HN2010002121A - 2,6-diamino-pirimidin-5-il-carboxamidas como inhibidores de syk o jak - Google Patents
2,6-diamino-pirimidin-5-il-carboxamidas como inhibidores de syk o jakInfo
- Publication number
- HN2010002121A HN2010002121A HN2010002121A HN2010002121A HN2010002121A HN 2010002121 A HN2010002121 A HN 2010002121A HN 2010002121 A HN2010002121 A HN 2010002121A HN 2010002121 A HN2010002121 A HN 2010002121A HN 2010002121 A HN2010002121 A HN 2010002121A
- Authority
- HN
- Honduras
- Prior art keywords
- syk
- compounds
- group
- diseases
- quinasa
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
LA INVENCION SE REFIERE A COMPUESTOS DE FORMULA I-V Y TAUTOMEROS CORRESPONDIENTES O SALES FARMACEUTICAMENTE ACEPTADAS ESTERES Y PROFARMACOS CORRESPONDIENTES QUE ACTUAN COMO INHIBIDORES DE QUINASA SYK. LA PRESENTE INVENCION TAMBIEN ESTA DIRIGIDA A INTERMEDIARIOSN UTILIZADOS EN LA ELABORACION DE DICHOS COMPUESTOS, LA PREPARACION DE DICHOS COMPUESTOS, COMPOSICIONES FARMACEUTICAS QUE CONTIENEN DICHOS COMPUESTOS METODOS PARA INHIBIR LA ACTIVADA DE QUINASA SYK, METODOS PARA INHIBIR LA ACUMULACION DE PLAQUETAS Y METODOS PARA PREVENIR O TRATAR UNA CANTIDAD DE ENFERMEDADES MEDIADAS AL MENOS PARCIALMENTE POR ACTIVIDAD DE QUINASA SYK, COMO ENFERMEDADES CARDIOVASCULARES, ENFERMEDADES INFLAMATORIAS, ENFERMEDADES AUTOINMUNES Y TRASTORNOS PROLIFERACTIVOS DE CELULAS. LA FORMULA(I) Y1 ES SELECCIONADA DEL GRUPO QUE CONSISTE EN (a) Y (b), Z es O o S, D1 ES SELECCIONADA DEL GRUPO QUE CONCISTE EN (a) FENILO SUSTITUIDO POR UN GRUPO,R5(b) NAFTILO(c) C3-8 CICLOALQUILO (d) HETEROARILO(e) HETEROCICLOLO.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4549908P | 2008-04-16 | 2008-04-16 | |
US4540608P | 2008-04-16 | 2008-04-16 | |
US4539908P | 2008-04-16 | 2008-04-16 | |
US12034108P | 2008-12-05 | 2008-12-05 | |
US12034608P | 2008-12-05 | 2008-12-05 | |
US12034808P | 2008-12-05 | 2008-12-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
HN2010002121A true HN2010002121A (es) | 2013-06-17 |
Family
ID=41696952
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HN2010002121A HN2010002121A (es) | 2008-04-16 | 2010-10-15 | 2,6-diamino-pirimidin-5-il-carboxamidas como inhibidores de syk o jak |
Country Status (16)
Country | Link |
---|---|
US (5) | US8063058B2 (es) |
AU (1) | AU2009244897B2 (es) |
BR (1) | BRPI0910921B1 (es) |
CO (1) | CO6331450A2 (es) |
EA (1) | EA019973B1 (es) |
EC (1) | ECSP10010608A (es) |
ES (1) | ES2546502T3 (es) |
GT (1) | GT201000299A (es) |
HK (1) | HK1155452A1 (es) |
HN (1) | HN2010002121A (es) |
IL (1) | IL208638A (es) |
MX (1) | MX2010011463A (es) |
NI (1) | NI201000175A (es) |
NZ (1) | NZ589315A (es) |
PT (1) | PT2323993E (es) |
ZA (1) | ZA201007046B (es) |
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US20120130073A1 (en) | 2012-05-24 |
GT201000299A (es) | 2015-02-09 |
US20150297595A1 (en) | 2015-10-22 |
US20100048567A1 (en) | 2010-02-25 |
US20120101275A1 (en) | 2012-04-26 |
US8063058B2 (en) | 2011-11-22 |
EA019973B1 (ru) | 2014-07-30 |
AU2009244897A1 (en) | 2009-11-12 |
NI201000175A (es) | 2011-08-08 |
US20130165431A1 (en) | 2013-06-27 |
US8349860B2 (en) | 2013-01-08 |
CO6331450A2 (es) | 2011-10-20 |
HK1155452A1 (en) | 2012-05-18 |
PT2323993E (pt) | 2015-10-12 |
NZ589315A (en) | 2012-11-30 |
IL208638A (en) | 2017-03-30 |
US9579320B2 (en) | 2017-02-28 |
ES2546502T3 (es) | 2015-09-24 |
ECSP10010608A (es) | 2011-02-28 |
US8318755B2 (en) | 2012-11-27 |
AU2009244897A2 (en) | 2011-01-20 |
US8952027B2 (en) | 2015-02-10 |
AU2009244897B2 (en) | 2014-11-13 |
EA201001618A1 (ru) | 2011-06-30 |
IL208638A0 (en) | 2010-12-30 |
ZA201007046B (en) | 2013-09-25 |
BRPI0910921A2 (pt) | 2021-04-20 |
BRPI0910921B1 (pt) | 2022-06-21 |
MX2010011463A (es) | 2011-06-03 |
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