HK1173219A1 - 利用沙利度胺靶向因子的篩選方法 - Google Patents
利用沙利度胺靶向因子的篩選方法Info
- Publication number
- HK1173219A1 HK1173219A1 HK13100395.6A HK13100395A HK1173219A1 HK 1173219 A1 HK1173219 A1 HK 1173219A1 HK 13100395 A HK13100395 A HK 13100395A HK 1173219 A1 HK1173219 A1 HK 1173219A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- thalidomide
- screening method
- method utilizing
- targeting factor
- targeting
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
- G01N33/567—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds utilising isolate of tissue or organ as binding agent
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Plural Heterocyclic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2009241290 | 2009-10-20 | ||
PCT/JP2010/068272 WO2011049043A1 (ja) | 2009-10-20 | 2010-10-18 | サリドマイド標的因子を利用したスクリーニング方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1173219A1 true HK1173219A1 (zh) | 2013-05-10 |
Family
ID=43900269
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK13100395.6A HK1173219A1 (zh) | 2009-10-20 | 2013-01-10 | 利用沙利度胺靶向因子的篩選方法 |
Country Status (11)
Country | Link |
---|---|
US (1) | US9217743B2 (zh) |
EP (1) | EP2492686B1 (zh) |
JP (1) | JP5660578B2 (zh) |
KR (1) | KR101692297B1 (zh) |
CN (1) | CN102576023B (zh) |
AU (1) | AU2010309035B2 (zh) |
CA (1) | CA2774871C (zh) |
HK (1) | HK1173219A1 (zh) |
HU (1) | HUE039781T2 (zh) |
RU (1) | RU2528380C2 (zh) |
WO (1) | WO2011049043A1 (zh) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5645816B2 (ja) | 2009-05-25 | 2014-12-24 | 国立大学法人東京工業大学 | 中枢神経細胞の増殖及び分化に係る中核因子を含む医薬組成物 |
MX353482B (es) | 2011-04-29 | 2018-01-16 | Celgene Corp | Metodos para el tratamiento del cancer y enfermedades inflamatorias utilizando cereblon como predictor. |
MX358517B (es) | 2012-06-29 | 2018-08-24 | Celgene Corp | Métodos para determinar eficacia de fármacos usando proteínas asociadas a cereblon. |
US9587281B2 (en) | 2012-08-14 | 2017-03-07 | Celgene Corporation | Cereblon isoforms and their use as biomarkers for therapeutic treatment |
WO2014028445A2 (en) * | 2012-08-14 | 2014-02-20 | Celgene Corporation | Cereblon isoforms and their use as biomarkers for therapeutic treatment |
EP2757379A1 (en) * | 2013-01-16 | 2014-07-23 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Method to screen for the teratogenic potential of substances |
KR20140100731A (ko) * | 2013-02-07 | 2014-08-18 | 광주과학기술원 | Crb n ko 마우스의 제조방법 및 이의 용도 |
WO2015077058A2 (en) * | 2013-11-08 | 2015-05-28 | The Broad Institute, Inc. | Compositions and methods for selecting a treatment for b-cell neoplasias |
ES2903155T3 (es) * | 2013-12-06 | 2022-03-31 | Celgene Corp | Métodos para determinar la eficacia del fármaco para el tratamiento de linfoma difuso de células B grandes, mieloma múltiple y cánceres mieloides |
ES2843973T3 (es) | 2014-06-27 | 2021-07-21 | Celgene Corp | Composiciones y métodos para inducir cambios conformacionales en cereblon y otras ubiquitina ligasas E3 |
US11459613B2 (en) | 2015-09-11 | 2022-10-04 | The Brigham And Women's Hospital, Inc. | Methods of characterizing resistance to modulators of Cereblon |
US10830762B2 (en) | 2015-12-28 | 2020-11-10 | Celgene Corporation | Compositions and methods for inducing conformational changes in cereblon and other E3 ubiquitin ligases |
US10513515B2 (en) | 2017-08-25 | 2019-12-24 | Biotheryx, Inc. | Ether compounds and uses thereof |
CN111629749A (zh) | 2017-10-18 | 2020-09-04 | 诺华股份有限公司 | 用于选择性蛋白质降解的组合物和方法 |
EP3706745A4 (en) * | 2017-11-09 | 2022-07-20 | Dana-Farber Cancer Institute, Inc. | METHODS FOR PREVENTING TERATOGENICITY OF IMID-LIKE MOLECULES AND IMID-BASED DEGRADERS/PROTACS |
US11236103B2 (en) | 2018-07-27 | 2022-02-01 | Biotheryx, Inc. | Bifunctional compounds |
JP2022507267A (ja) | 2018-11-13 | 2022-01-18 | バイオセリックス, インコーポレイテッド | 置換イソインドリノン |
WO2021222150A2 (en) | 2020-04-28 | 2021-11-04 | Anwita Biosciences, Inc. | Interleukin-2 polypeptides and fusion proteins thereof, and their pharmaceutical compositions and therapeutic applications |
CN111678756A (zh) * | 2020-06-12 | 2020-09-18 | 苏州木芮生物科技有限公司 | 斑马鱼软骨染色一步法试剂盒 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1518447A (zh) * | 2001-04-23 | 2004-08-04 | �������Ǵ�ѧר������� | 作为抗血管生成剂的新的苯邻二甲酰亚胺模拟物的合成和评估 |
KR20060124607A (ko) * | 2003-11-06 | 2006-12-05 | 셀진 코포레이션 | 암 및 그 밖의 질환의 치료 및 관리를 위하여탈리도마이드를 사용하는 방법 및 조성물 |
CN1696127A (zh) * | 2005-04-18 | 2005-11-16 | 中国科学院长春应用化学研究所 | 沙利度胺的类似物及其制备方法 |
JPWO2007097109A1 (ja) * | 2006-02-20 | 2009-07-09 | 国立大学法人 東京医科歯科大学 | 抗関節リウマチ活性を有する物質のスクリーニング方法及び評価方法 |
CN101017166A (zh) * | 2007-01-18 | 2007-08-15 | 复旦大学 | 人rtn4b蛋白在制备抗肿瘤药物中的应用 |
KR100901128B1 (ko) * | 2007-07-10 | 2009-06-04 | 한국과학기술연구원 | 탈리도마이드 처리에 따른, 최기형성 유발 약물 검색용마커유전자 및 이를 이용한 검색 방법 |
KR100974228B1 (ko) * | 2007-11-16 | 2010-08-06 | 한국과학기술연구원 | 최기형성 및 부작용 유발 약물 검색용 바이오마커 및 이를이용한 최기형성 및 부작용 유발 약물 검색 방법 |
-
2010
- 2010-10-18 EP EP10824892.3A patent/EP2492686B1/en active Active
- 2010-10-18 KR KR1020127008427A patent/KR101692297B1/ko active IP Right Grant
- 2010-10-18 CA CA2774871A patent/CA2774871C/en active Active
- 2010-10-18 AU AU2010309035A patent/AU2010309035B2/en not_active Ceased
- 2010-10-18 RU RU2012120710/04A patent/RU2528380C2/ru active
- 2010-10-18 US US13/498,067 patent/US9217743B2/en not_active Expired - Fee Related
- 2010-10-18 HU HUE10824892A patent/HUE039781T2/hu unknown
- 2010-10-18 WO PCT/JP2010/068272 patent/WO2011049043A1/ja active Application Filing
- 2010-10-18 JP JP2011537238A patent/JP5660578B2/ja active Active
- 2010-10-18 CN CN201080047469.0A patent/CN102576023B/zh active Active
-
2013
- 2013-01-10 HK HK13100395.6A patent/HK1173219A1/zh not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
RU2528380C2 (ru) | 2014-09-20 |
EP2492686A1 (en) | 2012-08-29 |
EP2492686A4 (en) | 2013-07-17 |
AU2010309035B2 (en) | 2014-01-30 |
US9217743B2 (en) | 2015-12-22 |
HUE039781T2 (hu) | 2019-02-28 |
CN102576023B (zh) | 2014-07-09 |
CA2774871A1 (en) | 2011-04-28 |
RU2012120710A (ru) | 2013-11-27 |
KR20120093852A (ko) | 2012-08-23 |
CA2774871C (en) | 2018-05-29 |
JP5660578B2 (ja) | 2015-01-28 |
EP2492686B1 (en) | 2018-06-13 |
AU2010309035A1 (en) | 2012-04-12 |
WO2011049043A1 (ja) | 2011-04-28 |
US20120192297A1 (en) | 2012-07-26 |
JPWO2011049043A1 (ja) | 2013-03-14 |
KR101692297B1 (ko) | 2017-01-04 |
CN102576023A (zh) | 2012-07-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20211016 |