HK1251582A1 - 人源化的抗-tau(ps422)抗體和使用方法 - Google Patents

人源化的抗-tau(ps422)抗體和使用方法

Info

Publication number
HK1251582A1
HK1251582A1 HK18110893.7A HK18110893A HK1251582A1 HK 1251582 A1 HK1251582 A1 HK 1251582A1 HK 18110893 A HK18110893 A HK 18110893A HK 1251582 A1 HK1251582 A1 HK 1251582A1
Authority
HK
Hong Kong
Prior art keywords
tau
antibodies
methods
humanized anti
humanized
Prior art date
Application number
HK18110893.7A
Other languages
English (en)
Inventor
Thomas Emrich
Fiona Grueninger
Adrian Hugenmatter
Ekkehard Moessner
Stefan Dengl
Guy Georges
Ulrich Goepfert
Anton Jochner
Hubert Kettenberger
Joerg Moelleken
Olaf Mundigl
Jens Niewoehner
Tilman Schlothauer
Michael Molhoj
Kevin Brady
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of HK1251582A1 publication Critical patent/HK1251582A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
HK18110893.7A 2015-06-24 2018-08-23 人源化的抗-tau(ps422)抗體和使用方法 HK1251582A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15173511 2015-06-24
PCT/EP2016/064465 WO2016207245A1 (en) 2015-06-24 2016-06-22 Humanized anti-tau(ps422) antibodies and methods of use

Publications (1)

Publication Number Publication Date
HK1251582A1 true HK1251582A1 (zh) 2019-02-01

Family

ID=53483738

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18110893.7A HK1251582A1 (zh) 2015-06-24 2018-08-23 人源化的抗-tau(ps422)抗體和使用方法

Country Status (10)

Country Link
US (4) US9862763B2 (zh)
EP (2) EP3313877B1 (zh)
JP (3) JP6619460B2 (zh)
CN (2) CN107810196B (zh)
AR (1) AR105089A1 (zh)
ES (1) ES2809728T3 (zh)
HK (1) HK1251582A1 (zh)
PL (1) PL3313877T3 (zh)
TW (1) TW201708254A (zh)
WO (1) WO2016207245A1 (zh)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
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TWI822683B (zh) * 2017-06-26 2023-11-21 日商榮研化學股份有限公司 各種動物之血清澱粉狀蛋白a之測定方法及其測定試劑
CA3227440A1 (en) 2021-07-27 2023-02-02 Stand Therapeutics Co., Ltd. Peptide tag and nucleic acid encoding same
WO2023092004A1 (en) 2021-11-17 2023-05-25 Voyager Therapeutics, Inc. Compositions and methods for the treatment of tau-related disorders
WO2023094282A1 (en) 2021-11-25 2023-06-01 F. Hoffmann-La Roche Ag Quantification of low amounts of antibody sideproducts
CN116948025B (zh) * 2023-09-14 2024-04-02 北京凯祥弘康生物科技有限公司 一种抗Tau蛋白的抗体

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Also Published As

Publication number Publication date
JP2018520133A (ja) 2018-07-26
US9862763B2 (en) 2018-01-09
CN107810196A (zh) 2018-03-16
US10822402B2 (en) 2020-11-03
JP6619460B2 (ja) 2019-12-11
TW201708254A (zh) 2017-03-01
ES2809728T3 (es) 2021-03-05
US20160376352A1 (en) 2016-12-29
JP6965328B2 (ja) 2021-11-10
JP2020037580A (ja) 2020-03-12
EP3313877B1 (en) 2020-06-03
CN113929779A (zh) 2022-01-14
JP2022023149A (ja) 2022-02-07
US11572404B2 (en) 2023-02-07
PL3313877T3 (pl) 2020-11-02
US20180079804A1 (en) 2018-03-22
JP7257482B2 (ja) 2023-04-13
US20210139571A1 (en) 2021-05-13
WO2016207245A1 (en) 2016-12-29
CN107810196B (zh) 2021-11-05
EP3313877A1 (en) 2018-05-02
US20230265177A1 (en) 2023-08-24
EP3744732A1 (en) 2020-12-02
AR105089A1 (es) 2017-09-06

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