CN105209488A - 变体因子viii多肽及其产生和使用方法 - Google Patents

变体因子viii多肽及其产生和使用方法 Download PDF

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Publication number
CN105209488A
CN105209488A CN201480027204.2A CN201480027204A CN105209488A CN 105209488 A CN105209488 A CN 105209488A CN 201480027204 A CN201480027204 A CN 201480027204A CN 105209488 A CN105209488 A CN 105209488A
Authority
CN
China
Prior art keywords
variant
amino acid
factor viii
substitutions
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201480027204.2A
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English (en)
Chinese (zh)
Inventor
U.格里特赞
P.克雷奇默
L.莱昂格
C.帕特尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Healthcare LLC
Original Assignee
Bayer Healthcare LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare LLC filed Critical Bayer Healthcare LLC
Publication of CN105209488A publication Critical patent/CN105209488A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN201480027204.2A 2013-03-15 2014-03-14 变体因子viii多肽及其产生和使用方法 Pending CN105209488A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361789112P 2013-03-15 2013-03-15
US61/789,112 2013-03-15
PCT/US2014/027443 WO2014152530A1 (en) 2013-03-15 2014-03-14 Variant factor viii polypeptides and methods of their production and use

Publications (1)

Publication Number Publication Date
CN105209488A true CN105209488A (zh) 2015-12-30

Family

ID=51581235

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201480027204.2A Pending CN105209488A (zh) 2013-03-15 2014-03-14 变体因子viii多肽及其产生和使用方法

Country Status (8)

Country Link
US (2) US9914764B2 (enExample)
EP (2) EP2988758B1 (enExample)
JP (1) JP6523244B2 (enExample)
CN (1) CN105209488A (enExample)
CA (1) CA2906602A1 (enExample)
ES (1) ES2680942T3 (enExample)
HK (1) HK1213274A1 (enExample)
WO (1) WO2014152530A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114828870A (zh) * 2019-12-06 2022-07-29 费城儿童医院 用于调节因子viii功能的组合物和方法

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019197524A1 (en) * 2018-04-12 2019-10-17 Biotest Ag De-immunized factor viii molecule and pharmaceutical compositions comprising the same
US20250250322A1 (en) * 2022-04-25 2025-08-07 The Children's Hospital Of Philadelphia Compositions and methods for modulating factor viii function

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990005530A1 (en) * 1988-11-14 1990-05-31 Genetics Institute, Inc. Hybrid procoagulant proteins
US20080227691A1 (en) * 2005-04-01 2008-09-18 Novo Nordisk Health Care Ag Blood Coagulation FVIII Analogues

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5451521A (en) 1986-05-29 1995-09-19 Genetics Institute, Inc. Procoagulant proteins
US8183344B2 (en) 1996-04-24 2012-05-22 University Of Michigan Inactivation resistant factor VIII
DE69735421T2 (de) 1996-04-24 2006-10-19 The Regents Of The University Of Michigan, Ann Arbor Gegen inaktivierung resistenter faktor viii
US5763401A (en) 1996-07-12 1998-06-09 Bayer Corporation Stabilized albumin-free recombinant factor VIII preparation having a low sugar content
JP2005538694A (ja) * 2002-04-18 2005-12-22 メルク　パテント　ゲゼルシャフト　ミット　ベシュレンクテル　ハフトング 修飾されたｖｉｉｉ因子
WO2006027111A1 (en) * 2004-09-06 2006-03-16 Zlb Behring Gmbh Modified coagulation factor viii with enhanced stability
AU2006233638A1 (en) 2005-04-14 2006-10-19 Csl Behring Gmbh Modified coagulation Factor VIII with enhanced stability and its derivates
US20080070251A1 (en) * 2006-06-30 2008-03-20 Kaufman Randal J Method of Producing Factor VIII Proteins by Recombinant Methods
US20120028900A1 (en) 2006-06-30 2012-02-02 Kaufman Randal J Method of producing factor viii proteins by recombinant methods
US20090203077A1 (en) * 2006-06-30 2009-08-13 The Regents Of The University Of Michigan Method of producing factor viii proteins by recombinant methods
CA2703948A1 (en) 2007-11-01 2009-05-07 University Of Rochester Recombinant factor viii having increased stability
US8637448B2 (en) * 2010-09-14 2014-01-28 University Of Rochester Recombinant factor VIII having enhanced stability following mutation at the A1-C2 domain interface

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990005530A1 (en) * 1988-11-14 1990-05-31 Genetics Institute, Inc. Hybrid procoagulant proteins
US20080227691A1 (en) * 2005-04-01 2008-09-18 Novo Nordisk Health Care Ag Blood Coagulation FVIII Analogues

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
H. WAKABAYASHI等: "Enhancing factor VIII and VIIIa stability by combining mutations at the A2 domain interface and A1-C2 domain interface", 《JOURNAL OF THROMBOSIS&HAEMOSTASIS》 *
WILLIAM H。KANE等: "Blood coagulation factors V and VIII： structural and functional similarities and their relationship to hemorrhagic and thrombotic disorders", 《BLOOD》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114828870A (zh) * 2019-12-06 2022-07-29 费城儿童医院 用于调节因子viii功能的组合物和方法

Also Published As

Publication number Publication date
US10266583B2 (en) 2019-04-23
EP2988758A1 (en) 2016-03-02
US20180148495A1 (en) 2018-05-31
EP2988758B1 (en) 2018-04-25
EP2988758A4 (en) 2016-04-27
WO2014152530A1 (en) 2014-09-25
JP2016513697A (ja) 2016-05-16
JP6523244B2 (ja) 2019-05-29
HK1213274A1 (zh) 2016-06-30
US9914764B2 (en) 2018-03-13
US20160031968A1 (en) 2016-02-04
ES2680942T3 (es) 2018-09-11
CA2906602A1 (en) 2014-09-25
EP3427744A1 (en) 2019-01-16

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