (en) 2000-02-17
NO20010603L (no) 2001-04-05
HN1999000105A (es) 2000-11-11
AR018686A1 (es) 2001-11-28
EE200100075A (et) 2002-06-17
TW513424B (en) 2002-12-11
TR200100403T2 (tr) 2001-07-23
CN1317968A (zh) 2001-10-17
EP1102762A2 (en) 2001-05-30
NO20010603D0 (no) 2001-02-05
YU8201A (sh) 2003-07-07
HK1040188A1 (zh) 2002-05-31

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