HK1213274A1 - 變體因子 多肽及其產生和使用方法 - Google Patents

變體因子 多肽及其產生和使用方法

Info

Publication number
HK1213274A1
HK1213274A1 HK16101335.4A HK16101335A HK1213274A1 HK 1213274 A1 HK1213274 A1 HK 1213274A1 HK 16101335 A HK16101335 A HK 16101335A HK 1213274 A1 HK1213274 A1 HK 1213274A1
Authority
HK
Hong Kong
Prior art keywords
viii
production
methods
polypeptides
variant factor
Prior art date
Application number
HK16101335.4A
Other languages
English (en)
Inventor
Uwe Gritzan
Peter Kretschmer
Lilley Leong
Chandra Patel
Original Assignee
Bayer Healthcare Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Llc filed Critical Bayer Healthcare Llc
Publication of HK1213274A1 publication Critical patent/HK1213274A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
HK16101335.4A 2013-03-15 2016-02-04 變體因子 多肽及其產生和使用方法 HK1213274A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361789112P 2013-03-15 2013-03-15
PCT/US2014/027443 WO2014152530A1 (en) 2013-03-15 2014-03-14 Variant factor viii polypeptides and methods of their production and use

Publications (1)

Publication Number Publication Date
HK1213274A1 true HK1213274A1 (zh) 2016-06-30

Family

ID=51581235

Family Applications (1)

Application Number Title Priority Date Filing Date
HK16101335.4A HK1213274A1 (zh) 2013-03-15 2016-02-04 變體因子 多肽及其產生和使用方法

Country Status (8)

Country Link
US (2) US9914764B2 (zh)
EP (2) EP3427744A1 (zh)
JP (1) JP6523244B2 (zh)
CN (1) CN105209488A (zh)
CA (1) CA2906602A1 (zh)
ES (1) ES2680942T3 (zh)
HK (1) HK1213274A1 (zh)
WO (1) WO2014152530A1 (zh)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3775194B1 (en) * 2018-04-12 2023-06-28 Biotest AG De-immunized factor viii molecule and pharmaceutical compositions comprising the same
WO2023212539A1 (en) * 2022-04-25 2023-11-02 The Children's Hospital Of Philadelphia Compositions and methods for modulating factor viii function

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5451521A (en) * 1986-05-29 1995-09-19 Genetics Institute, Inc. Procoagulant proteins
US5004803A (en) * 1988-11-14 1991-04-02 Genetics Institute, Inc. Production of procoagulant proteins
JP3987114B2 (ja) * 1996-04-24 2007-10-03 ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・ミシガン 不活性化耐性第▲８▼因子
US8183344B2 (en) 1996-04-24 2012-05-22 University Of Michigan Inactivation resistant factor VIII
US5763401A (en) 1996-07-12 1998-06-09 Bayer Corporation Stabilized albumin-free recombinant factor VIII preparation having a low sugar content
CA2482926A1 (en) 2002-04-18 2003-10-23 Merck Patent Gesellschaft Mit Beschraenkter Haftung Modified factor viii
WO2006027111A1 (en) * 2004-09-06 2006-03-16 Zlb Behring Gmbh Modified coagulation factor viii with enhanced stability
JP2008534559A (ja) * 2005-04-01 2008-08-28 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト 血液凝固ｆｖｉｉｉ類似体
AU2006233638A1 (en) * 2005-04-14 2006-10-19 Csl Behring Gmbh Modified coagulation Factor VIII with enhanced stability and its derivates
US20090203077A1 (en) * 2006-06-30 2009-08-13 The Regents Of The University Of Michigan Method of producing factor viii proteins by recombinant methods
AU2007269233B2 (en) * 2006-06-30 2011-06-09 Cnj Holdings, Inc. Method of producing Factor VIII proteins by recombinant methods
US20120028900A1 (en) * 2006-06-30 2012-02-02 Kaufman Randal J Method of producing factor viii proteins by recombinant methods
US8183345B2 (en) * 2007-11-01 2012-05-22 University Of Rochester Recombinant factor VIII having reduced inactivation by activated protein C
US8637448B2 (en) 2010-09-14 2014-01-28 University Of Rochester Recombinant factor VIII having enhanced stability following mutation at the A1-C2 domain interface

Also Published As

Publication number Publication date
EP2988758A4 (en) 2016-04-27
CA2906602A1 (en) 2014-09-25
ES2680942T3 (es) 2018-09-11
WO2014152530A1 (en) 2014-09-25
EP2988758A1 (en) 2016-03-02
EP2988758B1 (en) 2018-04-25
CN105209488A (zh) 2015-12-30
JP2016513697A (ja) 2016-05-16
US20180148495A1 (en) 2018-05-31
US9914764B2 (en) 2018-03-13
JP6523244B2 (ja) 2019-05-29
US20160031968A1 (en) 2016-02-04
EP3427744A1 (en) 2019-01-16
US10266583B2 (en) 2019-04-23

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