HRP20010089B1 - 2-substituted-1-piperidyl benzimidazole compounds as orl1-receptor agonists - Google Patents

2-substituted-1-piperidyl benzimidazole compounds as orl1-receptor agonists

Info

Publication number
HRP20010089B1
HRP20010089B1 HR970081A HRP20010089A HRP20010089B1 HR P20010089 B1 HRP20010089 B1 HR P20010089B1 HR 970081 A HR970081 A HR 970081A HR P20010089 A HRP20010089 A HR P20010089A HR P20010089 B1 HRP20010089 B1 HR P20010089B1
Authority
HR
Croatia
Prior art keywords
orl1
piperidyl
substituted
receptor agonists
benzimidazole compounds
Prior art date
Application number
HR970081A
Other languages
English (en)
Inventor
Fumitaka Ito
Hirohide Noguchi
Kondo Hiroshi
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of HRP20010089A2 publication Critical patent/HRP20010089A2/hr
Publication of HRP20010089B1 publication Critical patent/HRP20010089B1/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00Anaesthetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/12Drugs for disorders of the metabolism for electrolyte homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/02Antidotes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56Nitrogen atoms
    • C07D211/58Nitrogen atoms attached in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Toxicology (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HR970081A 1998-08-06 2001-02-02 2-substituted-1-piperidyl benzimidazole compounds as orl1-receptor agonists HRP20010089B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IBPCT/IB98/01206 1998-08-06
PCT/IB1999/001239 WO2000008013A2 (en) 1998-08-06 1999-07-05 2-substituted-1-piperidyl benzimidazole compounds as orl1-receptor agonists

Publications (2)

Publication Number Publication Date
HRP20010089A2 HRP20010089A2 (en) 2002-02-28
HRP20010089B1 true HRP20010089B1 (en) 2003-04-30

Family

ID=11004738

Family Applications (1)

Application Number Title Priority Date Filing Date
HR970081A HRP20010089B1 (en) 1998-08-06 2001-02-02 2-substituted-1-piperidyl benzimidazole compounds as orl1-receptor agonists

Country Status (44)

Country Link
US (1) US6172067B1 (sl)
EP (1) EP1102762B1 (sl)
JP (1) JP3367945B2 (sl)
CN (1) CN1317968A (sl)
AP (1) AP2001002063A0 (sl)
AR (1) AR018686A1 (sl)
AT (1) ATE227716T1 (sl)
AU (1) AU749166B2 (sl)
BG (1) BG105301A (sl)
BR (1) BR9912778A (sl)
CA (1) CA2339621C (sl)
CZ (1) CZ2001397A3 (sl)
DE (1) DE69903953T2 (sl)
DK (1) DK1102762T3 (sl)
EA (1) EA200100104A1 (sl)
EE (1) EE200100075A (sl)
ES (1) ES2185357T3 (sl)
GE (1) GEP20033000B (sl)
GT (1) GT199900125A (sl)
HK (1) HK1040188A1 (sl)
HN (1) HN1999000105A (sl)
HR (1) HRP20010089B1 (sl)
HU (1) HUP0103567A3 (sl)
ID (1) ID27212A (sl)
IL (1) IL141029A0 (sl)
IS (1) IS5812A (sl)
MA (1) MA26659A1 (sl)
NO (1) NO20010603L (sl)
NZ (1) NZ509299A (sl)
OA (1) OA11590A (sl)
PA (1) PA8477701A1 (sl)
PE (1) PE20000868A1 (sl)
PL (1) PL346211A1 (sl)
PT (1) PT1102762E (sl)
SI (1) SI1102762T1 (sl)
SK (1) SK1602001A3 (sl)
SV (1) SV1999000099A (sl)
TN (1) TNSN99142A1 (sl)
TR (1) TR200100403T2 (sl)
TW (1) TW513424B (sl)
UY (1) UY25659A1 (sl)
WO (1) WO2000008013A2 (sl)
YU (1) YU8201A (sl)
ZA (1) ZA200100900B (sl)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6340681B1 (en) * 1999-07-16 2002-01-22 Pfizer Inc 2-benzimidazolylamine compounds as ORL-1-receptor agonists
SE9902987D0 (sv) 1999-08-24 1999-08-24 Astra Pharma Prod Novel compounds
SE9903544D0 (sv) 1999-10-01 1999-10-01 Astra Pharma Prod Novel compounds
ES2249237T3 (es) * 2000-01-05 2006-04-01 Pfizer Inc. Compuestos de bencimidazol como antagonistas del receptor orl1.
GB2359081A (en) 2000-02-11 2001-08-15 Astrazeneca Uk Ltd Pharmaceutically active thiazolopyrimidines
GB2359078A (en) 2000-02-11 2001-08-15 Astrazeneca Uk Ltd Pharmaceutically active pyrimidine derivatives
GB2359551A (en) 2000-02-23 2001-08-29 Astrazeneca Uk Ltd Pharmaceutically active pyrimidine derivatives
GB0005642D0 (en) 2000-03-10 2000-05-03 Astrazeneca Uk Ltd Chemical compounds
SE0003828D0 (sv) 2000-10-20 2000-10-20 Astrazeneca Ab Novel compounds
EP1342717A4 (en) * 2000-11-15 2005-02-16 Banyu Pharma Co Ltd benzimidazole derivatives
GB0104050D0 (en) 2001-02-19 2001-04-04 Astrazeneca Ab Chemical compounds
GB0107228D0 (en) 2001-03-22 2001-05-16 Astrazeneca Ab Chemical compounds
SE0101322D0 (sv) 2001-04-12 2001-04-12 Astrazeneca Ab Novel compounds
JP4401076B2 (ja) * 2001-04-18 2010-01-20 ユーロ−セルティーク エス.エイ. ベンズイミダゾロン化合物
ATE413175T1 (de) 2001-04-18 2008-11-15 Euro Celtique Sa Spiroinden- und spiroindan-verbindungen
BR0209127A (pt) 2001-04-18 2006-03-21 Euro Celtique Sa compostos, composições farmacêuticas, métodos para o tratamento de dores, métodos para a modulação de uma resposta farmacológica e usos de compostos
EP1379246B1 (en) * 2001-04-18 2008-10-08 Euro-Celtique S.A. Nociceptin analogs
CA2444108C (en) * 2001-04-18 2012-07-24 Euro-Celtique, S.A. Nociceptin analogs
JP2005502619A (ja) * 2001-07-02 2005-01-27 オメロス コーポレイション オピオイドレセプター様レセプター1アゴニストと交替でオピオイドレセプターアゴニストを投与することを含む、痛覚脱失を生成するための方法
US20030040479A1 (en) * 2001-07-02 2003-02-27 Omeros Corporation Rotational intrathecal analgesia method and device
SE0102716D0 (sv) * 2001-08-14 2001-08-14 Astrazeneca Ab Novel compounds
SE0103818D0 (sv) 2001-11-15 2001-11-15 Astrazeneca Ab Chemical compounds
WO2003049736A1 (en) * 2001-12-11 2003-06-19 Sepracor, Inc. 4-substituted piperidines, and methods of use thereof
ES2392340T3 (es) 2002-03-29 2012-12-07 Mitsubishi Tanabe Pharma Corporation Remedio para los trastornos del sueño
GB0221829D0 (en) * 2002-09-20 2002-10-30 Astrazeneca Ab Novel compound
GB0221828D0 (en) 2002-09-20 2002-10-30 Astrazeneca Ab Novel compound
DE10252666A1 (de) * 2002-11-11 2004-08-05 Grünenthal GmbH N-Piperidyl-cyclohexan-Derivate
DE10252665A1 (de) 2002-11-11 2004-06-03 Grünenthal GmbH 4-Aminomethyl-1-aryl-cyclohexylamin-Derivate
GB0315203D0 (en) * 2003-06-28 2003-08-06 Celltech R&D Ltd Chemical compounds
SA04250305B1 (ar) 2003-09-25 2008-06-02 سولفاي فارماسوتيكالز بي . في مشتقات بنزيميدازولون cenzimidazolone وكينازولينون quinazolinone كمساعادات على مستقبلات ORL1 البشرية
GB0328243D0 (en) * 2003-12-05 2004-01-07 Astrazeneca Ab Methods
US20050228023A1 (en) * 2003-12-19 2005-10-13 Sri International Agonist and antagonist ligands of the nociceptin receptor
US20080021069A1 (en) * 2004-10-08 2008-01-24 Takeda Pharmaceutical Company Limited Receptor Function Regulating Agent
WO2006074991A1 (en) 2005-01-11 2006-07-20 Neurosearch A/S Novel 2-amino benzimidazole derivatives and their use as modulators of small-conductance calcium-activated potassium channels
CA2654666A1 (en) * 2006-07-03 2008-01-10 Neurosearch A/S Pharmaceutical compositions
NZ601683A (en) * 2007-01-16 2012-11-30 Shionogi & Co Heterocyclic-substituted piperidine compounds for modulating ORL-1 receptor function in a cell
KR20140139125A (ko) 2007-08-31 2014-12-04 퍼듀 퍼머 엘피 치환-퀴녹살린-형 피페리딘 화합물 및 그의 용도
US8119661B2 (en) * 2007-09-11 2012-02-21 Astrazeneca Ab Piperidine derivatives and their use as muscarinic receptor modulators
BRPI0911031B8 (pt) 2008-07-21 2021-05-25 Purdue Pharma Lp compostos de piperidina ligada do tipo quinoxalina substituídos e os usos destes
JP5795635B2 (ja) 2010-08-05 2015-10-14 アムジェン インコーポレイテッド 未分化リンパ腫キナーゼを阻害するベンゾイミダゾール化合物およびアザベンゾイミダゾール化合物
WO2013103598A2 (en) 2012-01-06 2013-07-11 Novus International Inc. Sulfoxide-based surfactants
WO2013119955A1 (en) 2012-02-09 2013-08-15 Novus International Inc. Functionalized polymer compositions
JO3300B1 (ar) 2012-06-06 2018-09-16 Novartis Ag مركبات وتركيبات لتعديل نشاط egfr
CN107753462B (zh) 2012-07-12 2021-01-08 诺华丝国际股份有限公司 用于保护生物活性剂的基质和层组合物
US9085561B2 (en) * 2012-07-30 2015-07-21 Purdue Pharma L.P. Cyclic urea- or lactam-substituted quinoxaline-type piperidines as ORL-1 modulators
US9090618B2 (en) 2012-12-27 2015-07-28 Purdue Pharma L.P. Substituted benzimidazole-type piperidine compounds and uses thereof
US9656994B2 (en) 2013-03-22 2017-05-23 The Scripps Research Institute Substituted benzimidazoles as nociceptin receptor modulators
KR102663309B1 (ko) 2014-03-20 2024-05-03 카펠라 테라퓨틱스, 인크. 암 치료용의 erbb 티로신 키나제 억제제로서의 벤즈이미다졸 유도체
BR112018009627A8 (pt) 2015-11-12 2019-02-26 Novus Int Inc compostos contendo enxofre como solventes
US10584306B2 (en) 2017-08-11 2020-03-10 Board Of Regents Of The University Of Oklahoma Surfactant microemulsions

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3318900A (en) * 1964-05-06 1967-05-09 Janssen Pharmaceutica Nv Derivatives of benzimidazolinyl piperidine
JPS5297978A (en) * 1976-06-02 1977-08-17 Yoshitomi Pharmaceut Ind Ltd Preparation of alicyclic derivatives
US5821219A (en) 1995-08-11 1998-10-13 Oregon Health Sciences University Opioid antagonists and methods of their use
ATE233812T1 (de) 1995-08-15 2003-03-15 Euroscreen Sa Peptide mit pronociceptiveigenschaften
US5866346A (en) 1995-09-27 1999-02-02 Indiana Unversity Foundation Methods of using dynorphins as ligands for XOR1 receptor
ATE341542T1 (de) * 1996-04-19 2006-10-15 Neurosearch As 1-(4-piperidyl)-benzimidazole mit neurotropher aktivität
EP0813065A3 (en) 1996-06-13 1998-07-22 F. Hoffmann-La Roche Ag Modulation of LC132 (opioid-like) receptor function
EP0829481A1 (en) * 1996-09-16 1998-03-18 Pfizer Inc. Morphinan hydroxamic acid compounds
US5718912A (en) * 1996-10-28 1998-02-17 Merck & Co., Inc. Muscarine agonists
US6258825B1 (en) 1997-05-30 2001-07-10 Banyu Pharmaceutical Co., Ltd. 2-oxoimidazole derivatives
WO1999003880A1 (en) 1997-07-15 1999-01-28 Novo Nordisk A/S Nociceptin analogues
US5929035A (en) 1998-04-14 1999-07-27 Regents Of The University Of Michigan Methods of treating intestinal disorders
ID29137A (id) 1998-07-27 2001-08-02 Schering Corp Ligan-ligan afinitas tinggi untuk reseptor nosiseptin orl-1

Also Published As

Publication number Publication date
GEP20033000B (en) 2003-06-25
NO20010603L (no) 2001-04-05
HUP0103567A2 (hu) 2002-02-28
AP2001002063A0 (en) 2001-03-31
EA200100104A1 (ru) 2001-08-27
IL141029A0 (en) 2002-02-10
BR9912778A (pt) 2001-09-25
JP2002522431A (ja) 2002-07-23
WO2000008013A3 (en) 2000-03-23
DE69903953T2 (de) 2003-03-27
DE69903953D1 (de) 2002-12-19
JP3367945B2 (ja) 2003-01-20
PA8477701A1 (es) 2000-09-29
EP1102762B1 (en) 2002-11-13
IS5812A (is) 2001-01-16
OA11590A (en) 2004-08-18
WO2000008013A2 (en) 2000-02-17
PE20000868A1 (es) 2000-08-31
EE200100075A (et) 2002-06-17
AR018686A1 (es) 2001-11-28
DK1102762T3 (da) 2002-12-16
AU749166B2 (en) 2002-06-20
HN1999000105A (es) 2000-11-11
NO20010603D0 (no) 2001-02-05
ID27212A (id) 2001-03-08
GT199900125A (es) 2001-01-27
CZ2001397A3 (cs) 2002-05-15
PL346211A1 (en) 2002-01-28
MA26659A1 (fr) 2004-12-20
CN1317968A (zh) 2001-10-17
SV1999000099A (es) 2000-09-05
CA2339621A1 (en) 2000-02-17
ATE227716T1 (de) 2002-11-15
HUP0103567A3 (en) 2003-01-28
SK1602001A3 (en) 2002-09-10
TR200100403T2 (tr) 2001-07-23
AU4385999A (en) 2000-02-28
ES2185357T3 (es) 2003-04-16
US6172067B1 (en) 2001-01-09
NZ509299A (en) 2003-05-30
UY25659A1 (es) 2000-02-23
CA2339621C (en) 2005-04-05
PT1102762E (pt) 2003-02-28
HRP20010089A2 (en) 2002-02-28
BG105301A (en) 2001-12-29
ZA200100900B (en) 2002-08-28
TNSN99142A1 (fr) 2005-11-10
YU8201A (sh) 2003-07-07
HK1040188A1 (zh) 2002-05-31
SI1102762T1 (sl) 2003-04-30
EP1102762A2 (en) 2001-05-30
TW513424B (en) 2002-12-11

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