CL2021000178A1 - Compuestos de piridin-2-ona útiles como antagonistas de smarca2 - Google Patents
Compuestos de piridin-2-ona útiles como antagonistas de smarca2Info
- Publication number
- CL2021000178A1 CL2021000178A1 CL2021000178A CL2021000178A CL2021000178A1 CL 2021000178 A1 CL2021000178 A1 CL 2021000178A1 CL 2021000178 A CL2021000178 A CL 2021000178A CL 2021000178 A CL2021000178 A CL 2021000178A CL 2021000178 A1 CL2021000178 A1 CL 2021000178A1
- Authority
- CL
- Chile
- Prior art keywords
- treatment
- smarca2
- methods
- pyridin
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Abstract
Esta invención se refiere generalmente a compuestos de piridin-2-ona y a métodos para usarlos en el tratamiento de un trastorno, tal como el cáncer o un trastorno asociado a SMARCA2, incluyendo como antagonistas (por ejemplo, inhibidores) de SMARCA2. La presente invención proporciona modalidades de tratamiento, por ejemplo, estrategias, métodos de tratamiento, métodos de estratificación de pacientes, compuestos, combinaciones y composiciones que<br /> son útiles para el tratamiento de trastornos, por ejemplo, trastornos proliferativos, tales como ciertos cánceres. Algunos aspectos de esta invención proporcionan modalidades de tratamiento, métodos, estrategias, compuestos, composiciones, combinaciones y formas de dosificación para el tratamiento de trastornos proliferativos celulares, por ejemplo, cánceres con actividad o función<br /> disminuida, o pérdida de función, de SMARCA4 con un antagonista de SMARCA2.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862702481P | 2018-07-24 | 2018-07-24 | |
US201962815208P | 2019-03-07 | 2019-03-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2021000178A1 true CL2021000178A1 (es) | 2021-07-09 |
Family
ID=67539641
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2021000178A CL2021000178A1 (es) | 2018-07-24 | 2021-01-22 | Compuestos de piridin-2-ona útiles como antagonistas de smarca2 |
Country Status (16)
Country | Link |
---|---|
US (1) | US20220356174A1 (es) |
EP (1) | EP3826999A1 (es) |
JP (1) | JP2021532181A (es) |
KR (1) | KR20210038911A (es) |
CN (1) | CN112739690A (es) |
AU (1) | AU2019309373A1 (es) |
BR (1) | BR112021001263A2 (es) |
CA (1) | CA3106671A1 (es) |
CL (1) | CL2021000178A1 (es) |
CO (1) | CO2021002024A2 (es) |
IL (1) | IL280182A (es) |
MA (1) | MA53377A (es) |
MX (1) | MX2021000881A (es) |
PH (1) | PH12021550119A1 (es) |
SG (1) | SG11202100158WA (es) |
WO (1) | WO2020023657A1 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10118890B2 (en) | 2014-10-10 | 2018-11-06 | The Research Foundation For The State University Of New York | Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration |
US11970486B2 (en) | 2016-10-24 | 2024-04-30 | Janssen Pharmaceutica Nv | Compounds and uses thereof |
WO2019084157A1 (en) | 2017-10-24 | 2019-05-02 | Yumanity Therapeutics, Inc. | COMPOUNDS AND USES THEREOF |
BR112020021648A2 (pt) | 2018-05-14 | 2021-01-26 | Gilead Sciences, Inc. | inibidores de mcl-1 |
TWI778443B (zh) | 2019-11-12 | 2022-09-21 | 美商基利科學股份有限公司 | Mcl1抑制劑 |
KR20220105661A (ko) | 2019-11-26 | 2022-07-27 | 길리애드 사이언시즈, 인코포레이티드 | Mcl1 억제제를 제조하기 위한 방법 및 중간체 |
CA3180069A1 (en) * | 2020-06-18 | 2021-12-23 | Allison E. DREW | Smarca4 inhibition for the treatment of cancer |
WO2022224924A1 (ja) * | 2021-04-23 | 2022-10-27 | 日本曹達株式会社 | 含窒素ヘテロアリール化合物並びに農園芸用殺菌剤、殺線虫剤、および医療用・動物用抗真菌剤 |
CN114057630B (zh) * | 2021-12-23 | 2023-06-02 | 郑州大学 | 吡非尼酮衍生物及其合成方法和应用 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
WO2009073139A2 (en) * | 2007-11-28 | 2009-06-11 | Osi Pharmaceuticals, Inc. | Combined treatment with an egfr kinase inhibitor and an inhibitor of c-kit |
EP2294065B1 (en) * | 2008-01-22 | 2014-03-19 | Vernalis (R&D) Ltd. | Indolyl-pyridone derivatives having checkpoint kinase 1 inhibitory activity |
MX2010014171A (es) * | 2008-06-19 | 2011-07-04 | Xcovery Holding Co Llc | Compuestos de piridazin-carboxamida sustituida como compuestos inhibidores de cinasa. |
GB0912499D0 (en) * | 2009-07-18 | 2009-08-26 | Vernalis R&D Ltd | Indopyl-pyridone derivatives |
JP6639497B2 (ja) * | 2014-11-10 | 2020-02-05 | ジェネンテック, インコーポレイテッド | ブロモドメインインヒビターおよびその使用 |
-
2019
- 2019-07-24 JP JP2021527010A patent/JP2021532181A/ja active Pending
- 2019-07-24 KR KR1020217005491A patent/KR20210038911A/ko unknown
- 2019-07-24 EP EP19749545.0A patent/EP3826999A1/en active Pending
- 2019-07-24 CA CA3106671A patent/CA3106671A1/en active Pending
- 2019-07-24 AU AU2019309373A patent/AU2019309373A1/en active Pending
- 2019-07-24 MX MX2021000881A patent/MX2021000881A/es unknown
- 2019-07-24 WO PCT/US2019/043274 patent/WO2020023657A1/en unknown
- 2019-07-24 MA MA053377A patent/MA53377A/fr unknown
- 2019-07-24 SG SG11202100158WA patent/SG11202100158WA/en unknown
- 2019-07-24 US US17/262,395 patent/US20220356174A1/en active Pending
- 2019-07-24 BR BR112021001263-0A patent/BR112021001263A2/pt unknown
- 2019-07-24 CN CN201980062462.7A patent/CN112739690A/zh active Pending
-
2021
- 2021-01-14 IL IL280182A patent/IL280182A/en unknown
- 2021-01-15 PH PH12021550119A patent/PH12021550119A1/en unknown
- 2021-01-22 CL CL2021000178A patent/CL2021000178A1/es unknown
- 2021-02-19 CO CONC2021/0002024A patent/CO2021002024A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
MX2021000881A (es) | 2021-06-08 |
CN112739690A (zh) | 2021-04-30 |
WO2020023657A1 (en) | 2020-01-30 |
EP3826999A1 (en) | 2021-06-02 |
CA3106671A1 (en) | 2020-01-30 |
PH12021550119A1 (en) | 2021-10-04 |
CO2021002024A2 (es) | 2021-05-20 |
BR112021001263A2 (pt) | 2021-04-27 |
AU2019309373A1 (en) | 2021-02-11 |
IL280182A (en) | 2021-03-01 |
US20220356174A1 (en) | 2022-11-10 |
MA53377A (fr) | 2021-06-02 |
JP2021532181A (ja) | 2021-11-25 |
SG11202100158WA (en) | 2021-02-25 |
KR20210038911A (ko) | 2021-04-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CL2021000178A1 (es) | Compuestos de piridin-2-ona útiles como antagonistas de smarca2 | |
BR112018070361A2 (pt) | redução da carga tumoral através da administração de antagonistas do ccr1 em combinação com inibidores de pd-1 ou inibidores de pd-l1 | |
CO2020016619A2 (es) | Anticuerpos biespecificos anti-pvrig/anti-tigit y métodos de uso | |
MX2016017288A (es) | Metodos para tratar el cancer con inhibidores de tigit y agentes contra el cancer. | |
PH12021500004A1 (en) | Pd-1/pd-l1 inhibitors | |
ECSP15042895A (es) | Compuestos de biaril-amida como inhibidores de cinasa | |
MX2017005553A (es) | Terapia de combinacion para cancer. | |
AU2024202398A1 (en) | Inhibition of SMARCA2 for treatment of cancer | |
CL2018000223A1 (es) | Combinación de antagonista de pd-1 con un inhibidor de egfr | |
MX2019008208A (es) | Métodos para tratar el cáncer con anticuerpos anti-tim-3. | |
CL2015001985A1 (es) | Compuestos de tiazolcarboxamidas y piridinacarboxamida, inhibidores de quinasa pim. | |
PE20180521A1 (es) | Inhibidores de tirosina-cinasas | |
MX2017007321A (es) | Terapias de combinacion. | |
NZ725459A (en) | Combination therapy for treating cancer with a recombinant poxvirus expressing a tumor antigen and an immune checkpoint molecule antagonist or agonist | |
MX2016005560A (es) | Compuestos agonistas triples de glucagon-glp-1-gip. | |
CL2015002194A1 (es) | Inhbidores de erk y sus usos | |
DOP2015000108A (es) | Compuestos de pirrolopirimidina como inhibidores de quinasas | |
MX2016012368A (es) | Combinaciones de un inhibidor del factor de crecimiento de fibroblasto (fgfr) y un inhibidor del receptor del factor de crecimiento 1 similar a insulina (igf1r). | |
CL2017000507A1 (es) | Derivados de benzodiazepina citotóxicos | |
JOP20140141B1 (ar) | استخدام 3،2- ثنائي هيدروإيميدازول-[2،1-c] كونازولينات مستبدلة لمعالجة الاورام الليمفاوية | |
CL2018001171A1 (es) | Compuestos de imidazo[4,5-c]quinolin-2-ona y su uso en el tratamiento del cáncer | |
UY35136A (es) | Métodos para tratar el cáncer de ovario con antagonistas de dll4. | |
ECSP16008797A (es) | Derivados de heterobicicloaril como inhibidores rorc2 y métodos de uso de los mismos | |
MX2020003126A (es) | Derivados de iminopirimidina ciclicos como inhibidores de cinasa. | |
ECSP22043592A (es) | Inhibidores de egfr alost?ricos y m?todos de uso de los mismos |