CL2019002067A1 - Isoquinolin-3-il-carboxamidas, y preparación y uso de las mismas. (divisional solicitud 201803050). - Google Patents

Isoquinolin-3-il-carboxamidas, y preparación y uso de las mismas. (divisional solicitud 201803050).

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Publication number
CL2019002067A1
CL2019002067A1 CL2019002067A CL2019002067A CL2019002067A1 CL 2019002067 A1 CL2019002067 A1 CL 2019002067A1 CL 2019002067 A CL2019002067 A CL 2019002067A CL 2019002067 A CL2019002067 A CL 2019002067A CL 2019002067 A1 CL2019002067 A1 CL 2019002067A1
Authority
CL
Chile
Prior art keywords
influenza
isoquinolin
carboxamides
preparation
divisional application
Prior art date
Application number
CL2019002067A
Other languages
English (en)
Inventor
Sunil Kumar Kc
Gopi Kumar Mittapalli
Brian Joseph Hofilena
Joseph Timothy Marakovits
Chandramouli Chiruta
Chi Ching Mak
Jianguo Cao
Original Assignee
Samumed Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Samumed Llc filed Critical Samumed Llc
Publication of CL2019002067A1 publication Critical patent/CL2019002067A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/02—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

SE DIVULGAN COMPUESTOS DE ISOQUINOLINA PARA TRATAR DIVERSAS ENFERMEDADES Y PATOLOGÍAS, TALES COMO TRASTORNOS CARACTERIZADOS POR LA ACTIVACIÓN DE LA SEÑALIZACIÓN DE LA VÍA WNT (COMO CÁNCER, PROLIFERACIÓN CELULAR ANORMAL, ANGIOGÉNESIS, ENFERMEDAD DE ALZHEIMER, ENFERMEDAD PULMONAR, INFLAMACIÓN, ENFERMEDADES AUTOINMUNITARIAS Y ARTROSIS), LA MODULACIÓN DE EVENTOS CELULARES MEDIADOS POR DICHA VÍA, ASÍ COMO AFECCIONES/TRASTORNOS/ENFERMEDADES NEUROLÓGICOS RELACIONADOS CON LA SOBREEXPRESIÓN DE DYRK1A.
CL2019002067A 2016-04-27 2019-07-24 Isoquinolin-3-il-carboxamidas, y preparación y uso de las mismas. (divisional solicitud 201803050). CL2019002067A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662328210P 2016-04-27 2016-04-27

Publications (1)

Publication Number Publication Date
CL2019002067A1 true CL2019002067A1 (es) 2020-07-10

Family

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Family Applications (2)

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CL2018003050A CL2018003050A1 (es) 2016-04-27 2018-10-26 Isoquinolin-3-il-carboxamidas, y preparación y uso de las mismas.
CL2019002067A CL2019002067A1 (es) 2016-04-27 2019-07-24 Isoquinolin-3-il-carboxamidas, y preparación y uso de las mismas. (divisional solicitud 201803050).

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CL2018003050A CL2018003050A1 (es) 2016-04-27 2018-10-26 Isoquinolin-3-il-carboxamidas, y preparación y uso de las mismas.

Country Status (19)

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US (5) US10508099B2 (es)
EP (2) EP3943086A1 (es)
JP (1) JP7023243B2 (es)
KR (1) KR102399206B1 (es)
CN (1) CN109311819B (es)
AR (1) AR108326A1 (es)
AU (1) AU2017258187B2 (es)
BR (1) BR112018072190A2 (es)
CA (1) CA3022044A1 (es)
CL (2) CL2018003050A1 (es)
CO (1) CO2018012655A2 (es)
IL (1) IL262495B (es)
MA (1) MA43605B1 (es)
MX (1) MX2018013173A (es)
PE (1) PE20190260A1 (es)
PH (1) PH12018502259A1 (es)
RU (1) RU2018141379A (es)
SG (2) SG10201914127PA (es)
WO (1) WO2017189823A2 (es)

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MX2018013173A (es) 2019-02-13
KR20190012167A (ko) 2019-02-08
US10508099B2 (en) 2019-12-17
RU2018141379A (ru) 2020-05-28
US11174244B2 (en) 2021-11-16
PH12018502259A1 (en) 2019-06-10
IL262495A (en) 2018-12-31
US10556885B2 (en) 2020-02-11
EP3943086A1 (en) 2022-01-26
US10287267B2 (en) 2019-05-14
EP3448838B1 (en) 2021-08-11
US20230104155A1 (en) 2023-04-06
AU2017258187B2 (en) 2021-08-26
CA3022044A1 (en) 2017-11-02
CL2018003050A1 (es) 2019-01-25
US20170313681A1 (en) 2017-11-02
EP3448838A4 (en) 2019-12-25
WO2017189823A2 (en) 2017-11-02
JP7023243B2 (ja) 2022-02-21
PE20190260A1 (es) 2019-02-25
CN109311819B (zh) 2022-10-25
IL262495B (en) 2021-12-01
US11673881B2 (en) 2023-06-13
US20200339536A1 (en) 2020-10-29
CN109311819A (zh) 2019-02-05
SG11201809310PA (en) 2018-11-29
SG10201914127PA (en) 2020-02-27
CO2018012655A2 (es) 2019-04-30
US20180222887A1 (en) 2018-08-09
JP2019515931A (ja) 2019-06-13
AR108326A1 (es) 2018-08-08
US20180208580A1 (en) 2018-07-26
MA43605B1 (fr) 2020-10-28
BR112018072190A2 (pt) 2019-02-12
WO2017189823A3 (en) 2018-02-08
EP3448838A2 (en) 2019-03-06
RU2018141379A3 (es) 2020-08-13
MA43605A1 (fr) 2020-04-30
AU2017258187A1 (en) 2018-11-15
KR102399206B1 (ko) 2022-05-17

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