CY1119373T1 - Βελτιωμενες διαδικασιες για παρασκευη υδραζιδιων - Google Patents
Βελτιωμενες διαδικασιες για παρασκευη υδραζιδιωνInfo
- Publication number
- CY1119373T1 CY1119373T1 CY20171100991T CY171100991T CY1119373T1 CY 1119373 T1 CY1119373 T1 CY 1119373T1 CY 20171100991 T CY20171100991 T CY 20171100991T CY 171100991 T CY171100991 T CY 171100991T CY 1119373 T1 CY1119373 T1 CY 1119373T1
- Authority
- CY
- Cyprus
- Prior art keywords
- water production
- hydrazine
- preparation
- acyl chloride
- improved procedures
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
- C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/46—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms, not being part of nitro or nitroso groups, further bound to other hetero atoms
- C07C323/48—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms, not being part of nitro or nitroso groups, further bound to other hetero atoms to nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C241/00—Preparation of compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
- C07C241/04—Preparation of hydrazides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
- C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
- C07C243/26—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C243/28—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of a saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/02—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols
- C07C319/12—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols by reactions not involving the formation of mercapto groups
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Coating Apparatus (AREA)
Abstract
Μία μέθοδος γνωστοποιείται για παρασκευή υδραζιδίων από υδραζίνη και ένα ακυλοχλωρίδιο η οποία περιλαμβάνει τα στάδια (a) της παρασκευής ενός αναδευόμενου ουσιαστικά ομοιόμορφου πολτού ο οποίος περιλαμβάνει υδραζίνη και έναν αδρανή διαλύτη σε χαμηλή θερμοκρασία" και (b) της προσθήκης ενός ακυλοχλωριδίου συνεχώς στον εν λόγω πολτό. Η μέθοδος αποφεύγει ή περιορίζει την παραγωγή ανεπιθύμητων παραπροϊόντων δις-υδραζιδίου. Η μέθοδος χρησιμοποιείται για παρασκευή υδραζιδίου του 3-μεθυλο-3-μερκαπτοβουτανοϊκού οξέος, ενός μορίου το οποίο χρησιμοποιείται για τη σύνδεση καλιχεαμικίνης με ένα μονόκλωνο αντίσωμα.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US93952907P | 2007-05-22 | 2007-05-22 | |
PCT/US2008/064213 WO2008147765A1 (en) | 2007-05-22 | 2008-05-20 | Improved processes for making hydrazides |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1119373T1 true CY1119373T1 (el) | 2018-02-14 |
Family
ID=39810161
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20171100991T CY1119373T1 (el) | 2007-05-22 | 2017-09-20 | Βελτιωμενες διαδικασιες για παρασκευη υδραζιδιων |
CY181100854T CY1120592T1 (el) | 2007-05-22 | 2018-08-13 | Βελτιωμενες διαδικασιες για παρασκευη υδραζιδιων |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY181100854T CY1120592T1 (el) | 2007-05-22 | 2018-08-13 | Βελτιωμενες διαδικασιες για παρασκευη υδραζιδιων |
Country Status (25)
Country | Link |
---|---|
US (5) | US8110705B2 (el) |
EP (2) | EP2155258B1 (el) |
JP (4) | JP5697446B2 (el) |
KR (1) | KR101547705B1 (el) |
CN (2) | CN101835494B (el) |
AR (1) | AR066674A1 (el) |
AU (1) | AU2008256905B2 (el) |
BR (1) | BRPI0811140B1 (el) |
CA (1) | CA2687852A1 (el) |
CL (1) | CL2008001490A1 (el) |
CY (2) | CY1119373T1 (el) |
DK (2) | DK2155258T3 (el) |
ES (2) | ES2686019T3 (el) |
HK (2) | HK1147736A1 (el) |
HU (2) | HUE039657T2 (el) |
IL (1) | IL202242A (el) |
MX (1) | MX2009012587A (el) |
PA (1) | PA8781201A1 (el) |
PE (1) | PE20090305A1 (el) |
PL (2) | PL2155258T3 (el) |
PT (2) | PT2465541T (el) |
SI (2) | SI2465541T1 (el) |
TW (1) | TW200904784A (el) |
WO (1) | WO2008147765A1 (el) |
ZA (1) | ZA200908229B (el) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101835494B (zh) * | 2007-05-22 | 2012-02-15 | 惠氏有限责任公司 | 制造酰肼的改良方法 |
PE20161413A1 (es) | 2013-11-04 | 2017-01-10 | Stemcentrx Inc | Conjugados de anticuerpo anti-efna4-farmaco |
CA3131631A1 (en) | 2013-11-04 | 2015-05-07 | Pfizer Inc. | Intermediates and methods for synthesizing calicheamicin derivatives |
KR102238032B1 (ko) | 2014-04-30 | 2021-04-08 | 화이자 인코포레이티드 | 항-ptk7 항체-약물 접합체 |
WO2016105330A1 (en) * | 2014-12-22 | 2016-06-30 | Hewlett Packard Enterprise Development Lp | Response to an inoperative network device managed by a controller |
WO2019018647A1 (en) | 2017-07-20 | 2019-01-24 | Pfizer Inc. | ANTI-GD3 ANTIBODIES AND CONJUGATES ANTIBODY-MEDICATION |
EP3693452A4 (en) | 2017-10-03 | 2021-06-23 | University Public Corporation Osaka | CELL CULTURE CONTAINERS, METHOD FOR CELL RECOVERY, AND METHOD FOR CULTIVATION OF CELLS |
CN109574870A (zh) * | 2018-12-25 | 2019-04-05 | 维思普新材料(苏州)有限公司 | 一种酰肼的连续制备方法 |
Family Cites Families (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US623230A (en) * | 1899-04-18 | Rotary ore-cooler | ||
DE2608336A1 (de) | 1975-03-11 | 1976-09-30 | Sandoz Ag | Neue organische verbindungen, ihre herstellung und verwendung |
US4291022A (en) * | 1975-03-11 | 1981-09-22 | Sandoz Ltd. | Organic compounds |
US4671958A (en) | 1982-03-09 | 1987-06-09 | Cytogen Corporation | Antibody conjugates for the delivery of compounds to target sites |
US4479953A (en) * | 1983-08-25 | 1984-10-30 | Merck & Co., Inc. | Pyrazine aldimine compounds as antimicrobial agents |
US4970198A (en) | 1985-10-17 | 1990-11-13 | American Cyanamid Company | Antitumor antibiotics (LL-E33288 complex) |
DE3771413D1 (de) * | 1986-08-04 | 1991-08-22 | Sandoz Ag | Benzhydroxamsaeure-derivate. |
US4729781A (en) * | 1986-08-04 | 1988-03-08 | Sandoz Ltd. | 3,6-dichloro-2-methoxybenzohydroxamic acid derivatives and use as herbicidal agents |
US4939244A (en) | 1987-01-30 | 1990-07-03 | American Cyanamid Company | Pseudoaglycones of LL-E33288 antibiotics |
US5079233A (en) | 1987-01-30 | 1992-01-07 | American Cyanamid Company | N-acyl derivatives of the LL-E33288 antitumor antibiotics, composition and methods for using the same |
US5053394A (en) * | 1988-09-21 | 1991-10-01 | American Cyanamid Company | Targeted forms of methyltrithio antitumor agents |
US5770701A (en) | 1987-10-30 | 1998-06-23 | American Cyanamid Company | Process for preparing targeted forms of methyltrithio antitumor agents |
JPH05222044A (ja) * | 1991-10-25 | 1993-08-31 | Eastman Kodak Co | 2当量ピラゾロトリアゾールマゼンタカプラーの製造 |
DE69217085T2 (de) * | 1991-11-22 | 1997-05-28 | Uniroyal Chem Co Inc | Insekttötende phenylhydrazin-derivate |
US5690904A (en) * | 1993-07-12 | 1997-11-25 | Amersham International Plc | Diagnostic radiopharmaceutical compounds (That) |
US5443953A (en) * | 1993-12-08 | 1995-08-22 | Immunomedics, Inc. | Preparation and use of immunoconjugates |
US5403015A (en) * | 1993-12-09 | 1995-04-04 | Forte; Steven L. | Cards and methods for playing casino 21 or blackjack |
WO1996006096A1 (fr) * | 1994-08-23 | 1996-02-29 | Nissan Chemical Industries, Ltd. | Derive de pyridine |
IT1292092B1 (it) | 1997-06-05 | 1999-01-25 | Geange Ltd | Impiego di derivati eterociclici aromatici azotati nel trattamento topico di affezioni di tessuti epiteliali |
DE69936998T2 (de) * | 1998-10-16 | 2008-05-21 | Merck Sharp & Dohme Ltd., Hoddesdon | Pyrazolotriazinderivate als gaba-rezeptorliganden |
GB0008696D0 (en) * | 2000-04-07 | 2000-05-31 | Merck Sharp & Dohme | Therapeutic agents |
CA2449544A1 (en) | 2001-06-08 | 2002-12-19 | Cytovia, Inc. | Substituted 3-aryl-5-aryl-[1,2,4]-oxadiazoles and analogs |
PL224150B1 (pl) * | 2002-05-02 | 2016-11-30 | Wyeth Corp | Kompozycja zawierająca koniugat leku obejmujący pochodne kalicheamycyny i przeciwciało, oraz kompozycja farmaceutyczna ją zawierająca |
US6803379B2 (en) * | 2002-06-04 | 2004-10-12 | Jose A. Fernandez-Pol | Pharmacological agents and methods of treatment that inactivate pathogenic prokaryotic and eukaryotic cells and viruses by attacking highly conserved domains in structural metalloprotein and metalloenzyme targets |
US7144876B2 (en) * | 2002-12-18 | 2006-12-05 | Cytovia, Inc. | 3,5-Disubstituted-[1,2,4]-oxadiazoles and analogs as activators of caspases and inducers of apoptosis and the use thereof |
RU2423353C1 (ru) | 2002-12-20 | 2011-07-10 | Глэксо Груп Лимитед | Новые производные бензазепина |
US7304161B2 (en) | 2003-02-10 | 2007-12-04 | Intrexon Corporation | Diaclhydrazine ligands for modulating the expression of exogenous genes in mammalian systems via an ecdysone receptor complex |
EP1622615A4 (en) | 2003-05-13 | 2009-02-18 | Smithkline Beecham Corp | INHIBITORS OF THE INTEGRASE OF NAPHTHYRIDINE |
BRPI0412040A (pt) | 2003-07-02 | 2006-09-05 | Sugen Inc | hidrazidas de indolinona como inibidores de c-met |
KR20060032190A (ko) | 2003-07-02 | 2006-04-14 | 버텍스 파마슈티칼스 인코포레이티드 | 전압 개폐 이온 채널의 조절제로서 유용한 피리미딘 |
SE0302486D0 (sv) | 2003-09-18 | 2003-09-18 | Astrazeneca Ab | Novel compounds |
EP1755574A4 (en) * | 2004-04-06 | 2009-05-13 | Semafore Pharmaceuticals Inc | PTEN INHIBITORS |
GT200500283A (es) * | 2004-10-08 | 2006-05-08 | Inmunoterapia de desordenes autoinmunes | |
TWI404706B (zh) * | 2006-01-11 | 2013-08-11 | Actelion Pharmaceuticals Ltd | 新穎噻吩衍生物 |
CN101835494B (zh) * | 2007-05-22 | 2012-02-15 | 惠氏有限责任公司 | 制造酰肼的改良方法 |
-
2008
- 2008-05-20 CN CN2008800216526A patent/CN101835494B/zh active Active
- 2008-05-20 ES ES12159159.8T patent/ES2686019T3/es active Active
- 2008-05-20 DK DK08755945.6T patent/DK2155258T3/en active
- 2008-05-20 WO PCT/US2008/064213 patent/WO2008147765A1/en active Application Filing
- 2008-05-20 PT PT12159159T patent/PT2465541T/pt unknown
- 2008-05-20 PT PT87559456T patent/PT2155258T/pt unknown
- 2008-05-20 SI SI200831994T patent/SI2465541T1/sl unknown
- 2008-05-20 US US12/123,777 patent/US8110705B2/en active Active
- 2008-05-20 MX MX2009012587A patent/MX2009012587A/es active IP Right Grant
- 2008-05-20 SI SI200831859T patent/SI2155258T1/sl unknown
- 2008-05-20 HU HUE12159159A patent/HUE039657T2/hu unknown
- 2008-05-20 PE PE2008000869A patent/PE20090305A1/es not_active Application Discontinuation
- 2008-05-20 CN CN201110434577.XA patent/CN102558001B/zh active Active
- 2008-05-20 DK DK12159159.8T patent/DK2465541T3/en active
- 2008-05-20 CA CA2687852A patent/CA2687852A1/en not_active Abandoned
- 2008-05-20 EP EP08755945.6A patent/EP2155258B1/en active Active
- 2008-05-20 BR BRPI0811140-5A patent/BRPI0811140B1/pt active IP Right Grant
- 2008-05-20 KR KR1020097026806A patent/KR101547705B1/ko active Protection Beyond IP Right Term
- 2008-05-20 EP EP12159159.8A patent/EP2465541B1/en active Active
- 2008-05-20 HU HUE08755945A patent/HUE036704T2/hu unknown
- 2008-05-20 PL PL08755945T patent/PL2155258T3/pl unknown
- 2008-05-20 JP JP2010509499A patent/JP5697446B2/ja active Active
- 2008-05-20 PL PL12159159T patent/PL2465541T3/pl unknown
- 2008-05-20 AU AU2008256905A patent/AU2008256905B2/en active Active
- 2008-05-20 ES ES08755945.6T patent/ES2642888T3/es active Active
- 2008-05-22 AR ARP080102165A patent/AR066674A1/es unknown
- 2008-05-22 PA PA20088781201A patent/PA8781201A1/es unknown
- 2008-05-22 TW TW097118930A patent/TW200904784A/zh unknown
- 2008-05-22 CL CL200801490A patent/CL2008001490A1/es unknown
-
2009
- 2009-11-19 IL IL202242A patent/IL202242A/en active IP Right Grant
- 2009-11-20 ZA ZA200908229A patent/ZA200908229B/xx unknown
-
2011
- 2011-02-23 HK HK11101744.4A patent/HK1147736A1/xx unknown
-
2012
- 2012-01-27 US US13/360,220 patent/US8383857B2/en active Active
- 2012-12-11 HK HK12112795.8A patent/HK1172008A1/zh unknown
-
2013
- 2013-01-31 US US13/755,886 patent/US8853451B2/en active Active
- 2013-08-23 JP JP2013172956A patent/JP2013234203A/ja not_active Withdrawn
-
2014
- 2014-10-02 US US14/504,738 patent/US9227924B2/en active Active
-
2015
- 2015-11-06 JP JP2015218118A patent/JP2016026219A/ja not_active Withdrawn
- 2015-12-18 US US14/973,869 patent/US9738602B2/en active Active
-
2017
- 2017-08-03 JP JP2017150482A patent/JP2017193584A/ja active Pending
- 2017-09-20 CY CY20171100991T patent/CY1119373T1/el unknown
-
2018
- 2018-08-13 CY CY181100854T patent/CY1120592T1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CY1119373T1 (el) | Βελτιωμενες διαδικασιες για παρασκευη υδραζιδιων | |
CY1123817T1 (el) | Μεθοδος για την παρασκευη ενωσεων που ειναι χρησιμες ως αναστολεις sglt | |
Prasad et al. | Metal free sulfenylation and bis-sulfenylation of indoles: persulfate mediated synthesis | |
CY1121321T1 (el) | Παρασκευη συζευγματων αντισωματoς-μεϋτανσινoεiδoυς δια μιας μεθοδου μιας βαθμιδας | |
CY1121002T1 (el) | Μονοκλωνα αντισωματα κατα κλαουδινης-18 για τη θεραπεια του καρκινου | |
CY1109809T1 (el) | Διαδικασια για την παρασκευη παραγωγων τετραζολης απο οργανο βοριο και οργανο αργιλιο αζιδια | |
CY1124387T1 (el) | Μεθοδος για παραγωγη νεας χημικης ενωσης που περιεχει αζωτο ή αλατος αυτης, και παραγωγη ενδιαμεσου της ιδιας | |
CY1112754T1 (el) | Μεθοδοι και ενδιαμεσα για την παρασκευη παραγωγων ν4-φαινυλ-κιναζολιν-4-αμινης | |
Petiot et al. | Copper-catalyzed N-arylation of azoles and diazoles using highly functionalized trivalent organobismuth reagents | |
Zhang et al. | A simple and straightforward synthesis of phenyl isothiocyanates, symmetrical and unsymmetrical thioureas under ball milling | |
CY1108792T1 (el) | Παραγωγα διοξανιου-2-αλκυλκαρβαμικου, η παρασκευη τους και η εφαρμογη τους στην θεραπευτικη αγωγη | |
EA200901175A1 (ru) | Способ получения 2,6-дихлор-4-(трифторметил)фенилгидразина, используя смеси дихлор-фтор-трифторметилбензолов | |
EA200701470A1 (ru) | Способы получения производных 4-(фенокси-5-метилпиримидин-4-илокси)пиперидин-1-карбоновой кислоты и родственных соединений | |
RU2329252C1 (ru) | Способ получения производных n-пиперидино-1,5-дифенилпиразол-3-карбоксамида | |
CY1113184T1 (el) | Μεθοδος για την παρασκευη θεραπευτικως πολυτιμων παραγωγων τριφαινυλβουτενιου | |
RU2018132264A (ru) | Промежуточные продукты в синтезе эрибулина и соответствующие способы синтеза | |
JP2008063336A5 (el) | ||
EA200401551A1 (ru) | Получение сульфинилацетамида | |
CY1119820T1 (el) | Βελτιωμενη παρασκευη παραγωγων χαλκονης | |
Li et al. | Aliphatic C–H azidation through a peroxydisulfate induced radical pathway | |
TW200728297A (en) | Alpha functionalization of cyclic, ketalized ketones | |
RU2018130327A (ru) | Улучшенный способ получения осимертиниба (azd9291) или его соли и "анилин-azd9291" или его соли | |
Kong et al. | KIO 3-catalyzed cross dehydrogenative coupling reaction: sulfenylation of phenol and arylamine derivatives in water at room temperature | |
DE602006005349D1 (de) | Verfahren zur herstellung von hydrazon-derivaten | |
Ai et al. | Rhodium-catalyzed carbonylative coupling of alkyl halides with thiols: a radical process faster than easier nucleophilic substitution |