HK1202801A1 - Combination therapy comprising tenofovir alafenamide hemifumarate and cobicistat for use in the treatment of viral infections - Google Patents
Combination therapy comprising tenofovir alafenamide hemifumarate and cobicistat for use in the treatment of viral infectionsInfo
- Publication number
- HK1202801A1 HK1202801A1 HK15103394.9A HK15103394A HK1202801A1 HK 1202801 A1 HK1202801 A1 HK 1202801A1 HK 15103394 A HK15103394 A HK 15103394A HK 1202801 A1 HK1202801 A1 HK 1202801A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- cobicistat
- treatment
- combination therapy
- viral infections
- tenofovir alafenamide
- Prior art date
Links
- 208000036142 Viral infection Diseases 0.000 title 1
- ZCIGNRJZKPOIKD-CQXVEOKZSA-N cobicistat Chemical compound S1C(C(C)C)=NC(CN(C)C(=O)N[C@@H](CCN2CCOCC2)C(=O)N[C@H](CC[C@H](CC=2C=CC=CC=2)NC(=O)OCC=2SC=NC=2)CC=2C=CC=CC=2)=C1 ZCIGNRJZKPOIKD-CQXVEOKZSA-N 0.000 title 1
- 229960002402 cobicistat Drugs 0.000 title 1
- 238000002648 combination therapy Methods 0.000 title 1
- SVUJNSGGPUCLQZ-FQQAACOVSA-N tenofovir alafenamide fumarate Chemical compound OC(=O)\C=C\C(O)=O.O([P@@](=O)(CO[C@H](C)CN1C2=NC=NC(N)=C2N=C1)N[C@@H](C)C(=O)OC(C)C)C1=CC=CC=C1.O([P@@](=O)(CO[C@H](C)CN1C2=NC=NC(N)=C2N=C1)N[C@@H](C)C(=O)OC(C)C)C1=CC=CC=C1 SVUJNSGGPUCLQZ-FQQAACOVSA-N 0.000 title 1
- 230000009385 viral infection Effects 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261594894P | 2012-02-03 | 2012-02-03 | |
| US201261618411P | 2012-03-30 | 2012-03-30 | |
| US201261624676P | 2012-04-16 | 2012-04-16 | |
| US201261692392P | 2012-08-23 | 2012-08-23 | |
| US201261737493P | 2012-12-14 | 2012-12-14 | |
| PCT/US2013/024438 WO2013116720A1 (en) | 2012-02-03 | 2013-02-01 | Combination therapy comprising tenofovir alafenamide hemifumarate and cobicistat for use in the treatment of viral infections |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1202801A1 true HK1202801A1 (en) | 2015-10-09 |
Family
ID=47722563
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK15103394.9A HK1202801A1 (en) | 2012-02-03 | 2015-04-07 | Combination therapy comprising tenofovir alafenamide hemifumarate and cobicistat for use in the treatment of viral infections |
| HK15105031.3A HK1204914A1 (en) | 2012-02-03 | 2015-05-27 | Combination therapy comprising tenofovir alafenamide hemifumarate and cobicistat for use in the treatment of viral infections |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK15105031.3A HK1204914A1 (en) | 2012-02-03 | 2015-05-27 | Combination therapy comprising tenofovir alafenamide hemifumarate and cobicistat for use in the treatment of viral infections |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US20150105350A1 (uk) |
| EP (1) | EP2809323A1 (uk) |
| JP (1) | JP6059255B2 (uk) |
| KR (1) | KR20140119177A (uk) |
| CN (1) | CN104105484A (uk) |
| AU (3) | AU2013204727A1 (uk) |
| BR (1) | BR112014018918A8 (uk) |
| CA (1) | CA2863662A1 (uk) |
| EA (1) | EA026138B1 (uk) |
| HK (2) | HK1202801A1 (uk) |
| IL (1) | IL233874A0 (uk) |
| MD (1) | MD20140091A2 (uk) |
| MX (1) | MX2014009172A (uk) |
| NZ (1) | NZ629896A (uk) |
| WO (2) | WO2013116730A1 (uk) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2487163T (pt) | 2007-02-23 | 2016-11-21 | Gilead Sciences Inc | Moduladores de propriedades farmacocinéticas de agentes terapêuticos |
| TW201639852A (zh) | 2008-12-09 | 2016-11-16 | 吉李德科學股份有限公司 | 用於製備可用作類鐸受體調節劑之化合物的中間體化合物 |
| UY34262A (es) | 2011-08-16 | 2013-04-05 | Gilead Sciences Inc | Hemifumarato de tenofovir alafenamida, sus composiciones, método de preparación, métodos para tratar infecciones virales y su uso para preparar medi camentos |
| CN103665043B (zh) | 2012-08-30 | 2017-11-10 | 江苏豪森药业集团有限公司 | 一种替诺福韦前药及其在医药上的应用 |
| MX2016002560A (es) * | 2013-08-29 | 2016-10-26 | Teva Pharma | Forma de dosificacion unitaria que comprende emtricitabina, tenofovir, darunavir y ritonavir y un comprimido monolitico que comprende darunavir y ritonavir. |
| IN2013CH05455A (uk) * | 2013-11-27 | 2015-08-07 | Laurus Labs Private Ltd | |
| US9463194B2 (en) | 2014-02-05 | 2016-10-11 | Gilead Sciences, Inc. | Methods of treating patients co-infected with HIV and tuberculosis |
| CA2942877A1 (en) * | 2014-04-08 | 2015-10-15 | Nitzan SHAHAR | Unit dosage form comprising emtricitabine, tenofovir, darunavir and ritonavir |
| CN105518011B (zh) * | 2014-04-21 | 2018-07-27 | 四川海思科制药有限公司 | 氨基磷酸酯类衍生物制备方法及其中间体和中间体的制备方法 |
| US11311519B2 (en) | 2014-05-01 | 2022-04-26 | Eiger Biopharmaceuticals, Inc. | Treatment of hepatitis delta virus infection |
| US10076512B2 (en) | 2014-05-01 | 2018-09-18 | Eiger Biopharmaceuticals, Inc. | Treatment of hepatitis delta virus infection |
| MX2017000026A (es) * | 2014-07-11 | 2017-05-01 | Gilead Sciences Inc | Moduladores de receptores tipo toll para el tratamiento de virus de inmunodeficiencia humana (vih). |
| SI3194401T1 (sl) | 2014-09-16 | 2020-12-31 | Gilead Sciences, Inc. | Trdne oblike modulatorja toličnega receptorja |
| CN105237571B (zh) * | 2014-11-28 | 2018-03-09 | 成都苑东生物制药股份有限公司 | 9‑[(r)‑2‑[[(s)‑[[(s)‑1‑(异丙氧基羰基)乙基]氨基]苯氧基氧膦基]甲氧基]丙基]腺嘌呤的盐 |
| US20180338993A1 (en) * | 2014-12-04 | 2018-11-29 | Eiger Biopharmaceuticals, Inc. | Treatment of hepatitis delta virus infection |
| RS62434B1 (sr) | 2014-12-26 | 2021-11-30 | Univ Emory | Antivirusni n4-hidroksicitidin derivati |
| AU2015373104B2 (en) * | 2015-01-03 | 2020-07-09 | Mylan Laboratories Limited | Processes for the preparation of amorphous tenofovir alafenamide hemifumarate and a premix thereof |
| DK3285768T3 (da) | 2015-04-21 | 2021-01-25 | Eiger Biopharmaceuticals Inc | Farmaceutiske sammensætninger omfattende lonafarnib og ritonavir |
| CN104817593B (zh) * | 2015-04-27 | 2016-11-16 | 广州同隽医药科技有限公司 | 半富马酸替诺福韦艾拉酚胺关键中间体的合成工艺 |
| PT4070788T (pt) * | 2015-06-30 | 2023-06-06 | Gilead Sciences Inc | Formulações farmacêuticas |
| CA2921336A1 (en) * | 2015-06-30 | 2016-12-30 | Gilead Sciences, Inc. | Pharmaceutical formulations |
| WO2017023694A1 (en) | 2015-08-03 | 2017-02-09 | Pop Test Oncology Llc | Pharmaceutical compositions and methods |
| CN105153231A (zh) * | 2015-08-28 | 2015-12-16 | 浙江车头制药股份有限公司 | 一种一苯基pmpa的制备方法 |
| JP6621933B2 (ja) * | 2015-11-09 | 2019-12-18 | ギリアード サイエンシス インコーポレーテッド | ヒト免疫不全ウイルスを処置するための治療組成物 |
| BR112018016517B1 (pt) * | 2016-02-12 | 2024-03-12 | Cipla Limited | Composições farmacêuticas incluindo uma droga antirretroviral e um intensificador farmacocinético, métodos operacionais das composições e kit com antirretroviral e intensificador |
| CN107179355B (zh) * | 2016-03-11 | 2021-08-10 | 广东东阳光药业有限公司 | 一种分离检测替诺福韦艾拉酚胺及其有关物质的方法 |
| EP3503895B1 (en) * | 2016-08-25 | 2021-09-15 | Merck Sharp & Dohme Corp. | Antiviral prodrugs of tenofovir |
| CN108070003A (zh) * | 2016-12-02 | 2018-05-25 | 上海博志研新药物技术有限公司 | 替诺福韦艾拉酚胺半反丁烯二酸盐晶型及制备方法和应用 |
| US20190374557A1 (en) * | 2017-02-28 | 2019-12-12 | Alexandre Vasilievich Ivachtchenko | Cyclobutyl (S)-2-[[[(R)-2-(6-aminopurin-9-yl)-1-methyl-ethoxy]methyl-phenoxy-phosphoryl]amino]-propanoates, and production process and application thereof |
| RU2659388C1 (ru) | 2017-02-28 | 2018-07-02 | Васильевич Иващенко Александр | Нуклеотиды, включающие N-[(S)-1-циклобутоксикарбонил]фосфорамидатный фрагмент, их аналоги и их применение |
| CN106928277A (zh) * | 2017-03-16 | 2017-07-07 | 江苏诚信药业有限公司 | 一种替诺福韦艾拉酚胺合成的工艺方法 |
| EP3600332B1 (en) | 2017-03-20 | 2023-12-13 | The United States of America, as represented by the Secretary, Department of Health and Human Services | Hiv post-exposure prophylaxis |
| RU2019136678A (ru) * | 2017-04-18 | 2021-05-18 | Сипла Лимитед | Комбинированная терапия для применения в лечении ретровирусных инфекций |
| RU2659693C1 (ru) * | 2017-06-30 | 2018-07-03 | Общество с ограниченной ответственностью "Изварино Фарма" | Фармацевтическая композиция, обладающая активностью против ВИЧ-инфекции |
| US20190151307A1 (en) * | 2017-10-24 | 2019-05-23 | Gilead Sciences, Inc. | Methods of treating patients co-infected with a virus and tuberculosis |
| KR102626210B1 (ko) | 2017-12-07 | 2024-01-18 | 에모리 유니버시티 | N4-하이드록시사이티딘 및 유도체 및 이와 관련된 항-바이러스 용도 |
| CN110305163A (zh) * | 2018-03-27 | 2019-10-08 | 北京济美堂医药研究有限公司 | 替诺福韦艾拉酚胺半富马酸盐的制备方法 |
| CN108484672A (zh) * | 2018-05-23 | 2018-09-04 | 中国药科大学制药有限公司 | 磷丙替诺福韦的手性拆分方法 |
| CN109081853A (zh) * | 2018-09-03 | 2018-12-25 | 南京正大天晴制药有限公司 | 一种磷丙替诺福韦有关物质的制备方法 |
| CA3146263A1 (en) | 2019-07-19 | 2021-01-28 | Jose Gerardo Garcia Lerma | Hiv pre-exposure prophylaxis |
| CN111606949A (zh) * | 2020-03-13 | 2020-09-01 | 浙江车头制药股份有限公司 | 一种磷丙替诺福韦杂质的制备方法 |
| CN111303209A (zh) * | 2020-03-21 | 2020-06-19 | 石家庄龙泽制药股份有限公司 | 一种丙酚替诺福韦降解杂质的制备方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB453061A (en) | 1935-03-23 | 1936-09-04 | Charles Howard Twigg | Improvements in and relating to gas heated geysers and water heaters |
| US5922695A (en) | 1996-07-26 | 1999-07-13 | Gilead Sciences, Inc. | Antiviral phosphonomethyoxy nucleotide analogs having increased oral bioavarilability |
| CN1291994C (zh) | 2000-07-21 | 2006-12-27 | 吉里德科学公司 | 核苷酸膦酸酯类似物前药及其筛选和制备方法 |
| DE10153078A1 (de) | 2001-10-30 | 2003-05-22 | Degussa | Verwendung von Granulaten auf Basis von pyrogen hergestelltem Siliciumdioxid in pharmazeutischen Zusammensetzungen |
| KR20090053867A (ko) | 2003-01-14 | 2009-05-27 | 길리애드 사이언시즈, 인코포레이티드 | 복합 항바이러스 치료를 위한 조성물 및 방법 |
| PT2487163T (pt) * | 2007-02-23 | 2016-11-21 | Gilead Sciences Inc | Moduladores de propriedades farmacocinéticas de agentes terapêuticos |
| US8354421B2 (en) | 2007-06-29 | 2013-01-15 | Korea Research Insitute Of Chemical Technology | HIV reverse transcriptase inhibitors |
| AU2010210598B2 (en) * | 2009-02-06 | 2015-03-05 | Gilead Sciences, Inc. | Tablets for combination therapy |
| UY34262A (es) * | 2011-08-16 | 2013-04-05 | Gilead Sciences Inc | Hemifumarato de tenofovir alafenamida, sus composiciones, método de preparación, métodos para tratar infecciones virales y su uso para preparar medi camentos |
-
2013
- 2013-02-01 CN CN201380007670.XA patent/CN104105484A/zh active Pending
- 2013-02-01 EP EP13704863.3A patent/EP2809323A1/en not_active Withdrawn
- 2013-02-01 AU AU2013204727A patent/AU2013204727A1/en not_active Abandoned
- 2013-02-01 JP JP2014555783A patent/JP6059255B2/ja active Active
- 2013-02-01 NZ NZ629896A patent/NZ629896A/en unknown
- 2013-02-01 CA CA 2863662 patent/CA2863662A1/en not_active Abandoned
- 2013-02-01 US US14/376,116 patent/US20150105350A1/en not_active Abandoned
- 2013-02-01 WO PCT/US2013/024451 patent/WO2013116730A1/en active Application Filing
- 2013-02-01 AU AU2013204731A patent/AU2013204731C1/en active Active
- 2013-02-01 WO PCT/US2013/024438 patent/WO2013116720A1/en active Application Filing
- 2013-02-01 BR BR112014018918A patent/BR112014018918A8/pt not_active IP Right Cessation
- 2013-02-01 KR KR20147024291A patent/KR20140119177A/ko not_active Application Discontinuation
- 2013-02-01 EA EA201491287A patent/EA026138B1/ru unknown
- 2013-02-01 MD MDA20140091A patent/MD20140091A2/ro not_active Application Discontinuation
- 2013-02-01 MX MX2014009172A patent/MX2014009172A/es unknown
-
2014
- 2014-07-30 IL IL233874A patent/IL233874A0/en unknown
-
2015
- 2015-04-07 HK HK15103394.9A patent/HK1202801A1/xx unknown
- 2015-05-27 HK HK15105031.3A patent/HK1204914A1/xx unknown
-
2016
- 2016-06-02 AU AU2016203666A patent/AU2016203666A1/en not_active Abandoned
- 2016-10-03 US US15/284,105 patent/US20170056423A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| BR112014018918A8 (pt) | 2017-07-11 |
| AU2013204727A1 (en) | 2013-08-22 |
| KR20140119177A (ko) | 2014-10-08 |
| WO2013116730A1 (en) | 2013-08-08 |
| IL233874A0 (en) | 2014-09-30 |
| US20170056423A1 (en) | 2017-03-02 |
| JP2015505565A (ja) | 2015-02-23 |
| JP6059255B2 (ja) | 2017-01-11 |
| AU2016203666A1 (en) | 2016-06-23 |
| AU2013204731A1 (en) | 2013-08-22 |
| AU2013204731B2 (en) | 2016-03-03 |
| AU2013204731C1 (en) | 2017-08-31 |
| BR112014018918A2 (uk) | 2017-06-20 |
| HK1204914A1 (en) | 2015-12-11 |
| MX2014009172A (es) | 2014-08-27 |
| MD20140091A2 (ro) | 2015-01-31 |
| US20150105350A1 (en) | 2015-04-16 |
| CN104105484A (zh) | 2014-10-15 |
| WO2013116720A1 (en) | 2013-08-08 |
| EA201491287A1 (ru) | 2015-04-30 |
| EA026138B1 (ru) | 2017-03-31 |
| NZ629896A (en) | 2016-03-31 |
| EP2809323A1 (en) | 2014-12-10 |
| CA2863662A1 (en) | 2013-08-08 |
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