HK1202265A1 - Mutant selectivity and combinations of a phosphoinositide kinase inhibitor compound and chemotherapeutic agents for the treatment of cancer - Google Patents

Mutant selectivity and combinations of a phosphoinositide kinase inhibitor compound and chemotherapeutic agents for the treatment of cancer

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Publication number
HK1202265A1
HK1202265A1 HK15102816.1A HK15102816A HK1202265A1 HK 1202265 A1 HK1202265 A1 HK 1202265A1 HK 15102816 A HK15102816 A HK 15102816A HK 1202265 A1 HK1202265 A1 HK 1202265A1
Authority
HK
Hong Kong
Prior art keywords
cancer
combinations
treatment
kinase inhibitor
chemotherapeutic agents
Prior art date
Application number
HK15102816.1A
Other languages
English (en)
Chinese (zh)
Inventor
Marcia Belvin
Lori Friedman
Deepak Sampath
Jeffrey Wallin
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of HK1202265A1 publication Critical patent/HK1202265A1/xx

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
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    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
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    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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    • A—HUMAN NECESSITIES
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    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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HK15102816.1A 2012-06-08 2015-03-19 Mutant selectivity and combinations of a phosphoinositide kinase inhibitor compound and chemotherapeutic agents for the treatment of cancer HK1202265A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261657484P 2012-06-08 2012-06-08
US201361808727P 2013-04-05 2013-04-05
PCT/EP2013/061765 WO2013182668A1 (en) 2012-06-08 2013-06-07 Mutant selectivity and combinations of a phosphoinositide 3 kinase inhibitor compound and chemotherapeutic agents for the treatment of cancer

Publications (1)

Publication Number Publication Date
HK1202265A1 true HK1202265A1 (en) 2015-09-25

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HK15102816.1A HK1202265A1 (en) 2012-06-08 2015-03-19 Mutant selectivity and combinations of a phosphoinositide kinase inhibitor compound and chemotherapeutic agents for the treatment of cancer

Country Status (15)

Country Link
US (3) US9107926B2 (de)
EP (2) EP2858666B1 (de)
JP (3) JP5933830B2 (de)
KR (3) KR101909801B1 (de)
CN (2) CN104379163A (de)
AU (2) AU2013273489B9 (de)
BR (1) BR112014028376A2 (de)
CA (1) CA2871359A1 (de)
HK (1) HK1202265A1 (de)
IL (1) IL235963A0 (de)
MX (2) MX2014014831A (de)
NZ (1) NZ702244A (de)
RU (1) RU2665949C2 (de)
SG (2) SG11201407537YA (de)
WO (1) WO2013182668A1 (de)

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AR104068A1 (es) * 2015-03-26 2017-06-21 Hoffmann La Roche Combinaciones de un compuesto inhibidor de fosfoinosítido 3-cinasa y un compuesto inhibidor de cdk4/6 para el tratamiento del cáncer
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