HK1231484A1 - 作为tnks1和/或tnks2的抑制剂的酰胺基取代的唑类化合物 - Google Patents

作为tnks1和/或tnks2的抑制剂的酰胺基取代的唑类化合物 Download PDF

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Publication number
HK1231484A1
HK1231484A1 HK17105307.8A HK17105307A HK1231484A1 HK 1231484 A1 HK1231484 A1 HK 1231484A1 HK 17105307 A HK17105307 A HK 17105307A HK 1231484 A1 HK1231484 A1 HK 1231484A1
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HK
Hong Kong
Prior art keywords
imidazole
phenyl
dicarboxamide
group
amino group
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HK17105307.8A
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English (en)
Chinese (zh)
Inventor
Knut Eis
Jens Ackerstaff
Sarah WAGNER
Daniel BASTING
Stefan Golz
Eckhard Bender
Volkhart Min-Jian Li
Philip Lienau
Ningshu Liu
Franziska SIEGEL
Marcus Bauser
Detlev Sülzle
Simon Holton
Michaela Bairlein
Philipp BUCHGRABER
József BÁLINT
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拜耳医药股份公司
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Application filed by 拜耳医药股份公司 filed Critical 拜耳医药股份公司
Publication of HK1231484A1 publication Critical patent/HK1231484A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
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    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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    • A61K31/42—Oxazoles
    • A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
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HK17105307.8A 2014-04-02 2015-04-01 作为tnks1和/或tnks2的抑制剂的酰胺基取代的唑类化合物 HK1231484A1 (zh)

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US201461973925P 2014-04-02 2014-04-02
US61/973,925 2014-04-02
EP14163261 2014-04-02
EP14163261.2 2014-04-02
PCT/EP2015/057167 WO2015150449A2 (en) 2014-04-02 2015-04-01 Amido-substituted azole compounds

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IL247678A0 (en) 2016-11-30
AP2016009476A0 (en) 2016-09-30
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CA2944370A1 (en) 2015-10-08
UY36060A (es) 2015-10-30
MA39824A (fr) 2017-02-08
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CN106459015A (zh) 2017-02-22
US9884063B2 (en) 2018-02-06
AU2015239548A1 (en) 2016-09-29
EA201691962A1 (ru) 2017-04-28
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EP3126337A2 (en) 2017-02-08
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PH12016501932A1 (en) 2016-12-19
WO2015150449A2 (en) 2015-10-08
PE20161386A1 (es) 2017-01-15
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BR112016022749A2 (pt) 2019-09-24
MX2016012937A (es) 2017-03-31

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