HK1215950A1 - 异源二聚免疫球蛋白的纯化 - Google Patents

异源二聚免疫球蛋白的纯化 Download PDF

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Publication number
HK1215950A1
HK1215950A1 HK16103843.5A HK16103843A HK1215950A1 HK 1215950 A1 HK1215950 A1 HK 1215950A1 HK 16103843 A HK16103843 A HK 16103843A HK 1215950 A1 HK1215950 A1 HK 1215950A1
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HK
Hong Kong
Prior art keywords
immunoglobulin
region
fragment
amino acid
protein
Prior art date
Application number
HK16103843.5A
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English (en)
Chinese (zh)
Inventor
斯坦尼斯拉斯‧布蘭
斯坦尼斯拉斯‧布兰
法布里齊奧‧康珀
法布里齐奥‧康珀
羅曼‧奧利耶
罗曼‧奥利耶
保羅‧瓦斯曼
保罗‧瓦斯曼
Original Assignee
艾科诺斯科技股份有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 艾科诺斯科技股份有限公司 filed Critical 艾科诺斯科技股份有限公司
Publication of HK1215950A1 publication Critical patent/HK1215950A1/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804—Affinity chromatography
    • B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G or L chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/522—CH1 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
HK16103843.5A 2012-09-25 2013-09-25 异源二聚免疫球蛋白的纯化 HK1215950A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261705278P 2012-09-25 2012-09-25
US61/705,278 2012-09-25
PCT/EP2013/069989 WO2014049003A1 (en) 2012-09-25 2013-09-25 Purification of hetero-dimeric immunoglobulins

Publications (1)

Publication Number Publication Date
HK1215950A1 true HK1215950A1 (zh) 2016-09-30

Family

ID=49237223

Family Applications (1)

Application Number Title Priority Date Filing Date
HK16103843.5A HK1215950A1 (zh) 2012-09-25 2013-09-25 异源二聚免疫球蛋白的纯化

Country Status (11)

Country Link
US (2) US20150239991A1 (enExample)
EP (2) EP2900696A1 (enExample)
JP (5) JP2015529236A (enExample)
KR (1) KR20150076172A (enExample)
CN (1) CN104968685A (enExample)
AU (2) AU2013322710A1 (enExample)
CA (2) CA3061557A1 (enExample)
HK (1) HK1215950A1 (enExample)
IL (2) IL237872B (enExample)
IN (1) IN2015MN00139A (enExample)
WO (1) WO2014049003A1 (enExample)

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Publication number Publication date
JP2015529236A (ja) 2015-10-05
CA3061557A1 (en) 2014-04-03
EP3401337A1 (en) 2018-11-14
CA2886036A1 (en) 2014-04-03
US20150239991A1 (en) 2015-08-27
US20200010568A1 (en) 2020-01-09
KR20150076172A (ko) 2015-07-06
AU2013322710A1 (en) 2015-04-16
IL237872B (en) 2019-09-26
JP6856610B2 (ja) 2021-04-07
JP2018104444A (ja) 2018-07-05
JP2020105203A (ja) 2020-07-09
JP2019073512A (ja) 2019-05-16
JP2022116326A (ja) 2022-08-09
AU2018204314A1 (en) 2018-07-05
EP2900696A1 (en) 2015-08-05
AU2013322710A2 (en) 2015-05-07
IN2015MN00139A (enExample) 2015-10-16
IL237872A0 (en) 2015-05-31
IL269207A (en) 2019-11-28
WO2014049003A1 (en) 2014-04-03
AU2018204314B2 (en) 2020-05-14
IL269207B (en) 2022-02-01
CN104968685A (zh) 2015-10-07

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