CA3061557A1 - Purification of hetero-dimeric immunoglobulins - Google Patents

Purification of hetero-dimeric immunoglobulins Download PDF

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Publication number
CA3061557A1
CA3061557A1 CA3061557A CA3061557A CA3061557A1 CA 3061557 A1 CA3061557 A1 CA 3061557A1 CA 3061557 A CA3061557 A CA 3061557A CA 3061557 A CA3061557 A CA 3061557A CA 3061557 A1 CA3061557 A1 CA 3061557A1
Authority
CA
Canada
Prior art keywords
protein
immunoglobulin
region
binding
hetero
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3061557A
Other languages
English (en)
French (fr)
Inventor
Stanislas Blein
Fabrizio Comper
Romain Ollier
Paul Wassmann
Original Assignee
Glenmark Pharmaceuticals SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glenmark Pharmaceuticals SA filed Critical Glenmark Pharmaceuticals SA
Publication of CA3061557A1 publication Critical patent/CA3061557A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804—Affinity chromatography
    • B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G or L chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/522—CH1 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CA3061557A 2012-09-25 2013-09-25 Purification of hetero-dimeric immunoglobulins Pending CA3061557A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261705278P 2012-09-25 2012-09-25
US61/705,278 2012-09-25
CA2886036A CA2886036A1 (en) 2012-09-25 2013-09-25 Purification of hetero-dimeric immunoglobulins

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2886036A Division CA2886036A1 (en) 2012-09-25 2013-09-25 Purification of hetero-dimeric immunoglobulins

Publications (1)

Publication Number Publication Date
CA3061557A1 true CA3061557A1 (en) 2014-04-03

Family

ID=49237223

Family Applications (2)

Application Number Title Priority Date Filing Date
CA3061557A Pending CA3061557A1 (en) 2012-09-25 2013-09-25 Purification of hetero-dimeric immunoglobulins
CA2886036A Abandoned CA2886036A1 (en) 2012-09-25 2013-09-25 Purification of hetero-dimeric immunoglobulins

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2886036A Abandoned CA2886036A1 (en) 2012-09-25 2013-09-25 Purification of hetero-dimeric immunoglobulins

Country Status (11)

Country Link
US (2) US20150239991A1 (enExample)
EP (2) EP3401337A1 (enExample)
JP (5) JP2015529236A (enExample)
KR (1) KR20150076172A (enExample)
CN (1) CN104968685A (enExample)
AU (2) AU2013322710A1 (enExample)
CA (2) CA3061557A1 (enExample)
HK (1) HK1215950A1 (enExample)
IL (2) IL237872B (enExample)
IN (1) IN2015MN00139A (enExample)
WO (1) WO2014049003A1 (enExample)

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Also Published As

Publication number Publication date
CN104968685A (zh) 2015-10-07
AU2018204314B2 (en) 2020-05-14
IL269207B (en) 2022-02-01
JP2022116326A (ja) 2022-08-09
JP6856610B2 (ja) 2021-04-07
JP2020105203A (ja) 2020-07-09
KR20150076172A (ko) 2015-07-06
JP2019073512A (ja) 2019-05-16
EP3401337A1 (en) 2018-11-14
AU2013322710A1 (en) 2015-04-16
IL237872B (en) 2019-09-26
IN2015MN00139A (enExample) 2015-10-16
AU2018204314A1 (en) 2018-07-05
HK1215950A1 (zh) 2016-09-30
US20150239991A1 (en) 2015-08-27
AU2013322710A2 (en) 2015-05-07
JP2015529236A (ja) 2015-10-05
WO2014049003A1 (en) 2014-04-03
EP2900696A1 (en) 2015-08-05
US20200010568A1 (en) 2020-01-09
IL269207A (en) 2019-11-28
JP2018104444A (ja) 2018-07-05
IL237872A0 (en) 2015-05-31
CA2886036A1 (en) 2014-04-03

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