MA43605B1 - Isoquinolin-3-yl carboxamides et préparation et utilisation de ceux-ci - Google Patents

Isoquinolin-3-yl carboxamides et préparation et utilisation de ceux-ci

Info

Publication number
MA43605B1
MA43605B1 MA43605A MA43605A MA43605B1 MA 43605 B1 MA43605 B1 MA 43605B1 MA 43605 A MA43605 A MA 43605A MA 43605 A MA43605 A MA 43605A MA 43605 B1 MA43605 B1 MA 43605B1
Authority
MA
Morocco
Prior art keywords
isoquinolin
carboxamides
preparation
disease
treatment
Prior art date
Application number
MA43605A
Other languages
English (en)
Other versions
MA43605A1 (fr
Inventor
Sunil Kumar Kc
Gopi Kumar Mittapalli
Brian Joseph Hofilena
Chi Ching Mak
Joseph Timothy Marakovits
Chandramouli Chiruta
Jianguo Cao
Original Assignee
Samumed Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Samumed Llc filed Critical Samumed Llc
Publication of MA43605A1 publication Critical patent/MA43605A1/fr
Publication of MA43605B1 publication Critical patent/MA43605B1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/02—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

L'invention concerne des composés d'isoquinoline pour le traitement de diverses maladies et pathologies. La présente invention concerne plus particulièrement l'utilisation d'un composé d'isoquinoline ou d'analogues de celui-ci dans le traitement de troubles caractérisés par l'activation de la signalisation de la voie des wnt (par ex., le cancer, une prolifération cellulaire anormale, l'angiogenèse, la maladie d'alzheimer, la pneumopathie, l'inflammation, les maladies auti-immunes et l'arthrose), la modula
MA43605A 2016-04-27 2017-04-27 Isoquinolin-3-yl carboxamides et préparation et utilisation de ceux-ci MA43605B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662328210P 2016-04-27 2016-04-27
PCT/US2017/029797 WO2017189823A2 (fr) 2016-04-27 2017-04-27 Isoquinolin-3-yl carboxamides et préparation et utilisation de ceux-ci

Publications (2)

Publication Number Publication Date
MA43605A1 MA43605A1 (fr) 2020-04-30
MA43605B1 true MA43605B1 (fr) 2020-10-28

Family

ID=60157342

Family Applications (1)

Application Number Title Priority Date Filing Date
MA43605A MA43605B1 (fr) 2016-04-27 2017-04-27 Isoquinolin-3-yl carboxamides et préparation et utilisation de ceux-ci

Country Status (19)

Country Link
US (5) US10508099B2 (fr)
EP (2) EP3943086A1 (fr)
JP (1) JP7023243B2 (fr)
KR (1) KR102399206B1 (fr)
CN (1) CN109311819B (fr)
AR (1) AR108326A1 (fr)
AU (1) AU2017258187B2 (fr)
BR (1) BR112018072190A2 (fr)
CA (1) CA3022044A1 (fr)
CL (2) CL2018003050A1 (fr)
CO (1) CO2018012655A2 (fr)
IL (1) IL262495B (fr)
MA (1) MA43605B1 (fr)
MX (1) MX2018013173A (fr)
PE (1) PE20190260A1 (fr)
PH (1) PH12018502259A1 (fr)
RU (1) RU2018141379A (fr)
SG (2) SG10201914127PA (fr)
WO (1) WO2017189823A2 (fr)

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AR108326A1 (es) 2016-04-27 2018-08-08 Samumed Llc Isoquinolin-3-il carboxamidas y preparación y uso de las mismas
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WO2019084497A1 (fr) 2017-10-27 2019-05-02 Samumed, Llc 6-(hétéroaryle et aryle à 6 chaînons)isoquinolin-3-yl carboxamides, leur préparation et leur utilisation
WO2019084496A1 (fr) 2017-10-27 2019-05-02 Samumed, Llc 6-(hétéroaryle à 5 chaînons)isoquinolin-3-yl-(hétéroaryle à 5 chaînons)carboxamides, leur préparation et leur utilisation
US10703748B2 (en) 2017-10-31 2020-07-07 Samumed, Llc Diazanaphthalen-3-yl carboxamides and preparation and use thereof
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Also Published As

Publication number Publication date
CA3022044A1 (fr) 2017-11-02
MA43605A1 (fr) 2020-04-30
SG10201914127PA (en) 2020-02-27
IL262495A (en) 2018-12-31
CO2018012655A2 (es) 2019-04-30
JP7023243B2 (ja) 2022-02-21
CL2018003050A1 (es) 2019-01-25
KR20190012167A (ko) 2019-02-08
BR112018072190A2 (pt) 2019-02-12
KR102399206B1 (ko) 2022-05-17
CN109311819A (zh) 2019-02-05
US10556885B2 (en) 2020-02-11
SG11201809310PA (en) 2018-11-29
US20170313681A1 (en) 2017-11-02
WO2017189823A2 (fr) 2017-11-02
MX2018013173A (es) 2019-02-13
IL262495B (en) 2021-12-01
RU2018141379A3 (fr) 2020-08-13
AR108326A1 (es) 2018-08-08
US10287267B2 (en) 2019-05-14
JP2019515931A (ja) 2019-06-13
PH12018502259A1 (en) 2019-06-10
CL2019002067A1 (es) 2020-07-10
AU2017258187B2 (en) 2021-08-26
EP3448838B1 (fr) 2021-08-11
RU2018141379A (ru) 2020-05-28
US10508099B2 (en) 2019-12-17
US20180208580A1 (en) 2018-07-26
US20200339536A1 (en) 2020-10-29
US20180222887A1 (en) 2018-08-09
US11174244B2 (en) 2021-11-16
PE20190260A1 (es) 2019-02-25
US20230104155A1 (en) 2023-04-06
EP3448838A2 (fr) 2019-03-06
CN109311819B (zh) 2022-10-25
AU2017258187A1 (en) 2018-11-15
WO2017189823A3 (fr) 2018-02-08
EP3943086A1 (fr) 2022-01-26
US11673881B2 (en) 2023-06-13
EP3448838A4 (fr) 2019-12-25

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