HK94387A - Novel antihistamines, process for their preparation and pharmaceutical compositions containing them - Google Patents

Novel antihistamines, process for their preparation and pharmaceutical compositions containing them

Info

Publication number
HK94387A
HK94387A HK943/87A HK94387A HK94387A HK 94387 A HK94387 A HK 94387A HK 943/87 A HK943/87 A HK 943/87A HK 94387 A HK94387 A HK 94387A HK 94387 A HK94387 A HK 94387A
Authority
HK
Hong Kong
Prior art keywords
group
alkyl
compounds
formula
pyridine
Prior art date
Application number
HK943/87A
Other languages
German (de)
English (en)
French (fr)
Inventor
Frank J. Villani
Original Assignee
Schering Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22578489&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK94387(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corporation filed Critical Schering Corporation
Publication of HK94387A publication Critical patent/HK94387A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
HK943/87A 1980-06-19 1987-12-10 Novel antihistamines, process for their preparation and pharmaceutical compositions containing them HK94387A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06160795 US4282233B1 (en) 1980-06-19 1980-06-19 Antihistaminic 11-(4-piperidylidene)-5h-benzoÄ5,6Ü-cyclohepta-Ä1,2Ü-pyridines

Publications (1)

Publication Number Publication Date
HK94387A true HK94387A (en) 1987-12-18

Family

ID=22578489

Family Applications (1)

Application Number Title Priority Date Filing Date
HK943/87A HK94387A (en) 1980-06-19 1987-12-10 Novel antihistamines, process for their preparation and pharmaceutical compositions containing them

Country Status (25)

Country Link
US (1) US4282233B1 (cs)
EP (1) EP0042544B1 (cs)
JP (1) JPS5735586A (cs)
KR (1) KR850000744B1 (cs)
AT (1) ATE9695T1 (cs)
AU (1) AU543054B2 (cs)
CA (1) CA1160230A (cs)
CY (1) CY1405A (cs)
DE (1) DE3166441D1 (cs)
DK (1) DK169817B1 (cs)
ES (1) ES503085A0 (cs)
FI (1) FI70213C (cs)
HK (1) HK94387A (cs)
HU (1) HU186774B (cs)
IE (1) IE51303B1 (cs)
IL (1) IL63122A (cs)
KE (1) KE3758A (cs)
LU (1) LU88359I2 (cs)
MY (1) MY8700761A (cs)
NL (1) NL930094I2 (cs)
NZ (1) NZ197435A (cs)
PH (1) PH19252A (cs)
PT (1) PT73200B (cs)
SG (1) SG70587G (cs)
ZA (1) ZA814062B (cs)

Families Citing this family (125)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU195800B (en) * 1983-10-13 1988-07-28 Sandoz Ltd Process for producing 4h-benzo/4,5/cylopenta/1,2-b/ thiofene derivatives and pharmaceutical compositions containing them
WO1985003707A1 (en) * 1984-02-15 1985-08-29 Schering Corporation 8-CHLORO-6,11-DIHYDRO-11-(4-PIPERIDYLIDENE)-5H-BENZO AD5,6 BDCYCLOHEPTA AD1,2-b BDPYRIDINE AND ITS SALTS, PROCESSES FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS
DE3677842D1 (de) * 1985-05-13 1991-04-11 Schering Corp Verfahren zur herstellung von piperidyliden-dihydrodibenzo(a,d)zykloheptenen und deren azoderivate, so hergestellte verbindungen und ihre anwendung zur vorbereitung von heilmitteln.
US4804666A (en) * 1985-08-14 1989-02-14 Schering Corporation Antiallergic 6,11-dihydro-11-(4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines
US5665726A (en) * 1986-10-31 1997-09-09 Schering Corporation Benzo[5,6]cycloheptapyridines, compositions and methods of use
US5089496A (en) * 1986-10-31 1992-02-18 Schering Corporation Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies
US4826853A (en) * 1986-10-31 1989-05-02 Schering Corporation 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use
US5438062A (en) * 1986-10-31 1995-08-01 Schering Corporation Benzo(5,6)cycloheptapyridines, compositions and methods of use
AU635400B2 (en) * 1986-10-31 1993-03-18 Schering Corporation Intermediates for producing benzo(5,6)cycloheptapyridines
ATE108453T1 (de) * 1988-04-28 1994-07-15 Schering Corp Benzopyridopiperidin, -piperidyliden und - piperazin-verbindungen, zusammensetzungen, methoden zur herstellung und verwendung.
US4912222A (en) * 1988-06-17 1990-03-27 Fisons Corporation Antihistamines related to cyproheptadine
US4863931A (en) * 1988-09-15 1989-09-05 Schering Corporation Antihistaminic fluoro substituted benzocycloheptapyridines
US4990535A (en) * 1989-05-03 1991-02-05 Schering Corporation Pharmaceutical composition comprising loratadine, ibuprofen and pseudoephedrine
CA2038417A1 (en) * 1990-04-11 1991-10-12 Yasuo Ito Piperidine compounds, method for preparation thereof, and a pharmaceutical composition comprising the same
NZ238629A (en) * 1990-06-22 1993-09-27 Schering Corp Bis-benzo- or benzopyrido-cyclohepta (where z is c, o, s or n) piperidine, piperidylidene or piperazine compounds, medicaments and methods of preparation
US5393753A (en) * 1990-10-10 1995-02-28 Schering Corporation Substituted imidazobenzazepines
JPH05506249A (ja) * 1990-10-10 1993-09-16 シェリング・コーポレーション ビスーベンゾシクロヘプタピペリジリデン、ピペリジンおよびピペラジン化合物、組成物および使用法
JPH06504772A (ja) * 1990-12-18 1994-06-02 ザ ウエルカム ファウンデーション リミテッド 抗癌剤の薬効を増強し抗多剤耐性を有する薬剤
KR920014799A (ko) * 1991-01-18 1992-08-25 나오가따 다이도 신규벤조[5,6]시클로헵타[1,2-b]피리딘 유도체 및 이를 함유하는 항알레르기제
EP0586560A1 (en) * 1991-05-23 1994-03-16 Schering Corporation Novel benzopyrido piperidylidene compounds, compositions, methods of manufacture and methods of use
EP0595989A1 (en) * 1991-07-23 1994-05-11 Schering Corporation Benzopyrido piperylidene compounds, compositions, methods of manufacture and methods of use
ES2040177B1 (es) * 1992-03-06 1994-05-16 S A Tamarang Procedimiento para la sintesis de la 8-cloro-6, 11-dihidro-11, (1-etoxicarbonil-4-piperidiliden) -5h-benzo (5,6) ciclohepta-(1,2-b) piridina.
JPH07505393A (ja) * 1992-03-27 1995-06-15 シェリング・コーポレーション 非橋渡しビスアリールカルビノール誘導体,組成物および使用法
JPH07505394A (ja) * 1992-03-27 1995-06-15 シェリング・コーポレーション 橋渡しビスアリールカルビノール誘導体,組成物および使用法
ES2042421B1 (es) * 1992-05-22 1994-08-01 Uriach & Cia Sa J Procedimiento para la obtencion de la 8-cloro-11-*1-*(5-metil-3-piridil)metil*-4-piperidiliden*-6,11-dihidro-5h-benzo*5,6*ciclohepta*1,2-b*piridina.
US5314697A (en) * 1992-10-23 1994-05-24 Schering Corporation Stable extended release oral dosage composition comprising loratadine and pseudoephedrine
US6676967B1 (en) 1993-09-20 2004-01-13 Kos Pharmaceuticals, Inc. Methods for reducing flushing in individuals being treated with nicotinic acid for hyperlipidemia
US6746691B2 (en) 1993-09-20 2004-06-08 Kos Pharmaceuticals, Inc. Intermediate release nicotinic acid compositions for treating hyperlipidemia having unique biopharmaceutical characteristics
US6818229B1 (en) 1993-09-20 2004-11-16 Kos Pharmaceuticals, Inc. Intermediate release nicotinic acid compositions for treating hyperlipidemia
US6080428A (en) * 1993-09-20 2000-06-27 Bova; David J. Nicotinic acid compositions for treating hyperlipidemia and related methods therefor
US6129930A (en) * 1993-09-20 2000-10-10 Bova; David J. Methods and sustained release nicotinic acid compositions for treating hyperlipidemia at night
AU699043B2 (en) * 1993-10-15 1998-11-19 Schering Corporation Tricyclic carbamate compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
US6075025A (en) 1993-10-15 2000-06-13 Schering Corporation Tricyclic carbamate compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
US5719148A (en) * 1993-10-15 1998-02-17 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
US5721236A (en) * 1993-10-15 1998-02-24 Schering Corporation Tricyclic carbamate compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
US6365588B1 (en) 1993-10-15 2002-04-02 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
CA2173963C (en) * 1993-10-15 2002-03-19 W. Robert Bishop Tricyclic sulfonamide compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
US5661152A (en) * 1993-10-15 1997-08-26 Schering Corporation Tricyclic sulfonamide compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
US5595997A (en) 1994-12-30 1997-01-21 Sepracor Inc. Methods and compositions for treating allergic rhinitis and other disorders using descarboethoxyloratadine
US7211582B1 (en) * 1994-12-30 2007-05-01 Sepracor Inc. Methods for treating urticaria using descarboethoxyloratadine
US7214683B1 (en) 1994-12-30 2007-05-08 Sepracor Inc. Compositions of descarboethoxyloratadine
US5700806A (en) * 1995-03-24 1997-12-23 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
US5684013A (en) * 1995-03-24 1997-11-04 Schering Corporation Tricyclic compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
US5712280A (en) * 1995-04-07 1998-01-27 Schering Corporation Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
US5891872A (en) * 1995-04-07 1999-04-06 Schering Corporation Tricyclic compounds
US5801175A (en) 1995-04-07 1998-09-01 Schering Corporation Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
IL117798A (en) * 1995-04-07 2001-11-25 Schering Plough Corp Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them
JP3779349B2 (ja) * 1995-04-24 2006-05-24 興和株式会社 ピペリジン誘導体
JPH09152696A (ja) 1995-11-30 1997-06-10 Fuji Photo Film Co Ltd ハロゲン化銀カラー写真感光材料
JP3383499B2 (ja) 1995-11-30 2003-03-04 富士写真フイルム株式会社 ハロゲン化銀カラー写真感光材料
US5874442A (en) * 1995-12-22 1999-02-23 Schering-Plough Corporation Tricyclic amides useful for inhibition of G-protein function and for treatment of proliferative disease
SK105698A3 (en) * 1996-02-08 1999-05-07 Merck & Co Inc Method of treatment and pharmaceutical composion
JP3882224B2 (ja) * 1996-05-31 2007-02-14 旭硝子株式会社 パロキセチンの製造方法
JP2001500509A (ja) * 1996-09-13 2001-01-16 シェーリング コーポレイション ファルネシルタンパク質トランスフェラーゼの阻害に有用な置換ベンゾシクロヘプタピリジン誘導体
US5945429A (en) * 1996-09-13 1999-08-31 Schering Corporation Compounds useful for inhibition of farnesyl protein transferase
US5900421A (en) * 1997-02-11 1999-05-04 Sepracor Inc. Methods and compositions for treating allergic asthma and dermatitis using descarboethoxyloratadine
US5939426A (en) * 1997-02-28 1999-08-17 Sepracor Inc. Methods for treating urinary incontinence using descarboethoxyloratadine
SE509618C2 (sv) 1997-03-06 1999-02-15 Goeran Blomqvist Farmaceutisk komposition för behandling av s k restless legs
US5998620A (en) * 1997-03-25 1999-12-07 Schering Corporation Synthesis of intermediates useful in preparing tricyclic compounds
US6506767B1 (en) 1997-07-02 2003-01-14 Schering Corporation 8-chloro-6,11-dihydro-11-(4-piperidylidine)-5H-benzo[5,6]cyclohepta[1-2-b] pyridine
US5869479A (en) * 1997-08-14 1999-02-09 Schering Corporation Treatment of upper airway allergic responses
US6335347B1 (en) * 1997-10-10 2002-01-01 Schering Corporation Ethyl 4-(8-chloro-5,6-dihydro-11 H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidene carboxylate polymorph
EP1021436A1 (en) * 1997-10-10 2000-07-26 Schering Corporation ETHYL 4-(8-CHLORO-5, 6-DIHYDRO-11H- BENZO 5,6]CYCLOHEPTA 1,2-b]PYRIDIN -11-YLIDENE)-1- PIPERIDENE CARBOXYLATE POLYMORPH
ATE274907T1 (de) * 1998-06-30 2004-09-15 Pfizer Prod Inc Loratadin zur verwendung als antiarrhythmikum
US6423721B1 (en) 1998-09-10 2002-07-23 Schering Corporation Methods and compositions for treating sinusitis, otitis media and other related disorders using antihistamines
AR028138A1 (es) 1998-11-20 2003-04-30 Schering Corp Sintesis de intermediarios utiles para preparar compuestos triciclicos
US6372909B1 (en) 1998-11-20 2002-04-16 Schering Corporation Synthesis of intermediates useful in preparing tricyclic compounds
US6271378B1 (en) 1998-12-18 2001-08-07 Schering Corporation Process for preparing tricyclic compounds having antihistaminic activity
ATE249453T1 (de) * 1998-12-18 2003-09-15 Schering Corp Verfahren zur herstellung von tricyclischen verbindungen mit antihistaminischer wirkung
US6686502B1 (en) 1999-03-26 2004-02-03 Ucb S.A. Compounds and methods for treatment of asthma, allergy and inflammatory disorders
PE20001566A1 (es) 1999-03-26 2001-02-05 Ucb Sa Piperazinas 1,4-sustituidas, piperidinas 1,4-sustituidas y 4-alquilidenilpiperidinas 1-sustituidas
US6894059B1 (en) 1999-03-26 2005-05-17 Ucb S.A. Compounds and methods for treatment of asthma, allergy and inflammatory disorders
US6555139B2 (en) 1999-06-28 2003-04-29 Wockhardt Europe Limited Preparation of micron-size pharmaceutical particles by microfluidization
US6100274A (en) * 1999-07-07 2000-08-08 Schering Corporation 8-chloro-6,11-dihydro-11- ](4-piperidylidine)-5H-benzo[5,6]cyclohepta[1,2-bpyridine oral compositions
US6475493B1 (en) 1999-09-02 2002-11-05 Norstrum Pharmaceuticals, Inc. Controlled release pellet formulation
US6267986B1 (en) 1999-09-24 2001-07-31 Ranbaxy Laboratories Limited Process for the preparation of a controlled drug delivery system containing pseudoephedrine and a long acting antihistamine
US6114346A (en) 1999-10-22 2000-09-05 Schering Corporation Treating sleep disorders using desloratadine
SK287105B6 (sk) 1999-12-20 2009-12-07 Schering Corporation Dvojvrstvový orálny dávkový prostriedok s predĺženým uvoľňovaním
WO2001045668A2 (en) * 1999-12-20 2001-06-28 Schering Corporation Stable extended release oral dosage composition comprising pseudoephedrine and desloratadine
US7405223B2 (en) 2000-02-03 2008-07-29 Schering Corporation Treating allergic and inflammatory conditions
JP2004501081A (ja) 2000-04-18 2004-01-15 シェーリング コーポレイション 三環式化合物の調製において有用な中間体の合成
RU2164796C1 (ru) * 2000-05-25 2001-04-10 Открытое акционерное общество "Химико-фармацевтический комбинат "Акрихин" Противогистаминное средство и способ его получения
RU2165255C1 (ru) * 2000-07-14 2001-04-20 Открытое акционерное общество "Химико-фармацевтический комбинат "Акрихин" Антигистаминная композиция
WO2002036077A2 (en) * 2000-11-06 2002-05-10 Andrx Pharmaceuticals, Inc. Once a day antihistamine and decongestant formulation
HU226998B1 (en) * 2000-11-23 2010-04-28 Richter Gedeon Nyrt Desloratadine hemisulphate, process for the preparation thereof and pharmaceutical compositions containing the same
US6599913B1 (en) * 2001-06-29 2003-07-29 Schering Corporation Treating allergic and inflammatory conditions
US6720002B2 (en) 2001-07-20 2004-04-13 R.P. Scherer Technologies, Inc. Antihistamine formulations for soft capsule dosage forms
US20030004179A1 (en) * 2002-05-21 2003-01-02 Affrime Melton B Treating allergic and inflammatory conditions
US20040033257A1 (en) * 2002-05-30 2004-02-19 Strides Inc. Pharmaceutical formulation in a drug delivery system and process for preparing the same
TW200400816A (en) * 2002-06-26 2004-01-16 Lilly Co Eli Tricyclic steroid hormone nuclear receptor modulators
US20040001885A1 (en) * 2002-06-27 2004-01-01 Unchalee Kositprapa Rapidly disintegrating antihistamine formulation
US20040101563A1 (en) * 2002-07-18 2004-05-27 Kundu Subhas C. Storage stable antihistaminic syrup formulations
US8092831B2 (en) * 2002-11-08 2012-01-10 Andrx Pharmaceuticals, Llc Antihistamine and decongestant system
US6635654B1 (en) 2003-01-09 2003-10-21 Allergan, Inc. Ophthalmic compositions containing loratadine
WO2004108700A1 (en) * 2003-03-12 2004-12-16 Teva Gyogyszergyar Reszvenytarsasag Processes for preparation of polymorphic forms of desloratadine
US20050026890A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an antihistamine for treatment of asthma or chronic obstructive pulmonary disease
JP3881640B2 (ja) * 2003-08-08 2007-02-14 塩野義製薬株式会社 ロラタジンを含むドライシロップ剤
US20060030550A1 (en) * 2004-08-04 2006-02-09 Lithgow Theodore L Pharmaceutical formulations
US20060154948A1 (en) * 2005-01-12 2006-07-13 Schering Corporation Treating allergic and inflammatory conditions
BRPI0610780A2 (pt) * 2005-04-22 2016-09-06 Teva Pharma formulação farmacéutica em tablete desintegrante, e, métodos para tratar um paciente em necessidade de tratamento com olanzapina, e para produzir a formulação farmacêutica em tablete
AU2005333081B2 (en) * 2005-06-17 2010-06-24 Aft Pharmaceuticals Limited Novel pharmaceutical composition and its use in a method for treatment of patients with upper respiratory mucosal congestion
US20080194823A1 (en) * 2006-04-04 2008-08-14 Mayur Devjibhai Khunt Preparation of loratadine form i
RU2454225C2 (ru) * 2006-06-01 2012-06-27 Эм Эс Ди Консьюмер Кэар, Инк. Фармацевтические лекарственные формы и композиции фенилэфрина для абсорбции в ободочной кишке
NZ573174A (en) 2006-06-01 2012-01-12 Msd Consumer Care Inc Sustained release pharmaceutical dosage form containing phenylephrine
WO2007143163A2 (en) * 2006-06-01 2007-12-13 Schering Corporation Pharmaceutical compositions for sustained release of phenyephrine
EP2023957A2 (en) * 2006-06-07 2009-02-18 Morton Grove Pharmaceuticals, Inc. Oral liquid loratadine formulations and methods
US20100152201A1 (en) * 2007-03-12 2010-06-17 Nektar Therapeutics Oligomer-Antihistamine Conjugates
US20090082385A1 (en) * 2007-09-26 2009-03-26 Protia, Llc Deuterium-enriched desloratidine
WO2010021681A2 (en) * 2008-08-18 2010-02-25 Combinatorx (Singapore) Pte. Ltd. Compositions and methods for treatment of viral diseases
CA2764830A1 (en) 2009-06-16 2010-12-23 Schering Corporation Novel [3,2-c] heteroaryl steroids as glucocorticoid receptor agonists, compositions and uses thereof
US20110130711A1 (en) * 2009-11-19 2011-06-02 Follica, Inc. Hair growth treatment
CA2690490C (en) 2010-01-19 2012-06-26 Accucaps Industries Limited Pharmaceutical formulations of loratadine for encapsulation and combinations thereof
AR088204A1 (es) 2011-09-29 2014-05-14 Shionogi & Co Medicamentos para el tratamiento de la rinitis alergica que comprenden un antagonista de pgd2 y un antagonista de histamina
US10525057B2 (en) 2013-09-24 2020-01-07 Otsuka Pharmaceutical Co., Ltd. Method of providing aripiprazole to patients having impaired CYP2D6 or CYP3A4 enzyme function
CN106478595B (zh) * 2016-09-18 2019-05-21 西安交通大学 氯雷他定晶型及其制备方法和用途
CN110845473B (zh) * 2019-10-08 2023-04-07 深圳市南山区人民医院 一种抗金黄色葡萄球菌毒力和生物被膜形成的抑制剂Lo-乙酸乙酯及其用途
CN110818684B (zh) * 2019-10-08 2023-04-07 深圳市南山区人民医院 一种抗金黄色葡萄球菌毒力和生物被膜形成的抑制剂Lo-SH及其用途
CN110818685A (zh) * 2019-10-08 2020-02-21 深圳市南山区人民医院 一种抗金黄色葡萄球菌毒力和生物被膜形成的抑制剂Lo-异己基及其用途
EP4053116A4 (en) * 2019-10-31 2023-10-11 JD Bioscience Inc. TRICYCLIC COMPOUND AND ITS PHARMACEUTICAL USE
KR102242382B1 (ko) 2020-02-28 2021-04-20 삼익제약주식회사 용해성, 안정성 및 쓴맛이 개선된 로라타딘 함유 시럽 조성물
WO2022106923A1 (en) 2020-11-18 2022-05-27 BioPharma Synergies, S. L. Orodispersible powder composition comprising an antihistamine compound
CN112645928A (zh) * 2020-12-23 2021-04-13 常州大学 一种连续流制备氯雷他定ⅱ晶型的方法
CN113135893B (zh) * 2021-06-21 2022-02-11 北京鑫开元医药科技有限公司 苯并环庚烷并吡啶化合物、其制备方法及其用途
CN115778924A (zh) * 2022-12-22 2023-03-14 河北三禾实创生物科技有限公司 一种氯雷他定制剂及其制备方法
CN116496259B (zh) * 2023-04-24 2025-08-29 黑龙江珍宝岛药业股份有限公司 一种富马酸卢帕他定的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL132137C (cs) * 1963-04-24
US3419565A (en) * 1963-04-24 1968-12-31 Schering Corp Aza-dibenzocycloheptenes
US3264342A (en) * 1963-05-24 1966-08-02 Geigy Chem Corp Derivatives of 5h-dibenzo[a, d] cycloheptene
US3491103A (en) * 1963-12-19 1970-01-20 Sandoz Ag Certain 4h-benzo(4,5)cyclohepta-(1,2-b) thiophenes
US3464983A (en) * 1964-02-04 1969-09-02 Sandoz Ag 4h-benzo(4,5)cyclohepta(1,2-b)thiophenes
US3435073A (en) * 1966-04-19 1969-03-25 Colgate Palmolive Co 5-(n-benzyl-n-lower alkylaminoalkylene)-5h-dibenzo(a,d)cycloheptenes
US3513201A (en) * 1966-10-25 1970-05-19 Merck & Co Inc Process for preparing 5-(3-alkylaminopropyl)-5h-dibenzo(a,d)cycloheptenes
US3917669A (en) * 1966-11-08 1975-11-04 Hoffmann La Roche Intermediates for tricyclic amines
ES356805A1 (es) * 1967-08-03 1970-05-01 Hoffmann La Roche Procedimiento para la preparacion de compuestos tricicli- cos.
US3952017A (en) * 1968-05-03 1976-04-20 Hoffmann-La Roche Inc. Tricyclic compounds
CH531000A (de) * 1970-03-11 1972-11-30 Sandoz Ag Verfahren zur Herstellung neuer Benzocycloheptathiophene
GB1329733A (en) * 1970-12-02 1973-09-12 Science Union & Cie Derivatives of isonipecotic acid and a process for their prepa- ration

Also Published As

Publication number Publication date
US4282233A (en) 1981-08-04
FI70213B (fi) 1986-02-28
FI811878L (fi) 1981-12-20
JPS5735586A (en) 1982-02-26
JPS6355513B2 (cs) 1988-11-02
MY8700761A (en) 1987-12-31
FI70213C (fi) 1986-09-15
DK263481A (da) 1981-12-20
HU186774B (en) 1985-09-30
IL63122A (en) 1985-06-30
AU543054B2 (en) 1985-03-28
SG70587G (en) 1988-02-19
DE3166441D1 (en) 1984-11-08
ATE9695T1 (de) 1984-10-15
NZ197435A (en) 1984-03-30
PH19252A (en) 1986-02-17
LU88359I2 (fr) 1994-05-04
IE811328L (en) 1981-12-19
ZA814062B (en) 1982-07-28
EP0042544A3 (en) 1982-04-07
KR830006218A (ko) 1983-09-20
KR850000744B1 (ko) 1985-05-24
NL930094I2 (nl) 1994-12-01
PT73200B (en) 1983-04-26
EP0042544B1 (en) 1984-10-03
IE51303B1 (en) 1986-11-26
EP0042544A2 (en) 1981-12-30
PT73200A (en) 1981-07-01
CY1405A (en) 1988-04-22
NL930094I1 (nl) 1993-10-01
CA1160230A (en) 1984-01-10
US4282233B1 (en) 2000-09-05
DK169817B1 (da) 1995-03-06
ES8300779A1 (es) 1982-11-01
AU7186281A (en) 1981-12-24
KE3758A (en) 1987-10-02
ES503085A0 (es) 1982-11-01

Similar Documents

Publication Publication Date Title
EP0042544B1 (en) Novel antihistamines, process for their preparation and pharmaceutical compositions containing them
US4355036A (en) Tricyclic-substituted piperidine antihistamines
US5654308A (en) Bicyclic amide derivatives, compositions and methods of treatment
FI96768C (fi) Menetelmä valmistaa farmakologisesti arvokasta bentso/5,6/sykloheptapyridiiniä
KR0170458B1 (ko) 신규한 아세틸 콜린에스테라제 저해제로서의 헤테로아릴 아민
US5151423A (en) Heterocyclic n-oxide derivatives of substituted benzo[5,6]cycloheptapyridines, compositions and methods of use
CA1341044C (en) Benzopyrido piperidine, piperidylidene and peperazine compounds, compositions, methods of manufacture and methods of use
JPH05507092A (ja) ビス―ベンゾまたはベンゾピリドシクロヘプタピペリジン、ピペリジリデンおよびピペラジン化合物および組成物
US5104876A (en) Benzopyrido piperidine, piperidylidene and piperazine compounds, compositions, methods of manufacture and methods of use
AU612339B2 (en) 6,11-dihydro-11-(4-piperidylidene)-5H-benzo(5,6) cyclohepta(1,2-b) pyridines and compositions and methods of use
AU4704693A (en) Condensed indole derivatives as 5HT-2C and 5HT-2B antagonists
US5430032A (en) Benzopyrido piperidylidene compounds, compositions, methods of manufacture and methods of use
TW472055B (en) Pharmaceutical compositions for use in treating gastrointestinal motility disorders
US5665735A (en) Unbridged bis-aryl carbinol derivatives compositions and methods of use
US4454143A (en) Tricyclic antihistamines
US6166034A (en) Spiro piperidine derivatives as 5HT1D receptor antagonists
US5665726A (en) Benzo[5,6]cycloheptapyridines, compositions and methods of use
US4840953A (en) 9-(Substituted thio)-4H-pyrido[1,2,-A]pyrimidin-4-one derivatives
NO173062B (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive benzo(5,6)cykloheptapyridiner

Legal Events

Date Code Title Description
PE Patent expired