HK1185619A1 - 新的取代異喹啉衍生物 - Google Patents
新的取代異喹啉衍生物Info
- Publication number
- HK1185619A1 HK1185619A1 HK13113181.7A HK13113181A HK1185619A1 HK 1185619 A1 HK1185619 A1 HK 1185619A1 HK 13113181 A HK13113181 A HK 13113181A HK 1185619 A1 HK1185619 A1 HK 1185619A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- novel substituted
- isoquinoline derivative
- substituted isoquinoline
- derivative
- novel
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Ophthalmology & Optometry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010286445 | 2010-12-22 | ||
| PCT/JP2011/079725 WO2012086727A1 (ja) | 2010-12-22 | 2011-12-21 | 新たな置換イソキノリン誘導体 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1185619A1 true HK1185619A1 (zh) | 2014-02-21 |
Family
ID=46313995
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK13113181.7A HK1185619A1 (zh) | 2010-12-22 | 2013-11-26 | 新的取代異喹啉衍生物 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US8883792B2 (zh) |
| EP (1) | EP2657227B1 (zh) |
| JP (1) | JP5781093B2 (zh) |
| KR (1) | KR101911324B1 (zh) |
| CN (1) | CN103270024B (zh) |
| AU (1) | AU2011345969B2 (zh) |
| BR (1) | BR112013015604B1 (zh) |
| CA (1) | CA2822787C (zh) |
| CY (1) | CY1117560T1 (zh) |
| DK (1) | DK2657227T3 (zh) |
| EA (1) | EA022646B1 (zh) |
| ES (1) | ES2571529T3 (zh) |
| HK (1) | HK1185619A1 (zh) |
| HR (1) | HRP20160465T1 (zh) |
| HU (1) | HUE029976T2 (zh) |
| MX (1) | MX2013007296A (zh) |
| NZ (1) | NZ612336A (zh) |
| PL (1) | PL2657227T3 (zh) |
| PT (1) | PT2657227T (zh) |
| TW (1) | TWI527799B (zh) |
| WO (1) | WO2012086727A1 (zh) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2021042126A (ja) * | 2017-12-27 | 2021-03-18 | 佐藤製薬株式会社 | アリールオキシ化合物 |
| DK3901141T3 (da) | 2018-12-17 | 2024-02-26 | D Western Therapeutics Inst Inc | Ny form af isoquinolin-sulfonamid |
| JPWO2020129877A1 (ja) | 2018-12-18 | 2021-10-28 | 株式会社デ・ウエスタン・セラピテクス研究所 | イソキノリンスルホニルクロリド酸付加塩及びその製造方法 |
| US20220119350A1 (en) | 2019-02-22 | 2022-04-21 | Glaukos Corporation | Compounds for the treatment of ocular disease |
| MX2021015850A (es) * | 2019-07-01 | 2022-04-18 | Curasen Therapeutics Inc | Agonista beta adrenergico y metodos de uso del mismo. |
| CN110616439B (zh) * | 2019-10-31 | 2020-06-30 | 安阳师范学院 | 电化学氧化合成4-磺酸取代异喹啉酮衍生物的方法 |
| EP4204414A1 (en) * | 2020-08-31 | 2023-07-05 | Viewpoint Therapeutics, Inc. | Compounds and formulations for treating ophthalmic diseases |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6169085B1 (en) | 1995-03-10 | 2001-01-02 | G. D. Searle & Company | Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors |
| US6667307B2 (en) | 1997-12-19 | 2003-12-23 | G.D. Searle & Co. | Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors |
| US5705500A (en) * | 1995-03-10 | 1998-01-06 | G.D. Searle & Co. | Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors |
| US5985870A (en) | 1995-03-10 | 1999-11-16 | G.D. Searle & Co. | Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors |
| ATE289815T1 (de) * | 1995-12-21 | 2005-03-15 | Alcon Lab Inc | Verwendung von substituierten isochinolinsulfonyl-verbindungen zur herstellung eines medikaments für die behandlung von glaukom und okularer ischämie |
| JP2005232175A (ja) * | 2004-01-21 | 2005-09-02 | Asahi Kasei Pharma Kk | ５−置換イソキノリン医薬 |
| US20090275099A1 (en) | 2004-04-27 | 2009-11-05 | Regents Of The University Of Michigan | Methods and compositions for treating diseases and conditions associated with mitochondrial function |
| US20050272723A1 (en) | 2004-04-27 | 2005-12-08 | The Regents Of The University Of Michigan | Methods and compositions for treating diseases and conditions associated with mitochondrial function |
| EP1799637A1 (en) * | 2004-09-23 | 2007-06-27 | Amgen, Inc | Substituted sulfonamidopropionamides and methods of use |
| US7517991B2 (en) | 2004-10-12 | 2009-04-14 | Bristol-Myers Squibb Company | N-sulfonylpiperidine cannabinoid receptor 1 antagonists |
| US8455514B2 (en) | 2008-01-17 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-and 7-amino isoquinoline compounds and methods for making and using the same |
| JP2011516482A (ja) | 2008-04-04 | 2011-05-26 | メルク・シャープ・エンド・ドーム・コーポレイション | β３アドレナリン作動性受容体アゴニストとしてのヒドロキシメチルピロリジン |
| ES2656793T3 (es) | 2008-07-08 | 2018-02-28 | Catabasis Pharmaceuticals, Inc. | Salicilatos acetilados de ácidos grasos y sus usos |
| ES2834451T3 (es) | 2009-05-01 | 2021-06-17 | Aerie Pharmaceuticals Inc | Inhibidores de mecanismo doble para el tratamiento de enfermedades |
| EA019523B1 (ru) | 2009-06-19 | 2014-04-30 | Д. Вестерн Терапьютикс Инститьют, Инк. | Производное замещенного изохинолина, содержащая его фармацевтическая композиция и применение для лечения заболеваний |
-
2011
- 2011-12-21 KR KR1020137015956A patent/KR101911324B1/ko active IP Right Grant
- 2011-12-21 NZ NZ612336A patent/NZ612336A/en unknown
- 2011-12-21 BR BR112013015604-0A patent/BR112013015604B1/pt active IP Right Grant
- 2011-12-21 AU AU2011345969A patent/AU2011345969B2/en active Active
- 2011-12-21 EA EA201390939A patent/EA022646B1/ru unknown
- 2011-12-21 WO PCT/JP2011/079725 patent/WO2012086727A1/ja active Application Filing
- 2011-12-21 CN CN201180061578.2A patent/CN103270024B/zh active Active
- 2011-12-21 DK DK11851146.8T patent/DK2657227T3/en active
- 2011-12-21 JP JP2012549860A patent/JP5781093B2/ja active Active
- 2011-12-21 MX MX2013007296A patent/MX2013007296A/es active IP Right Grant
- 2011-12-21 PL PL11851146.8T patent/PL2657227T3/pl unknown
- 2011-12-21 US US13/995,300 patent/US8883792B2/en active Active
- 2011-12-21 HU HUE11851146A patent/HUE029976T2/en unknown
- 2011-12-21 ES ES11851146T patent/ES2571529T3/es active Active
- 2011-12-21 EP EP11851146.8A patent/EP2657227B1/en active Active
- 2011-12-21 PT PT118511468T patent/PT2657227T/pt unknown
- 2011-12-21 CA CA2822787A patent/CA2822787C/en active Active
- 2011-12-22 TW TW100148109A patent/TWI527799B/zh active
-
2013
- 2013-11-26 HK HK13113181.7A patent/HK1185619A1/zh unknown
-
2016
- 2016-05-03 HR HRP20160465TT patent/HRP20160465T1/hr unknown
- 2016-05-27 CY CY20161100465T patent/CY1117560T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN103270024B (zh) | 2015-07-08 |
| ES2571529T3 (es) | 2016-05-25 |
| WO2012086727A1 (ja) | 2012-06-28 |
| JP5781093B2 (ja) | 2015-09-16 |
| HUE029976T2 (en) | 2017-04-28 |
| DK2657227T3 (en) | 2016-08-01 |
| NZ612336A (en) | 2014-05-30 |
| EP2657227B1 (en) | 2016-04-27 |
| EP2657227A4 (en) | 2013-11-27 |
| KR20130142163A (ko) | 2013-12-27 |
| BR112013015604A2 (pt) | 2018-07-24 |
| MX2013007296A (es) | 2013-08-26 |
| BR112013015604B1 (pt) | 2021-11-03 |
| CN103270024A (zh) | 2013-08-28 |
| AU2011345969B2 (en) | 2016-04-21 |
| KR101911324B1 (ko) | 2018-10-25 |
| JPWO2012086727A1 (ja) | 2014-06-05 |
| EP2657227A1 (en) | 2013-10-30 |
| US20130274269A1 (en) | 2013-10-17 |
| HRP20160465T1 (hr) | 2016-06-03 |
| EA201390939A1 (ru) | 2013-12-30 |
| TW201305112A (zh) | 2013-02-01 |
| PT2657227T (pt) | 2016-08-01 |
| TWI527799B (zh) | 2016-04-01 |
| PL2657227T3 (pl) | 2016-09-30 |
| CY1117560T1 (el) | 2017-04-26 |
| AU2011345969A1 (en) | 2013-07-11 |
| CA2822787C (en) | 2018-07-17 |
| CA2822787A1 (en) | 2012-06-28 |
| EA022646B1 (ru) | 2016-02-29 |
| US8883792B2 (en) | 2014-11-11 |
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