EA201390939A1 - Новое замещенное производное изохинолина - Google Patents

Новое замещенное производное изохинолина

Info

Publication number
EA201390939A1
EA201390939A1 EA201390939A EA201390939A EA201390939A1 EA 201390939 A1 EA201390939 A1 EA 201390939A1 EA 201390939 A EA201390939 A EA 201390939A EA 201390939 A EA201390939 A EA 201390939A EA 201390939 A1 EA201390939 A1 EA 201390939A1
Authority
EA
Eurasian Patent Office
Prior art keywords
optionally substituted
group
derivative
hydrogen atom
isohinoline
Prior art date
Application number
EA201390939A
Other languages
English (en)
Other versions
EA022646B1 (ru
Inventor
Хироеси Хидака
Кенго Суми
Коуити Такахаси
Йосихиро Иноуэ
Original Assignee
Д. Вестерн Терапьютикс Инститьют, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Д. Вестерн Терапьютикс Инститьют, Инк. filed Critical Д. Вестерн Терапьютикс Инститьют, Инк.
Publication of EA201390939A1 publication Critical patent/EA201390939A1/ru
Publication of EA022646B1 publication Critical patent/EA022646B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Настоящее изобретение относится к новому производному изохинолин-6-сульфонамида, которое пригодно в качестве лекарственного средства. Настоящее изобретение относится к производному изохинолин-6-сульфонамида, соответствующему формуле (1), его соли или сольвату производного или соли, где каждый из Rи Rнезависимо обозначает атом водорода или т.п.; каждый из Rи Rнезависимо обозначает атом водорода, алкильную группу или т.п.; Rобозначает атом водорода, необязательно замещенную алкильную группу, необязательно замещенную алкенильную группу, необязательно замещенную алкинильную группу, необязательно замещенную циклоалкильную группу, необязательно замещенную алканоильную группу или т.п.; и А обозначает линейную или разветвленную алкиленовую группу, имеющую от 2 до 6 атомов углерода.
EA201390939A 2010-12-22 2011-12-21 Замещенное производное изохинолина EA022646B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2010286445 2010-12-22
PCT/JP2011/079725 WO2012086727A1 (ja) 2010-12-22 2011-12-21 新たな置換イソキノリン誘導体

Publications (2)

Publication Number Publication Date
EA201390939A1 true EA201390939A1 (ru) 2013-12-30
EA022646B1 EA022646B1 (ru) 2016-02-29

Family

ID=46313995

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201390939A EA022646B1 (ru) 2010-12-22 2011-12-21 Замещенное производное изохинолина

Country Status (21)

Country Link
US (1) US8883792B2 (ru)
EP (1) EP2657227B1 (ru)
JP (1) JP5781093B2 (ru)
KR (1) KR101911324B1 (ru)
CN (1) CN103270024B (ru)
AU (1) AU2011345969B2 (ru)
BR (1) BR112013015604B1 (ru)
CA (1) CA2822787C (ru)
CY (1) CY1117560T1 (ru)
DK (1) DK2657227T3 (ru)
EA (1) EA022646B1 (ru)
ES (1) ES2571529T3 (ru)
HK (1) HK1185619A1 (ru)
HR (1) HRP20160465T1 (ru)
HU (1) HUE029976T2 (ru)
MX (1) MX2013007296A (ru)
NZ (1) NZ612336A (ru)
PL (1) PL2657227T3 (ru)
PT (1) PT2657227T (ru)
TW (1) TWI527799B (ru)
WO (1) WO2012086727A1 (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021042126A (ja) * 2017-12-27 2021-03-18 佐藤製薬株式会社 アリールオキシ化合物
EP3901141B1 (en) * 2018-12-17 2024-02-07 D. Western Therapeutics Institute, Inc. Novel form of isoquinoline sulfonamide
KR20210104730A (ko) 2018-12-18 2021-08-25 가부시키가이샤 디. 웨스턴 세라퓨틱스 겡큐쇼 이소퀴놀린술포닐클로라이드 산부가염 및 그 제조 방법
US20220119350A1 (en) 2019-02-22 2022-04-21 Glaukos Corporation Compounds for the treatment of ocular disease
CN114340740A (zh) * 2019-07-01 2022-04-12 库拉森疗法公司 β肾上腺素能激动剂及其使用方法
CN110616439B (zh) * 2019-10-31 2020-06-30 安阳师范学院 电化学氧化合成4-磺酸取代异喹啉酮衍生物的方法
WO2022047315A1 (en) * 2020-08-31 2022-03-03 Viewpoint Therapeutics, Inc. Compounds and formulations for treating ophthalmic diseases

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5705500A (en) * 1995-03-10 1998-01-06 G.D. Searle & Co. Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
US5985870A (en) 1995-03-10 1999-11-16 G.D. Searle & Co. Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
US6667307B2 (en) 1997-12-19 2003-12-23 G.D. Searle & Co. Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
US6169085B1 (en) 1995-03-10 2001-01-02 G. D. Searle & Company Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
JP3719609B2 (ja) * 1995-12-21 2005-11-24 アルコン ラボラトリーズ，インコーポレイテッド 緑内障および眼虚血の治療のための特定のイソキノリンスルホニル化合物の使用
JP2005232175A (ja) * 2004-01-21 2005-09-02 Asahi Kasei Pharma Kk ５−置換イソキノリン医薬
US20090275099A1 (en) 2004-04-27 2009-11-05 Regents Of The University Of Michigan Methods and compositions for treating diseases and conditions associated with mitochondrial function
US20050272723A1 (en) 2004-04-27 2005-12-08 The Regents Of The University Of Michigan Methods and compositions for treating diseases and conditions associated with mitochondrial function
WO2006036664A1 (en) * 2004-09-23 2006-04-06 Amgen Inc. Substituted sulfonamidopropionamides and methods of use
US7517991B2 (en) 2004-10-12 2009-04-14 Bristol-Myers Squibb Company N-sulfonylpiperidine cannabinoid receptor 1 antagonists
US8455514B2 (en) 2008-01-17 2013-06-04 Aerie Pharmaceuticals, Inc. 6-and 7-amino isoquinoline compounds and methods for making and using the same
AU2009231967B2 (en) 2008-04-04 2013-02-07 Merck Sharp & Dohme Corp. Hydroxymethyl pyrrolidines as beta 3 adrenergic receptor agonists
ES2656793T3 (es) 2008-07-08 2018-02-28 Catabasis Pharmaceuticals, Inc. Salicilatos acetilados de ácidos grasos y sus usos
EP3053913B1 (en) * 2009-05-01 2018-03-07 Aerie Pharmaceuticals, Inc. Dual mechanism inhibitors for the treatment of disease
TWI527798B (zh) 2009-06-19 2016-04-01 Western Therapeutics Inst Inc D Substituted isoquinoline derivatives

Also Published As

Publication number Publication date
CN103270024A (zh) 2013-08-28
EP2657227B1 (en) 2016-04-27
EA022646B1 (ru) 2016-02-29
WO2012086727A1 (ja) 2012-06-28
HRP20160465T1 (hr) 2016-06-03
DK2657227T3 (en) 2016-08-01
CY1117560T1 (el) 2017-04-26
TWI527799B (zh) 2016-04-01
CA2822787A1 (en) 2012-06-28
BR112013015604B1 (pt) 2021-11-03
PL2657227T3 (pl) 2016-09-30
MX2013007296A (es) 2013-08-26
JPWO2012086727A1 (ja) 2014-06-05
CN103270024B (zh) 2015-07-08
PT2657227T (pt) 2016-08-01
AU2011345969A1 (en) 2013-07-11
BR112013015604A2 (pt) 2018-07-24
NZ612336A (en) 2014-05-30
HK1185619A1 (zh) 2014-02-21
HUE029976T2 (en) 2017-04-28
US8883792B2 (en) 2014-11-11
CA2822787C (en) 2018-07-17
KR101911324B1 (ko) 2018-10-25
EP2657227A1 (en) 2013-10-30
TW201305112A (zh) 2013-02-01
US20130274269A1 (en) 2013-10-17
EP2657227A4 (en) 2013-11-27
AU2011345969B2 (en) 2016-04-21
KR20130142163A (ko) 2013-12-27
JP5781093B2 (ja) 2015-09-16
ES2571529T3 (es) 2016-05-25

Similar Documents

Publication Publication Date Title
EA201390939A1 (ru) Новое замещенное производное изохинолина
UA108510C2 (en) Cyclopropane compound
EA201490445A1 (ru) Циклопропанаминовое соединение
CY1115226T1 (el) Παραγωγα βενζαζεπινης χρησιμα ως ανταγωνιστες της βαζοπρεσινης
MY152972A (en) Azabicyclo compound and salt thereof
EP3051350A3 (en) Alcoholic compound and method for producing alcoholic compound
RU2014140735A (ru) ПРОИЗВОДНЫЕ ПИРАЗОЛО[1, 5-a]ПИРИМИДИНА, КОМПОЗИЦИИ, СОДЕРЖАЩИЕ УКАЗАННЫЕ СОЕДИНЕНИЯ, И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
EA201690019A1 (ru) Производное аминотриазина и содержащая его фармацевтическая композиция
MY149180A (en) Uracil compound having inhibitor activity on human deoxyuridine triphosphatase or salt thereof
UY28878A1 (es) Compuestos de aril-o heteroarilamida ortosustituidos y composiciones
CR20130129A (es) Anàlogos de buprenorfina
UA107657C2 (ru) Производные бензофурана
IN2014CN03976A (ru)
UY31232A1 (es) Compuestos derivados de dibenzotifenilamino-cromen-4-onas activas sustituidas y sus isomeros y aplicaciones
IN2014MN01521A (ru)
MY161134A (en) Piperazine compound having a pgds inhibitory effect
MA32192B1 (fr) Composés dérivés d'azétidines, leur préparation et leur application en thérapeutique
EA201001087A1 (ru) Новые дигидроиндолоновые соединения, способ их получения и фармацевтические композиции, содержащие их
MX2013007938A (es) Compuesto biciclico novedoso o sal del mismo.
MX2009008772A (es) Derivado piridil-triazolopirimidina o su sal, pesticida que lo contiene y proceso para su produccion.
MY197742A (en) Morphinan derivative
UA111709C2 (uk) Застосування похідних n-бензоїлсерину для запобігання або ослаблення пігментації
UA111950C2 (uk) Гетероциклічні сполуки для лікування або профілактики розладів, викликаних зниженою нейротрансмісією серотоніну, норепінефрину або допаміну
EA200601569A1 (ru) 5,6-диалкил-7-амино-триазолопиримидины, способ их получения и их применение для борьбы с патогенными растениями, а также содержащие их средства
IN2012DN03104A (ru)