HK1209790A1 - Method of producing recombinant iduronate-2-sulfatase -2- - Google Patents

Method of producing recombinant iduronate-2-sulfatase -2-

Info

Publication number
HK1209790A1
HK1209790A1 HK15110518.5A HK15110518A HK1209790A1 HK 1209790 A1 HK1209790 A1 HK 1209790A1 HK 15110518 A HK15110518 A HK 15110518A HK 1209790 A1 HK1209790 A1 HK 1209790A1
Authority
HK
Hong Kong
Prior art keywords
sulfatase
producing recombinant
recombinant iduronate
iduronate
producing
Prior art date
Application number
HK15110518.5A
Other languages
English (en)
Chinese (zh)
Inventor
Chun Zhang
Ferenc Boldog
Original Assignee
Shire Human Genetic Therapies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shire Human Genetic Therapies filed Critical Shire Human Genetic Therapies
Publication of HK1209790A1 publication Critical patent/HK1209790A1/xx

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/16Hydrolases (3) acting on ester bonds (3.1)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/465Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y108/00Oxidoreductases acting on sulfur groups as donors (1.8)
    • C12Y108/99Oxidoreductases acting on sulfur groups as donors (1.8) with other acceptors (1.8.99)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y301/00Hydrolases acting on ester bonds (3.1)
    • C12Y301/06Sulfuric ester hydrolases (3.1.6)
    • C12Y301/06013Iduronate-2-sulfatase (3.1.6.13)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/30Organic components
    • C12N2500/32Amino acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/30Organic components
    • C12N2500/40Nucleotides, nucleosides, bases
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/30Organic components
    • C12N2500/44Thiols, e.g. mercaptoethanol
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/60Buffer, e.g. pH regulation, osmotic pressure
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2523/00Culture process characterised by temperature

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK15110518.5A 2012-06-29 2015-10-26 Method of producing recombinant iduronate-2-sulfatase -2- HK1209790A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261666712P 2012-06-29 2012-06-29
PCT/US2013/048601 WO2014005036A1 (en) 2012-06-29 2013-06-28 Method of producing recombinant iduronate-2-sulfatase

Publications (1)

Publication Number Publication Date
HK1209790A1 true HK1209790A1 (en) 2016-04-08

Family

ID=49778402

Family Applications (2)

Application Number Title Priority Date Filing Date
HK15110043.9A HK1209458A1 (en) 2012-06-29 2015-10-14 Method of producing recombinant iduronate-2-sulfatase -2-
HK15110518.5A HK1209790A1 (en) 2012-06-29 2015-10-26 Method of producing recombinant iduronate-2-sulfatase -2-

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HK15110043.9A HK1209458A1 (en) 2012-06-29 2015-10-14 Method of producing recombinant iduronate-2-sulfatase -2-

Country Status (21)

Country Link
US (1) US20140004097A1 (xx)
EP (1) EP2867367A4 (xx)
JP (1) JP2015523074A (xx)
KR (1) KR20150037908A (xx)
CN (1) CN104583414A (xx)
AU (1) AU2013282417A1 (xx)
BR (1) BR112014032544A2 (xx)
CA (1) CA2877492A1 (xx)
CL (1) CL2014003569A1 (xx)
CO (1) CO7240395A2 (xx)
CR (1) CR20140587A (xx)
DO (1) DOP2014000297A (xx)
EA (1) EA201492185A1 (xx)
HK (2) HK1209458A1 (xx)
IL (1) IL236324A0 (xx)
IN (1) IN2014DN11272A (xx)
MX (1) MX2015000188A (xx)
PE (1) PE20150603A1 (xx)
PH (1) PH12014502870A1 (xx)
SG (1) SG11201408755TA (xx)
WO (1) WO2014005036A1 (xx)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160145589A1 (en) 2011-06-24 2016-05-26 Green Cross Corporation Composition and formulation comprising recombinant human iduronate-2-sulfatase and preparation method thereof
KR101380740B1 (ko) 2012-06-29 2014-04-11 쉐어 휴먼 제네텍 세러피스, 인코포레이티드 이듀로네이트-2-설파타제의 정제
US9150841B2 (en) 2012-06-29 2015-10-06 Shire Human Genetic Therapies, Inc. Cells for producing recombinant iduronate-2-sulfatase
CA2880162C (en) * 2012-07-31 2023-04-04 Bioasis Technologies, Inc. Dephosphorylated lysosomal storage disease proteins and methods of use thereof
WO2014160438A1 (en) 2013-03-13 2014-10-02 Bioasis Technologies Inc. Fragments of p97 and uses thereof
DK3107562T3 (da) * 2014-02-19 2019-12-16 Bioasis Technologies Inc P97-ids-fusionsproteiner
KR102638596B1 (ko) * 2015-02-05 2024-02-21 알.피.쉐러 테크놀러지즈 엘엘씨 활성화된 포르밀글리신-생성 효소 및 그것의 생산 및 사용 방법
CN108290059A (zh) * 2015-10-07 2018-07-17 乔尔·胡伊赞加 重设生物途径以防御和修复来自人类老化的退化
EP3487609A4 (en) * 2016-07-25 2020-04-22 Repligen Corporation FAST HARVESTING WITH ALTERNATING TANGENTIAL FLOW
WO2019070577A1 (en) 2017-10-02 2019-04-11 Denali Therapeutics Inc. FUSION PROTEINS COMPRISING SUBSTITUTE ENZYM THERAPY ENZYMES

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000517188A (ja) 1996-08-30 2000-12-26 ライフ テクノロジーズ,インコーポレイテッド 無血清哺乳動物細胞培養培地およびその使用
ATE348173T1 (de) * 1999-04-26 2007-01-15 Genentech Inc Zellenzuchtverfahren für glycoproteine
US6890736B1 (en) * 2002-09-20 2005-05-10 Immunex Corporation Methods for producing proteins in cultured cells
NZ570201A (en) * 2003-02-11 2011-03-31 Shire Human Genetic Therapies Diagnosis and treatment of multiple sulfatase deficiency and other using a formylglycine generating enzyme (fge)
US20050019914A1 (en) * 2003-07-24 2005-01-27 Aventis Pharma Deutschland Gmbh Perfusion process for producing erythropoietin
WO2005113765A2 (en) 2004-05-06 2005-12-01 Biomarin Pharmaceutical Inc. Methods of activation of sulfatases and methods and compositions of using the same
ATE557038T1 (de) * 2005-06-03 2012-05-15 Ares Trading Sa Herstellung von rekombinantem il-18 bindendem protein
ES2434494T3 (es) * 2005-12-08 2013-12-16 Amgen, Inc. Células huésped mejoradas y métodos de cultivo
SI2245145T1 (sl) * 2008-01-18 2017-05-31 Biomarin Pharmaceutical Inc. Izdelava aktivnih visoko fosforiliranih humanih encimov lizosomske sulfataze in njihova uporaba
HUE044865T2 (hu) * 2009-10-09 2019-11-28 Armagen Inc Eljárások és készítmények a központi idegrendszerben iduronát-2-szulfatáz-aktivitás növelésére
US20130196410A1 (en) * 2010-03-05 2013-08-01 Alnylam Pharmaceuticals, Inc Compositions and methods for modifying the glycosylation pattern of a polypeptide
MX2020001395A (es) 2010-06-25 2022-03-24 Shire Human Genetic Therapies Composiciones y su uso para suministro de iduronato-2-sulfatasa al sistema nervioso central.
KR101158673B1 (ko) * 2011-06-24 2012-07-03 주식회사 지씨바이오 재조합 인간 이듀로네이트-2-설파타아제를 포함하는 조성물, 제제 및 이의 제조방법
US9150841B2 (en) * 2012-06-29 2015-10-06 Shire Human Genetic Therapies, Inc. Cells for producing recombinant iduronate-2-sulfatase

Also Published As

Publication number Publication date
EP2867367A1 (en) 2015-05-06
PE20150603A1 (es) 2015-05-27
US20140004097A1 (en) 2014-01-02
CR20140587A (es) 2015-04-06
IL236324A0 (en) 2015-02-26
CA2877492A1 (en) 2014-01-03
CN104583414A (zh) 2015-04-29
EA201492185A1 (ru) 2015-10-30
HK1209458A1 (en) 2016-04-01
BR112014032544A2 (pt) 2017-08-01
AU2013282417A1 (en) 2015-01-29
MX2015000188A (es) 2015-04-08
SG11201408755TA (en) 2015-02-27
WO2014005036A1 (en) 2014-01-03
PH12014502870A1 (en) 2015-02-23
JP2015523074A (ja) 2015-08-13
EP2867367A4 (en) 2016-02-24
KR20150037908A (ko) 2015-04-08
CO7240395A2 (es) 2015-04-17
CL2014003569A1 (es) 2015-04-17
IN2014DN11272A (xx) 2015-10-09
DOP2014000297A (es) 2015-04-15

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