HK1210172A1 - Crystal of dispiropyrrolidine derivative - Google Patents
Crystal of dispiropyrrolidine derivativeInfo
- Publication number
- HK1210172A1 HK1210172A1 HK15111029.5A HK15111029A HK1210172A1 HK 1210172 A1 HK1210172 A1 HK 1210172A1 HK 15111029 A HK15111029 A HK 15111029A HK 1210172 A1 HK1210172 A1 HK 1210172A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- crystal
- dispiropyrrolidine
- derivative
- dispiropyrrolidine derivative
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012195761 | 2012-09-06 | ||
| PCT/JP2013/073865 WO2014038606A1 (ja) | 2012-09-06 | 2013-09-05 | ジスピロピロリジン誘導体の結晶 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1210172A1 true HK1210172A1 (en) | 2016-04-15 |
Family
ID=50237214
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK15111029.5A HK1210172A1 (en) | 2012-09-06 | 2015-11-09 | Crystal of dispiropyrrolidine derivative |
Country Status (13)
| Country | Link |
|---|---|
| US (8) | US9359368B2 (ru) |
| EP (1) | EP2894156B1 (ru) |
| JP (1) | JP6016284B2 (ru) |
| KR (1) | KR102217410B1 (ru) |
| CN (1) | CN104812757B (ru) |
| BR (1) | BR112015004816B1 (ru) |
| CA (1) | CA2884238C (ru) |
| ES (1) | ES2637150T3 (ru) |
| HK (1) | HK1210172A1 (ru) |
| IN (1) | IN2015MN00464A (ru) |
| RU (1) | RU2647840C2 (ru) |
| TW (1) | TWI586668B (ru) |
| WO (1) | WO2014038606A1 (ru) |
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| TWI586668B (zh) | 2012-09-06 | 2017-06-11 | 第一三共股份有限公司 | 二螺吡咯啶衍生物之結晶 |
| MX2015008196A (es) | 2012-12-20 | 2015-09-16 | Merck Sharp & Dohme | Imidazopiridinas sustituidas como inhibidores de doble minuto 2 humana. |
| GB201311891D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compound |
| GB201311888D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| US20170327469A1 (en) | 2015-01-20 | 2017-11-16 | Arvinas, Inc. | Compounds and methods for the targeted degradation of androgen receptor |
| CA2974367A1 (en) | 2015-01-20 | 2016-07-28 | Arvinas, Inc. | Compounds and methods for the targeted degradation of the androgen receptor |
| TWI711452B (zh) * | 2015-02-20 | 2020-12-01 | 日商第一三共股份有限公司 | 癌症的倂用治療法 |
| US10485794B2 (en) | 2015-04-13 | 2019-11-26 | Daiichi Sankyo Company, Limited | Treatment method by combined use of MDM2 inhibitor and BTK inhibitor |
| WO2016197114A1 (en) | 2015-06-05 | 2016-12-08 | Arvinas, Inc. | Tank-binding kinase-1 protacs and associated methods of use |
| US10772962B2 (en) | 2015-08-19 | 2020-09-15 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of bromodomain-containing proteins |
| TW202332444A (zh) * | 2015-10-23 | 2023-08-16 | 日商第一三共股份有限公司 | 用於治療癌症之醫藥組成物 |
| TW201722428A (zh) * | 2015-10-23 | 2017-07-01 | 第一三共股份有限公司 | 用於治療急性骨髓性白血病（ａｍｌ）之醫藥組成物及對有此需要者進行急性骨髓性白血病治療之方法 |
| JP2019522633A (ja) | 2016-05-20 | 2019-08-15 | ジェネンテック， インコーポレイテッド | Ｐｒｏｔａｃ抗体コンジュゲート及び使用方法 |
| EP3535265A4 (en) | 2016-11-01 | 2020-07-08 | Arvinas, Inc. | PROTACS TARGETING ON TAU PROTEIN AND RELATED METHODS FOR USE |
| FI3689868T3 (fi) | 2016-12-01 | 2023-12-18 | Arvinas Operations Inc | Tetrahydronaftaleenin ja tetrahydroisokinoliinin johdannaisia estrogeenireseptorin hajottajina |
| AU2017382436C1 (en) | 2016-12-23 | 2021-05-27 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of Rapidly Accelerated Fibrosarcoma polypeptides |
| US11173211B2 (en) | 2016-12-23 | 2021-11-16 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of rapidly accelerated Fibrosarcoma polypeptides |
| EP3559006A4 (en) | 2016-12-23 | 2021-03-03 | Arvinas Operations, Inc. | COMPOUNDS AND METHODS FOR TARGETED DEGRADATION OF FETAL LIVER KINASE POLYPEPTIDES |
| EP3559002A4 (en) | 2016-12-23 | 2021-02-17 | Arvinas Operations, Inc. | CHEMERICAL MOLECULES TARGETING EGFR PROTEOLYSIS AND RELATED METHODS OF USE |
| US11191741B2 (en) | 2016-12-24 | 2021-12-07 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of enhancer of zeste homolog 2 polypeptide |
| CN117551089A (zh) | 2017-01-26 | 2024-02-13 | 阿尔维纳斯运营股份有限公司 | 雌激素受体蛋白水解调节剂及相关使用方法 |
| EP3710443A1 (en) | 2017-11-17 | 2020-09-23 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of interleukin-1 receptor-associated kinase 4 polypeptides |
| US11161841B2 (en) | 2018-04-04 | 2021-11-02 | Arvinas Operations, Inc. | Modulators of proteolysis and associated methods of use |
| WO2020041331A1 (en) | 2018-08-20 | 2020-02-27 | Arvinas Operations, Inc. | Proteolysis targeting chimeric (protac) compound with e3 ubiquitin ligase binding activity and targeting alpha-synuclein protein for treating neurodegenerative diseases |
| WO2023056069A1 (en) | 2021-09-30 | 2023-04-06 | Angiex, Inc. | Degrader-antibody conjugates and methods of using same |
| WO2024054591A1 (en) | 2022-09-07 | 2024-03-14 | Arvinas Operations, Inc. | Rapidly accelerated fibrosarcoma (raf) degrading compounds and associated methods of use |
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| US6740495B1 (en) | 2000-04-03 | 2004-05-25 | Rigel Pharmaceuticals, Inc. | Ubiquitin ligase assay |
| US6979551B2 (en) | 2000-04-03 | 2005-12-27 | Rigel Pharmaceuticals, Inc. | Assays for identifying ubiquitin agents and for identifying agents that modify the activity of ubiquitin agents |
| JP4361798B2 (ja) | 2001-12-18 | 2009-11-11 | エフ．ホフマン−ラ ロシュ アーゲー | Ｍｄｍ２インヒビターとしてのシス−イミダゾリン |
| MXPA04005906A (es) | 2001-12-18 | 2004-09-13 | Hoffmann La Roche | Cis-2,4,5-trifenil-.imidazolinas y uso de la misma para tratamiento de tumores. |
| US7425638B2 (en) | 2003-06-17 | 2008-09-16 | Hoffmann-La Roche Inc. | Cis-imidazolines |
| US7132421B2 (en) | 2003-06-17 | 2006-11-07 | Hoffmann-La Roche Inc. | CIS-imidazoles |
| ES2314660T3 (es) | 2004-05-18 | 2009-03-16 | F. Hoffmann-La Roche Ag | Nuevas cis-imidazolinas. |
| GB0419481D0 (en) | 2004-09-02 | 2004-10-06 | Cancer Rec Tech Ltd | Isoindolin-1-one derivatives |
| CA2752738C (en) * | 2005-02-22 | 2014-05-27 | The Regents Of The University Of Michigan | Small molecule inhibitors of mdm2 and uses thereof |
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| ZA200901224B (en) | 2006-08-30 | 2010-05-26 | Univ Michigan | New small molecule inhibitors of MDM2 the uses thereof |
| KR101109438B1 (ko) | 2006-09-21 | 2012-07-12 | 에프. 호프만-라 로슈 아게 | 항암제로서의 옥신돌 유도체 |
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| AR073578A1 (es) | 2008-09-15 | 2010-11-17 | Priaxon Ag | Pirrolidin-2-onas |
| US8354444B2 (en) | 2008-09-18 | 2013-01-15 | Hoffmann-La Roche Inc. | Substituted pyrrolidine-2-carboxamides |
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| US20100190814A1 (en) | 2009-01-26 | 2010-07-29 | Li Chen | Spiroindolinone derivative prodrugs |
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| US8017607B2 (en) | 2009-10-14 | 2011-09-13 | Hoffmann-La Roche Inc. | N-substituted-pyrrolidines as inhibitors of MDM2-P-53 interactions |
| MX2012005507A (es) | 2009-11-12 | 2012-07-03 | Univ Michigan | Antagonistas de espiro-oxindol de mdm2. |
| US20110118283A1 (en) | 2009-11-17 | 2011-05-19 | Qingjie Ding | Substituted Pyrrolidine-2-Carboxamides |
| US8088815B2 (en) | 2009-12-02 | 2012-01-03 | Hoffman-La Roche Inc. | Spiroindolinone pyrrolidines |
| US8288431B2 (en) | 2010-02-17 | 2012-10-16 | Hoffmann-La Roche Inc. | Substituted spiroindolinones |
| KR20130050938A (ko) | 2010-04-09 | 2013-05-16 | 더 리젠츠 오브 더 유니버시티 오브 미시건 | 질환 치료시 사용하기 위한 ｍｄｍ2 억제제에 대한 바이오마커 |
| US8217044B2 (en) | 2010-04-28 | 2012-07-10 | Hoffmann-La Roche Inc. | Spiroindolinone pyrrolidines |
| US20120010235A1 (en) | 2010-07-12 | 2012-01-12 | Xin-Jie Chu | N-substituted pyrrolidines |
| US20120046306A1 (en) | 2010-08-18 | 2012-02-23 | David Joseph Bartkovitz | Substituted Heteroaryl Spiropyrrolidine MDM2 Antagonists |
| SG10201506215WA (en) | 2010-09-08 | 2015-09-29 | Basf Se | Aqueous polishing compositions containing n-substituted diazenium dioxides and/or n'-hydroxy-diazenium oxide salts |
| US20120065210A1 (en) | 2010-09-15 | 2012-03-15 | Xin-Jie Chu | Substituted hexahydropyrrolo[1,2-c]imidazolones |
| US20120071499A1 (en) * | 2010-09-20 | 2012-03-22 | Xin-Jie Chu | Substituted Spiro[3H-Indole-3,6'(5'H)-[1H]Pyrrolo[1,2c]Imidazole-1',2(1H,2'H)-diones |
| WO2012076513A1 (en) | 2010-12-09 | 2012-06-14 | F. Hoffmann-La Roche Ag | 3-cyano-1-hydroxymethyl-2-phenylpyrrolidine derivatives as inhibitors of mdm2-p53 interactions useful for the treatment of cancer |
| SI2684880T1 (en) | 2011-03-10 | 2018-08-31 | Daiichi Sankyo Company, Limited | DERIVAT DISPIROPYROLIDINE |
| ES2624808T3 (es) * | 2011-05-11 | 2017-07-17 | The Regents Of The University Of Michigan | Antagonistas de MDM2 espirooxindólicos |
| TWI586668B (zh) | 2012-09-06 | 2017-06-11 | 第一三共股份有限公司 | 二螺吡咯啶衍生物之結晶 |
-
2013
- 2013-09-04 TW TW102131754A patent/TWI586668B/zh active
- 2013-09-05 BR BR112015004816-1A patent/BR112015004816B1/pt active IP Right Grant
- 2013-09-05 KR KR1020157005386A patent/KR102217410B1/ko active IP Right Grant
- 2013-09-05 CA CA2884238A patent/CA2884238C/en active Active
- 2013-09-05 WO PCT/JP2013/073865 patent/WO2014038606A1/ja active Application Filing
- 2013-09-05 JP JP2014534398A patent/JP6016284B2/ja active Active
- 2013-09-05 ES ES13835941.9T patent/ES2637150T3/es active Active
- 2013-09-05 EP EP13835941.9A patent/EP2894156B1/en active Active
- 2013-09-05 CN CN201380057995.9A patent/CN104812757B/zh active Active
- 2013-09-05 IN IN464MUN2015 patent/IN2015MN00464A/en unknown
- 2013-09-05 RU RU2015112098A patent/RU2647840C2/ru active
- 2013-09-05 US US14/426,630 patent/US9359368B2/en active Active
-
2015
- 2015-11-09 HK HK15111029.5A patent/HK1210172A1/xx unknown
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2016
- 2016-05-02 US US15/144,485 patent/US9540386B2/en active Active
- 2016-12-06 US US15/370,380 patent/US9718831B2/en active Active
- 2016-12-06 US US15/370,292 patent/US9718830B2/en active Active
- 2016-12-06 US US15/370,160 patent/US9884871B2/en active Active
- 2016-12-06 US US15/370,618 patent/US9745315B2/en active Active
-
2018
- 2018-02-02 US US15/887,444 patent/US10023578B2/en active Active
- 2018-02-02 US US15/887,648 patent/US10030030B2/en active Active
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