HK1210380A1 - Genetically modified non-human animals and methods of use thereof - Google Patents

Genetically modified non-human animals and methods of use thereof

Info

Publication number
HK1210380A1
HK1210380A1 HK15111316.7A HK15111316A HK1210380A1 HK 1210380 A1 HK1210380 A1 HK 1210380A1 HK 15111316 A HK15111316 A HK 15111316A HK 1210380 A1 HK1210380 A1 HK 1210380A1
Authority
HK
Hong Kong
Prior art keywords
methods
genetically modified
human animals
modified non
animals
Prior art date
Application number
HK15111316.7A
Other languages
English (en)
Chinese (zh)
Inventor
Richard Flavell
Till Strowig
Markus G Manz
Chiara Borsotti
Madhav Dhodapkar
Andrew J Murphy
Sean Stevens
George D Yancopoulos
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of HK1210380A1 publication Critical patent/HK1210380A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/12—Animals modified by administration of exogenous cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A01K2217/052—Animals comprising random inserted nucleic acids (transgenic) inducing gain of function
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0331—Animal model for proliferative diseases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/524—Thrombopoietin, i.e. C-MPL ligand
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5403—IL-3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5412—IL-6
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C12N2015/8527—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic for producing animal models, e.g. for tests or diseases
    • C12N2015/8572—Animal models for proliferative diseases, e.g. comprising an oncogene

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Environmental Sciences (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Pathology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
HK15111316.7A 2012-11-05 2015-11-17 Genetically modified non-human animals and methods of use thereof HK1210380A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261722437P 2012-11-05 2012-11-05
PCT/US2013/068569 WO2014071397A2 (en) 2012-11-05 2013-11-05 Genetically modified non-human animals and methods of use thereof

Publications (1)

Publication Number Publication Date
HK1210380A1 true HK1210380A1 (en) 2016-04-22

Family

ID=49876957

Family Applications (2)

Application Number Title Priority Date Filing Date
HK15111316.7A HK1210380A1 (en) 2012-11-05 2015-11-17 Genetically modified non-human animals and methods of use thereof
HK18113057.3A HK1253909A1 (zh) 2012-11-05 2018-10-12 免疫缺陷的經遺傳修飾的嚙齒類及其使用方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK18113057.3A HK1253909A1 (zh) 2012-11-05 2018-10-12 免疫缺陷的經遺傳修飾的嚙齒類及其使用方法

Country Status (20)

Country Link
US (5) US9901082B2 (xx)
EP (5) EP4389764A3 (xx)
JP (4) JP6422441B2 (xx)
KR (5) KR20240042142A (xx)
CN (3) CN108401987B (xx)
AU (3) AU2013337242B2 (xx)
CA (1) CA2887706C (xx)
DK (4) DK3939423T3 (xx)
ES (3) ES2884598T3 (xx)
FI (1) FI3939423T3 (xx)
HK (2) HK1210380A1 (xx)
IL (5) IL311744A (xx)
MX (3) MX370856B (xx)
MY (1) MY175400A (xx)
NO (1) NO2946162T3 (xx)
NZ (3) NZ724353A (xx)
PT (4) PT3939423T (xx)
RU (1) RU2673156C2 (xx)
SG (2) SG11201502685XA (xx)
WO (1) WO2014071397A2 (xx)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US20050144655A1 (en) 2000-10-31 2005-06-30 Economides Aris N. Methods of modifying eukaryotic cells
DK3056082T3 (en) 2009-10-06 2018-12-17 Regeneron Pharma RE-MODIFIED MICE AND INPUT
ES2948210T3 (es) 2011-02-15 2023-09-06 Regeneron Pharma Ratones humanizados con M-CSF y uso de los mismos
KR20240045263A (ko) * 2012-09-07 2024-04-05 예일 유니버시티 유전적으로 변형된 비-인간 동물 및 이것들의 사용 방법
EP4389764A3 (en) 2012-11-05 2024-08-14 Regeneron Pharmaceuticals, Inc. Genetically modified non-human animals and methods of use thereof
KR102313047B1 (ko) 2013-02-20 2021-10-19 리제너론 파아마슈티컬스, 인크. 사람화된 ｔ-세포 보조-수용체를 발현하는 마우스
CN105164154B (zh) 2013-02-22 2019-06-07 瑞泽恩制药公司 表达人源化主要组织相容性复合物的小鼠
US9193977B2 (en) 2013-09-23 2015-11-24 Regeneron Pharmaceuticals, Inc. Non-human animals having a humanized signal-regulatory protein gene
CA2926090C (en) 2013-10-15 2022-07-05 Regeneron Pharmaceuticals, Inc. Humanized il-15 animals
JP6505689B2 (ja) 2013-11-19 2019-04-24 リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． ヒト化ｂ細胞活性化因子遺伝子を有する非ヒト動物
ES2794942T3 (es) 2014-04-08 2020-11-19 Regeneron Pharma Animales no humanos que tienen receptores Fc-gamma humanizados
CN111647627A (zh) 2014-04-28 2020-09-11 重组股份有限公司 多重基因编辑
NZ726602A (en) 2014-05-05 2024-05-31 Regeneron Pharmaceuticals Inc Humanized c5 and c3 animals
NO2785538T3 (xx) 2014-05-07 2018-08-04
RU2711744C1 (ru) * 2014-05-19 2020-01-21 Ридженерон Фармасьютикалз, Инк. Генетически модифицированные животные, отличные от человека, экспрессирующие epo человека
WO2015196051A1 (en) 2014-06-19 2015-12-23 Regeneron Pharmaceuticals, Inc. Non-human animals having a humanized programmed cell death 1 gene
CN113016720B (zh) 2014-11-24 2023-02-21 瑞泽恩制药公司 表达人源化cd3复合物的非人类动物
LT3850946T (lt) * 2014-12-05 2024-01-10 Regeneron Pharmaceuticals, Inc. Gyvūnai, išskyrus žmogų, turintys humanizuotą ląstelės diferenciacijos klasterio 47 geną
RU2711729C2 (ru) 2014-12-09 2020-01-21 Регенерон Фармасьютикалз, Инк. Не относящиеся к человеку животные, имеющие гуманизированный ген кластера дифференцировки 274
WO2016137841A1 (en) * 2015-02-26 2016-09-01 William Paterson University Of New Jersey Transgenic mice
AU2016246698B2 (en) 2015-04-06 2022-06-02 Regeneron Pharmaceuticals, Inc. Humanized T cell mediated immune responses in non-human animals
FI3282835T3 (fi) * 2015-04-13 2023-07-20 Regeneron Pharma Humanisoituja sirpa-il15-poistogeenisiä hiiriä ja niiden käyttömenetelmiä
WO2017087780A1 (en) 2015-11-20 2017-05-26 Regeneron Pharmaceuticals, Inc. Non-human animals having a humanized lymphocyte-activation gene 3
KR102493894B1 (ko) 2016-02-29 2023-01-31 리제너론 파마슈티칼스 인코포레이티드 인간화 tmprss 유전자를 갖는 설치류
AU2017308121A1 (en) * 2016-08-11 2019-03-07 The Jackson Laboratory Methods and compositions relating to improved human red blood cell survival in genetically modified immunodeficient non-human animals
JOP20190009A1 (ar) 2016-09-21 2019-01-27 Alx Oncology Inc أجسام مضادة ضد بروتين ألفا منظم للإشارات وطرق استخدامها
CN110740641A (zh) * 2016-11-30 2020-01-31 杰克逊实验室 具有改善的人先天免疫细胞发育的人源化小鼠模型
ES2953875T3 (es) * 2017-02-27 2023-11-16 Regeneron Pharma Modelos de retinosquisis en roedor
CN107115424B (zh) * 2017-05-09 2018-05-29 江西樟树市正康医药生物科技有限公司 改变酸性体质保钙及清热解毒的中药组合物及制备方法
EP3621433B1 (en) * 2017-05-12 2022-07-27 The Jackson Laboratory Nsg mice lacking mhc class i and class ii
BR112020003609A2 (pt) 2017-09-29 2020-09-01 Regeneron Pharmaceuticals, Inc. sistema e método para formar uma emulsão
US11712026B2 (en) 2017-10-18 2023-08-01 The Jackson Laboratory Murine-MHC-deficient HLA-transgenic nod-mouse models for T1D therapy development
KR102709884B1 (ko) 2017-11-30 2024-09-26 리제너론 파마슈티칼스 인코포레이티드 인간화된 trkb 유전자좌를 포함하는 비인간 동물
KR20200133376A (ko) 2018-03-21 2020-11-27 알렉소 온콜로지 인크. 신호-조절 단백질 알파에 대한 항체 및 사용 방법
JP7328243B2 (ja) 2018-03-26 2023-08-16 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 治療薬を試験するためのヒト化げっ歯類
US11589562B2 (en) 2018-07-16 2023-02-28 Regeneran Pharmaceuticals, Inc. Mouse model of DITRA disease and uses thereof
CN111057721B (zh) * 2018-10-12 2021-03-16 百奥赛图(北京)医药科技股份有限公司 人源化IL-4和/或IL-4Rα改造动物模型的制备方法及应用
CN111172190B (zh) * 2018-12-25 2021-07-30 百奥赛图江苏基因生物技术有限公司 人源化细胞因子csf2基因改造非人动物的构建方法及应用
SG11202108454RA (en) 2019-04-04 2021-09-29 Regeneron Pharma Non-human animals comprising a humanized coagulation factor 12 locus
JP2022534867A (ja) 2019-06-04 2022-08-04 リジェネロン・ファーマシューティカルズ・インコーポレイテッド ベータスリップ変異を有するヒト化ｔｔｒ遺伝子座を含む非ヒト動物と使用方法
CN113939595A (zh) 2019-06-07 2022-01-14 瑞泽恩制药公司 包括人源化白蛋白基因座的非人动物
CN111304246B (zh) * 2019-12-17 2021-05-04 百奥赛图江苏基因生物技术有限公司 一种人源化细胞因子动物模型、制备方法及应用
US20230072216A1 (en) * 2020-01-10 2023-03-09 Biocytogen Pharmaceuticals (Beijing) Co., Ltd. Genetically modified non-human animal with human or chimeric mhc protein complex
US10973908B1 (en) 2020-05-14 2021-04-13 David Gordon Bermudes Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine
WO2024020057A1 (en) 2022-07-19 2024-01-25 Regeneron Pharmaceuticals, Inc. Genetically modified animal model and its use to model the human immune system

Family Cites Families (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4870009A (en) 1982-11-22 1989-09-26 The Salk Institute For Biological Studies Method of obtaining gene product through the generation of transgenic animals
US4736866B1 (en) 1984-06-22 1988-04-12 Transgenic non-human mammals
US5573930A (en) 1985-02-05 1996-11-12 Cetus Oncology Corporation DNA encoding various forms of colony stimulating factor-1
HU215241B (hu) 1986-10-24 1998-11-30 Cetus Corp. Eljárás telepstimuláló faktor-1 új formáinak előállítására, valamint az eljárásban alkalmazható expressziós kazetta, vektor és rekombináns gazdasejtek előállítására
EP0322240B1 (en) 1987-12-23 1995-03-01 The Board Of Trustees Of The Leland Stanford Junior University Chimeric immunocompromised mammals and their use
JP2981486B2 (ja) 1988-06-14 1999-11-22 メディカル・バイオロジー・インスティチュート 哺乳動物の免疫系研究方法
JP2935511B2 (ja) * 1989-10-20 1999-08-16 忠三 岸本 ヒトｉｌ―６レセプターの製造方法
US5652373A (en) 1990-01-15 1997-07-29 Yeda Research And Development Co. Ltd. Engraftment and development of xenogeneic cells in normal mammals having reconstituted hematopoetic deficient immune systems
DE69131331T2 (de) 1990-01-15 2000-03-02 Yeda Research And Development Co., Ltd. Dauerhafte Verpflanzung und Entwicklung menschlicher hämatopoietischer Zellinien bei normalen Säugetieren
US5849288A (en) 1990-01-15 1998-12-15 Yeda Research And Development Co. Ltd. Method for production of monoclonal antibodies in chimeric mice or rats having xenogeneic antibody-producing cells
AU637914B2 (en) 1990-05-03 1993-06-10 Systemix, Inc. Human lymphoid tissue in an immunocompromised host
JPH05500617A (ja) 1990-05-25 1993-02-12 システミックス，インコーポレイティド 免疫処理された宿主におけるヒト末梢血液細胞
US5633426A (en) 1990-05-25 1997-05-27 Systemix, Inc. In vivo use of human bone marrow for investigation and production
EP0571525A1 (en) 1991-02-11 1993-12-01 OMMAYA, Ayub K. Spinal fluid driven artificial organ
US5222982A (en) 1991-02-11 1993-06-29 Ommaya Ayub K Spinal fluid driven artificial organ
EP0517199A1 (en) 1991-06-04 1992-12-09 Yeda Research And Development Company, Ltd. Durable engraftment of human tissue and cells in normal mammals
WO1993005796A1 (en) 1991-09-19 1993-04-01 The Scripps Research Institute Method for producing human antibodies in a non-human animal, and animals therefor
DE69229254T2 (de) 1991-10-30 1999-09-23 Idemitsu Kosan Co. Ltd., Tokio/Tokyo Verfahren zur Herstellung von menschlichen Lymphozyten und menschlichen Antikörpern; und so hergestellte Antikörper
US6353150B1 (en) 1991-11-22 2002-03-05 Hsc Research And Development Limited Partnership Chimeric mammals with human hematopoietic cells
WO1993018144A1 (en) 1992-03-05 1993-09-16 The Trustees Of Columbia University Of The City Of New York Recombination activating gene deficient animal
US5866757A (en) 1992-06-02 1999-02-02 Yeda Research And Development Co. Ltd. Engraftment and development of xenogeneic cells in normal mammals having reconstituted hematopoetic deficient immune systems
US6018096A (en) 1993-05-03 2000-01-25 Surrogen, Inc. Animal model for engraftment, proliferation and differentiation of human hematopoietic stem cells
US5663481A (en) 1993-08-06 1997-09-02 Mount Sinai Hospital Corporation Animal model of the human immune system
JPH10503092A (ja) 1994-07-27 1998-03-24 メルク エンド カンパニー インコーポレーテッド ブラジキニンｂ２受容体が改変されたトランスジェニック非ヒト動物
US6455756B1 (en) 1994-08-12 2002-09-24 Novartis Ag Long term xenogeneic myeloid and lymphoid cell production in chimeric immunocompromised mice
US7273753B2 (en) 1996-08-02 2007-09-25 Center Of Blood Research Purification and uses of dendritic cells and monocytes
IL132164A0 (en) 1997-04-09 2001-03-19 Chang Lung Ji Animal model for evaluation of vaccines
US6248721B1 (en) 1997-04-09 2001-06-19 Lung-Ji Chang Method of using mouse model for evaluation of HIV vaccines
GB2337755B (en) * 1998-05-29 2003-10-29 Secr Defence Virus vaccine
JP2003508038A (ja) 1999-08-31 2003-03-04 ジェネンコア インターナショナル インコーポレーテッド ドナー特異的機能性免疫の産生を容易にすることができるトランスジェニック哺乳類
US20030028911A1 (en) 1999-08-31 2003-02-06 Manley Huang Transgenic mammal capable of facilitating production of donor-specific functional immunity
WO2001042484A1 (en) 1999-12-09 2001-06-14 Human Genome Sciences, Inc. Il-6 like polynucleotide
WO2002022786A1 (en) 2000-09-14 2002-03-21 Genetrol Biotherapeutics, Inc. Method and cell composition for screening compounds for anti-inflammatory activity
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US6586251B2 (en) 2000-10-31 2003-07-01 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
EP1414996B1 (en) * 2001-07-10 2010-12-01 Johnson & Johnson Research Pty Limited Methods for genetic modification of hematopoietic progenitor cells and uses of the modified cells
US20030124091A1 (en) * 2001-10-26 2003-07-03 Large Scale Biology Corporation Endothelial cell derived hematopoietic growth factor
EP1994824A1 (en) 2001-11-15 2008-11-26 Kirin Pharma Kabushiki Kaisha Chimeric non-human animal
JPWO2004005496A1 (ja) 2002-07-05 2005-11-04 麒麟麦酒株式会社 臍帯血、骨髄、末梢血等に含まれる新規な未分化幹細胞集団
CN101250553A (zh) 2002-07-13 2008-08-27 上海医学遗传研究所 一种促人血小板生成素表达载体及其构建方法
WO2004022738A1 (en) 2002-09-09 2004-03-18 California Institute Of Technology Methods and compositions for the generation of humanized mice
EP1418185A1 (en) 2002-11-11 2004-05-12 Aventis Pharma Deutschland GmbH Use of EDG2 receptor in an animal model of heart failure
EP1573313A4 (en) 2002-12-16 2006-05-17 Genentech Inc TRANSGENIC MICE EXPRESSING CD20 AND / OR CD16 HUMAN (S)
CN102225194B (zh) * 2003-03-12 2014-07-16 健泰科生物技术公司 Bv8和/或EG-VEGF促进造血的用途
EP1598364A1 (en) * 2004-05-21 2005-11-23 AGIRx Limited Chimerical soluble hyper IL-11 receptor and use thereof
ES2463476T3 (es) 2004-10-19 2014-05-28 Regeneron Pharmaceuticals, Inc. Método para generar un ratón homocigótico para una modificación genética
US7759541B2 (en) * 2004-12-13 2010-07-20 Iti Life Sciences Transgenic animals for assessing drug metabolism and toxicity
GB2434578A (en) 2006-01-26 2007-08-01 Univ Basel Transgenic animals
DK2019683T4 (da) 2006-04-25 2022-08-29 Univ California Indgivelse af vækstfaktorer til behandling af CNS-lidelser
EP1878342A1 (en) 2006-07-13 2008-01-16 Institut Pasteur Immunodeficient mice transgenic for HLA class I and HLA class II molecules and their uses
US20080081064A1 (en) 2006-09-28 2008-04-03 Surmodics, Inc. Implantable Medical Device with Apertures for Delivery of Bioactive Agents
WO2008069659A1 (en) 2006-12-05 2008-06-12 Academisch Ziekenhuis Bij De Universiteit Van Amsterdam Improved xenogenic immune system in a non-human mammal
EP2155873B1 (en) 2007-05-23 2016-11-09 Sangamo BioSciences, Inc. Methods and compositions for increased transgene expression
GB0718029D0 (en) 2007-09-14 2007-10-24 Iti Scotland Ltd Two step cluster deletion and humanisation
US20110118446A1 (en) 2007-09-28 2011-05-19 The General Hospital Corporation Methods and compositions for antibody production
JP2011510750A (ja) 2008-01-29 2011-04-07 クライマン、ギルバート・エイチ 薬物送達デバイス、キット及びそれらの方法
CN102695517B (zh) * 2009-04-13 2015-01-28 埃普塞斯有限责任两合公司 经改造的间充质干细胞和用其治疗肿瘤的方法
SG176118A1 (en) * 2009-06-29 2011-12-29 Qingfeng Chen Methods of producing humanized non-human mammals
DK2448967T3 (en) 2009-06-29 2015-07-20 Ilya B Leskov NON-HUMAN MAMMALS MODEL OF CANCER human hematopoietic
RU2425880C2 (ru) 2009-07-30 2011-08-10 Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН Способ получения трансгенных мышей
DK3056082T3 (en) 2009-10-06 2018-12-17 Regeneron Pharma RE-MODIFIED MICE AND INPUT
SG10201408415PA (en) * 2009-12-21 2015-01-29 Regeneron Pharma HUMANIZED FCγ R MICE
WO2012040207A2 (en) 2010-09-20 2012-03-29 Yale University HUMAM SIRPAα TRANSGENIC ANIMALS AND THEIR METHODS OF USE
WO2012051572A1 (en) 2010-10-15 2012-04-19 Massachusetts Institute Of Technology A humanized non-human mammal model of malaria and uses thereof
ES2948210T3 (es) 2011-02-15 2023-09-06 Regeneron Pharma Ratones humanizados con M-CSF y uso de los mismos
PT2663575E (pt) 2011-10-28 2014-12-05 Regeneron Pharma Il-6 e receptor de il-6 humanizados
KR20240045263A (ko) 2012-09-07 2024-04-05 예일 유니버시티 유전적으로 변형된 비-인간 동물 및 이것들의 사용 방법
EP4389764A3 (en) 2012-11-05 2024-08-14 Regeneron Pharmaceuticals, Inc. Genetically modified non-human animals and methods of use thereof
US9193977B2 (en) 2013-09-23 2015-11-24 Regeneron Pharmaceuticals, Inc. Non-human animals having a humanized signal-regulatory protein gene
CA2926090C (en) 2013-10-15 2022-07-05 Regeneron Pharmaceuticals, Inc. Humanized il-15 animals
RU2711744C1 (ru) 2014-05-19 2020-01-21 Ридженерон Фармасьютикалз, Инк. Генетически модифицированные животные, отличные от человека, экспрессирующие epo человека
FI3282835T3 (fi) 2015-04-13 2023-07-20 Regeneron Pharma Humanisoituja sirpa-il15-poistogeenisiä hiiriä ja niiden käyttömenetelmiä

Also Published As

Publication number Publication date
IL299887B1 (en) 2024-05-01
IL270124B1 (xx) 2023-02-01
JP2022132376A (ja) 2022-09-08
AU2022200302A1 (en) 2022-02-10
IL299887B2 (en) 2024-09-01
EP4389764A3 (en) 2024-08-14
KR20210087567A (ko) 2021-07-12
US20180049413A1 (en) 2018-02-22
US9901082B2 (en) 2018-02-27
ES2748662T3 (es) 2020-03-17
IL238478B (en) 2018-05-31
IL258968B (en) 2019-10-31
HK1253909A1 (zh) 2019-07-05
PT2914102T (pt) 2018-01-15
JP6772234B2 (ja) 2020-10-21
EP2914102B1 (en) 2017-10-18
MX2015005654A (es) 2016-04-28
JP2019037238A (ja) 2019-03-14
CN108401987B (zh) 2022-04-29
KR20150081285A (ko) 2015-07-13
MX370856B (es) 2020-01-08
EP4389764A2 (en) 2024-06-26
KR102275412B1 (ko) 2021-07-12
KR20220148307A (ko) 2022-11-04
CN114766432A (zh) 2022-07-22
IL299887A (en) 2023-03-01
SG11201502685XA (en) 2015-05-28
CN104918483A (zh) 2015-09-16
NZ724353A (en) 2022-05-27
ES2884598T3 (es) 2021-12-10
US20160366862A1 (en) 2016-12-22
EP3556206B1 (en) 2021-06-02
PT3556206T (pt) 2021-08-24
WO2014071397A2 (en) 2014-05-08
AU2013337242A1 (en) 2015-04-30
RU2015121195A (ru) 2016-12-27
CN104918483B (zh) 2018-05-11
AU2019204775A1 (en) 2019-07-25
MX2020012427A (es) 2022-06-08
AU2013337242B2 (en) 2019-04-04
EP3308641B1 (en) 2019-07-03
EP3556206A1 (en) 2019-10-23
RU2018140189A3 (xx) 2022-05-04
DK3939423T3 (da) 2024-05-06
CN108401987A (zh) 2018-08-17
JP7105844B2 (ja) 2022-07-25
IL238478A0 (en) 2015-06-30
JP2015534819A (ja) 2015-12-07
IL270124A (xx) 2019-12-31
WO2014071397A3 (en) 2014-06-26
NZ631614A (en) 2016-10-28
EP2914102A2 (en) 2015-09-09
NZ749626A (en) 2023-11-24
KR20220075242A (ko) 2022-06-07
IL270124B2 (en) 2023-06-01
CA2887706C (en) 2022-08-02
KR102458016B1 (ko) 2022-10-25
DK3556206T3 (da) 2021-08-09
US20210100228A1 (en) 2021-04-08
KR20240042142A (ko) 2024-04-01
EP3939423B1 (en) 2024-03-06
DK3308641T3 (da) 2019-10-07
KR102649893B1 (ko) 2024-03-25
JP2021010371A (ja) 2021-02-04
US20140134662A1 (en) 2014-05-15
SG10201707449TA (en) 2017-10-30
KR102402806B1 (ko) 2022-05-30
PT3308641T (pt) 2019-10-24
EP3939423A1 (en) 2022-01-19
FI3939423T3 (fi) 2024-05-23
IL258968A (en) 2018-06-28
MY175400A (en) 2020-06-24
US9986724B2 (en) 2018-06-05
MX2019015882A (es) 2020-02-07
AU2019204775B2 (en) 2021-10-21
CN114766432B (zh) 2024-08-02
CA2887706A1 (en) 2014-05-08
JP6422441B2 (ja) 2018-11-14
US10785968B2 (en) 2020-09-29
PT3939423T (pt) 2024-05-29
US11778995B2 (en) 2023-10-10
DK2914102T3 (en) 2017-12-11
IL311744A (en) 2024-05-01
RU2018140189A (ru) 2018-12-10
US20240099278A1 (en) 2024-03-28
EP3308641A1 (en) 2018-04-18
RU2673156C2 (ru) 2018-11-22
NO2946162T3 (xx) 2018-06-09
ES2655442T3 (es) 2018-02-20

Similar Documents

Publication Publication Date Title
IL282472A (en) Genetically modified non-human animals and methods of their use
IL258968A (en) Genetically modified non-human animals and methods of their use
EP2827707A4 (en) NON-HUMAN ANIMAL DEPRESSION MODELS AND METHODS OF USE THEREOF
EP2863736A4 (en) GENETICALLY MODIFIED ANIMALS AND METHODS OF PRODUCTION THEREFOR
IL224327B (en) Transgenic animals and methods of use
EP2678434A4 (en) GENETICALLY MODIFIED ANIMALS AND METHODS FOR PRODUCING THE SAME
EP2770823A4 (en) TRANSGENIC ANIMALS AND METHOD FOR THEIR USE
GB201216564D0 (en) Genetically edited animal
GB201505771D0 (en) Protective case and methods of making
EP2912178A4 (en) SUPER AMPLIFIER AND METHOD FOR USE THEREOF
PL2852279T3 (pl) Układ do szczotkowania zwierząt i sposób obsługi układu do szczotkowania zwierząt
EP2618656A4 (en) HUMAN SIRPAalpha TRANSGENIC ANIMALS AND METHODS OF USE THEREOF
EP2852397A4 (en) HUWENTOXIN IV VARIANTS AND METHODS OF USE
IL290429A (en) Improved methods for genetic modification in animal cells
IL245306A0 (en) Preparations and methods for the production of genetically modified animals
HK1211177A1 (en) Cloned non-human animals free of selective markers
EP2836068A4 (en) CAGE OF CONTENTION FOR FOOT PARKING AND USE THEREOF
GB201216939D0 (en) Gebetically modified non-human mammal and uses thereof