JP6523244B2 - 変異体第ｖｉｉｉ因子ポリペプチドならびにそれらの製造方法および使用方法 - Google Patents
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/37—Factors VIII
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- Health & Medical Sciences (AREA)
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- Chemical & Material Sciences (AREA)
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- Diabetes (AREA)
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- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
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| US201361789112P | 2013-03-15 | 2013-03-15 | |
| US61/789,112 | 2013-03-15 | ||
| PCT/US2014/027443 WO2014152530A1 (en) | 2013-03-15 | 2014-03-14 | Variant factor viii polypeptides and methods of their production and use |
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| JP2016513697A JP2016513697A (ja) | 2016-05-16 |
| JP2016513697A5 JP2016513697A5 (enExample) | 2017-04-06 |
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| HK (1) | HK1213274A1 (enExample) |
| WO (1) | WO2014152530A1 (enExample) |
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| WO2019197524A1 (en) * | 2018-04-12 | 2019-10-17 | Biotest Ag | De-immunized factor viii molecule and pharmaceutical compositions comprising the same |
| WO2021113800A1 (en) * | 2019-12-06 | 2021-06-10 | The Children's Hospital Of Philadelphia | Compositions and methods for modulating factor viii function |
| US20250250322A1 (en) * | 2022-04-25 | 2025-08-07 | The Children's Hospital Of Philadelphia | Compositions and methods for modulating factor viii function |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US5451521A (en) | 1986-05-29 | 1995-09-19 | Genetics Institute, Inc. | Procoagulant proteins |
| US5004803A (en) * | 1988-11-14 | 1991-04-02 | Genetics Institute, Inc. | Production of procoagulant proteins |
| US8183344B2 (en) | 1996-04-24 | 2012-05-22 | University Of Michigan | Inactivation resistant factor VIII |
| DE69735421T2 (de) | 1996-04-24 | 2006-10-19 | The Regents Of The University Of Michigan, Ann Arbor | Gegen inaktivierung resistenter faktor viii |
| US5763401A (en) | 1996-07-12 | 1998-06-09 | Bayer Corporation | Stabilized albumin-free recombinant factor VIII preparation having a low sugar content |
| JP2005538694A (ja) * | 2002-04-18 | 2005-12-22 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | 修飾されたｖｉｉｉ因子 |
| WO2006027111A1 (en) * | 2004-09-06 | 2006-03-16 | Zlb Behring Gmbh | Modified coagulation factor viii with enhanced stability |
| JP2008534559A (ja) * | 2005-04-01 | 2008-08-28 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | 血液凝固ｆｖｉｉｉ類似体 |
| AU2006233638A1 (en) | 2005-04-14 | 2006-10-19 | Csl Behring Gmbh | Modified coagulation Factor VIII with enhanced stability and its derivates |
| US20080070251A1 (en) * | 2006-06-30 | 2008-03-20 | Kaufman Randal J | Method of Producing Factor VIII Proteins by Recombinant Methods |
| US20120028900A1 (en) | 2006-06-30 | 2012-02-02 | Kaufman Randal J | Method of producing factor viii proteins by recombinant methods |
| US20090203077A1 (en) * | 2006-06-30 | 2009-08-13 | The Regents Of The University Of Michigan | Method of producing factor viii proteins by recombinant methods |
| CA2703948A1 (en) | 2007-11-01 | 2009-05-07 | University Of Rochester | Recombinant factor viii having increased stability |
| US8637448B2 (en) * | 2010-09-14 | 2014-01-28 | University Of Rochester | Recombinant factor VIII having enhanced stability following mutation at the A1-C2 domain interface |
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2014
- 2014-03-14 ES ES14770221.1T patent/ES2680942T3/es active Active
- 2014-03-14 US US14/773,702 patent/US9914764B2/en not_active Expired - Fee Related
- 2014-03-14 HK HK16101335.4A patent/HK1213274A1/zh unknown
- 2014-03-14 EP EP14770221.1A patent/EP2988758B1/en not_active Not-in-force
- 2014-03-14 EP EP18159477.1A patent/EP3427744A1/en not_active Withdrawn
- 2014-03-14 CA CA2906602A patent/CA2906602A1/en not_active Abandoned
- 2014-03-14 JP JP2016502439A patent/JP6523244B2/ja not_active Expired - Fee Related
- 2014-03-14 CN CN201480027204.2A patent/CN105209488A/zh active Pending
- 2014-03-14 WO PCT/US2014/027443 patent/WO2014152530A1/en not_active Ceased
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2018
- 2018-01-23 US US15/878,012 patent/US10266583B2/en not_active Expired - Fee Related
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| US10266583B2 (en) | 2019-04-23 |
| CN105209488A (zh) | 2015-12-30 |
| EP2988758A1 (en) | 2016-03-02 |
| US20180148495A1 (en) | 2018-05-31 |
| EP2988758B1 (en) | 2018-04-25 |
| EP2988758A4 (en) | 2016-04-27 |
| WO2014152530A1 (en) | 2014-09-25 |
| JP2016513697A (ja) | 2016-05-16 |
| HK1213274A1 (zh) | 2016-06-30 |
| US9914764B2 (en) | 2018-03-13 |
| US20160031968A1 (en) | 2016-02-04 |
| ES2680942T3 (es) | 2018-09-11 |
| CA2906602A1 (en) | 2014-09-25 |
| EP3427744A1 (en) | 2019-01-16 |
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