HK1255208A1 - 作为用於嵌合抗原受体(car)疗法的t细胞来源的骨髓浸润淋巴细胞(mil) - Google Patents

作为用於嵌合抗原受体(car)疗法的t细胞来源的骨髓浸润淋巴细胞(mil) Download PDF

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Publication number
HK1255208A1
HK1255208A1 HK18114336.4A HK18114336A HK1255208A1 HK 1255208 A1 HK1255208 A1 HK 1255208A1 HK 18114336 A HK18114336 A HK 18114336A HK 1255208 A1 HK1255208 A1 HK 1255208A1
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Hong Kong
Prior art keywords
cell
mils
cells
antigen
mage
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HK18114336.4A
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English (en)
Chinese (zh)
Inventor
Ivan M. Borrello
Susan Lee
Kimberly A. NOONAN
Drew M. Pardoll
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The Johns Hopkins University
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Publication of HK1255208A1 publication Critical patent/HK1255208A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61K40/00—Cellular immunotherapy
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    • A61K40/42—Cancer antigens
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    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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HK18114336.4A 2015-07-08 2016-07-08 作为用於嵌合抗原受体(car)疗法的t细胞来源的骨髓浸润淋巴细胞(mil) HK1255208A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562189928P 2015-07-08 2015-07-08
US62/189928 2015-07-08
PCT/US2016/041521 WO2017008019A1 (en) 2015-07-08 2016-07-08 Marrow infiltrating lymphocytes (mils) as a source of t-cells for chimeric antigen receptor (car) therapy

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HK1255208A1 true HK1255208A1 (zh) 2019-08-09

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HK18114336.4A HK1255208A1 (zh) 2015-07-08 2016-07-08 作为用於嵌合抗原受体(car)疗法的t细胞来源的骨髓浸润淋巴细胞(mil)
HK18113281.1A HK1254313A1 (zh) 2015-07-08 2016-07-08 作为嵌合抗原受体疗法的t细胞来源的骨髓浸润淋巴细胞

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US (3) US11478548B2 (enExample)
EP (1) EP3320087A4 (enExample)
JP (2) JP2018518978A (enExample)
KR (1) KR20180039068A (enExample)
CN (1) CN108026510A (enExample)
AU (1) AU2016291199B2 (enExample)
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HK (2) HK1255208A1 (enExample)
IL (1) IL256434B2 (enExample)
MA (1) MA42902A (enExample)
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WO (1) WO2017008019A1 (enExample)

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CN112638428A (zh) * 2018-06-12 2021-04-09 H·李·莫菲特癌症中心和研究所公司 嵌合抗原受体肿瘤浸润淋巴细胞
WO2020004337A1 (ja) * 2018-06-27 2020-01-02 国立大学法人名古屋大学 Ｃｄ３７特異的キメラ抗原レセプター
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US20210338730A1 (en) * 2018-11-05 2021-11-04 Windmil Therapeutics, Inc. Marrow Infiltrating Lymphocytes With Increased Clonality and Uses Thereof
MX2021006399A (es) * 2018-11-30 2021-07-15 Windmil Therapeutics Inc Linfocitos infiltrantes de medula osea (mils) que expresan receptores de antigenos quimericos (car), metodo de fabricacion de los mismos y metodo de uso en terapia.
CN114072158A (zh) * 2019-03-22 2022-02-18 温德弥尔治疗公司 肺癌特异性骨髓浸润淋巴细胞及其用途
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US20230100744A1 (en) * 2020-02-28 2023-03-30 Windmil Therapeutics, Inc. Methods for enriching marrow infiltrating lymphocytes ("mils"), compositions containing enriched mils, and methods of using enriched mils
WO2022066872A1 (en) * 2020-09-24 2022-03-31 Windmil Therapeutics, Inc. Marrow infiltrating lymphocytes (mils) expressing t cell receptors, methods of manufacturing same, and method of using in therapy
WO2022076606A1 (en) * 2020-10-06 2022-04-14 Iovance Biotherapeutics, Inc. Treatment of nsclc patients with tumor infiltrating lymphocyte therapies
JP2023546359A (ja) * 2020-10-06 2023-11-02 アイオバンス バイオセラピューティクス，インコーポレイテッド 腫瘍浸潤リンパ球療法によるｎｓｃｌｃ患者の治療
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WO2017008019A1 (en) * 2015-07-08 2017-01-12 The Johns Hopkins University Marrow infiltrating lymphocytes (mils) as a source of t-cells for chimeric antigen receptor (car) therapy

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KR20180039068A (ko) 2018-04-17
CA2990694A1 (en) 2017-01-12
WO2017008019A1 (en) 2017-01-12
US20230210990A1 (en) 2023-07-06
IL256434B2 (en) 2025-02-01
MX2017017083A (es) 2018-05-23
US11478548B2 (en) 2022-10-25
IL256434B1 (en) 2024-10-01
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