HK1172008A1 - 製造酰肼的改良方法 - Google Patents

製造酰肼的改良方法

Info

Publication number
HK1172008A1
HK1172008A1 HK12112795.8A HK12112795A HK1172008A1 HK 1172008 A1 HK1172008 A1 HK 1172008A1 HK 12112795 A HK12112795 A HK 12112795A HK 1172008 A1 HK1172008 A1 HK 1172008A1
Authority
HK
Hong Kong
Prior art keywords
improved processes
hydrazides
making
making hydrazides
processes
Prior art date
Application number
HK12112795.8A
Other languages
English (en)
Inventor
喬治．
．基亞雷洛
艾曼．薩赫利
Original Assignee
惠氏有限責任公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 惠氏有限責任公司 filed Critical 惠氏有限責任公司
Publication of HK1172008A1 publication Critical patent/HK1172008A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/46—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms, not being part of nitro or nitroso groups, further bound to other hetero atoms
    • C07C323/48—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms, not being part of nitro or nitroso groups, further bound to other hetero atoms to nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C241/00—Preparation of compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C241/04—Preparation of hydrazides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
    • C07C243/26—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C243/28—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/02—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols
    • C07C319/12—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols by reactions not involving the formation of mercapto groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Coating Apparatus (AREA)
HK12112795.8A 2007-05-22 2012-12-11 製造酰肼的改良方法 HK1172008A1 (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US93952907P 2007-05-22 2007-05-22

Publications (1)

Publication Number Publication Date
HK1172008A1 true HK1172008A1 (zh) 2013-04-12

Family

ID=39810161

Family Applications (2)

Application Number Title Priority Date Filing Date
HK11101744.4A HK1147736A1 (en) 2007-05-22 2011-02-23 Improved processes for making hydrazides
HK12112795.8A HK1172008A1 (zh) 2007-05-22 2012-12-11 製造酰肼的改良方法

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HK11101744.4A HK1147736A1 (en) 2007-05-22 2011-02-23 Improved processes for making hydrazides

Country Status (25)

Country Link
US (5) US8110705B2 (zh)
EP (2) EP2155258B1 (zh)
JP (4) JP5697446B2 (zh)
KR (1) KR101547705B1 (zh)
CN (2) CN101835494B (zh)
AR (1) AR066674A1 (zh)
AU (1) AU2008256905B2 (zh)
BR (1) BRPI0811140B1 (zh)
CA (1) CA2687852A1 (zh)
CL (1) CL2008001490A1 (zh)
CY (2) CY1119373T1 (zh)
DK (2) DK2155258T3 (zh)
ES (2) ES2686019T3 (zh)
HK (2) HK1147736A1 (zh)
HU (2) HUE036704T2 (zh)
IL (1) IL202242A (zh)
MX (1) MX2009012587A (zh)
PA (1) PA8781201A1 (zh)
PE (1) PE20090305A1 (zh)
PL (2) PL2155258T3 (zh)
PT (2) PT2155258T (zh)
SI (2) SI2465541T1 (zh)
TW (1) TW200904784A (zh)
WO (1) WO2008147765A1 (zh)
ZA (1) ZA200908229B (zh)

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* Cited by examiner, † Cited by third party
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MX2009012587A (es) * 2007-05-22 2010-05-14 Wyeth Llc Proceso mejorado para la elaboracion de hidrazidas.
WO2015065954A1 (en) 2013-11-04 2015-05-07 Pfizer, Inc. Anti-efna4 antibody-drug conjugates
CN105683159B (zh) * 2013-11-04 2017-12-19 辉瑞大药厂 用于合成加利车霉素衍生物的中间体和方法
ES2856927T3 (es) 2014-04-30 2021-09-28 Pfizer Conjugados de fármaco-anticuerpo anti-PTK7
US10135670B2 (en) * 2014-12-22 2018-11-20 Hewlett Packard Enterprise Development Lp Response to an inoperative network device managed by a controller
US20190048073A1 (en) 2017-07-20 2019-02-14 Pfizer Inc. Anti-gd3 antibodies and antibody-drug conjugates
US20200318053A1 (en) 2017-10-03 2020-10-08 University Public Corporation Osaka Cell culture container, method for acquiring cells, and method for culturing cells
CN109574870A (zh) * 2018-12-25 2019-04-05 维思普新材料（苏州）有限公司 一种酰肼的连续制备方法

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US4671958A (en) 1982-03-09 1987-06-09 Cytogen Corporation Antibody conjugates for the delivery of compounds to target sites
US4479953A (en) 1983-08-25 1984-10-30 Merck & Co., Inc. Pyrazine aldimine compounds as antimicrobial agents
US4970198A (en) 1985-10-17 1990-11-13 American Cyanamid Company Antitumor antibiotics (LL-E33288 complex)
HUT48093A (en) * 1986-08-04 1989-05-29 Sandoz Ag Herbicides comprising benzohydroxamic acid or benzoic acid hydrazide derivatives as active ingredient and process for producing benzohydroxamic acid or benzoic acid hydrazide derivatives
US4729781A (en) 1986-08-04 1988-03-08 Sandoz Ltd. 3,6-dichloro-2-methoxybenzohydroxamic acid derivatives and use as herbicidal agents
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KR20040004705A (ko) * 2001-06-08 2004-01-13 시토비아 인크. 카스파제의 활성제 및 아폽토시스의 유도제로서의 치환된3-아릴-5-아릴-[1,2,4]-옥사디아졸과 유사체 및 이의 용도
PT3127553T (pt) * 2002-05-02 2022-01-24 Wyeth Holdings Llc Conjugados de derivado da caliqueamicina - transportador
US6803379B2 (en) 2002-06-04 2004-10-12 Jose A. Fernandez-Pol Pharmacological agents and methods of treatment that inactivate pathogenic prokaryotic and eukaryotic cells and viruses by attacking highly conserved domains in structural metalloprotein and metalloenzyme targets
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Also Published As

Publication number Publication date
CN101835494A (zh) 2010-09-15
CN102558001A (zh) 2012-07-11
CY1120592T1 (el) 2019-12-11
KR101547705B1 (ko) 2015-08-26
PL2155258T3 (pl) 2017-12-29
PT2155258T (pt) 2017-10-18
US8853451B2 (en) 2014-10-07
MX2009012587A (es) 2010-05-14
PT2465541T (pt) 2018-10-17
US9227924B2 (en) 2016-01-05
US8110705B2 (en) 2012-02-07
JP2010528031A (ja) 2010-08-19
JP2013234203A (ja) 2013-11-21
US20080312422A1 (en) 2008-12-18
CL2008001490A1 (es) 2008-07-25
EP2465541B1 (en) 2018-07-18
US8383857B2 (en) 2013-02-26
EP2155258A1 (en) 2010-02-24
TW200904784A (en) 2009-02-01
AU2008256905B2 (en) 2014-05-08
EP2155258B1 (en) 2017-08-16
ZA200908229B (en) 2010-08-25
RU2009143524A (ru) 2011-06-27
KR20100031514A (ko) 2010-03-22
SI2155258T1 (sl) 2017-10-30
HUE039657T2 (hu) 2019-01-28
ES2686019T3 (es) 2018-10-16
HUE036704T2 (hu) 2018-07-30
ES2642888T3 (es) 2017-11-20
US20150099865A1 (en) 2015-04-09
AU2008256905A1 (en) 2008-12-04
WO2008147765A1 (en) 2008-12-04
AR066674A1 (es) 2009-09-02
IL202242A0 (en) 2010-06-16
US20120130052A1 (en) 2012-05-24
JP2017193584A (ja) 2017-10-26
IL202242A (en) 2016-03-31
JP5697446B2 (ja) 2015-04-08
CY1119373T1 (el) 2018-02-14
JP2016026219A (ja) 2016-02-12
PL2465541T3 (pl) 2018-12-31
CN102558001B (zh) 2015-09-23
DK2465541T3 (en) 2018-09-17
CA2687852A1 (en) 2008-12-04
DK2155258T3 (en) 2017-09-18
US9738602B2 (en) 2017-08-22
SI2465541T1 (sl) 2018-10-30
PA8781201A1 (es) 2008-12-18
US20130211053A1 (en) 2013-08-15
EP2465541A1 (en) 2012-06-20
BRPI0811140A2 (pt) 2015-10-27
HK1147736A1 (en) 2011-08-19
US20160176809A1 (en) 2016-06-23
BRPI0811140B1 (pt) 2022-08-16
CN101835494B (zh) 2012-02-15
PE20090305A1 (es) 2009-03-15

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