HK1213274A1 - 變體因子viii多肽及其產生和使用方法 - Google Patents

變體因子viii多肽及其產生和使用方法 Download PDF

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Publication number
HK1213274A1
HK1213274A1 HK16101335.4A HK16101335A HK1213274A1 HK 1213274 A1 HK1213274 A1 HK 1213274A1 HK 16101335 A HK16101335 A HK 16101335A HK 1213274 A1 HK1213274 A1 HK 1213274A1
Authority
HK
Hong Kong
Prior art keywords
variant
amino acid
factor viii
substitution
seq
Prior art date
Application number
HK16101335.4A
Other languages
English (en)
Chinese (zh)
Inventor
Uwe Gritzan
Peter Kretschmer
Lilley Leong
Chandra Patel
Original Assignee
拜耳医药保健有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 拜耳医药保健有限公司 filed Critical 拜耳医药保健有限公司
Publication of HK1213274A1 publication Critical patent/HK1213274A1/zh

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
HK16101335.4A 2013-03-15 2014-03-14 變體因子viii多肽及其產生和使用方法 HK1213274A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361789112P 2013-03-15 2013-03-15
US61/789,112 2013-03-15
PCT/US2014/027443 WO2014152530A1 (en) 2013-03-15 2014-03-14 Variant factor viii polypeptides and methods of their production and use

Publications (1)

Publication Number Publication Date
HK1213274A1 true HK1213274A1 (zh) 2016-06-30

Family

ID=51581235

Family Applications (1)

Application Number Title Priority Date Filing Date
HK16101335.4A HK1213274A1 (zh) 2013-03-15 2014-03-14 變體因子viii多肽及其產生和使用方法

Country Status (8)

Country Link
US (2) US9914764B2 (enExample)
EP (2) EP2988758B1 (enExample)
JP (1) JP6523244B2 (enExample)
CN (1) CN105209488A (enExample)
CA (1) CA2906602A1 (enExample)
ES (1) ES2680942T3 (enExample)
HK (1) HK1213274A1 (enExample)
WO (1) WO2014152530A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019197524A1 (en) * 2018-04-12 2019-10-17 Biotest Ag De-immunized factor viii molecule and pharmaceutical compositions comprising the same
WO2021113800A1 (en) * 2019-12-06 2021-06-10 The Children's Hospital Of Philadelphia Compositions and methods for modulating factor viii function
US20250250322A1 (en) * 2022-04-25 2025-08-07 The Children's Hospital Of Philadelphia Compositions and methods for modulating factor viii function

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5451521A (en) 1986-05-29 1995-09-19 Genetics Institute, Inc. Procoagulant proteins
US5004803A (en) * 1988-11-14 1991-04-02 Genetics Institute, Inc. Production of procoagulant proteins
US8183344B2 (en) 1996-04-24 2012-05-22 University Of Michigan Inactivation resistant factor VIII
DE69735421T2 (de) 1996-04-24 2006-10-19 The Regents Of The University Of Michigan, Ann Arbor Gegen inaktivierung resistenter faktor viii
US5763401A (en) 1996-07-12 1998-06-09 Bayer Corporation Stabilized albumin-free recombinant factor VIII preparation having a low sugar content
JP2005538694A (ja) * 2002-04-18 2005-12-22 メルク　パテント　ゲゼルシャフト　ミット　ベシュレンクテル　ハフトング 修飾されたｖｉｉｉ因子
WO2006027111A1 (en) * 2004-09-06 2006-03-16 Zlb Behring Gmbh Modified coagulation factor viii with enhanced stability
JP2008534559A (ja) * 2005-04-01 2008-08-28 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト 血液凝固ｆｖｉｉｉ類似体
AU2006233638A1 (en) 2005-04-14 2006-10-19 Csl Behring Gmbh Modified coagulation Factor VIII with enhanced stability and its derivates
US20080070251A1 (en) * 2006-06-30 2008-03-20 Kaufman Randal J Method of Producing Factor VIII Proteins by Recombinant Methods
US20120028900A1 (en) 2006-06-30 2012-02-02 Kaufman Randal J Method of producing factor viii proteins by recombinant methods
US20090203077A1 (en) * 2006-06-30 2009-08-13 The Regents Of The University Of Michigan Method of producing factor viii proteins by recombinant methods
CA2703948A1 (en) 2007-11-01 2009-05-07 University Of Rochester Recombinant factor viii having increased stability
US8637448B2 (en) * 2010-09-14 2014-01-28 University Of Rochester Recombinant factor VIII having enhanced stability following mutation at the A1-C2 domain interface

Also Published As

Publication number Publication date
US10266583B2 (en) 2019-04-23
CN105209488A (zh) 2015-12-30
EP2988758A1 (en) 2016-03-02
US20180148495A1 (en) 2018-05-31
EP2988758B1 (en) 2018-04-25
EP2988758A4 (en) 2016-04-27
WO2014152530A1 (en) 2014-09-25
JP2016513697A (ja) 2016-05-16
JP6523244B2 (ja) 2019-05-29
US9914764B2 (en) 2018-03-13
US20160031968A1 (en) 2016-02-04
ES2680942T3 (es) 2018-09-11
CA2906602A1 (en) 2014-09-25
EP3427744A1 (en) 2019-01-16

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