RU2664464C9 - Связывающие белки, содержащие по меньшей мере две повторяющиеся области-антагонисты HER2 - Google Patents

Связывающие белки, содержащие по меньшей мере две повторяющиеся области-антагонисты HER2 Download PDF

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RU2664464C9
RU2664464C9 RU2015120663A RU2015120663A RU2664464C9 RU 2664464 C9 RU2664464 C9 RU 2664464C9 RU 2015120663 A RU2015120663 A RU 2015120663A RU 2015120663 A RU2015120663 A RU 2015120663A RU 2664464 C9 RU2664464 C9 RU 2664464C9
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Ульрике ФИДЛЕР
Игнасио ДОЛАДО
Хайке Штробель
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Молекуляр Партнерс Аг
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35Valency
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2318/00Antibody mimetics or scaffolds
    • C07K2318/20Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/20Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cell Biology (AREA)
RU2015120663A 2012-11-30 2013-12-02 Связывающие белки, содержащие по меньшей мере две повторяющиеся области-антагонисты HER2 RU2664464C9 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12195156.0 2012-11-30
EP12195156.0A EP2738180A1 (en) 2012-11-30 2012-11-30 Binding proteins comprising at least two binding domains against HER2.
PCT/EP2013/075290 WO2014083208A1 (en) 2012-11-30 2013-12-02 Binding proteins comprising at least two repeat domains against her2

Publications (3)

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RU2015120663A RU2015120663A (ru) 2017-01-10
RU2664464C2 RU2664464C2 (ru) 2018-08-17
RU2664464C9 true RU2664464C9 (ru) 2018-12-19

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US (1) US10370414B2 (cg-RX-API-DMAC7.html)
EP (2) EP2738180A1 (cg-RX-API-DMAC7.html)
JP (1) JP6410724B2 (cg-RX-API-DMAC7.html)
KR (1) KR102290592B1 (cg-RX-API-DMAC7.html)
CN (1) CN104918959A (cg-RX-API-DMAC7.html)
AU (2) AU2013351096C9 (cg-RX-API-DMAC7.html)
CA (1) CA2892747C (cg-RX-API-DMAC7.html)
HK (1) HK1211297A1 (cg-RX-API-DMAC7.html)
MX (1) MX366223B (cg-RX-API-DMAC7.html)
RU (1) RU2664464C9 (cg-RX-API-DMAC7.html)
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JP2023525518A (ja) 2020-05-06 2023-06-16 モレキュラー パートナーズ アクチェンゲゼルシャフト 新規アンキリンリピート結合タンパク質とその用途
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JP2024509890A (ja) 2021-03-09 2024-03-05 モレキュラー パートナーズ アクチェンゲゼルシャフト プロテアーゼ切断可能なプロドラッグ
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WO2014083208A1 (en) 2014-06-05
KR20150091138A (ko) 2015-08-07
JP6410724B2 (ja) 2018-10-24
AU2013351096B2 (en) 2018-08-09
JP2015537044A (ja) 2015-12-24
EP2925784B1 (en) 2021-02-17
AU2013351096A1 (en) 2015-07-09
WO2014083208A9 (en) 2014-12-24
RU2015120663A (ru) 2017-01-10
MX366223B (es) 2019-07-03
RU2664464C2 (ru) 2018-08-17
CA2892747A1 (en) 2014-06-05
US10370414B2 (en) 2019-08-06
EP2925784A1 (en) 2015-10-07
CN104918959A (zh) 2015-09-16
CA2892747C (en) 2022-07-19
AU2013351096C9 (en) 2019-01-31
BR112015012436A2 (pt) 2017-09-12
EP2738180A1 (en) 2014-06-04
MX2015006548A (es) 2015-10-15
KR102290592B1 (ko) 2021-08-19
HK1211297A1 (zh) 2016-05-20
AU2018256592A1 (en) 2018-11-22
AU2013351096C1 (en) 2018-11-08
WO2014083208A8 (en) 2014-10-30
US20150299265A1 (en) 2015-10-22

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