HN2010002157A - Antagonistas de la trayectoria hedgehog de ftalazina disustituida - Google Patents
Antagonistas de la trayectoria hedgehog de ftalazina disustituidaInfo
- Publication number
- HN2010002157A HN2010002157A HN2010002157A HN2010002157A HN2010002157A HN 2010002157 A HN2010002157 A HN 2010002157A HN 2010002157 A HN2010002157 A HN 2010002157A HN 2010002157 A HN2010002157 A HN 2010002157A HN 2010002157 A HN2010002157 A HN 2010002157A
- Authority
- HN
- Honduras
- Prior art keywords
- hedgehog
- antagonists
- ftalazina
- disttituted
- history
- Prior art date
Links
- 241000027355 Ferocactus setispinus Species 0.000 title abstract 3
- 239000005557 antagonist Substances 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000024245 cell differentiation Effects 0.000 abstract 1
- 230000004663 cell proliferation Effects 0.000 abstract 1
- 230000011664 signaling Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 230000030968 tissue homeostasis Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4872908P | 2008-04-29 | 2008-04-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HN2010002157A true HN2010002157A (es) | 2014-09-08 |
Family
ID=40846962
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HN2010002157A HN2010002157A (es) | 2008-04-29 | 2010-10-21 | Antagonistas de la trayectoria hedgehog de ftalazina disustituida |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US7981892B2 (https=) |
| EP (1) | EP2294061A2 (https=) |
| JP (1) | JP5442717B2 (https=) |
| KR (1) | KR101260116B1 (https=) |
| CN (1) | CN102066353B (https=) |
| AU (1) | AU2009241561B2 (https=) |
| BR (1) | BRPI0911618A2 (https=) |
| CA (1) | CA2723042A1 (https=) |
| CO (1) | CO6300945A2 (https=) |
| CR (1) | CR11741A (https=) |
| DO (1) | DOP2010000302A (https=) |
| EA (1) | EA201071248A1 (https=) |
| EC (1) | ECSP10010577A (https=) |
| HN (1) | HN2010002157A (https=) |
| IL (1) | IL208211A0 (https=) |
| MA (1) | MA32349B1 (https=) |
| MX (1) | MX2010011948A (https=) |
| MY (1) | MY159491A (https=) |
| NZ (1) | NZ588001A (https=) |
| UA (1) | UA102250C2 (https=) |
| WO (1) | WO2009134574A2 (https=) |
| ZA (1) | ZA201006695B (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA102250C2 (ru) | 2008-04-29 | 2013-06-25 | Эли Лилли Энд Компани | Двухзамещенные фталазины - антагонисты проводящего пути hedgehog |
| MX2011004683A (es) | 2008-11-03 | 2011-06-20 | Lilly Co Eli | Antagonistas de la via hedgehog de ftalazina disustituida. |
| KR101342184B1 (ko) | 2008-11-17 | 2013-12-19 | 일라이 릴리 앤드 캄파니 | 사치환된 피리다진 헷지호그 경로 길항제 |
| BRPI0921777A2 (pt) | 2008-11-17 | 2016-01-12 | Lilly Co Eli | antagonistas da via hedgehog de piridazina tetrassubstituída |
| AR077014A1 (es) * | 2009-06-19 | 2011-07-27 | Lilly Co Eli | Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer |
| KR20120107962A (ko) * | 2009-11-18 | 2012-10-04 | 노파르티스 아게 | 고형 종양 및 다른 악성종양의 치료를 위한 방법 및 조성물 |
| CN102702108A (zh) * | 2012-06-27 | 2012-10-03 | 上海大学 | 1,2-二氢酞嗪类化合物及其合成方法 |
| WO2014043608A2 (en) * | 2012-09-17 | 2014-03-20 | Duke University | Smoothened modulators and methods of use thereof |
| CN102863393A (zh) * | 2012-09-26 | 2013-01-09 | 上海大学 | 1,2-二氢酞嗪类化合物及其合成方法 |
| GB201309508D0 (en) * | 2013-05-28 | 2013-07-10 | Redx Pharma Ltd | Compounds |
| GB2528298A (en) * | 2014-07-16 | 2016-01-20 | Redx Pharma Plc | Compounds |
| CN105985320B (zh) * | 2015-02-11 | 2018-10-26 | 复旦大学 | 苄基酞嗪化合物及其制备方法和用途 |
| CN105985319B (zh) * | 2015-02-11 | 2019-02-26 | 复旦大学 | 芳基酞嗪化合物及其制备方法和用途 |
| CN105985321B (zh) * | 2015-02-11 | 2018-10-26 | 复旦大学 | 吡唑酞嗪化合物及其制备方法和用途 |
| CN107163028B (zh) * | 2017-05-24 | 2019-07-12 | 东南大学 | 一种苯甲酰胺类Hedgehog抑制剂及其制备方法和应用 |
| US12605377B2 (en) | 2020-10-13 | 2026-04-21 | Endeavor Biomedicines, Inc. | Methods of treating fibrosis |
| JP2023546536A (ja) | 2020-10-13 | 2023-11-02 | エンデバー バイオメディシンズ， インコーポレイテッド | 線維症を処置する方法 |
| IL319619A (en) * | 2022-09-23 | 2025-05-01 | Merck Sharp & Dohme Llc | Phthalazine derivatives used as NOD-LIKE PROTEIN 3 receptor inhibitors |
| WO2025188802A1 (en) | 2024-03-05 | 2025-09-12 | Endeavor Biomedicines, Inc. | Methods of improving lung function |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1293565A (en) * | 1969-05-03 | 1972-10-18 | Aspro Nicholas Ltd | Aminophthalazines and pharmaceutical compositions thereof |
| MY117098A (en) * | 1996-01-15 | 2004-05-31 | Janssen Pharmaceutica Nv | Angiogenesis inhibiting pyridazinamines |
| US6432970B2 (en) * | 1998-04-09 | 2002-08-13 | Johns Hopkins University School Of Medicine | Inhibitors of hedgehog signaling pathways, compositions and uses related thereto |
| JP5067986B2 (ja) | 1998-04-09 | 2012-11-07 | ジョンズ ホプキンズ ユニヴァーシティー スクール オブ メディシン | ヘッジホッグシグナリング経路の阻害剤としてのステロイドアルカロイド誘導体の使用 |
| ATE283700T1 (de) | 1999-06-08 | 2004-12-15 | Lorantis Ltd | Therapeutische verwendung eines inhibitors des hedgehog signalübertragungsweges |
| EP1496905B1 (en) | 2002-04-22 | 2008-08-13 | Johns Hopkins University School of Medicine | Modulators of hedgehog signaling pathways, compositions and uses related thereto |
| WO2004020599A2 (en) | 2002-08-29 | 2004-03-11 | Curis, Inc. | Hedgehog antagonists, methods and uses related thereto |
| WO2005033288A2 (en) * | 2003-09-29 | 2005-04-14 | The Johns Hopkins University | Hedgehog pathway antagonists |
| TW200533356A (en) | 2004-02-24 | 2005-10-16 | Mitsubishi Pharma Corp | Fused pyridazine derivatives |
| WO2006004589A2 (en) | 2004-05-08 | 2006-01-12 | Neurogen Corporation | 3-aryl-5,6-disubstituted pyridazines |
| ES2377430T3 (es) | 2004-09-02 | 2012-03-27 | Genentech, Inc. | Inhibidores piridílicos de la señalización de hedgehog |
| EP1900731A1 (de) | 2006-09-07 | 2008-03-19 | Bayer Schering Pharma Aktiengesellschaft | N-(1-Phthalazin-1-yl-piperidin-4-yl)-amide als EP2-Rezeptor Modulatoren |
| CA2681162C (en) | 2007-03-15 | 2015-11-24 | Novartis Ag | Benzyl and pyridine derivatives as modulators of hedgehog pathway |
| US8153633B2 (en) * | 2007-06-25 | 2012-04-10 | Amgen Inc. | Phthalazine compounds, compositions and methods of use |
| US8222251B2 (en) | 2007-09-07 | 2012-07-17 | Amgen Inc. | Pyridopyridazine compounds, compositions and methods of use |
| UA102250C2 (ru) | 2008-04-29 | 2013-06-25 | Эли Лилли Энд Компани | Двухзамещенные фталазины - антагонисты проводящего пути hedgehog |
| US20100041663A1 (en) | 2008-07-18 | 2010-02-18 | Novartis Ag | Organic Compounds as Smo Inhibitors |
| MX2011004683A (es) | 2008-11-03 | 2011-06-20 | Lilly Co Eli | Antagonistas de la via hedgehog de ftalazina disustituida. |
| BRPI0921777A2 (pt) | 2008-11-17 | 2016-01-12 | Lilly Co Eli | antagonistas da via hedgehog de piridazina tetrassubstituída |
| KR101342184B1 (ko) | 2008-11-17 | 2013-12-19 | 일라이 릴리 앤드 캄파니 | 사치환된 피리다진 헷지호그 경로 길항제 |
| AR077014A1 (es) * | 2009-06-19 | 2011-07-27 | Lilly Co Eli | Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer |
-
2009
- 2009-04-01 UA UAA201012722A patent/UA102250C2/ru unknown
- 2009-04-01 EP EP09739376A patent/EP2294061A2/en not_active Withdrawn
- 2009-04-01 AU AU2009241561A patent/AU2009241561B2/en not_active Ceased
- 2009-04-01 WO PCT/US2009/039065 patent/WO2009134574A2/en not_active Ceased
- 2009-04-01 MY MYPI2010005097A patent/MY159491A/en unknown
- 2009-04-01 CN CN2009801152085A patent/CN102066353B/zh not_active Expired - Fee Related
- 2009-04-01 JP JP2011507512A patent/JP5442717B2/ja not_active Expired - Fee Related
- 2009-04-01 KR KR1020107024209A patent/KR101260116B1/ko not_active Expired - Fee Related
- 2009-04-01 EA EA201071248A patent/EA201071248A1/ru unknown
- 2009-04-01 CA CA2723042A patent/CA2723042A1/en not_active Abandoned
- 2009-04-01 MX MX2010011948A patent/MX2010011948A/es active IP Right Grant
- 2009-04-01 BR BRPI0911618A patent/BRPI0911618A2/pt not_active IP Right Cessation
- 2009-04-01 US US12/935,655 patent/US7981892B2/en not_active Expired - Fee Related
- 2009-04-01 NZ NZ588001A patent/NZ588001A/en not_active IP Right Cessation
-
2010
- 2010-09-16 IL IL208211A patent/IL208211A0/en unknown
- 2010-09-17 ZA ZA2010/06695A patent/ZA201006695B/en unknown
- 2010-10-11 DO DO2010000302A patent/DOP2010000302A/es unknown
- 2010-10-15 CR CR11741A patent/CR11741A/es unknown
- 2010-10-21 HN HN2010002157A patent/HN2010002157A/es unknown
- 2010-10-25 MA MA33284A patent/MA32349B1/fr unknown
- 2010-10-27 EC EC2010010577A patent/ECSP10010577A/es unknown
- 2010-11-11 CO CO10141824A patent/CO6300945A2/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2723042A1 (en) | 2009-11-05 |
| CR11741A (es) | 2011-01-05 |
| EA201071248A1 (ru) | 2011-06-30 |
| MX2010011948A (es) | 2010-12-14 |
| MY159491A (en) | 2017-01-13 |
| CN102066353B (zh) | 2013-12-11 |
| AU2009241561A1 (en) | 2009-11-05 |
| CN102066353A (zh) | 2011-05-18 |
| US7981892B2 (en) | 2011-07-19 |
| NZ588001A (en) | 2012-06-29 |
| UA102250C2 (ru) | 2013-06-25 |
| JP2011527666A (ja) | 2011-11-04 |
| ECSP10010577A (es) | 2010-11-30 |
| EP2294061A2 (en) | 2011-03-16 |
| WO2009134574A3 (en) | 2014-09-04 |
| KR101260116B1 (ko) | 2013-05-02 |
| WO2009134574A2 (en) | 2009-11-05 |
| US20110046143A1 (en) | 2011-02-24 |
| ZA201006695B (en) | 2012-09-26 |
| CO6300945A2 (es) | 2011-07-21 |
| KR20100126580A (ko) | 2010-12-01 |
| AU2009241561B2 (en) | 2013-05-16 |
| DOP2010000302A (es) | 2010-11-15 |
| MA32349B1 (fr) | 2011-06-01 |
| IL208211A0 (en) | 2010-12-30 |
| JP5442717B2 (ja) | 2014-03-12 |
| BRPI0911618A2 (pt) | 2019-09-24 |
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