PE20180521A1 - Inhibidores de tirosina-cinasas - Google Patents

Inhibidores de tirosina-cinasas

Info

Publication number
PE20180521A1
PE20180521A1 PE2017002512A PE2017002512A PE20180521A1 PE 20180521 A1 PE20180521 A1 PE 20180521A1 PE 2017002512 A PE2017002512 A PE 2017002512A PE 2017002512 A PE2017002512 A PE 2017002512A PE 20180521 A1 PE20180521 A1 PE 20180521A1
Authority
PE
Peru
Prior art keywords
tyrosine
compounds
kinase inhibitors
inhibitors
btk
Prior art date
Application number
PE2017002512A
Other languages
English (en)
Inventor
David Goldstein
Timothy D Owens
Original Assignee
Principia Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Principia Biopharma Inc filed Critical Principia Biopharma Inc
Publication of PE20180521A1 publication Critical patent/PE20180521A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/26Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32Nitrogen atom
    • C07D473/34Nitrogen atom attached in position 6, e.g. adenine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/16Otologicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Transplantation (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente divulgacion proporciona compuestos que son inhibidores de tirosina-cinasas, en particular inhibidores de la tirosina-cinasa de Bruton (BTK), y, por lo tanto, son utiles para el tratamiento de enfermedades que se pueden tratar mediante la inhibicion de BTK tales como el cancer, enfermedades autoinmunitarias, inflamatorias y tromboembolicas. Tambien se proporcionan composiciones farmaceuticas que contienen tales compuestos y procesos para preparar tales compuestos.
PE2017002512A 2015-06-03 2016-06-02 Inhibidores de tirosina-cinasas PE20180521A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562170547P 2015-06-03 2015-06-03
US201562271689P 2015-12-28 2015-12-28

Publications (1)

Publication Number Publication Date
PE20180521A1 true PE20180521A1 (es) 2018-03-14

Family

ID=56118090

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2017002512A PE20180521A1 (es) 2015-06-03 2016-06-02 Inhibidores de tirosina-cinasas

Country Status (32)

Country Link
US (4) US20180162861A1 (es)
EP (3) EP3303334B1 (es)
JP (2) JP6646072B2 (es)
KR (1) KR102552653B1 (es)
CN (2) CN106459049B (es)
AU (2) AU2016270973B2 (es)
CA (1) CA2987335A1 (es)
CL (2) CL2017003073A1 (es)
CO (1) CO2017012947A2 (es)
CR (1) CR20170593A (es)
DK (1) DK3303334T3 (es)
DO (1) DOP2017000279A (es)
EA (1) EA039006B1 (es)
ES (1) ES2878030T3 (es)
HK (1) HK1252378A1 (es)
HR (1) HRP20211249T1 (es)
HU (1) HUE055419T2 (es)
IL (2) IL255946A (es)
LT (1) LT3303334T (es)
MX (2) MX2021006571A (es)
MY (1) MY190548A (es)
PE (1) PE20180521A1 (es)
PH (1) PH12017502203A1 (es)
PL (1) PL3303334T3 (es)
PT (1) PT3303334T (es)
RS (1) RS62290B1 (es)
SG (1) SG10201912443XA (es)
SI (1) SI3303334T1 (es)
TN (1) TN2017000501A1 (es)
TW (2) TWI732765B (es)
UA (1) UA124090C2 (es)
WO (1) WO2016196840A1 (es)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150044271A1 (en) 2012-02-27 2015-02-12 O-Ray Pharma, Inc. Solid drug implants for intracochlear delivery of therapeutics for the treatment of otic disorders
MX361815B (es) 2012-09-10 2018-12-17 Principia Biopharma Inc Compuestos pirazolopirimidinicos como inhibidores de cinasas.
CN105764814B (zh) 2013-11-29 2019-02-19 株式会社大造 内容物收容容器、使用其的内容物收容制品、排出制品及排出装置
MX2016010754A (es) 2014-02-21 2017-03-03 Principia Biopharma Inc Sales y forma solida de un inhibidor btk.
US10485797B2 (en) 2014-12-18 2019-11-26 Principia Biopharma Inc. Treatment of pemphigus
LT3303334T (lt) * 2015-06-03 2021-07-12 Principia Biopharma Inc. Tirozinkinazės inhibitoriai
EP3313839A1 (en) 2015-06-24 2018-05-02 Principia Biopharma Inc. Tyrosine kinase inhibitors
CN105753863B (zh) * 2015-09-11 2018-07-31 东莞市真兴贝特医药技术有限公司 氧代二氢咪唑并吡啶类化合物及其应用
CA3008653A1 (en) * 2015-10-14 2017-04-20 Zibo Biopolar Changsheng Pharmaceutical Co. Ltd. Bruton's tyrosine kinase inhibitors
BR112018077503A2 (pt) 2016-06-29 2019-04-09 Principia Biopharma Inc. formulações de liberação modificada de 2-[3-[4-amino-3-(2-fluoro-4- fenoxi-fenil)pirazolo [3,4-d]pirimidin-1-il]piperidino-1- carbonil]-4-metil-4-[4-(oxetan-3-il)piperazin-1-il] pent-2-enenitrila
ES2899114T3 (es) * 2016-07-25 2022-03-10 Nerviano Medical Sciences Srl Análogos de purina y 3-deazapurina como inhibidores de colina cinasa
JP2020508326A (ja) * 2017-02-24 2020-03-19 ギリアド サイエンシズ, インコーポレイテッド ブルトン型チロシンキナーゼの阻害剤
EP3789040A4 (en) * 2018-04-27 2022-03-09 ONO Pharmaceutical Co., Ltd. PREVENTIVE AND/OR THERAPEUTIC AGENT FOR AUTOIMMUNE DISEASES WITH A COMPOUND WITH BTK INHIBITING ACTIVITY AS AN INGREDIENT
PE20210406A1 (es) 2018-07-25 2021-03-02 Novartis Ag Inhibidores de inflamasoma nlrp3
CN113194928A (zh) 2018-07-31 2021-07-30 罗索肿瘤学公司 (s)-5-氨基-3-(4-((5-氟-2-甲氧基苯甲酰胺基)甲基)苯基)-1-(1,1,1-三氟丙-2-基)-1h-吡唑-4-甲酰胺的喷雾干燥的分散体和制剂
WO2020054788A1 (ja) * 2018-09-13 2020-03-19 キッセイ薬品工業株式会社 イミダゾピリジノン化合物
BR112021018168B1 (pt) 2019-03-21 2023-11-28 Onxeo Composição farmacêutica, combinação e kit compreendendo uma molécula dbait e um inibidor de quinase para o tratamento de câncer
AR119731A1 (es) 2019-05-17 2022-01-05 Novartis Ag Inhibidores del inflamasoma nlrp3
JP2023500906A (ja) 2019-11-08 2023-01-11 インサーム(インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシェ メディカル) キナーゼ阻害剤に対する獲得抵抗性を有するがんの処置方法
CN113045484B (zh) * 2019-12-27 2024-01-26 南京药石科技股份有限公司 一种2-氨基-2-(1-甲基-4-哌啶基)丙烷-1-醇的制备方法
CN113149891B (zh) * 2020-01-07 2024-02-02 南京药石科技股份有限公司 一种2-氨基-2-(1-甲基-4-哌啶基)乙醇的制备方法
TW202140002A (zh) 2020-01-20 2021-11-01 美商健臻公司 用於復發型多發性硬化症的治療性酪胺酸激酶抑制劑
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
WO2021202478A1 (en) * 2020-03-30 2021-10-07 IGIA Pharmaceuticals, Inc. Pediatric formulation of tyrosine kinase inhibitors
CR20230125A (es) 2020-08-14 2023-05-11 Novartis Ag Derivados de espiropiperidinilo sustituidos con heteroarilo y usos farmacéuticos de los mismos
CN116507627A (zh) 2020-11-02 2023-07-28 勃林格殷格翰国际有限公司 作为egfr抑制剂的经取代1h-吡唑并[4,3-c]吡啶及衍生物
MX2023006854A (es) * 2020-12-10 2023-07-20 Genzyme Corp Forma cristalina de tolebrutinib, metodo de preparacion y uso de la misma.
WO2022140511A1 (en) * 2020-12-23 2022-06-30 Genzyme Corporation 4-amino-3-(4-phenoxyphenyl)-1,3- dihydro-2h-imidazo[4,5-c]pyridin-2-one derivatives and salts thereof
WO2022212893A1 (en) 2021-04-02 2022-10-06 Biogen Ma Inc. Combination treatment methods of multiple sclerosis
WO2022218430A1 (zh) * 2021-04-16 2022-10-20 南京明德新药研发有限公司 咪唑并吡啶类化合物及其应用
EP4328226A1 (en) 2021-04-23 2024-02-28 Hangzhou Solipharma Co., Ltd. Tolebrutinib crystal form, amorphous form, preparation method therefor and use thereof
EP4342468A1 (en) 2021-05-21 2024-03-27 Hangzhou Solipharma Co., Ltd. Tolebrutinib salt and crystal form thereof, preparation method therefor, pharmaceutical composition thereof, and use thereof
CA3221129A1 (en) 2021-06-11 2022-12-15 Minhua Chen Crystal form of tolebrutinib, preparation method therefor and use thereof
WO2023280132A1 (zh) * 2021-07-06 2023-01-12 苏州晶云药物科技股份有限公司 氧代二氢咪唑并吡啶类化合物的晶型及其制备方法
US11793820B2 (en) * 2021-09-24 2023-10-24 Chadwick Donaldson Dry powder foamable formulations for delivery of medicaments through the mucosa
TW202334146A (zh) 2021-12-21 2023-09-01 美商健臻公司 (r)-1-(1-丙烯醯基哌啶-3-基)-4-胺基-3-(4-苯氧基苯基)-1h-咪唑並[4,5-c]吡啶-2(3h)-酮及其衍生物的晶型
WO2023172663A1 (en) * 2022-03-09 2023-09-14 Teva Pharmaceuticals International Gmbh Solid state forms of tolebrutinib and of tolebrutinib salts
US20230399313A1 (en) * 2022-06-10 2023-12-14 Advenchen Pharmaceuticals, LLC Biological activities of 5-(2-(4-(4-fluoro-2-methyl-1h-indol-5-yloxy)-6-methoxyquinolin-7-yloxy)ethyl)-5-azaspiro[2.4]-heptan-7-ol crystalline, phosphoric acid salt and its enantiomers
WO2023244587A1 (en) * 2022-06-14 2023-12-21 Genzyme Corporation Methods of making tolebrutinib
WO2023249980A1 (en) * 2022-06-22 2023-12-28 Genzyme Corporation Methods of making modified btk inhibitors
WO2024006406A1 (en) 2022-06-30 2024-01-04 Genzyme Corporation Therapeutic tyrosine kinase inhibitors for multiple sclerosis and myasthenia gravis
TW202406550A (zh) 2022-08-03 2024-02-16 瑞士商諾華公司 Nlrp3炎性小體抑制劑
WO2024081168A1 (en) 2022-10-11 2024-04-18 Genzyme Corporation Therapeutic tyrosine kinase inhibitors for multiple sclerosis
WO2024099242A1 (zh) * 2022-11-07 2024-05-16 天津征程医药科技有限公司 氘代的氨基吡啶衍生物以及包含该化合物的药物组合物

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2809918A (en) 1955-10-17 1957-10-15 Victor M Hermelin Sustained release pharmaceutical preparations
DE2010416B2 (de) 1970-03-05 1979-03-29 Hoechst Ag, 6000 Frankfurt Oral anwendbare Arzneiform mit Retardwirkung
US3760984A (en) 1971-09-29 1973-09-25 Alza Corp Osmotically powered agent dispensing device with filling means
US4107288A (en) 1974-09-18 1978-08-15 Pharmaceutical Society Of Victoria Injectable compositions, nanoparticles useful therein, and process of manufacturing same
US3952741A (en) 1975-01-09 1976-04-27 Bend Research Inc. Controlled release delivery system by an osmotic bursting mechanism
US4728512A (en) 1985-05-06 1988-03-01 American Home Products Corporation Formulations providing three distinct releases
US4794001A (en) 1986-03-04 1988-12-27 American Home Products Corporation Formulations providing three distinct releases
US5145684A (en) 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
WO2003037890A2 (en) 2001-11-01 2003-05-08 Icagen, Inc. Piperidines
US20060045822A1 (en) 2004-09-01 2006-03-02 Board Of Regents, The University Of Texas System Plasma polymerization for encapsulating particles
CN101824034A (zh) * 2004-09-14 2010-09-08 诺华疫苗和诊断公司 咪唑并喹啉化合物
CA2597587A1 (en) * 2005-02-11 2006-08-17 Coley Pharmaceutical Group, Inc. Oxime and hydroxylamine substituted imidazo[4,5-c] ring compounds and methods
WO2007142755A2 (en) 2006-05-31 2007-12-13 The Regents Of The University Of California Purine analogs
TW200804383A (en) 2006-06-05 2008-01-16 Astrazeneca Ab New compounds
EP2526933B1 (en) * 2006-09-22 2015-02-25 Pharmacyclics, Inc. Inhibitors of Bruton's tyrosine kinase
CN105063001A (zh) 2009-09-16 2015-11-18 新基阿维罗米克斯研究公司 蛋白激酶复合物和含有该复合物的药物组合物以及它们的用途
US7741330B1 (en) * 2009-10-12 2010-06-22 Pharmacyclics, Inc. Pyrazolo-pyrimidine inhibitors of Bruton's tyrosine kinase
HUE030720T2 (en) * 2010-05-31 2017-06-28 Ono Pharmaceutical Co Purinone derivative as btk kinase inhibitor
AU2012255759B2 (en) * 2011-05-17 2017-08-10 Principia Biopharma, Inc. Kinase inhibitors
EP2710006A1 (en) * 2011-05-17 2014-03-26 Principia Biopharma Inc. Azaindole derivatives as tyrosine kinase inhibitors
KR102027598B1 (ko) * 2011-05-17 2019-10-01 프린시피아 바이오파마, 인코퍼레이티드 타이로신 키나아제 저해제
KR20180034705A (ko) * 2011-11-29 2018-04-04 오노 야꾸힝 고교 가부시키가이샤 퓨리논 유도체 염산염
US8501724B1 (en) 2012-01-31 2013-08-06 Pharmacyclics, Inc. Purinone compounds as kinase inhibitors
AU2013277582B2 (en) 2012-06-18 2017-11-30 Principia Biopharma Inc. Reversible covalent pyrrolo- or pyrazolopyrimidines useful for the treatment cancer and autoimmune diseases
EP2872491B1 (en) 2012-07-11 2021-05-05 Blueprint Medicines Corporation Inhibitors of the fibroblast growth factor receptor
MX361815B (es) * 2012-09-10 2018-12-17 Principia Biopharma Inc Compuestos pirazolopirimidinicos como inhibidores de cinasas.
US20140142099A1 (en) * 2012-11-20 2014-05-22 Principia Biopharma Inc. Purinone Derivatives as Tyrosine Kinase Inhibitors
US8957080B2 (en) * 2013-04-09 2015-02-17 Principia Biopharma Inc. Tyrosine kinase inhibitors
LT3303334T (lt) * 2015-06-03 2021-07-12 Principia Biopharma Inc. Tirozinkinazės inhibitoriai
CN105753863B (zh) 2015-09-11 2018-07-31 东莞市真兴贝特医药技术有限公司 氧代二氢咪唑并吡啶类化合物及其应用
CA3008653A1 (en) 2015-10-14 2017-04-20 Zibo Biopolar Changsheng Pharmaceutical Co. Ltd. Bruton's tyrosine kinase inhibitors

Also Published As

Publication number Publication date
PL3303334T3 (pl) 2021-11-08
IL279258A (en) 2021-01-31
TW201713654A (zh) 2017-04-16
SI3303334T1 (sl) 2021-09-30
HUE055419T2 (hu) 2021-11-29
RS62290B1 (sr) 2021-09-30
BR112017025850A2 (pt) 2018-08-14
JP2018516935A (ja) 2018-06-28
EP3303334A1 (en) 2018-04-11
EP4112618A1 (en) 2023-01-04
PT3303334T (pt) 2021-07-02
AU2020203447B2 (en) 2021-04-01
KR102552653B1 (ko) 2023-07-07
MX2021006571A (es) 2022-08-25
US20210171526A1 (en) 2021-06-10
CO2017012947A2 (es) 2018-03-28
US9688676B2 (en) 2017-06-27
LT3303334T (lt) 2021-07-12
CN106459049A (zh) 2017-02-22
TWI810582B (zh) 2023-08-01
US20180162861A1 (en) 2018-06-14
TWI732765B (zh) 2021-07-11
SG10201912443XA (en) 2020-02-27
CN113149983B (zh) 2024-03-29
MX2017015470A (es) 2018-08-15
IL279258B (en) 2022-04-01
TN2017000501A1 (en) 2019-04-12
DOP2017000279A (es) 2018-04-15
US20230151012A1 (en) 2023-05-18
AU2016270973B2 (en) 2020-05-14
IL255946A (en) 2018-01-31
MY190548A (en) 2022-04-27
CR20170593A (es) 2018-05-14
EP3303334B1 (en) 2021-06-02
HRP20211249T1 (hr) 2021-11-12
CA2987335A1 (en) 2016-12-08
CL2017003073A1 (es) 2018-06-08
DK3303334T3 (da) 2021-06-28
CN113149983A (zh) 2021-07-23
ES2878030T3 (es) 2021-11-18
EP3912979A1 (en) 2021-11-24
UA124090C2 (uk) 2021-07-21
US20170129890A1 (en) 2017-05-11
JP2020073561A (ja) 2020-05-14
JP6646072B2 (ja) 2020-02-14
WO2016196840A1 (en) 2016-12-08
KR20180021730A (ko) 2018-03-05
EA039006B1 (ru) 2021-11-19
PH12017502203A1 (en) 2018-06-11
TW202210478A (zh) 2022-03-16
CL2019002150A1 (es) 2019-11-29
AU2016270973A1 (en) 2018-01-18
JP6985433B2 (ja) 2021-12-22
EA201792529A1 (ru) 2018-05-31
HK1252378A1 (zh) 2019-05-24
CN106459049B (zh) 2020-11-27
KR20220146657A (ko) 2022-11-01
AU2020203447A1 (en) 2020-06-11

Similar Documents

Publication Publication Date Title
PE20180521A1 (es) Inhibidores de tirosina-cinasas
PH12017501921A1 (en) Novel compounds
PH12018501268A1 (en) Compounds useful as kinase inhibitors
NZ729603A (en) Heteroaryl compounds as btk inhibitors and uses thereof
PH12018500587A1 (en) Pyrazolopyrimidine derivatives as btk inhibitors for the treatment of cancer
MX2017006366A (es) Derivados de 6-amino-7-biciclo-7-deaza-purina como inhibidores de la proteina quinasa.
CL2015001985A1 (es) Compuestos de tiazolcarboxamidas y piridinacarboxamida, inhibidores de quinasa pim.
CO2017007121A2 (es) Compuestos bicíclicos fusionados para el tratamiento de enfermedades
PH12016502291A1 (en) Indolizine derivatives as phosphoinositide 3-kinases inhibitors
BR112017007063A2 (pt) ?composições e métodos para o tratamento de insônia?
CR20170249A (es) Formas en estado sólido de pirrolidinonas heteroaromáticas fusionadas
BR112017008045A2 (pt) compostos como inibidores de nik
BR112017007715A2 (pt) derivados de tienopirimidina como inibidores de nik
WO2016160621A3 (en) Nk-92 cells in combination therapy with cancer drugs
MX2017013137A (es) Derivados de cromeno como inhibidores de las fosfoinositido-3-cina sas.
CO2017000586A2 (es) Formulación en forma de tableta de 2-fluor-n-metil-4-[7-(quinolin-6-ylmetil)imidazo[1,2-b][1,2,4]triazin-2-il]benzamida
MX2016009655A (es) Metodos novedosos para el tratamiento del cancer.
BR112018008931A2 (pt) ?compostos para tratamento de distúrbios hipoproliferativos?
PH12017501122A1 (en) Substituted pyridyl-cycloalkyl-carboxylic acids, compositions containing them and medical uses thereof
MX2017009608A (es) Compuestos anticancerigenos.
MX2017014752A (es) Nuevos etinos de amidoheteroaril aroil hidrazida.
MX2016004094A (es) Composicion farmaceutica que comprende capecitabina y ciclofosfamida.
ECSP18000097A (es) Inhibidores de tirosina-cinasas