HK1206724A1 - 取代的苯並噻吩並嘧啶 - Google Patents

取代的苯並噻吩並嘧啶

Info

Publication number
HK1206724A1
HK1206724A1 HK15107191.5A HK15107191A HK1206724A1 HK 1206724 A1 HK1206724 A1 HK 1206724A1 HK 15107191 A HK15107191 A HK 15107191A HK 1206724 A1 HK1206724 A1 HK 1206724A1
Authority
HK
Hong Kong
Prior art keywords
benzothienopyrimidines
substituted
substituted benzothienopyrimidines
Prior art date
Application number
HK15107191.5A
Other languages
English (en)
Inventor
Ulrich Klar
Georg Kettschau
Dirk Kosemund
Florian Phler
Knut Eis
Philip Lienau
Ulf Bmer
Detlev Slzle
Lars Wortmann
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of HK1206724A1 publication Critical patent/HK1206724A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HK15107191.5A 2012-05-21 2015-07-28 取代的苯並噻吩並嘧啶 HK1206724A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12168672 2012-05-21
EP13153616 2013-02-01
PCT/EP2013/060220 WO2013174735A1 (en) 2012-05-21 2013-05-17 Substituted benzothienopyrimidines

Publications (1)

Publication Number Publication Date
HK1206724A1 true HK1206724A1 (zh) 2016-01-15

Family

ID=48446378

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15107191.5A HK1206724A1 (zh) 2012-05-21 2015-07-28 取代的苯並噻吩並嘧啶

Country Status (8)

Country Link
US (1) US9296757B2 (zh)
EP (1) EP2852595B1 (zh)
JP (1) JP6235001B2 (zh)
CN (1) CN104470931B (zh)
CA (1) CA2873967A1 (zh)
ES (1) ES2592404T3 (zh)
HK (1) HK1206724A1 (zh)
WO (1) WO2013174735A1 (zh)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6234444B2 (ja) 2012-05-21 2017-11-22 バイエル ファーマ アクチエンゲゼルシャフト チエノピリミジン類
TW201412740A (zh) 2012-09-20 2014-04-01 Bayer Pharma AG 經取代之吡咯并嘧啶胺基苯并噻唑酮
JP2016512491A (ja) 2013-03-06 2016-04-28 バイエル・ファルマ・アクティエンゲゼルシャフト 置換チアゾロピリミジン類
TW201605867A (zh) * 2013-11-20 2016-02-16 拜耳製藥公司 噻吩并嘧啶
CN106661049A (zh) * 2014-05-26 2017-05-10 拜耳制药股份公司 取代的四氢吡啶并噻吩并嘧啶
US20170197979A1 (en) * 2014-05-27 2017-07-13 Bayer Pharma Aktiengesellschaft Benzothiadiazolamines
KR20170095985A (ko) 2014-12-19 2017-08-23 바이엘 파마 악티엔게젤샤프트 Mknk1 및 mknk2 억제제로서의 피라졸로피리딘아민
DK3285809T3 (da) 2015-04-20 2019-11-18 Effector Therapeutics Inc Inhibitorer af immunkontrolpunktsmodulatorer til anvendelse i behandling af kræft og infektioner.
US20170191136A1 (en) 2015-12-31 2017-07-06 Effector Therapeutics, Inc. Mnk biomarkers and uses thereof
CN110709402B (zh) * 2017-06-15 2022-05-10 浙江海正药业股份有限公司 杂芳基并嘧啶酮类衍生物、其制备方法及其在医药上用途
CN109912620B (zh) * 2019-04-08 2021-07-09 沈阳药科大学 四氢苯并[4,5]噻吩并[2,3-d]嘧啶类化合物及其应用
CN114957280B (zh) * 2021-12-31 2024-09-17 成都赜灵生物医药科技有限公司 噻吩[2,3-d]嘧啶衍生物及其用途

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WO1997018212A1 (en) 1995-11-14 1997-05-22 Pharmacia & Upjohn S.P.A. Aryl and heteroaryl purine compounds
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CN100343258C (zh) * 2001-04-30 2007-10-17 美国拜尔公司 新的4－氨基－5,6－取代的噻吩并[2,3－d]嘧啶化合物
ES2280040T3 (es) 2003-07-24 2007-09-01 Bayer Pharmaceuticals Corporation Compuestos de tetrahidrobenzotienopirimidinamina sustituidos utiles para tratar trastornos hiperproliferativos.
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DE102004024439A1 (de) 2004-05-14 2005-12-08 Degussa Ag Härtbare Zusammensetzungen auf Basis von Epoxidharzen und 3(4)-(Aminomethyl)-cyclohexan-propanamin und 1,4(5)-Cyclooctandimethanamin
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UY33241A (es) 2010-02-26 2011-09-30 Boehringer Ingelheim Int ?Tienopirimidinas que contienen heterocicloalquilo para composiciones farmacéuticas?.
EA201201191A1 (ru) 2010-02-26 2013-04-30 Бёрингер Ингельхайм Интернациональ Гмбх 4-[циклоалкилокси(гетеро)ариламино]тиено[2,3-d]пиримидины, обладающие ингибирующей активностью по отношению к mnkl/mnk2, предназначенные для фармацевтических композиций
AR080328A1 (es) 2010-02-26 2012-03-28 Boehringer Ingelheim Int Tienopirimidinas que contienen un grupo alquilo sustituido inhibidoras de quinasas mnk1 y/o mnk2, composiciones farmaceuticas que las contienen y uso de las mismas para el tratamiento de trastornos metabolicos tales como diabetes y obesidad, y trastornos hiperproliferativos, entre otros
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TW201412740A (zh) 2012-09-20 2014-04-01 Bayer Pharma AG 經取代之吡咯并嘧啶胺基苯并噻唑酮
CA2885783A1 (en) 2012-09-26 2014-04-03 Bayer Pharma Aktiengesellschaft Substituted indazol-pyrrolopyrimidines useful in the treatment of hyperproliferative diseases
WO2014048894A1 (en) 2012-09-26 2014-04-03 Bayer Pharma Aktiengesellschaft Substituted indazol-pyrrolopyrimidines useful in the treatment of hyperfoliferative disorders

Also Published As

Publication number Publication date
WO2013174735A1 (en) 2013-11-28
EP2852595A1 (en) 2015-04-01
CA2873967A1 (en) 2013-11-28
CN104470931B (zh) 2016-10-26
JP2015520761A (ja) 2015-07-23
CN104470931A (zh) 2015-03-25
ES2592404T3 (es) 2016-11-30
US20150152121A1 (en) 2015-06-04
JP6235001B2 (ja) 2017-11-22
EP2852595B1 (en) 2016-06-22
US9296757B2 (en) 2016-03-29

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20210516