HK1211297A1 - 包含至少两个针对her2的重复序列结构域的结合蛋白 - Google Patents

包含至少两个针对her2的重复序列结构域的结合蛋白 Download PDF

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HK1211297A1
HK1211297A1 HK15110090.1A HK15110090A HK1211297A1 HK 1211297 A1 HK1211297 A1 HK 1211297A1 HK 15110090 A HK15110090 A HK 15110090A HK 1211297 A1 HK1211297 A1 HK 1211297A1
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repeat
domain
seq
her2
amino acid
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HK15110090.1A
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English (en)
Chinese (zh)
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烏爾麗克‧菲德勒
乌尔丽克‧菲德勒
伊格納西奧‧多拉多
伊格纳西奥‧多拉多
海克‧施特羅貝爾
海克‧施特罗贝尔
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分子组合公司
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Publication of HK1211297A1 publication Critical patent/HK1211297A1/xx

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2318/00—Antibody mimetics or scaffolds
    • C07K2318/20—Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cell Biology (AREA)
HK15110090.1A 2012-11-30 2013-12-02 包含至少两个针对her2的重复序列结构域的结合蛋白 HK1211297A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12195156.0 2012-11-30
EP12195156.0A EP2738180A1 (en) 2012-11-30 2012-11-30 Binding proteins comprising at least two binding domains against HER2.
PCT/EP2013/075290 WO2014083208A1 (en) 2012-11-30 2013-12-02 Binding proteins comprising at least two repeat domains against her2

Publications (1)

Publication Number Publication Date
HK1211297A1 true HK1211297A1 (zh) 2016-05-20

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HK15110090.1A HK1211297A1 (zh) 2012-11-30 2013-12-02 包含至少两个针对her2的重复序列结构域的结合蛋白

Country Status (11)

Country Link
US (1) US10370414B2 (cg-RX-API-DMAC7.html)
EP (2) EP2738180A1 (cg-RX-API-DMAC7.html)
JP (1) JP6410724B2 (cg-RX-API-DMAC7.html)
KR (1) KR102290592B1 (cg-RX-API-DMAC7.html)
CN (1) CN104918959A (cg-RX-API-DMAC7.html)
AU (2) AU2013351096C9 (cg-RX-API-DMAC7.html)
CA (1) CA2892747C (cg-RX-API-DMAC7.html)
HK (1) HK1211297A1 (cg-RX-API-DMAC7.html)
MX (1) MX366223B (cg-RX-API-DMAC7.html)
RU (1) RU2664464C9 (cg-RX-API-DMAC7.html)
WO (1) WO2014083208A1 (cg-RX-API-DMAC7.html)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI510246B (zh) 2010-04-30 2015-12-01 Molecular Partners Ag 抑制ｖｅｇｆ－ａ受體交互作用的經修飾結合性蛋白質
EP2643348B1 (en) * 2010-11-26 2025-02-12 Molecular Partners AG Improved capping modules for designed ankyrin repeat proteins
AU2013331763B2 (en) * 2012-10-15 2018-02-15 Universitat Zurich Bispecific HER2 ligands for cancer therapy
JP6486908B2 (ja) 2013-05-31 2019-03-20 モレキュラー パートナーズ アクチェンゲゼルシャフト 肝細胞増殖因子に結合する設計アンキリン反復タンパク質
CA2931356A1 (en) 2013-11-27 2015-06-04 Zymeworks Inc. Bispecific antigen-binding constructs targeting her2
JP6872482B2 (ja) 2014-11-27 2021-05-19 ザイムワークス，インコーポレイテッド Ｈｅｒ２を標的とする二重特異性抗原結合性構築物の使用方法
US10858405B2 (en) 2015-02-06 2020-12-08 Navigo Proteins Gmbh EGFR binding proteins
IL276944B (en) 2015-04-02 2022-07-01 Molecular Partners Ag Designed ankyrin repeat domains with binding specificity for serum albumin
PL3322721T4 (pl) 2015-07-16 2022-06-06 Navigo Proteins Gmbh Nowe białka wiążące immunoglobulinę i ich zastosowanie w oczyszczaniu na bazie powinowactwa
US10584152B2 (en) 2015-07-20 2020-03-10 Navigo Proteins Gmbh Binding proteins based on di-ubiquitin muteins and methods for generation
CN107849147B (zh) * 2015-07-20 2021-09-17 纳维格蛋白质有限公司 基于二泛素突变蛋白的Her2结合蛋白
CA3022751A1 (en) 2016-05-04 2017-11-09 Navigo Proteins Gmbh Targeted compounds for the site-specific coupling of chemical moieties comprising a peptide linker
RU2627215C1 (ru) * 2016-05-24 2017-08-03 Федеральное государственное автономное образовательное учреждение высшего образования "Национальный исследовательский Нижегородский государственный университет им. Н.И. Лобачевского" Рекомбинантный таргетный токсин, специфичный к клеткам, экспрессирующим рецептор her2
CN109476712B (zh) 2016-08-11 2022-08-02 纳维格蛋白质有限公司 新型对碱稳定的免疫球蛋白结合蛋白
NZ751689A (en) * 2016-09-22 2021-07-30 Molecular Partners Ag Recombinant binding proteins and their use
MX2019006374A (es) 2016-12-02 2019-09-11 Univ Southern California Receptores inmunes sinteticos y metodos de usos de ellos.
EP3706804B1 (en) 2017-11-07 2022-02-23 Navigo Proteins GmbH Fusion proteins with specificity for ed-b and long serum half-life for diagnosis or treatment of cancer
CA3139164A1 (en) 2019-06-04 2020-12-10 Molecular Partners Ag Recombinant fap binding proteins and their use
AU2020286715A1 (en) * 2019-06-04 2021-12-23 Molecular Partners Ag Recombinant 4-1 BB binding proteins and their use
WO2020245171A1 (en) * 2019-06-04 2020-12-10 Molecular Partners Ag Designed ankyrin repeat domain with improved stability
WO2020245746A1 (en) 2019-06-04 2020-12-10 Molecular Partners Ag Multispecific proteins
CA3147423A1 (en) 2019-07-26 2021-02-04 Abl Bio Inc. Anti-her2/anti-4-1bb bispecific antibody and use thereof
CN114929730A (zh) 2019-12-11 2022-08-19 分子合作伙伴股份公司 重组肽-mhc复合物结合蛋白及其生成和用途
JP2023525518A (ja) 2020-05-06 2023-06-16 モレキュラー パートナーズ アクチェンゲゼルシャフト 新規アンキリンリピート結合タンパク質とその用途
WO2021229067A1 (en) 2020-05-14 2021-11-18 Molecular Partners Ag Multispecific proteins
CN115996945A (zh) * 2020-05-14 2023-04-21 分子合作伙伴股份公司 重组cd40结合蛋白及其用途
US20240108746A1 (en) 2020-12-16 2024-04-04 Molecular Partners Ag Novel slow-release prodrugs
JP2024509890A (ja) 2021-03-09 2024-03-05 モレキュラー パートナーズ アクチェンゲゼルシャフト プロテアーゼ切断可能なプロドラッグ
CA3211248A1 (en) 2021-03-09 2022-09-15 Nina RESCHKE Novel darpin based cd33 engagers
MX2023010543A (es) 2021-03-09 2023-10-13 Molecular Partners Ag Ligadores multiespecificos de celulas t novedosos basados en darpin.
WO2022190018A1 (en) 2021-03-09 2022-09-15 Molecular Partners Ag Novel darpin based cd123 engagers
AU2022413461A1 (en) 2021-12-14 2024-06-06 Molecular Partners Ag Designed repeat domains with dual binding specificity and their use
US20240228545A9 (en) 2022-08-01 2024-07-11 Molecular Partners Ag Charge modified designed repeat domains and their use
WO2024038307A1 (en) 2022-08-19 2024-02-22 Novartis Ag Dosing regimens for sars-cov-2 binding molecules
WO2024179981A1 (en) 2023-02-27 2024-09-06 Molecular Partners Ag Darpins for use in reducing renal accumulation of drugs
WO2024251628A1 (en) 2023-06-06 2024-12-12 Molecular Partners Ag Recombinant cd16a binding proteins and their use
WO2025146491A1 (en) 2024-01-05 2025-07-10 Molecular Partners Ag Designed repeat domains with dual binding specificity for cd117 and cd47-binding agent

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE68927933T2 (de) 1988-09-02 1997-08-14 Dyax Corp Herstellung und auswahl von rekombinantproteinen mit verschiedenen bindestellen
US5270170A (en) 1991-10-16 1993-12-14 Affymax Technologies N.V. Peptide library and screening method
US5348867A (en) 1991-11-15 1994-09-20 George Georgiou Expression of proteins on bacterial surface
US7371376B1 (en) 1996-10-18 2008-05-13 Genentech, Inc. Anti-ErbB2 antibodies
CA2196496A1 (en) 1997-01-31 1998-07-31 Stephen William Watson Michnick Protein fragment complementation assay for the detection of protein-protein interactions
JP4086325B2 (ja) 1997-04-23 2008-05-14 プリュックテュン，アンドレアス 標的分子と相互作用する（ポリ）ペプチドをコードする核酸分子の同定方法
HK1039355B (en) 1998-12-02 2007-09-21 Bristol-Myers Squibb Company Dna-protein fusions and uses thereof
AU2002218166A1 (en) 2000-09-08 2002-03-22 Universitat Zurich Collections of repeat proteins comprising repeat modules
US8124085B2 (en) * 2004-05-05 2012-02-28 Merrimack Pharmaceuticals, Inc. Bispecific binding agents for modulating biological activity
KR20150140417A (ko) * 2004-07-22 2015-12-15 제넨테크, 인크. Ｈｅｒ２ 항체 조성물
WO2007006665A1 (en) 2005-07-08 2007-01-18 University Of Zürich Phage display using cotranslational translocation of fusion polypeptides
AU2007223888A1 (en) 2006-03-06 2007-09-13 Amunix, Inc. Genetic packages and uses thereof
EA021222B8 (ru) 2007-06-21 2015-11-30 ИксЭль-ПРОТЕИН ГМБХ Биологически активные белки, имеющие повышенную стабильность in vivo и/или in vitro
WO2009040338A1 (en) 2007-09-24 2009-04-02 University Of Zürich Designed armadillo repeat proteins
US20110189203A1 (en) 2007-11-27 2011-08-04 Ablynx N.V. Immunoglobulin constructs
US20100260668A1 (en) * 2008-04-29 2010-10-14 Abbott Laboratories Dual Variable Domain Immunoglobulins and Uses Thereof
MX359570B (es) 2008-11-03 2018-10-01 Molecular Partners Ag Proteinas de union que inhiben la interaccion en el receptor de vegf-a.
TW201120210A (en) * 2009-11-05 2011-06-16 Hoffmann La Roche Glycosylated repeat-motif-molecule conjugates
TWI510246B (zh) 2010-04-30 2015-12-01 Molecular Partners Ag 抑制ｖｅｇｆ－ａ受體交互作用的經修飾結合性蛋白質
EP2643348B1 (en) 2010-11-26 2025-02-12 Molecular Partners AG Improved capping modules for designed ankyrin repeat proteins
JP2014519808A (ja) 2011-04-29 2014-08-21 ヤンセン バイオテツク，インコーポレーテツド Ｉｌ４／ｉｌ１３に結合する反復タンパク質及び使用
WO2012162418A1 (en) * 2011-05-23 2012-11-29 The University Of North Carolina At Chapel Hill Methods and compositions for heterodimeric targeting ligands
AU2013283296A1 (en) 2012-06-28 2015-02-05 Molecular Partners Ag Designed ankyrin repeat proteins binding to platelet-derived growth factor
AU2013331763B2 (en) 2012-10-15 2018-02-15 Universitat Zurich Bispecific HER2 ligands for cancer therapy
JP6486908B2 (ja) 2013-05-31 2019-03-20 モレキュラー パートナーズ アクチェンゲゼルシャフト 肝細胞増殖因子に結合する設計アンキリン反復タンパク質

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WO2014083208A1 (en) 2014-06-05
KR20150091138A (ko) 2015-08-07
JP6410724B2 (ja) 2018-10-24
AU2013351096B2 (en) 2018-08-09
JP2015537044A (ja) 2015-12-24
RU2664464C9 (ru) 2018-12-19
EP2925784B1 (en) 2021-02-17
AU2013351096A1 (en) 2015-07-09
WO2014083208A9 (en) 2014-12-24
RU2015120663A (ru) 2017-01-10
MX366223B (es) 2019-07-03
RU2664464C2 (ru) 2018-08-17
CA2892747A1 (en) 2014-06-05
US10370414B2 (en) 2019-08-06
EP2925784A1 (en) 2015-10-07
CN104918959A (zh) 2015-09-16
CA2892747C (en) 2022-07-19
AU2013351096C9 (en) 2019-01-31
BR112015012436A2 (pt) 2017-09-12
EP2738180A1 (en) 2014-06-04
MX2015006548A (es) 2015-10-15
KR102290592B1 (ko) 2021-08-19
AU2018256592A1 (en) 2018-11-22
AU2013351096C1 (en) 2018-11-08
WO2014083208A8 (en) 2014-10-30
US20150299265A1 (en) 2015-10-22

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