IL256434B2 - Bone marrow-derived lymphocytes as a source of T cells for chimeric antigen receptor therapy - Google Patents
Bone marrow-derived lymphocytes as a source of T cells for chimeric antigen receptor therapyInfo
- Publication number
- IL256434B2 IL256434B2 IL256434A IL25643417A IL256434B2 IL 256434 B2 IL256434 B2 IL 256434B2 IL 256434 A IL256434 A IL 256434A IL 25643417 A IL25643417 A IL 25643417A IL 256434 B2 IL256434 B2 IL 256434B2
- Authority
- IL
- Israel
- Prior art keywords
- cell
- cells
- mils
- car
- antigen
- Prior art date
Links
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Applications Claiming Priority (2)
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| US201562189928P | 2015-07-08 | 2015-07-08 | |
| PCT/US2016/041521 WO2017008019A1 (en) | 2015-07-08 | 2016-07-08 | Marrow infiltrating lymphocytes (mils) as a source of t-cells for chimeric antigen receptor (car) therapy |
Publications (3)
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| IL256434A IL256434A (en) | 2018-02-28 |
| IL256434B1 IL256434B1 (en) | 2024-10-01 |
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| IL256434A IL256434B2 (en) | 2015-07-08 | 2016-07-08 | Bone marrow-derived lymphocytes as a source of T cells for chimeric antigen receptor therapy |
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| EP (1) | EP3320087A4 (enExample) |
| JP (2) | JP2018518978A (enExample) |
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| MX (1) | MX2017017083A (enExample) |
| WO (1) | WO2017008019A1 (enExample) |
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| WO2017008019A1 (en) * | 2015-07-08 | 2017-01-12 | The Johns Hopkins University | Marrow infiltrating lymphocytes (mils) as a source of t-cells for chimeric antigen receptor (car) therapy |
| GB201700621D0 (en) | 2017-01-13 | 2017-03-01 | Guest Ryan Dominic | Method,device and kit for the aseptic isolation,enrichment and stabilsation of cells from mammalian solid tissue |
| WO2018209115A1 (en) * | 2017-05-10 | 2018-11-15 | Iovance Biotherapeutics, Inc. | Expansion of tumor infiltrating lymphocytes from liquid tumors and therapeutic uses thereof |
| JP2021503885A (ja) * | 2017-11-22 | 2021-02-15 | アイオバンス バイオセラピューティクス，インコーポレイテッド | 末梢血からの末梢血リンパ球（ｐｂｌ）の拡大培養 |
| EP3765094A4 (en) | 2018-03-15 | 2021-12-22 | KSQ Therapeutics, Inc. | GENE REGULATORY COMPOSITIONS AND PROCEDURES FOR IMPROVED IMMUNOTHERAPY |
| US20210000876A1 (en) * | 2018-03-22 | 2021-01-07 | Windmil Therapeutics, Inc. | Prostate Cancer Specific Marrow Infiltrating Lymphocytes and Uses Thereof |
| CN112638428A (zh) * | 2018-06-12 | 2021-04-09 | H·李·莫菲特癌症中心和研究所公司 | 嵌合抗原受体肿瘤浸润淋巴细胞 |
| JPWO2020004337A1 (ja) * | 2018-06-27 | 2021-08-02 | 国立大学法人東海国立大学機構 | Ｃｄ３７特異的キメラ抗原レセプター |
| KR20210031898A (ko) * | 2018-07-13 | 2021-03-23 | 난징 레전드 바이오테크 씨오., 엘티디. | 전염병을 치료하기 위한 공동수용체 시스템 |
| JP2022507113A (ja) * | 2018-11-05 | 2022-01-18 | ウィンドミル セラピューティクス インコーポレイテッド | クローン性の増大した骨髄浸潤リンパ球およびそれらの使用 |
| SG11202104637VA (en) * | 2018-11-30 | 2021-06-29 | Windmil Therapeutics Inc | MARROW INFILTRATING LYMPHOCYTES (MILs) EXPRESSING CHIMERIC ANTIGEN RECEPTORS (CAR), METHOD OF MANUFACTURING SAME, AND METHOD OF USING IN THERAPY |
| CN114072158A (zh) * | 2019-03-22 | 2022-02-18 | 温德弥尔治疗公司 | 肺癌特异性骨髓浸润淋巴细胞及其用途 |
| JP2023507432A (ja) | 2019-12-20 | 2023-02-22 | インスティル バイオ （ユーケイ） リミテッド | 腫瘍浸潤リンパ球を単離するためのデバイスおよび方法ならびにそれらの使用 |
| US20230100744A1 (en) * | 2020-02-28 | 2023-03-30 | Windmil Therapeutics, Inc. | Methods for enriching marrow infiltrating lymphocytes ("mils"), compositions containing enriched mils, and methods of using enriched mils |
| WO2022066872A1 (en) * | 2020-09-24 | 2022-03-31 | Windmil Therapeutics, Inc. | Marrow infiltrating lymphocytes (mils) expressing t cell receptors, methods of manufacturing same, and method of using in therapy |
| WO2022076606A1 (en) * | 2020-10-06 | 2022-04-14 | Iovance Biotherapeutics, Inc. | Treatment of nsclc patients with tumor infiltrating lymphocyte therapies |
| CA3195019A1 (en) | 2020-10-06 | 2022-04-14 | Maria Fardis | Treatment of nsclc patients with tumor infiltrating lymphocyte therapies |
| WO2022098985A1 (en) * | 2020-11-05 | 2022-05-12 | Windmil Therapeutics, Inc. | Glioblastoma specific marrow infiltrating lymphocytes and uses thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016037054A1 (en) * | 2014-09-04 | 2016-03-10 | The Johns Hopkins University | Activation of marrow infiltrating lymphocytes in hypoxic alternating with normoxic conditions |
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| WO2014085437A2 (en) * | 2012-11-27 | 2014-06-05 | The Johns Hopkins University | Use of post-transplant cyclophosphamide treated allogeneic marrow infiltrating lymphocytes to augment anti-tumor immunity |
| WO2010062742A2 (en) * | 2008-11-03 | 2010-06-03 | The Johns Hopkins University | Methods for freparation and use of marrow infiltrating lymphocytes (mils) |
| PH12013501201A1 (en) * | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| US9272002B2 (en) * | 2011-10-28 | 2016-03-01 | The Trustees Of The University Of Pennsylvania | Fully human, anti-mesothelin specific chimeric immune receptor for redirected mesothelin-expressing cell targeting |
| WO2013109759A1 (en) * | 2012-01-17 | 2013-07-25 | Northeastern University | Methods and compositions for expanding immunosuppressive t regulatory cells in vitro and uses thereof |
| KR20150029714A (ko) * | 2012-07-13 | 2015-03-18 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 이중특이적 항체의 공-도입에 의한 ｃａｒ 세포의 활성 증강 |
| SG11201505896YA (en) * | 2013-02-20 | 2015-09-29 | Novartis Ag | Treatment of cancer using humanized anti-egfrviii chimeric antigen receptor |
| UY35468A (es) * | 2013-03-16 | 2014-10-31 | Novartis Ag | Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19 |
| WO2015092024A2 (en) * | 2013-12-20 | 2015-06-25 | Cellectis | Method of engineering multi-input signal sensitive t cell for immunotherapy |
| MX2018000278A (es) * | 2015-06-29 | 2018-03-08 | Univ Johns Hopkins | Terapia de receptores quimericos de puntos de control inmunitarios. |
| WO2017008019A1 (en) * | 2015-07-08 | 2017-01-12 | The Johns Hopkins University | Marrow infiltrating lymphocytes (mils) as a source of t-cells for chimeric antigen receptor (car) therapy |
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2016
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2021
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-
2022
- 2022-09-15 US US17/945,729 patent/US20230016031A1/en not_active Abandoned
- 2022-11-30 US US18/072,164 patent/US20230210990A1/en not_active Abandoned
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016037054A1 (en) * | 2014-09-04 | 2016-03-10 | The Johns Hopkins University | Activation of marrow infiltrating lymphocytes in hypoxic alternating with normoxic conditions |
Non-Patent Citations (2)
| Title |
|---|
| MAUS, MARCELA V., ET AL, ANTIBODY-MODIFIED T CELLS: CARS TAKE THE FRONT SEAT FOR HEMATOLOGIC MALIGNANCIES., 24 April 2014 (2014-04-24) * |
| NOONAN, KIMBERLY A., ET AL., ADOPTIVE TRANSFER OF ACTIVATED MARROW-INFILTRATING LYMPHOCYTES INDUCES MEASURABLE ANTITUMOR IMMUNITY IN THE BONE MARROW IN MULTIPLE MYELOMA, 20 May 2015 (2015-05-20) * |
Also Published As
| Publication number | Publication date |
|---|---|
| US20180200367A1 (en) | 2018-07-19 |
| CN108026510A (zh) | 2018-05-11 |
| US20230016031A1 (en) | 2023-01-19 |
| EP3320087A1 (en) | 2018-05-16 |
| JP2018518978A (ja) | 2018-07-19 |
| JP2021121230A (ja) | 2021-08-26 |
| HK1255208A1 (zh) | 2019-08-09 |
| US11478548B2 (en) | 2022-10-25 |
| MA42902A (fr) | 2018-05-16 |
| MX2017017083A (es) | 2018-05-23 |
| CA2990694A1 (en) | 2017-01-12 |
| IL256434A (en) | 2018-02-28 |
| US20230210990A1 (en) | 2023-07-06 |
| IL256434B1 (en) | 2024-10-01 |
| KR20180039068A (ko) | 2018-04-17 |
| EP3320087A4 (en) | 2019-01-23 |
| WO2017008019A1 (en) | 2017-01-12 |
| AU2016291199A1 (en) | 2018-02-15 |
| AU2016291199B2 (en) | 2022-12-22 |
| HK1254313A1 (zh) | 2019-07-19 |
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