HK1200835A1 - 4'-azido, 3'-fluoro substituted nucleoside derivatives as inhibitors of hcv rna replication - Google Patents
4'-azido, 3'-fluoro substituted nucleoside derivatives as inhibitors of hcv rna replication Download PDFInfo
- Publication number
- HK1200835A1 HK1200835A1 HK15101193.6A HK15101193A HK1200835A1 HK 1200835 A1 HK1200835 A1 HK 1200835A1 HK 15101193 A HK15101193 A HK 15101193A HK 1200835 A1 HK1200835 A1 HK 1200835A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- compound
- azido
- fluoro
- tetrahydro
- furan
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161577712P | 2011-12-20 | 2011-12-20 | |
| US61/577,712 | 2011-12-20 | ||
| PCT/EP2012/075688 WO2013092447A1 (en) | 2011-12-20 | 2012-12-17 | 4'-azido, 3'-fluoro substituted nucleoside derivatives as inhibitors of hcv rna replication |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1200835A1 true HK1200835A1 (en) | 2015-08-14 |
Family
ID=47469968
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK15101193.6A HK1200835A1 (en) | 2011-12-20 | 2012-12-17 | 4'-azido, 3'-fluoro substituted nucleoside derivatives as inhibitors of hcv rna replication |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US9708357B2 (cs) |
| EP (1) | EP2794628B1 (cs) |
| JP (1) | JP6118336B2 (cs) |
| KR (1) | KR101687084B1 (cs) |
| CN (2) | CN104011060A (cs) |
| AU (1) | AU2012357986B2 (cs) |
| BR (1) | BR112014015066A2 (cs) |
| CA (1) | CA2869317C (cs) |
| CL (1) | CL2014001599A1 (cs) |
| CO (1) | CO6990719A2 (cs) |
| CR (1) | CR20140255A (cs) |
| CY (1) | CY1119015T1 (cs) |
| DK (1) | DK2794628T3 (cs) |
| EA (1) | EA024847B1 (cs) |
| ES (1) | ES2626484T3 (cs) |
| HK (1) | HK1200835A1 (cs) |
| HU (1) | HUE033332T2 (cs) |
| IL (1) | IL232843B (cs) |
| IN (1) | IN2014CN04530A (cs) |
| LT (1) | LT2794628T (cs) |
| MA (1) | MA35749B1 (cs) |
| MX (1) | MX350810B (cs) |
| PE (1) | PE20141599A1 (cs) |
| PH (1) | PH12014501283A1 (cs) |
| PL (1) | PL2794628T3 (cs) |
| PT (1) | PT2794628T (cs) |
| SG (1) | SG11201403086YA (cs) |
| SI (1) | SI2794628T1 (cs) |
| UA (1) | UA110428C2 (cs) |
| WO (1) | WO2013092447A1 (cs) |
| ZA (1) | ZA201404444B (cs) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201329096A (zh) | 2011-09-12 | 2013-07-16 | Idenix Pharmaceuticals Inc | 經取代羰氧基甲基磷酸醯胺化合物及用於治療病毒感染之藥學組成物 |
| US9708357B2 (en) | 2011-12-20 | 2017-07-18 | Riboscience, LLC | 4′-azido, 3′-fluoro substituted nucleoside derivatives as inhibitors of HCV RNA replication |
| EP2852604B1 (en) | 2012-05-22 | 2017-04-12 | Idenix Pharmaceuticals LLC | 3',5'-cyclic phosphoramidate prodrugs for hcv infection |
| PE20150132A1 (es) | 2012-05-22 | 2015-02-14 | Idenix Pharmaceuticals Inc | Compuestos d-aminoacidos para enfermedad hepatica |
| EP2852605B1 (en) | 2012-05-22 | 2018-01-31 | Idenix Pharmaceuticals LLC | 3',5'-cyclic phosphate prodrugs for hcv infection |
| CN104395330B (zh) | 2012-05-25 | 2018-03-13 | 爱尔兰詹森科学公司 | 尿嘧啶基螺氧杂环丁烷核苷 |
| US9192621B2 (en) | 2012-09-27 | 2015-11-24 | Idenix Pharmaceuticals Llc | Esters and malonates of SATE prodrugs |
| MX353422B (es) | 2012-10-08 | 2018-01-12 | Idenix Pharmaceuticals Llc | Análogos de 2'-cloronucleósido para infección por vhc. |
| WO2014066239A1 (en) | 2012-10-22 | 2014-05-01 | Idenix Pharmaceuticals, Inc. | 2',4'-bridged nucleosides for hcv infection |
| US9211300B2 (en) | 2012-12-19 | 2015-12-15 | Idenix Pharmaceuticals Llc | 4′-fluoro nucleosides for the treatment of HCV |
| US9309275B2 (en) | 2013-03-04 | 2016-04-12 | Idenix Pharmaceuticals Llc | 3′-deoxy nucleosides for the treatment of HCV |
| WO2014137930A1 (en) | 2013-03-04 | 2014-09-12 | Idenix Pharmaceuticals, Inc. | Thiophosphate nucleosides for the treatment of hcv |
| EP2970357B1 (en) | 2013-03-13 | 2025-01-01 | Idenix Pharmaceuticals LLC | Amino acid phosphoramidate pronucleotides of 2'-cyano, azido and amino nucleosides for the treatment of hcv |
| US9187515B2 (en) | 2013-04-01 | 2015-11-17 | Idenix Pharmaceuticals Llc | 2′,4′-fluoro nucleosides for the treatment of HCV |
| MA38678A1 (fr) * | 2013-05-16 | 2017-07-31 | Riboscience Llc | Dérivés nucléosidiques 4'-azido, 3'désoxy-3'-fluoro substitués |
| WO2014197578A1 (en) | 2013-06-05 | 2014-12-11 | Idenix Pharmaceuticals, Inc. | 1',4'-thio nucleosides for the treatment of hcv |
| WO2015017713A1 (en) | 2013-08-01 | 2015-02-05 | Idenix Pharmaceuticals, Inc. | D-amino acid phosphoramidate pronucleotides of halogeno pyrimidine compounds for liver disease |
| US10202411B2 (en) | 2014-04-16 | 2019-02-12 | Idenix Pharmaceuticals Llc | 3′-substituted methyl or alkynyl nucleosides nucleotides for the treatment of HCV |
| CA2997170A1 (en) * | 2015-09-02 | 2017-03-09 | Abbvie Inc. | Anti-viral tetrahydrofurane derivatives |
| US12297224B2 (en) * | 2018-07-02 | 2025-05-13 | Henan Genuine Biotech Co., Ltd. | Crystal form, preparation method, and application of 4'-substituted nucleoside |
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| AU498131B2 (en) | 1974-02-26 | 1979-02-15 | Ciba-Geigy Ag | Production of cephems by cyclization |
| US4147864A (en) | 1975-02-20 | 1979-04-03 | Ciba-Geigy Corporation | Process for the manufacture of 7β-amino-3-cephem-3-ol-4 carboxylic acid compounds |
| US4322347A (en) | 1978-04-03 | 1982-03-30 | Bristol-Myers Company | 2-Carbamoyloxymethyl-penicillin derivatives |
| WO1986006380A1 (en) | 1985-04-30 | 1986-11-06 | Takeda Chemical Industries, Ltd. | Antibacterial compounds, use and preparation thereof |
| JPS6422823A (en) * | 1987-07-17 | 1989-01-25 | Asahi Glass Co Ltd | Antiulcer agent |
| US5449664A (en) | 1988-11-21 | 1995-09-12 | Syntex (U.S.A.) Inc. | Antiviral agents |
| US5807876A (en) | 1996-04-23 | 1998-09-15 | Vertex Pharmaceuticals Incorporated | Inhibitors of IMPDH enzyme |
| US6054472A (en) | 1996-04-23 | 2000-04-25 | Vertex Pharmaceuticals, Incorporated | Inhibitors of IMPDH enzyme |
| CN1515248A (zh) | 1996-04-23 | 2004-07-28 | ��̩��˹ҩ��ɷ�����˾ | 用作肌苷-5'-一磷酸脱氢酶抑制剂的脲衍生物 |
| WO1998017679A1 (en) | 1996-10-18 | 1998-04-30 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases, particularly hepatitis c virus ns3 protease |
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| JP2004509066A (ja) | 2000-05-10 | 2004-03-25 | スミスクライン・ビーチャム・コーポレイション | 新規抗感染症薬 |
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-
2012
- 2012-12-17 US US14/366,189 patent/US9708357B2/en not_active Expired - Fee Related
- 2012-12-17 CN CN201280064193.6A patent/CN104011060A/zh active Pending
- 2012-12-17 EP EP12808791.3A patent/EP2794628B1/en not_active Not-in-force
- 2012-12-17 PE PE2014000990A patent/PE20141599A1/es not_active Application Discontinuation
- 2012-12-17 UA UAA201408090A patent/UA110428C2/uk unknown
- 2012-12-17 EA EA201491180A patent/EA024847B1/ru not_active IP Right Cessation
- 2012-12-17 DK DK12808791.3T patent/DK2794628T3/en active
- 2012-12-17 WO PCT/EP2012/075688 patent/WO2013092447A1/en active Application Filing
- 2012-12-17 PT PT128087913T patent/PT2794628T/pt unknown
- 2012-12-17 AU AU2012357986A patent/AU2012357986B2/en not_active Ceased
- 2012-12-17 BR BR112014015066A patent/BR112014015066A2/pt not_active IP Right Cessation
- 2012-12-17 SG SG11201403086YA patent/SG11201403086YA/en unknown
- 2012-12-17 PL PL12808791T patent/PL2794628T3/pl unknown
- 2012-12-17 SI SI201230977A patent/SI2794628T1/sl unknown
- 2012-12-17 IN IN4530CHN2014 patent/IN2014CN04530A/en unknown
- 2012-12-17 KR KR1020147020094A patent/KR101687084B1/ko not_active Expired - Fee Related
- 2012-12-17 HK HK15101193.6A patent/HK1200835A1/xx unknown
- 2012-12-17 CN CN201810341927.XA patent/CN108409820A/zh not_active Withdrawn
- 2012-12-17 ES ES12808791.3T patent/ES2626484T3/es active Active
- 2012-12-17 CA CA2869317A patent/CA2869317C/en not_active Expired - Fee Related
- 2012-12-17 JP JP2014547882A patent/JP6118336B2/ja active Active
- 2012-12-17 HU HUE12808791A patent/HUE033332T2/en unknown
- 2012-12-17 MX MX2014007028A patent/MX350810B/es active IP Right Grant
- 2012-12-17 LT LTEP12808791.3T patent/LT2794628T/lt unknown
-
2014
- 2014-05-28 IL IL232843A patent/IL232843B/en not_active IP Right Cessation
- 2014-05-28 CR CR20140255A patent/CR20140255A/es unknown
- 2014-06-06 PH PH12014501283A patent/PH12014501283A1/en unknown
- 2014-06-17 ZA ZA2014/04444A patent/ZA201404444B/en unknown
- 2014-06-18 CL CL2014001599A patent/CL2014001599A1/es unknown
- 2014-06-20 CO CO14133951A patent/CO6990719A2/es unknown
- 2014-06-25 MA MA37157A patent/MA35749B1/fr unknown
-
2017
- 2017-06-28 CY CY20171100679T patent/CY1119015T1/el unknown
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