HK153896A - 1,2-dehydrogenation of steroidal 21-esters with A. simplex - Google Patents

1,2-dehydrogenation of steroidal 21-esters with A. simplex

Info

Publication number
HK153896A
HK153896A HK153896A HK153896A HK153896A HK 153896 A HK153896 A HK 153896A HK 153896 A HK153896 A HK 153896A HK 153896 A HK153896 A HK 153896A HK 153896 A HK153896 A HK 153896A
Authority
HK
Hong Kong
Prior art keywords
dehydrogenation
simplex
steroidal
esters
hemiester
Prior art date
Application number
HK153896A
Other languages
English (en)
Inventor
Leo A Kominek
Holly Jo Wolf
Paula S Steiert
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of HK153896A publication Critical patent/HK153896A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/02—Dehydrogenating; Dehydroxylating
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/007—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 17 (20)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/83—Arthrobacter

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK153896A 1987-03-12 1996-08-08 1,2-dehydrogenation of steroidal 21-esters with A. simplex HK153896A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2512787A 1987-03-12 1987-03-12
PCT/US1988/000405 WO1988007092A1 (fr) 1987-03-12 1988-02-19 DESHYDROGENATON-1,2 D'ESTERS STEROIDES 21 A l'AIDE D'A. SIMPLEX

Publications (1)

Publication Number Publication Date
HK153896A true HK153896A (en) 1996-08-16

Family

ID=21824196

Family Applications (1)

Application Number Title Priority Date Filing Date
HK153896A HK153896A (en) 1987-03-12 1996-08-08 1,2-dehydrogenation of steroidal 21-esters with A. simplex

Country Status (12)

Country Link
US (1) US5225335A (fr)
EP (1) EP0350488B1 (fr)
JP (1) JP2680870B2 (fr)
KR (1) KR960013094B1 (fr)
AT (1) ATE94212T1 (fr)
AU (1) AU1340888A (fr)
BG (1) BG50389A3 (fr)
DE (1) DE3883973T2 (fr)
DK (1) DK175173B1 (fr)
HK (1) HK153896A (fr)
HU (1) HU204305B (fr)
WO (1) WO1988007092A1 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1270660B (it) * 1994-10-13 1997-05-07 Poli Ind Chimica Spa Procedimento microbiologico per la preparazione di 3-oxo-4-azasteroidi-17beta-carbossi sostituiti e uso dei prodotti come inibitori dell'enzima 5alfa-riduttasi
WO2001004342A1 (fr) * 1999-07-07 2001-01-18 Pharmacia & Upjohn Company Procede de preparation d'exemestane
WO2002102826A1 (fr) * 2001-06-18 2002-12-27 Pharmacia & Upjohn Company Procede de preparation de 21-acetate de 11$g(b),17$g(a),21-trihydroxy-6$g(a)-methylpregna-1,4-diene-3,20-dione
HU227117B1 (en) 2002-05-10 2010-07-28 Richter Gedeon Nyrt Process for dehydrogenation of aza-androstane compounds
US20090142342A1 (en) * 2006-12-27 2009-06-04 Johns Hopkins University B7-h4 receptor agonist compositions and methods for treating inflammation and auto-immune diseases
NZ589444A (en) 2008-05-28 2013-03-28 Validus Biopharma Inc NON-HORMONAL STEROID MODULATORS OF NF-Kappa B FOR TREATMENT OF DISEASE
EP2556083A4 (fr) 2010-04-05 2013-12-04 Validus Biopharma Inc Modulateurs stéroïdes non hormonaux de nf- kappa b pour le traitement de maladies
RU2480475C1 (ru) * 2011-11-16 2013-04-27 Российская Федерация, От Имени Которой Выступает Министерство Промышленности И Торговли Российской Федерации Микробиологический способ получения 21-ацетоксипрегна-1,4,9( 11 ),16-тетраен-3,20-диона из 21-ацетоксипрегна-4,9( 11 ),16-триен-3,20-диона
CN103159817A (zh) * 2011-12-13 2013-06-19 辽宁海思科制药有限公司 一种琥珀酸甲泼尼龙的制备方法
CN104650172A (zh) * 2015-03-25 2015-05-27 浙江仙琚制药股份有限公司 琥珀酸甲泼尼龙的制备方法
WO2017004205A1 (fr) 2015-06-29 2017-01-05 Reveragen Biopharma, Inc. Modulateurs stéroïdiens non hormonaux de nf-κb pour le traitement de maladies
US11382922B2 (en) 2019-03-07 2022-07-12 Reveragen Biopharma, Inc. Aqueous oral pharmaceutical suspension compositions

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2837464A (en) * 1955-01-11 1958-06-03 Schering Corp Process for production of dienes by corynebacteria
US2822318A (en) * 1956-12-07 1958-02-04 Olin Mathieson Production of 3-keto-delta pregnadienes by bacterium cyclo-oxydans
US2902411A (en) * 1957-06-28 1959-09-01 Upjohn Co Use of second steroid to accelerate 1-dehydrogenation of substrate steroid
US2902410A (en) * 1957-09-26 1959-09-01 Upjohn Co Process for the 1,2-dehydrogenation of a steroid with septomyxa
US3360439A (en) * 1964-08-19 1967-12-26 Squibb & Sons Inc Process for preparing 1-dehydro steroids
US3770586A (en) * 1971-03-24 1973-11-06 Upjohn Co Process for the microbiological 1-dehydrogenation of certain 4,9-(11)-pregnadienes
US4524134A (en) * 1982-07-30 1985-06-18 The Upjohn Company Process for preparing 1,2-dehydro steroids
DE3322120A1 (de) * 1982-07-30 1984-02-02 The Upjohn Co., 49001 Kalamazoo, Mich. Verfahren zur umwandlung von 1,2-gesaettigten 3-ketosteroiden in 1,2-dehydrosteroide
US4704358A (en) * 1982-10-25 1987-11-03 The Upjohn Company Δ1 -dehydrogenation with heat or air-dried B. cyclooxidans
US4749649A (en) * 1983-05-16 1988-06-07 The Upjohn Company Microbial Δ1-dehydrogenation process using a scavenger of toxic oxygen

Also Published As

Publication number Publication date
KR960013094B1 (ko) 1996-09-30
DE3883973T2 (de) 1994-02-17
EP0350488A1 (fr) 1990-01-17
DK630988A (da) 1988-11-11
JPH02502514A (ja) 1990-08-16
BG50389A3 (en) 1992-07-15
DE3883973D1 (de) 1993-10-14
KR890700679A (ko) 1989-04-26
EP0350488B1 (fr) 1993-09-08
WO1988007092A1 (fr) 1988-09-22
US5225335A (en) 1993-07-06
HUT50881A (en) 1990-03-28
DK630988D0 (da) 1988-11-11
JP2680870B2 (ja) 1997-11-19
ATE94212T1 (de) 1993-09-15
DK175173B1 (da) 2004-06-21
HU204305B (en) 1991-12-30
AU1340888A (en) 1988-10-10

Similar Documents

Publication Publication Date Title
HK153896A (en) 1,2-dehydrogenation of steroidal 21-esters with A. simplex
ZA943983B (en) Lipopeptides from actinoplanes sp. with pharmacological action process for their preparation and the use thereof
EP0162395A3 (en) Process for the preparation of cephalosporins
ZA933940B (en) Preparation process for an 11-keto steroid derivative
PL244685A1 (en) Process for preparing novel 6 -methylcorticoids
PL314965A1 (en) Method of transforming bisnoralcohol into bisnoraldehyde
DE3265509D1 (en) Process for the preparation of cholesterol derivatives, and intermediate derivatives therefor
GR3031398T3 (en) Steroid intermediates and process for their preparation.
AU7087087A (en) Process for the preparation of styrenated hydroquinone
AU567934B2 (en) Preparation 21-hydroxy-20-keto-delta 16 steroids and intermediates
ES8308306A1 (es) Procedimiento de preparacion de derivados bencilidenicos.
AU668161B2 (en) Novel process and intermediates
ES8102555A1 (es) Un procedimiento para la preparacion de acido 6-cloro-alfa- metilcarbazol-2-acetico
GB2279650A (en) Process for isomerization of compound of aldose structure into compound of ketose structure,and isomerization agent or accelerator used therein
FI915675A0 (fi) Oeverfoering av 16-steroid till ^17(20)-20-silyleter.
ES8107190A1 (es) Un procedimiento para la preparacion de w-lactamas que con- tienen 5 a 14 atomos de carbono
DE3160507D1 (en) Process for the preparation of 3,20-dioxo-pregn-4-ene and/or 3,20-dioxo-pregna-1,4-diene
HK166095A (en) Conversion of steroidal 17-cyanohydrins to corticoids
HUT54102A (en) Process for producing phenyl-glycine-chloride-hydrochloride
GB1105980A (en) New steroids and a process for their manufacture
DE3480007D1 (en) Process for the preparation of 3-oxo-delta-1,4 steroids
JPS55150893A (en) Novel microorganism

Legal Events

Date Code Title Description
PF Patent in force
PE Patent expired

Effective date: 20080218