Classifications

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  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K31/00—Medicinal preparations containing organic active ingredients
  • A61K31/33—Heterocyclic compounds
  • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
  • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
  • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
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  • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
  • A61K31/4164—1,3-Diazoles
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  • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
  • A61K31/4164—1,3-Diazoles
  • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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  • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
  • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
  • A61K31/42—Oxazoles
  • A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
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  • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
  • A61K31/42—Oxazoles
  • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
• • A—HUMAN NECESSITIES
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  • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
  • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
  • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
  • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
  • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
• • A—HUMAN NECESSITIES
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  • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
  • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
  • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
  • A61K31/445—Non condensed piperidines, e.g. piperocaine
  • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
  • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
• • A—HUMAN NECESSITIES
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  • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
  • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
  • A61K31/445—Non condensed piperidines, e.g. piperocaine
  • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
  • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
• • A—HUMAN NECESSITIES
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  • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
  • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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  • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
  • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
  • A61K31/4965—Non-condensed pyrazines
  • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
• • A—HUMAN NECESSITIES
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  • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
  • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
  • A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
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  • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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  • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
  • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
  • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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  • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
  • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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  • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
  • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
  • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
  • C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain
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  • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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  • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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  • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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Definitions

• the present invention relates to amido-substituted azole compounds of general formula (I) as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neoplasms, as a sole agent or in combination with other active ingredients.
• Cancer is the leading cause of death in developed countries and the second leading cause of death in developing countries. Deaths from cancer worldwide are projected to continue rising, with an estimated 12 million deaths in 2030. While substantial progress has been made in developing effective therapies, there is a need for additional therapeutic modalities that target cancer and related diseases.
• cancer stem cells represent the apex in the hierarchical model of tumor genesis, heterogeneity and metastasis. CSCs possess the capacity for unlimited selfrenewal, the ability to give rise to progeny cells, and also an innate resistance to cytotoxic therapeutics [Corbin E.
• Wnts are secreted glycoproteins which bind to cell surface receptors to initiate signaling cascades.
• Wnt signaling cascades have classified into two categories: canonical and non-canonical, differentiated by their dependence on ⁇ -catenin.
• Non-canonical Wnt pathways such as the planar cell polarity (PCP) and Ca2+ pathway, function through ⁇ -catenin independent mechanisms.
• ⁇ -catenin In the absence of Wnt stimulus, ⁇ -catenin is held in an inactive state by a multimeric "destruction" complex comprised of adenomatous polyposis coli (APC), Axin, glycogen synthase kinase 3B (GSK36) and casein kinase 1 a (CK1 a).
• APC and Axin function as a scaffold, permitting GSK36- and CK1 a-mediated phosphorylation of critical residues within ⁇ -catenin.
• ⁇ -catenin is stabilized and translocated to nucleus. Once in the nucleus, ⁇ -catenin forms a complex with members of the T- cell factor/lymphoid enhancer factor (TCF/LEF) family of transcription factors, recruiting co-factors such as CBP, p300, TNIK, Bcl9 and Pygopus, and ultimately driving transcription of target genes including c-myc, Oct4, cyclin D, surviving Joshua C. Curtin and Matthew V. Lorenzi. Drug Discovery Approaches to Target Wnt Signaling in Cancer Stem Cells. Oncotarget 1: 552, 2010].
• TCF/LEF T- cell factor/lymphoid enhancer factor
• Tankyrases play a key role in the destruction complex by regulating the stability of the rate-limiting AXIN proteins, RNF146 and tankyrase itself.
• the E3 ubiquitin ligase RNF146 recognizes tankyrase-mediated PARsylation and eartags AXIN, tankyrase and itself for proteasome-mediated degradation.
• tankyrases control the protein stability and turnover of key components of the destruction complex, and consequently the cellular levels of ⁇ -catenin [Shih-Min A. Huang, Yuji M. Mishina, Shanming Liu, Atwood Cheung, Frank Stegmeier, et al. Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling.
• RNF146 is a poly(ADP- ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling. Nature Cell Biology 13:623-629, 2011].
• Wnt/B-catenin signaling pathway Aberrant regulation of the Wnt/B-catenin signaling pathway is a common feature across a broad spectrum of human cancers and evolves as a central mechanism in cancer biology.
• Wnt overexpression could lead to malignant transformation of mouse mammary tissue [Klaus A, BirchmeierW. Wnt signalling and its impact on development and cancer. Nat Rev Cancer 8: 387-398, 2008].
• Second, tumor genome sequencing discovered the mutations in Wnt/6-catenin pathway components as well as epigenetic mechanisms that altered the expression of genes relevant to Wnt/6-catenin pathway [Ying,Y. et al. Epigenetic disruption of the WNT/beta-catenin signaling pathway in human cancers. Epigenetics 4:307, 2009].
• Wnt/6-catenin pathway also cooperates with other oncogenic signaling pathways in cancer and regulates tumorigenesis, growth, and metastasis[Maus A, BirchmeierW. Wnt signalling and its impact on development and cancer. Nat Rev Cancer 8: 387-398, 2008].
• WNT signaling between tumor and stromal cell interaction leading to tumorigenesis and metastasis [Shahi P, Park D, Pond AC, Seethammagari M, Chiou S-H, Cho K, et al. Activation of Wnt signaling by chemically induced dimerization of LRP5 disrupts cellular homeostasis.
• PLoS ONE 7: e30814, 2012
• stem-like colon cells with a high level of 6- catenin signaling have a much greater tumorigenic potential than counterpart cells with low ⁇ -catenin signaling [Vermeulen L, De Sousa EMF, van der Heijden M, Cameron K, de Jong JH, Borovski T, Tuynman JB, Todaro M, Merz C, Rodermond H, Sprick MR, Kemper K, Richel DJ, Stassi G, Medema JP. Wnt activity defines colon cancer stem cells and is regulated by the microenvironment. Nat Cell Biol. 12: 468-76, 2010].
• activation of Wnt/6-catenin signalling pathway is also one of the major mechanism causing tumor recurrence and drug resistance. All these provide clear rationale to develop therapeutics targeting Wnt/6-catenin signaling pathway for the treatment of cancer.
• Inhibition of TNKS blocks PARsylation of AXIN1 and AXIN2 and prevents their proteasomal degradation.
• TNKS inhibition enhances the activity of the ⁇ - catenin destruction complex and suppresses ⁇ -catenin nuclear transclocation and the expression of ⁇ -catenin target genes.
• tankyrases are also implicated in other cellular functions, including telomere homeostasis, mitotic spindle formation, vesicle transport linked to glucose metabolism, and viral replication. In these processes, tankyrases interact with target proteins, catalyze poly (ADP-ribosyl)ation, and regulate protein interactions and stability.
• TNKS1 controls telomere homeostasis, which promotes telomeric extension by PARsylating TRF1 .
• TRF1 is then targeted for proteasomal degradation by the E3 ubiquitin ligases F- box only protein 4 and /or RING finger LIM domain-binding protein (RLIM/RNF12), which facilitates telomere maintenance [Donigian JR and de Lange T. The role of the poly(ADP-ribose) polymerase tankyrasel in telomere length control by the TRF1 component of the shelterin complex. J Biol Chem 282:22662, 2007].
• telomeric end- capping also requires canonical DNA repair proteins such as DNA-dependent protein kinase (DNAPK) TNKS1 stabilizes the catalytic subunit of DNAPK (DNAPKcs) by PARsylation [Dregalla RC, Zhou J, Idate RR, Battaglia CI, Liber HL, Bailey SM. Regulatory roles of tankyrase 1 at telomeres and in DNA repair: suppression of T- SCE and stabilization of DNA-PKcs. Aging 2(10):691, 2010] . Altered expression of TNKS1 and/or TNKS2, as well as genetic alterations in the tankyrase locus, have been detected in multiple tumors, e.g.
• tankyrases appear to have impact on viral infections. For example, HSV infection, it was shown that the virus cannot replicate efficiently in cells that with depletion of both TNKS1 and TNKS2.
• TNKS1 knockout mice appeared to have reduced fat pads, suggesting a potential connection of TNKS and obesity. TNKS may also play a role in tissue fibrosis.
• tankyrases are promising drug targets in regulating WNT signalling, telomere length (e.g. telomere shortening and DNA damage induced cell death), lung fibrogenesis, myelination and viral infection.
• the invention presented here describes a novel class of tankyrase inhibitors and their potential clinical utility for the treatment of various diseases, such as cancer, aging, metabolic diseases (e.g. diabetes and obesity), fibrosis (e.g. lung fibrogenesis) and viral infection.
• WO 2008/042283 discloses imidazole-4,5-dicarboxamide derivatives as JAK2 modulators.
• WO 2001 /000575 discloses heterocyclic dicarboxylic acid diamide derivatives as insecticides, including amido-substituted azole compounds.
• the state of the art described above does not describe the specific substituted amido-substituted azole compounds of general formula (I) of the present invention as defined herein, i.e. an imidazole or an oxazole moiety, bearing : - in its 4-position, a group of structure:
• - * indicates the point of attachment of said groups with the rest of the molecule
• - R 1 represents -OR 9 , or -N(R 10 )R 11 , which are as defined herein, and - in its 5-position, a group of structure:
• - * indicates the point of attachment of said groups with the rest of the molecule
• - X 2 represents CR 6 or N
• R 4 , R 5 , R 6 , R 7 and R 8 are as defined herein, and - in its 2-position, a substituent R 2 ,
• - R 2 represents a group selected from hydrogen, Ci -C3-alkyl, or C 3 -C4-cycloalkyl ; or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same, as described and defined herein, and as hereinafter referred to as "compounds of the present invention", or their pharmacological activity.
• said compounds of the present invention have surprisingly been found to effectively inhibit TNKS1 and/or TNKS2 and may therefore be used for the treatment or prophylaxis of diseases of uncontrolled cell growth, proliferation and/or survival, inappropriate cellular immune responses, or inappropriate cellular inflammatory responses or diseases which are accompanied with uncontrolled cell growth, proliferation and/or survival, inappropriate cellular immune responses, or inappropriate cellular inflammatory responses mediated by TNKS1 and/or TNKS2 and/or mediated by the Wnt pathway, for example, haematological tumours, solid tumours, and /or metastases thereof, e.g.
• Compounds of the present invention may additionally show improved selectivity for TNKS1 and/or TNKS2 (e.g.
• PARP poly(ADP- ribose)-polymerase
• X 2 represents a CR 6 or N
• R 1 represents a group selected from : -OR 9 , and -N(R 10 )R 11 ,
• R 2 represents a group selected from : hydrogen, Ci-C3-alkyl, and C3-C 4 -cycloalkyl,
• R 3 represents a hydrogen atom
• R 4 represents a hydrogen atom
• R 5 represents a group selected from : hydrogen, Ci -C 3 -alkyl, Ci-C 3 -alkoxy, Ci-C 3 -haloalkyl, Ci -C 3 -haloalkoxy, and halogen,
• R 6 represents a group selected from : hydrogen, and halogen
• R 7 represents a hydrogen atom
• R 8 represents a group selected from : aryl, and heteroaryl, wherein aryl and heteroaryl groups are optionally substituted with one, two or three substituents, which are independently of each other selected from :
• Ci-C6-alkyl Ci -C3-alkoxy, C 3 -C 6 -cycloalkyl, C 3 -Cs-cycloalkoxy,
• R 9 represents a group selected from :
• Ci-C 6 -alkyl C 3 -C 6 -cycloalkyl, C 2 -C6-hydroxyalkyl-, and
• R 10 and R 11 are independently of each other selected from : hydrogen, Ci-C 6 -alkyl, C 3 -Cs-cycloalkyl, (C 3 -C6-cycloalkyl)-Ci-C6-alkyl)-, C 2 -C6-hydroxyalkyl, (Ci-C 3 -alkoxy)-(C 2 -Cs-alkyl)-, Ci -C6-haloalkyl,
• R 11 together with the nitrogen atom to which they are attached form a group selected from :
• * indicates the point of attachment of said group with the rest of the molecule , represents a group selected from : hydrogen, and Ci -C3-alkyl, represents a group selected from : hydrogen, Ci -C 6 -alkyl, d -Cs-hydroxyalkyl, C 3 -C 6 -cycloalkyl,
• Ci -C 3 -haloalkyl, Ci -C 3 -haloalkoxy, halogen, cyano, and hydroxy represents a group selected from : hydrogen, Ci -C 3 -alkyl, Ci -C 3 -haloalkyl, and C 3 -C 4 -cycloalkyl
• R 16 represents a group selected from :
• each definition is independent.
• R 9 , R 10 , R 11 , R 12 and/or R 13 occur more than one time in any compound of formula (I) each definition of R 9 , R 10 , R 11 , R 12 and R 13 is independent.
• a hyphen at the beginning or at the end of the constituent marks the point of attachment to the rest of the molecule. Should a ring be substituted the substitutent could be at any suitable position of the ring, also on a ring nitrogen atom if suitable.
• halogen halogen atom
• halo- halo- or Hal-
• fluorine chlorine, bromine or iodine atom.
• Ci-C6-alkyl is to be understood as preferably meaning a linear or branched, saturated, monovalent hydrocarbon group having 1 , 2, 3, 4, 5, or 6 carbon atoms, e.g. a methyl, ethyl, propyl, butyl, pentyl, hexyl, iso-propyl, iso- butyl, sec-butyl, tert-butyl, iso-pentyl, 2-methylbutyl, 1 -methylbutyl, 1 - ethylpropyl, 1 ,2-dimethylpropyl, neo-pentyl, 1 , 1 -dimethylpropyl, 4-methylpentyl, 3-methylpentyl, 2-methylpentyl, 1 -methylpentyl, 2-ethylbutyl, 1 -ethylbutyl, 3,3- dimethylbutyl, 2,2-dimethylbutyl, 1 , 1 , 1
• said group has 1 , 2, 3 or 4 carbon atoms ("Ci-C4-alkyl”), e.g. a methyl, ethyl, propyl, butyl, iso-propyl, iso-butyl, sec-butyl, tert-butyl group, more particularly 1 , 2 or 3 carbon atoms ("Ci-C3-alkyl”), e.g. a methyl, ethyl, n-propyl- or iso-propyl group, even more particularly 1 or 2 carbon atoms ("Ci -C 2 -alkyl”), e.g. a methyl, ethyl group.
• Ci-C4-alkyl e.g. a methyl, ethyl, propyl, butyl, iso-propyl, iso-butyl, sec-butyl, tert-butyl group, more particularly 1 , 2 or 3 carbon atoms (“C
• Ci -Cs-hydroxyalkyl is to be understood as preferably meaning a linear or branched, saturated, monovalent hydrocarbon group in which the term "C1-C6- alkyl” is defined supra, and in which one or more hydrogen atoms is replaced by a hydroxy group, e.g. a hydroxymethyl, 1 -hydroxyethyl, 2-hydroxyethyl, 1 ,2- dihydroxyethyl, 3-hydroxypropyl, 2-hydroxypropyl, 2,3-dihydroxypropyl, 1 ,3- dihydroxypropan-2-yl, 3-hydroxy-2-methyl-propyl, 2-hydroxy-2-methyl-propyl, 1 - hydroxy-2-methyl-propyl group.
• Ci-C6-haloalkyl is to be understood as preferably meaning a linear or branched, saturated, monovalent hydrocarbon group in which the term "d -Cs- alkyl” is defined supra, and in which one or more hydrogen atoms is replaced by a halogen atom, in identically or differently, i.e. one halogen atom being independent from another. Particularly, said halogen atom is F.
• Ci-C 6 - haloalkyl group is, for example, -CF 3 , -CHF 2 , -CH 2 F, -CF 2 CF 3 , -CH 2 CH 2 F, -CH 2 CHF 2 , - CH 2 CF 3 , or -CH 2 CH 2 CF 3 .
• Ci-C6-alkoxy is to be understood as preferably meaning a linear or branched, saturated, monovalent, hydrocarbon group of formula -O-alkyl having 1 , 2, 3, 4, 5, or 6 carbon atoms, in which the term “alkyl” is defined supra, e.g. a methoxy, ethoxy, n-propoxy, iso-propoxy, n-butoxy, iso-butoxy, tert-butoxy, sec- butoxy, pentoxy, iso-pentoxy, or n-hexoxy group, or an isomer thereof.
• Ci-C6-haloalkoxy is to be understood as preferably meaning a linear or branched, saturated, monovalent Ci-C 6 -alkoxy group, as defined supra, in which one or more of the hydrogen atoms is replaced, in identically or differently, by a halogen atom. Particularly, said halogen atom is F.
• Said Ci-C6-haloalkoxy group is, for example, -OCF 3 , -OCHF 2 , -OCH 2 F, -OCF 2 CF 3 , or -OCH 2 CF 3 .
• C 3 -C6-cycloalkyl is to be understood as meaning a saturated, monovalent, monocyclic hydrocarbon ring which contains 3, 4, 5 or 6 carbon atoms ("C 3 -C6-cycloalkyl").
• Said C 3 -C 6 -cycloalkyl group is for example, a monocyclic hydrocarbon ring, e.g. a cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl ring.
• C 3 -C6-cycloalkoxy is to be understood as preferably meaning a saturated, monovalent, hydrocarbon ring which contains 3, 4, 5 or 6 carbon atoms of formula -O-cycloalkyl, in which the term “cycloalkyl” is defined supra, e.g. a cyclopropyloxy, cyclobutyloxy, cyclopentyloxy or cyclohexyloxy.
• said heterocycloalkyl can be a 4- membered ring, such as an azetidinyl, oxetanyl, or a 5-membered ring, such as tetrahydrofuranyl, dioxolinyl, pyrrolidinyl, imidazolidinyl, pyrazolidinyl, or a 6- membered ring, such as tetrahydropyranyl, piperidinyl, morpholinyl, dithianyl, thiomorpholinyl, piperazinyl, or N-methylpiperazinyl.
• said heterocycloalkyl can be benzo fused.
• 4- to 6-membered heterocycloalkyl can be selected from piperazinyl, tetrahydro-2H- pyranyl, tetrahydrofuranyl, pyrrolidinyl, piperidinyl, morpholinyl, azetidinyl, 2-oxoimidazolidinyl, 2-oxopyrrolidinyl and 1 , 1 - dioxidothiomorpholinyl.
• 4- to 6- membered heterocycloalkyl can be selected from piperazin- 1 -yl, tetrahydro-2H- pyran-4-yl, tetrahydrofuran-3-yl, pyrrolidin- 1 -yl, pyrrolidin-2-yl, pyrrolidin-3-yl, piperidin-4-yl, piperidin- 1 -yl, piperidin-2-yl, piperidin-3-yl, morpholin-4-yl, azetidin- 1 -yl, tetrahydrofuran-2-yl, 2-oxoimidazolidin- 1 -yl, 2-oxopyrrolidin- 1 -yl and 1 , 1 -dioxidothiomorpholin-4-yl.
• aryl is to be understood as preferably meaning a monovalent, aromatic or partially aromatic, mono- or bicyclic hydrocarbon ring having 6, 7, 8, 9 or 10 carbon atoms (a "C6-Cio-aryl” group), particularly a ring having 6 carbon atoms (a "C6-aryl” group), e.g. a phenyl group; or a ring having 9 carbon atoms (a "C9-aryl” group), e.g. an indanyl or indenyl group, or a ring having 10 carbon atoms (a "Cio- aryl” group), e.g. a tetralinyl, dihydronaphthyl, or naphthyl group.
• heteroaryl is understood as preferably meaning a monovalent, monocyclic aromatic ring system having 5 or 6 ring atoms (a "5- to 6-membered heteroaryl” group), which contains at least one heteroatom which may be identical or different, said heteroatom being such as oxygen, nitrogen or sulfur.
• heteroaryl is selected from thienyl, furanyl, pyrrolyl, oxazolyl, thiazolyl, imidazolyl, pyrazolyl, isoxazolyl, isothiazolyl, oxadiazolyl, triazolyl, thiadiazolyl etc.
• heteroaryl can be selected from pyrazolyl , thienyl, pyridyl , furanyl , thiazolyl , oxazolyl , and pyrazinyl.
• the heteroarylic or heteroarylenic radicals include all the possible isomeric forms thereof, e.g. the positional isomers thereof.
• the term pyridinyl or pyridinylene includes pyridin-2-yl, pyridin-2-ylene, pyridin-3-yl, pyridin-3-ylene, pyridin-4-yl and pyridin-4-ylene; or the term thienyl or thienylene includes thien-2- yl, thien-2-ylene, thien-3-yl and thien-3-ylene.
• heteroarylic radicals include all the possible isomeric forms thereof, e.g. the positional isomers thereof.
• pyridinyl includes pyridin-2-yl, pyridin-3-yl and pyridin-4-yl.
• aromatic and non-aromatic (hetero)cyclic groups may optionally be substituted as defined herein.
• the substituents may be present both when said aromatic and non-aromatic (hetero)cyclic groups exist as a (unitary) constituent, such as, for example, C3-C6- cycloalkyl, 4-6-membered heterocycloalkyl, aryl and heteroaryl groups, or as part of a constituent composed of more than one part, such as, for example, (d-d- cycloalkyl)-Ci -C6-alkyl-, (4-6 membered heterocycloalkyl) -(C 2 -C6-alkyl)-, aryl- (Ci -Cs-alkyl)-, and heteroaryl- (Ci -C6-alkyl)-, for example.
• the present invention includes all suitably substituted aromatic and non-aromatic (hetero)cyclic groups both as a (unitary) constituent, or as part of a constituent composed of more than one part.
• aromatic and non-aromatic (hetero)cyclic groups both as a (unitary) constituent, or as part of a constituent composed of more than one part.
• suitable is to be understood as meaning chemically possible to be made by methods within the knowledge of a skilled person.
• d-Cs as used throughout this text, e.g. in the context of the definition of "Ci -Ce-alkyl”, “Ci -Cs-haloalkyl", “d-d-hydroxyalkyl”, “d-d-alkoxy”, or “d-d- haloalkoxy” is to be understood as meaning an alkyl group having a finite number of carbon atoms of 1 to 6, i.e. 1 , 2, 3, 4, 5, or 6 carbon atoms. It is to be understood further that said term “C1 -C6” is to be interpreted as any sub- range comprised therein, e.g.
• d-d as used throughout this text, e.g. in the context of the definitions of "d-d-alkyl", and “d-d-hydroxyalkyl” is to be understood as meaning an alkyl group or a hydroxyalkyl group having a finite number of carbon atoms of 2 to 6, i.e. 2, 3, 4, 5, or 6 carbon atoms. It is to be understood further that said term “d-d” is to be interpreted as any sub-range comprised therein, e.g. d-d , d-d , d-d , d-d , d-d , d-d ; particularly d-d.
• d-d as used throughout this text, e.g. in the context of the definition of "d-d-cycloalkyl”, is to be understood as meaning a cycloalkyl group having a finite number of carbon atoms of 3 to 6, i.e. 3, 4, 5 or 6 carbon atoms. It is to be understood further that said term “d-d” is to be interpreted as any sub- range comprised therein, e.g. C3-C6 , C4-C5 , C3-C5 , C3-C4 , C 4 - Ce, C5-C6 ; particularly C3-C6.
• substituted means that one or more hydrogens on the designated atom is replaced with a selection from the indicated group, provided that the designated atom's normal valency under the existing circumstances is not exceeded, and that the substitution results in a stable compound. Combinations of substituents and/or variables are permissible only if such combinations result in stable compounds.
• Ring system substituent means a substituent attached to an aromatic or nonaromatic ring system which, for example, replaces an available hydrogen on the ring system.
• the term "one or more”, e.g. in the definition of the substituents of the compounds of the general formulae of the present invention, is understood as meaning “one, two, three, four or five, particularly one, two, three or four, more particularly one, two or three, even more particularly one or two".
• the invention also includes all suitable isotopic variations of a compound of the invention.
• An isotopic variation of a compound of the invention is defined as one in which at least one atom is replaced by an atom having the same atomic number but an atomic mass different from the atomic mass usually or predominantly found in nature.
• isotopes that can be incorporated into a compound of the invention include isotopes of hydrogen, carbon, nitrogen, oxygen, phosphorus, sulphur, fluorine, chlorine, bromine and iodine, such as 2 H (deuterium), 3 H (tritium), 11 C, 13 C, 14 C, 15 N, 17 0, 18 0, 32 P, 33 P, 33 S, 34 S, 35 S, 36 S, 18 F, 36 Cl, 82 Br, 123 l, 124 l, 125 l, 129 l and 131 1, respectively.
• isotopic variations of a compound of the invention are useful in drug and/or substrate tissue distribution studies. Tritiated and carbon-14, i.e., 14 C, isotopes are particularly preferred for their ease of preparation and detectability. Further, substitution with isotopes such as deuterium may afford certain therapeutic advantages resulting from greater metabolic stability, for example, increased in vivo half-life or reduced dosage requirements and hence is preferred in some circumstances.
• isotopic variations of a compound of the invention can generally be prepared by conventional procedures known by a person skilled in the art such as by the illustrative methods or by the preparations described in the examples hereafter using appropriate isotopic variations of suitable reagents.
• stable compound' or “stable structure” is meant a compound that is sufficiently robust to survive isolation to a useful degree of purity from a reaction mixture, and formulation into an efficacious therapeutic agent.
• the compounds of this invention optionally contain one or more asymmetric centre, depending upon the location and nature of the various substituents desired.
• Asymmetric carbon atoms is present in the (R) or (S) configuration, resulting in racemic mixtures in the case of a single asymmetric centre, and diastereomeric mixtures in the case of multiple asymmetric centres.
• asymmetry may also be present due to restricted rotation about a given bond, for example, the central bond adjoining two substituted aromatic rings of the specified compounds.
• the compounds of the present invention optionally contain sulphur atoms which are asymmetric, such as an asymmetric sulfoxide, of structure: , for example, in which * indicates atoms to which the rest of the molecule can be bound.
• Preferred compounds are those which produce the more desirable biological activity.
• Separated, pure or partially purified isomers and stereoisomers or racemic or diastereomeric mixtures of the compounds of this invention are also included within the scope of the present invention.
• the purification and the separation of such materials can be accomplished by standard techniques known in the art.
• the optical isomers can be obtained by resolution of the racemic mixtures according to conventional processes, for example, by the formation of diastereoisomeric salts using an optically active acid or base or formation of covalent diastereomers.
• appropriate acids are tartaric, diacetyltartaric, ditoluoyltartaric and camphorsulfonic acid.
• Mixtures of diastereoisomers can be separated into their individual diastereomers on the basis of their physical and /or chemical differences by methods known in the art, for example, by chromatography or fractional crystallisation.
• the optically active bases or acids are then liberated from the separated diastereomeric salts.
• a different process for separation of optical isomers involves the use of chiral chromatography (e.g. , chiral HPLC columns), with or without conventional derivatisation, optimally chosen to maximise the separation of the enantiomers.
• Suitable chiral HPLC columns are manufactured by Daicel, e.g. , Chiracel OD and Chiracel OJ among many others, all routinely selectable.
• Enzymatic separations, with or without derivatisation are also useful.
• the optically active compounds of this invention can likewise be obtained by chiral syntheses utilizing optically active starting materials.
• lUPAC Rules Section E Pure Appl Chem 45, 1 1 -30, 1976).
• the present invention includes all possible stereoisomers of the compounds of the present invention as single stereoisomers, or as any mixture of said stereoisomers, e.g. R- or S- isomers, or E- or Z-isomers, in any ratio.
• Isolation of a single stereoisomer, e.g. a single enantiomer or a single diastereomer, of a compound of the present invention is achieved by any suitable state of the art method, such as chromatography, especially chiral chromatography, for example.
• the compounds of the present invention may exist as tautomers.
• any compound of the present invention which contains a pyrazole moiety as a heteroaryl group for example can exist as a 1 H tautomer, or a 2H tautomer, or even a mixture in any amount of the two tautomers, namely :
• the present invention can exist as one of the below tautomers, or even in a mixture in any amount of the two tautomers, namely:
• the present invention includes all possible tautomers of the compounds of the present invention as single tautomers, or as any mixture of said tautomers, in any ratio.
• the compounds of the present invention can exist as N -oxides, which are defined in that at least one nitrogen of the compounds of the present invention is oxidised.
• the present invention includes all such possible N -oxides.
• the present invention also relates to useful forms of the compounds as disclosed herein, such as metabolites, hydrates, solvates, prodrugs, salts, in particular pharmaceutically acceptable salts, and co-precipitates.
• the compounds of the present invention can exist as a hydrate, or as a solvate, wherein the compounds of the present invention contain polar solvents, in particular water, methanol or ethanol for example as structural element of the crystal lattice of the compounds.
• polar solvents in particular water, methanol or ethanol for example as structural element of the crystal lattice of the compounds.
• the amount of polar solvents, in particular water may exist in a stoichiometric or non-stoichiometric ratio.
• stoichiometric solvates e.g. a hydrate, hemi-, (semi-), mono-, sesqui-, di-, tri-, tetra-, penta- etc. solvates or hydrates, respectively, are possible.
• the present invention includes all such hydrates or solvates.
• the compounds of the present invention can exist in free form, e.g. as a free base, or as a free acid, or as a zwitterion, or can exist in the form of a salt.
• Said salt may be any salt, either an organic or inorganic addition salt, particularly any pharmaceutically acceptable organic or inorganic addition salt, customarily used in pharmacy.
• pharmaceutically acceptable salt refers to a relatively non-toxic, inorganic or organic acid addition salt of a compound of the present invention.
• pharmaceutically acceptable salt refers to a relatively non-toxic, inorganic or organic acid addition salt of a compound of the present invention.
• S. M. Berge, et al. “Pharmaceutical Salts, " J. Pharm. Sci. 1977, 66, 1 -19.
• a suitable pharmaceutically acceptable salt of the compounds of the present invention may be, for example, an acid-addition salt of a compound of the present invention bearing a nitrogen atom, in a chain or in a ring, for example, which is sufficiently basic, such as an acid-addition salt with an inorganic acid, such as hydrochloric, hydrobromic, hydroiodic, sulfuric, bisulfuric, phosphoric, or nitric acid, for example, or with an organic acid, such as formic, acetic, acetoacetic, pyruvic, trifluoroacetic, propionic, butyric, hexanoic, heptanoic, undecanoic, lauric, benzoic, salicylic, 2- (4-hydroxybenzoyl)-benzoic, camphoric, cinnamic, cyclopentanepropionic, digluconic, 3-hydroxy-2-naphthoic, nicotinic, pamoic, pectinic,
• an alkali metal salt for example a sodium or potassium salt
• an alkaline earth metal salt for example a calcium or magnesium salt
• an ammonium salt or a salt with an organic base which affords a physiologically acceptable cation, for example a salt with N-methyl-glucamine, dimethyl-glucamine, ethyl-glucamine, lysine, dicyclohexylamine, 1 ,6-hexadiamine, ethanolamine, glucosamine, sarcosine, serinol, tris-hydroxy-methyl-aminomethane, aminopropandiol, sovak-base, 1 -amino-2,3,4-butantriol.
• basic nitrogen containing groups may be quaternised with such agents as lower alkyl halides such as methyl, ethyl, propyl, and butyl chlorides, bromides and iodides ; dialkyl sulfates like dimethyl, diethyl, and dibutyl sulfate ; and diamyl sulfates, long chain halides such as decyl, lauryl, myristyl and strearyl chlorides, bromides and iodides, aralkyl halides like benzyl and phenethyl bromides and others.
• lower alkyl halides such as methyl, ethyl, propyl, and butyl chlorides, bromides and iodides
• dialkyl sulfates like dimethyl, diethyl, and dibutyl sulfate
• diamyl sulfates long chain halides such as decyl, la
• acid addition salts of the claimed compounds may be prepared by reaction of the compounds with the appropriate inorganic or organic acid via any of a number of known methods.
• alkali and alkaline earth metal salts of acidic compounds of the invention are prepared by reacting the compounds of the invention with the appropriate base via a variety of known methods.
• the present invention includes all possible salts of the compounds of the present invention as single salts, or as any mixture of said salts, in any ratio.
• in vivo hydrolysable ester is understood as meaning an in vivo hydrolysable ester of a compound of the present invention containing a carboxy or hydroxy group, for example, a pharmaceutically acceptable ester which is hydrolysed in the human or animal body to produce the parent acid or alcohol.
• Suitable pharmaceutically acceptable esters for carboxy include for example alkyl, cycloalkyl and optionally substituted phenylalkyl, in particular benzyl esters, Ci -C 6 alkoxymethyl esters, e.g. methoxymethyl, Ci -C 6 alkanoyloxymethyl esters, e.g. pivaloyloxymethyl, phthalidyl esters, C3-C8 cycloalkoxy-carbonyloxy-Ci-C6 alkyl esters, e.g. 1 -cyclohexylcarbonyloxyethyl ; 1 ,3-dioxolen-2-onylmethyl esters, e.g.
• An in vivo hydrolysable ester of a compound of the present invention containing a hydroxy group includes inorganic esters such as phosphate esters and [alpha] - acyloxyalkyl ethers and related compounds which as a result of the in vivo hydrolysis of the ester breakdown to give the parent hydroxy group.
• inorganic esters such as phosphate esters and [alpha] - acyloxyalkyl ethers and related compounds which as a result of the in vivo hydrolysis of the ester breakdown to give the parent hydroxy group.
• [alpha] -acyloxyalkyl ethers include acetoxymethoxy and 2,2- dimethylpropionyloxymethoxy.
• a selection of in vivo hydrolysable ester forming groups for hydroxy include alkanoyl, benzoyl, phenylacetyl and substituted benzoyl and phenylacetyl, alkoxycarbonyl (to give alkyl carbonate esters), dialkylcarbamoyl and N-(dialkylaminoethyl)-N-alkylcarbamoyl (to give carbamates), dialkylaminoacetyl and carboxyacetyl.
• the present invention covers all such esters.
• the present invention includes all possible crystalline forms, or polymorphs, of the compounds of the present invention, either as single polymorph, or as a mixture of more than one polymorph, in any ratio.
• the present invention covers compounds of general formula (I), supra, in which :
• X 1 represents NR 3 or 0,
• X 2 represents CR 6 or N
• R 1 represents a group selected from : -OR 9 , and -N(R 10 )R 11
• R 2 represents a group selected from : hydrogen, and Ci-C 3 -alkyl
• R 3 represents a hydrogen atom
• R 4 represents a hydrogen atom
• R 5 represents a group selected from : hydrogen, Ci -C 3 -alkyl, Ci-C 3 -alkoxy and Ci -C 3 -haloalkoxy
• R 6 represents a group selected from : hydrogen, and halogen
• R 7 represents a hydrogen atom
• R 8 represents a group selected from : aryl, and heteroaryl, wherein aryl and heteroaryl groups are optionally substituted with one, two or three substituents, which are independently of each other selected from :
• Ci-C6-alkyl Ci -C3-alkoxy, C 3 -C 6 -cycloalkyl, C 3 -Cs-cycloalkoxy,
• R 9 represents a group selected from :
• Ci-C 6 -alkyl C 3 -C 6 -cycloalkyl, C 2 -C6-hydroxyalkyl-, and
• R 10 and R 11 are independently of each other selected from : hydrogen, Ci-C 6 -alkyl, C 3 -Cs-cycloalkyl, (C 3 -C6-cycloalkyl)- (Ci-C6-alkyl)-, C 2 -C6-hydroxyalkyl, (Ci-C 3 -alkoxy)-(C 2 -Cs-alkyl)-, Ci -C6-haloalkyl,
• R 11 together with the nitrogen atom to which they are attached form a group selected from :
• * indicates the point of attachment of said group with the rest of the molecule , represents a group selected from : hydrogen, and Ci -C3-alkyl, represents a group selected from : hydrogen, Ci -C 6 -alkyl, d -Cs-hydroxyalkyl, C 3 -C 6 -cycloalkyl,
• Ci -C 3 -haloalkyl, Ci -C 3 -haloalkoxy, halogen, cyano, and hydroxy represents a group selected from : hydrogen, Ci -C 3 -alkyl, Ci -C 3 -haloalkyl, and C 3 -C 4 -cycloalkyl
• R 16 represents a group selected from :
• the present invention covers compounds of general formula (I), supra, in which :
• X 1 represents NR 3 or 0,
• X 2 represents CR 6 or N
• R 1 represents a group selected from : -OR 9 , and -N(R 10 )R 11
• R 2 represents a group selected from : hydrogen, and Ci -C 3 -alkyl
• R 3 represents a hydrogen atom
• R 4 represents a hydrogen atom
• R 5 represents a group selected from : hydrogen, and Ci -C 3 -alkyl
• R 6 represents a group selected from : hydrogen, and halogen
• R 7 represents a hydrogen atom
• R 8 represents a group selected from : aryl, and heteroaryl, wherein aryl and heteroaryl groups are optionally substituted with one, two or three substituents, which are independently of each other selected from :
• Ci-C3-haloalkyl Ci-C3-haloalkoxy, halogen, cyano, nitro, hydroxy,
• R 9 represents a group selected from : d-Cs-alkyl, C3-C 6 -cycloalkyl, C 2 -Cs-hydroxyalkyl- , and
• R 10 and R 11 are independently of each other selected from : hydrogen, Ci-C 6 -alkyl, C3-C 6 -cycloalkyl, (C3-Cs-cycloalkyl)-(Ci-C6-alkyl)- ,
• aryl-(Ci-C6-alkyl)- aryl-(Ci-C6-alkyl)- , and heteroaryl-(Ci-C6-alkyl)-, wherein 4-6-membered heterocycloalkyl groups are optionally substituted with one or two substituents, which are independently of each other selected from :
• R 10 and R 11 together with the nitrogen atom to which they are attached form a group selected from :
• R 12 represents a group selected from : hydrogen, and Ci-C3-alkyl
• R 13 represents a group selected from : hydrogen, Ci-C 6 -alkyl, Ci-C6-hydroxyalkyl, C3-Cs-cycloalkyl,
• CrCs-haloalkyl (Ci-C3-alkoxy)-(Ci-C6-alkyl)-, aryl, and heteroaryl, wherein aryl and heteroaryl groups are optionally substituted with one or two substituents, which are independently of each other selected from :
• Ci-C 3 -haloalkyl Ci-C 3 -haloalkoxy, halogen, cyano, and hydroxy
• R 14 represents a group selected from : hydrogen, Ci-C 3 -alkyl, Ci-C 3 -haloalkyl, and C 3 -C 4 -cycloalkyl
• R 16 represents a group selected from : Ci-C 4 -alkyl, and C 3 -C 4 -cycloalkyl, or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same.
• the present invention covers compounds of general formula (I), supra, in which :
• X 1 represents NR 3 or 0,
• X 2 represents CR 6 or N
• R 1 represents a group selected from : -OR 9 , and -N(R 10 )R 11
• R 2 represents a group selected from : hydrogen, and Ci-C 3 -alkyl
• R 3 represents a hydrogen atom
• R 4 represents a hydrogen atom
• R 5 represents a group selected from : hydrogen, Ci-C 3 -alkyl, Ci-C 3 -alkoxy and Ci-C 3 -haloalkoxy
• R 6 represents a group selected from : hydrogen, and halogen
• R 7 represents a hydrogen atom
• R 8 represents a group selected from : aryl, and heteroaryl, wherein aryl and heteroaryl groups are optionally substituted with one, two or three substituents, which are independently of each other selected from :
• Ci-C6-alkyl Ci-C3-alkoxy, C3-C 6 -cycloalkyl, C3-Cs-cycloalkoxy, Ci-C3-haloalkyl, Ci-C3-haloalkoxy, halogen, cyano, nitro, hydroxy,
• R 11 are independently of each other selected from hydrogen, Ci-C 6 -alkyl, C3-Cs-cycloalkyl, (C3-C6-cycloalkyl)-(Ci-C6-alkyl)-, C 2 -C6-hydroxyalkyl, (Ci-C3-alkoxy)-(C 2 -Cs-alkyl)-, Ci-C6-haloalkyl, H 2 N-(C 2 -C6 alkyl)-, (Ci-C 3 -alkyl)N(H)(C 2 -C 6 -alkyl)-, (Ci-C 3 -alkyl) 2 N(C 2 -C 6 -alkyl)-, 4-6 membered heterocycloalkyl, (4-6 membered heterocycloalkyl)- (C 2 -C 6 -alkyl) aryl-(Ci-C6-alkyl)-
• R 10 and R 11 together with the nitrogen atom to which they are attached form a roup selected from :
• R 12 represents a group selected from hydrogen, and Ci-C3-alkyl
• R 13 represents a group selected from : hydrogen, Ci-C6-alkyl, d-Cs-hydroxyalkyl, C3-C6-cycloalkyl,
• R 14 represents a group selected from : hydrogen, Ci-C 3 -alkyl, Ci-C 3 -haloalkyl, and C 3 -C 4 -cycloalkyl,
• R 16 represents a group selected from : CrC 4 -alkyl, and C 3 -C 4 -cycloalkyl, or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same.
• the present invention covers compounds of general formula (I), supra, in which :
• X 1 represents NR 3 or 0,
• X 2 represents CR 6 or N
• R 1 represents a group selected from : -OR 9 , and -N(R 10 )R 11 ,
• R 2 represents a group selected from : hydrogen, and Ci -C3-alkyl
• R 3 represents a hydrogen atom
• R 4 represents a hydrogen atom
• R 5 represents a group selected from : hydrogen, and Ci -C 3 -alkyl
• R 6 represents a group selected from : hydrogen, and halogen
• R 7 represents a hydrogen atom
• R 8 represents a group selected from : aryl, and heteroaryl, wherein aryl and heteroaryl groups are optionally substituted with one, two or three substituents, which are independently of each other selected from :
• Ci -Cs-alkyl Ci-C 3 -alkoxy, C 3 -C 6 -cycloalkyl, C 3 -C6-cycloalkoxy,
• Ci -C 3 -haloalkyl Ci-C 3 -haloalkoxy, halogen, cyano, nitro, hydroxy,
• R 9 represents a d -Cs-alkyl group
• R 10 and R 11 are independently of each other selected from : hydrogen, Ci-C6-alkyl, C3-C6-cycloalkyl, (C3-C6-cycloalkyl)-(Ci-C6-alkyl)- ,
• R 10 and R 11 together with the nitrogen atom to which they are attached form a group selected from :
• R 12 represents a group selected from : hydrogen, and Ci -C3-alkyl
• R 13 represents a group selected from : hydrogen, Ci -C 6 -alkyl, Ci -C6-hydroxyalkyl, C3-Cs-cycloalkyl,
• Ci -C 3 -haloalkyl Ci -C 3 -haloalkoxy, halogen, cyano, and hydroxy
• R 14 represents a group selected from : hydrogen, Ci -C 3 -alkyl, Ci -C 3 -haloalkyl, and C 3 -C 4 -cycloalkyl
• R 16 represents a group selected from :
• the present invention covers compounds of general formula (I), supra, in which :
• X 1 represents NR 3 or 0,
• X 2 represents CR 6 or N
• R 1 represents a group selected from : -OR 9 , and -N (R 10 )R 11 ,
• R 2 represents a group selected from : hydrogen, and Ci -C3-alkyl
• R 3 represents a hydrogen atom
• R 4 represents a hydrogen atom
• R 5 represents a group selected from : hydrogen, Ci -C3-alkyl, Ci -C3-alkoxy and Ci -C3-haloalkoxy,
• R 6 represents a group selected from : hydrogen, and halogen
• R 7 represents a hydrogen atom
• R 8 represents a group selected from : aryl, and heteroaryl, wherein aryl and heteroaryl groups are optionally substituted with one, two or three substituents, which are independently of each other selected from :
• R 10 and R 11 are independently of each other selected from : hydrogen, Ci-C 6 -alkyl, C3-Cs-cycloalkyl, (C3-C6-cycloalkyl)-(Ci-C6-alkyl)-, C 2 -C6-hydroxyalkyl, (Ci-C3-alkoxy)-(C 2 -Cs-alkyl)-, Ci-C6-haloalkyl, H 2 N-(C 2 -C6- alkyl)-, (Ci-C 3 -alkyl)N(H)(C 2 -C6-alkyl)-,(Ci-C3-alkyl) 2 N(C 2 -C 6 -alkyl)-, 4-6 membered heterocycloalkyl, (4-6 membered heterocycloalkyl)-(C 2 -C6-alkyl)-, aryl-(Ci-C6-alkyl)- and heteroaryl-(Ci-
• R 11 together with the nitrogen atom to which they are attached form a group selected from :
• R 12 represents a hydrogen atom
• R 13 represents a group selected from : hydrogen, and Ci-C 6 -alkyl
• R 14 represents a group selected from : hydrogen, Ci-C 3 -alkyl, Ci-C 3 -haloalkyl, and C 3 -C 4 -cycloalkyl
• R 16 represents a group selected from : Ci -C 4 -alkyl, or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same.
• the present invention covers compounds of general formula (I), supra, in which :
• X 1 represents NR 3 or 1
• X 2 represents CR 6 or N
• R 1 represents a group selected from : -OR 9 , and -N (R 10 )R 11 ,
• R 2 represents a group selected from : hydrogen, and Ci -C3-alkyl
• R 3 represents a hydrogen atom
• R 4 represents a hydrogen atom
• R 5 represents a group selected from : hydrogen, and Ci -C3-alkyl
• R 6 represents a hydrogen atom
• R 7 represents a hydrogen atom
• R 8 represents a group selected from : aryl, and heteroaryl, wherein aryl and heteroaryl groups are optionally substituted with one, two or three substituents, which are independently of each other selected from : d -Cs-alkyl, Ci-C3-alkoxy, Ci-C3-haloalkyl, halogen, nitro,
• R 9 represents a d -Cs-alkyl group
• R 10 and R 11 are independently of each other selected from : hydrogen, d-Cs-alkyl, C3-C 6 -cycloalkyl, (C3-Cs-cycloalkyl)-(Ci-C6-alkyl)- ,
• Ci -C3-haloalkyl, Ci-C3-haloalkoxy, halogen, cyano, -C( 0)OH,
• R 10 and R 11 together with the nitrogen atom to which they are attached form a group selected from :
• R 12 represents a hydrogen atom
• R 13 represents a group selected from : hydrogen, and Ci-C6-alkyl
• R 14 represents a group selected from : hydrogen, Ci-C 3 -alkyl, Ci-C 3 -haloalkyl, and C 3 -C 4 -cycloalkyl,
• R 16 represents a group selected from :
• Ci-C 4 -alkyl or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same.
• the present invention covers compounds of general formula (I), supra, in which :
• X 1 represents NR 3 or 0,
• X 2 represents CR 6 or N ,
• R 1 represents a group selected from : -OR 9 , and -N (R 10 )R 11 ,
• R 2 represents a group selected from : hydrogen, and Ci -C3-alkyl
• R 3 represents a hydrogen atom
• R 4 represents a hydrogen atom
• R 5 represents a group selected from : hydrogen, methoxy, trifluoromethoxy and methyl
• R 6 represents a hydrogen or a fluorine atom
• R 7 represents a hydrogen atom
• R 8 represents a group selected from : Phenyl , pyrazolyl , thienyl , pyridyl , furanyl , thiazolyl , oxazolyl ,and pyrazinyl wherein said groups are optionally substituted with one, two or three substituents, which are independently of each other selected from :
• R 9 represents a Ci-C 2 -alkyl group
• R 10 and R 11 are independently of each other selected from : hydrogen, Ci-Cs-alkyl, cyclopropyl, (C3-C5-cycloalkyl)-(Ci-C 2 -alkyl)-, C 2 -Cs- hydroxyalkyl, (Ci-C3-alkoxy)-(C 2 -C3-alkyl)-, Ci-C 2 -haloalkyl, H 2 N-(C 2 -C5-alkyl)- , (Ci-C 3 -alkyl)N(H)(C 2 -alkyl)- , (Ci-C 3 -alkyl) 2 N(C 2 -C 5 -alkyl)- , piperazin- 1 -yl, tetrahydro-2H-pyran-4-yl, tetrahydrofuran-3-yl, pyrrolidin-3-yl, piperidin-4- yl, (piperidin- 1 -
• Ci-C 2 -alkyl methoxy, hydroxy and fluorine
• R 12 represents a hydrogen atom
• R 13 represents a methyl group
• R 14 represents hydrogen or a methyl group, represents a hydrogen atom, represents an ethyl group,
• the present invention covers compounds of general formula (I), supra, in which :
• X 1 represents NR 3 or 0, represents CR 6 or N
• R 1 represents a group selected from : -OR 9 , and -N(R 10 )R 11
• R 2 represents a group selected from : hydrogen, and Ci-C 2 -alkyl
• R 3 represents a hydrogen atom
• R 4 represents a hydrogen atom
• R 5 represents a group selected from : hydrogen, methoxy, trifluoromethoxy and methyl
• R 6 represents a hydrogen or a fluorine atom
• R 7 represents a hydrogen atom
• R 8 represents a group selected from :
• R 9 represents a Ci-C 2 -alkyl group
• R 10 and R 11 are independently of each other selected from : hydrogen, Ci-Cs-alkyl, cyclopropyl, C 2 -Cs-hydroxyalkyl, CH 3 OCH 2 CH 2 -, C1-C2- haloalkyl, H 2 N-(C 2 -C 5 -alkyl)-, (Ci-C 3 -alkyl)N(H)(C 2 -alkyl)-, (Ci-C 3 -alkyl) 2 N(C 2 - C 4 -alkyl)-, piperazin- 1 -yl, tetrahydro-2H-pyran-4-yl, tetrahydrofuran-3-yl, pyrrolidin-3-yl, piperidin-4-yl, (piperidin- 1 -yl)-(C 2 -alkyl)- , (piperidin- 1 -yl)- (C3-C 4 -alkyl)-, (p1per1d
• Ci-C 2 -alkyl methoxy, hydroxy and fluorine
• R 10 and R 11 together with the nitrogen atom to which they are attached form a : group , wherein * indicates the point of attachment of said group with the rest of the molecule ,
• the present invention covers compounds of general formula (I), supra, in which :
• X 1 represents NR 3 or 0,
• X 2 represents CR 6 or N ,
• R 1 represents a group selected from : -OR 9 , and -N (R 10 )R 11 ,
• R 2 represents a group selected from : hydrogen, and Ci -C3-alkyl
• R 3 represents a hydrogen atom
• R 4 represents a hydrogen atom
• R 5 represents a group selected from : hydrogen, and methyl
• R 6 represents a hydrogen atom
• R 7 represents a hydrogen atom
• R 9 represents a Ci -C 2 -alkyl group
• R 10 and R 11 are independently of each other selected from : hydrogen, Ci -Cs-alkyl, cyclopropyl, cyclopropylmethyl-, C 2 -hydroxyalkyl,
• R 10 and R 11 together with the nitrogen atom to which they are attached form a : group , wherein * indicates the point of attachment of said group with the rest of the molecule ,
• R 12 represents a hydrogen atom
• R 13 represents a methyl group
• R 14 represents a methyl group
• R 15 represents a hydrogen atom
• R 16 represents an ethyl group, or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same.
• the present invention covers a compound of general formula (I), supra,which is selected from the group consisting of :
• the present invention covers a compound of general formula (I), supra,which is selected from the group consisting of :
• carboxamide or a stereoisomer, a tautomer, an N -oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same.
• the present invention covers a compound of general formula (I), supra,which is selected from the group consisting of :

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