MX2021015850A - Agonista beta adrenergico y metodos de uso del mismo. - Google Patents

Agonista beta adrenergico y metodos de uso del mismo.

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Publication number
MX2021015850A
MX2021015850A MX2021015850A MX2021015850A MX2021015850A MX 2021015850 A MX2021015850 A MX 2021015850A MX 2021015850 A MX2021015850 A MX 2021015850A MX 2021015850 A MX2021015850 A MX 2021015850A MX 2021015850 A MX2021015850 A MX 2021015850A
Authority
MX
Mexico
Prior art keywords
methods
same
adrenergic agonist
beta adrenergic
compounds
Prior art date
Application number
MX2021015850A
Other languages
English (en)
Inventor
Wei Chen
Anthony P Ford
David Scott Carter
Jiaxin Yu
Original Assignee
Curasen Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US16/831,370 external-priority patent/US10947196B2/en
Application filed by Curasen Therapeutics Inc filed Critical Curasen Therapeutics Inc
Publication of MX2021015850A publication Critical patent/MX2021015850A/es

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    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D215/22Oxygen atoms attached in position 2 or 4
    • C07D215/227Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
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    • A61K31/365Lactones
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    • A61K31/37Coumarins, e.g. psoralen
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Abstract

La presente revelación está dirigida a compuestos químicos y al uso de dichos compuestos en el tratamiento de enfermedades asociadas con un receptor adrenérgico.
MX2021015850A 2019-07-01 2020-06-30 Agonista beta adrenergico y metodos de uso del mismo. MX2021015850A (es)

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US16/831,370 US10947196B2 (en) 2019-03-27 2020-03-26 Beta adrenergic agonist and methods of using the same
US16/831,285 US11040944B2 (en) 2019-03-27 2020-03-26 Beta adrenergic agonist and methods of using the same
US202063018431P 2020-04-30 2020-04-30
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US4082847A (en) * 1976-12-06 1978-04-04 Merck & Co., Inc. Substituted aminoethanols and pharmaceutical use
US4460581A (en) * 1982-10-12 1984-07-17 Boehringer Ingelheim Kg (1-Hydroxy-2-amino-alkyl)-substituted benzoxazinones and benzoxazolinones
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US5484612A (en) * 1993-09-22 1996-01-16 The Board Of Trustees Of The Leland Stanford Junior University Method of treating a mammal having a solid tumor susceptible to treatment with cisplatin
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