HK1176938A1 - ' - 作為抗 化合物的 '-叠氮基-核苷 - Google Patents
' - 作為抗 化合物的 '-叠氮基-核苷Info
- Publication number
- HK1176938A1 HK1176938A1 HK13104289.7A HK13104289A HK1176938A1 HK 1176938 A1 HK1176938 A1 HK 1176938A1 HK 13104289 A HK13104289 A HK 13104289A HK 1176938 A1 HK1176938 A1 HK 1176938A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- hcv
- compunds
- nucleosides
- azido
- hcv compunds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29922910P | 2010-01-28 | 2010-01-28 | |
| PCT/EP2011/050971 WO2011092158A1 (en) | 2010-01-28 | 2011-01-25 | 4 ' - azido - nucleosides as anti - hcv compunds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1176938A1 true HK1176938A1 (zh) | 2013-08-09 |
Family
ID=43587111
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK13104289.7A HK1176938A1 (zh) | 2010-01-28 | 2013-04-09 | ' - 作為抗 化合物的 '-叠氮基-核苷 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8236779B2 (zh) |
| EP (1) | EP2528930B1 (zh) |
| JP (1) | JP5675849B2 (zh) |
| KR (1) | KR101384389B1 (zh) |
| CN (1) | CN102725303B (zh) |
| BR (1) | BR112012015951A2 (zh) |
| CA (1) | CA2784330C (zh) |
| DK (1) | DK2528930T3 (zh) |
| ES (1) | ES2437933T3 (zh) |
| HK (1) | HK1176938A1 (zh) |
| MX (1) | MX337050B (zh) |
| PL (1) | PL2528930T3 (zh) |
| PT (1) | PT2528930E (zh) |
| RU (1) | RU2556991C2 (zh) |
| TW (1) | TW201141488A (zh) |
| WO (1) | WO2011092158A1 (zh) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2011305652B2 (en) * | 2010-09-22 | 2016-10-20 | Janssen Biopharma, Inc. | Azido nucleosides and nucleotide analogs |
| CN103842369A (zh) | 2011-03-31 | 2014-06-04 | 埃迪尼克斯医药公司 | 用于治疗病毒感染的化合物和药物组合物 |
| TW201329096A (zh) | 2011-09-12 | 2013-07-16 | Idenix Pharmaceuticals Inc | 經取代羰氧基甲基磷酸醯胺化合物及用於治療病毒感染之藥學組成物 |
| EP2768838A1 (en) | 2011-10-14 | 2014-08-27 | IDENIX Pharmaceuticals, Inc. | Substituted 3',5'-cyclic phosphates of purine nucleotide compounds and pharmaceutical compositions for the treatment of viral infections |
| NZ702744A (en) | 2012-05-22 | 2016-12-23 | Idenix Pharmaceuticals Llc | D-amino acid compounds for liver disease |
| WO2013177195A1 (en) | 2012-05-22 | 2013-11-28 | Idenix Pharmaceuticals, Inc. | 3',5'-cyclic phosphate prodrugs for hcv infection |
| WO2013177188A1 (en) | 2012-05-22 | 2013-11-28 | Idenix Pharmaceuticals, Inc. | 3',5'-cyclic phosphoramidate prodrugs for hcv infection |
| WO2013174962A1 (en) | 2012-05-25 | 2013-11-28 | Janssen R&D Ireland | Uracyl spirooxetane nucleosides |
| EP2900682A1 (en) | 2012-09-27 | 2015-08-05 | IDENIX Pharmaceuticals, Inc. | Esters and malonates of sate prodrugs |
| KR102001280B1 (ko) | 2012-10-08 | 2019-07-17 | 아이데닉스 파마슈티칼스 엘엘씨 | Hcv 감염에 대한 2'-클로로 뉴클레오시드 유사체 |
| US10723754B2 (en) | 2012-10-22 | 2020-07-28 | Idenix Pharmaceuticals Llc | 2′,4′-bridged nucleosides for HCV infection |
| US9211300B2 (en) | 2012-12-19 | 2015-12-15 | Idenix Pharmaceuticals Llc | 4′-fluoro nucleosides for the treatment of HCV |
| US9309275B2 (en) | 2013-03-04 | 2016-04-12 | Idenix Pharmaceuticals Llc | 3′-deoxy nucleosides for the treatment of HCV |
| US9339541B2 (en) | 2013-03-04 | 2016-05-17 | Merck Sharp & Dohme Corp. | Thiophosphate nucleosides for the treatment of HCV |
| WO2014160484A1 (en) | 2013-03-13 | 2014-10-02 | Idenix Pharmaceuticals, Inc. | Amino acid phosphoramidate pronucleotides of 2'-cyano, azido and amino nucleosides for the treatment of hcv |
| US9187515B2 (en) | 2013-04-01 | 2015-11-17 | Idenix Pharmaceuticals Llc | 2′,4′-fluoro nucleosides for the treatment of HCV |
| US10005779B2 (en) | 2013-06-05 | 2018-06-26 | Idenix Pharmaceuticals Llc | 1′,4′-thio nucleosides for the treatment of HCV |
| WO2015017713A1 (en) | 2013-08-01 | 2015-02-05 | Idenix Pharmaceuticals, Inc. | D-amino acid phosphoramidate pronucleotides of halogeno pyrimidine compounds for liver disease |
| EP3131914B1 (en) | 2014-04-16 | 2023-05-10 | Idenix Pharmaceuticals LLC | 3'-substituted methyl or alkynyl nucleosides for the treatment of hcv |
| WO2015189386A1 (en) * | 2014-06-13 | 2015-12-17 | Teva Pharmaceuticals International Gmbh | Composition with a high drug load of sofosbuvir |
| BR112017013858A2 (pt) | 2014-12-26 | 2018-02-27 | Univ Emory | n4-hidroxicitidina e derivados e usos antivirais relacionados aos mesmos |
| US10448015B2 (en) * | 2015-06-16 | 2019-10-15 | Lg Electronics Inc. | Method and device for performing adaptive filtering according to block boundary |
| MX2020005392A (es) | 2017-12-07 | 2020-12-07 | Univ Emory | N4-hidroxicitidina y derivados y usos antivirales relacionados con los mismos. |
| CN113880903A (zh) * | 2021-09-23 | 2022-01-04 | 厦门蔚嘉制药有限公司 | 莫那比拉韦的制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20100003313A (ko) * | 2000-04-13 | 2010-01-07 | 파마셋 인코포레이티드 | 간염 바이러스 감염 치료를 위한 3'- 또는 2'-하이드록시메틸 치환된 뉴클레오시드 유도체 |
| KR101005299B1 (ko) * | 2000-10-18 | 2011-01-04 | 파마셋 인코포레이티드 | 바이러스 감염 및 비정상적인 세포 증식의 치료를 위한 변형된 뉴클레오시드 |
| CZ20032005A3 (en) * | 2001-01-22 | 2004-04-14 | Merck & Co., Inc. | Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase |
| GB0114286D0 (en) * | 2001-06-12 | 2001-08-01 | Hoffmann La Roche | Nucleoside Derivatives |
| CN1653077A (zh) * | 2002-05-06 | 2005-08-10 | 健亚生物科技公司 | 治疗c型肝炎病毒感染的核苷衍生物 |
| CN100351264C (zh) * | 2002-11-19 | 2007-11-28 | 霍夫曼-拉罗奇有限公司 | 抗病毒核苷衍生物 |
| TWI332507B (en) * | 2002-11-19 | 2010-11-01 | Hoffmann La Roche | Antiviral nucleoside derivatives |
| PL1962808T3 (pl) * | 2005-12-14 | 2011-03-31 | Hoffmann La Roche | Preparat proleku przeciw HCV |
| US20090318380A1 (en) * | 2007-11-20 | 2009-12-24 | Pharmasset, Inc. | 2',4'-substituted nucleosides as antiviral agents |
| CL2008003511A1 (es) * | 2007-11-29 | 2010-02-19 | Metabasis Therapeutics Inc | Compuestos derivados nucleotidicos, inhibidores de polimerasa ns5b del virus de la hepatitis c; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de la hepatitis c. |
-
2011
- 2011-01-25 TW TW100102705A patent/TW201141488A/zh unknown
- 2011-01-25 BR BR112012015951A patent/BR112012015951A2/pt active Search and Examination
- 2011-01-25 PL PL11701107T patent/PL2528930T3/pl unknown
- 2011-01-25 WO PCT/EP2011/050971 patent/WO2011092158A1/en active Application Filing
- 2011-01-25 ES ES11701107.2T patent/ES2437933T3/es active Active
- 2011-01-25 CA CA2784330A patent/CA2784330C/en not_active Expired - Fee Related
- 2011-01-25 DK DK11701107.2T patent/DK2528930T3/da active
- 2011-01-25 JP JP2012550415A patent/JP5675849B2/ja not_active Expired - Fee Related
- 2011-01-25 EP EP11701107.2A patent/EP2528930B1/en not_active Not-in-force
- 2011-01-25 KR KR1020127022217A patent/KR101384389B1/ko not_active IP Right Cessation
- 2011-01-25 RU RU2012136379/04A patent/RU2556991C2/ru not_active IP Right Cessation
- 2011-01-25 PT PT117011072T patent/PT2528930E/pt unknown
- 2011-01-25 MX MX2012008443A patent/MX337050B/es active IP Right Grant
- 2011-01-25 CN CN201180007367.0A patent/CN102725303B/zh not_active Expired - Fee Related
- 2011-01-26 US US13/014,022 patent/US8236779B2/en not_active Expired - Fee Related
-
2013
- 2013-04-09 HK HK13104289.7A patent/HK1176938A1/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| BR112012015951A2 (pt) | 2018-10-16 |
| EP2528930A1 (en) | 2012-12-05 |
| JP2013518076A (ja) | 2013-05-20 |
| CN102725303B (zh) | 2015-05-27 |
| EP2528930B1 (en) | 2013-10-30 |
| CA2784330A1 (en) | 2011-08-04 |
| DK2528930T3 (da) | 2013-11-11 |
| RU2012136379A (ru) | 2014-03-10 |
| RU2556991C2 (ru) | 2015-07-20 |
| CA2784330C (en) | 2018-02-13 |
| KR20120110177A (ko) | 2012-10-09 |
| US20110150829A1 (en) | 2011-06-23 |
| MX337050B (es) | 2016-02-10 |
| JP5675849B2 (ja) | 2015-02-25 |
| MX2012008443A (es) | 2012-08-15 |
| US8236779B2 (en) | 2012-08-07 |
| TW201141488A (en) | 2011-12-01 |
| CN102725303A (zh) | 2012-10-10 |
| PT2528930E (pt) | 2013-11-26 |
| WO2011092158A1 (en) | 2011-08-04 |
| ES2437933T3 (es) | 2014-01-15 |
| KR101384389B1 (ko) | 2014-04-10 |
| PL2528930T3 (pl) | 2014-03-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20190120 |