HK1166325A1 - Novel 7-deazapurine nucleosides for therapeutic uses - Google Patents

Novel 7-deazapurine nucleosides for therapeutic uses

Info

Publication number
HK1166325A1
HK1166325A1 HK12107027.8A HK12107027A HK1166325A1 HK 1166325 A1 HK1166325 A1 HK 1166325A1 HK 12107027 A HK12107027 A HK 12107027A HK 1166325 A1 HK1166325 A1 HK 1166325A1
Authority
HK
Hong Kong
Prior art keywords
novel
therapeutic uses
deazapurine nucleosides
deazapurine
nucleosides
Prior art date
Application number
HK12107027.8A
Other languages
English (en)
Inventor
Aurelie Bourderioux
Michal Hocek
Petr Naus
Original Assignee
Acad Of Science Czech Republic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acad Of Science Czech Republic filed Critical Acad Of Science Czech Republic
Publication of HK1166325A1 publication Critical patent/HK1166325A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/14—Pyrrolo-pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK12107027.8A 2009-04-22 2012-07-18 Novel 7-deazapurine nucleosides for therapeutic uses HK1166325A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17165609P 2009-04-22 2009-04-22
PCT/CZ2010/000050 WO2010121576A2 (en) 2009-04-22 2010-04-19 Novel 7-deazapurine nucleosides for therapeutic uses

Publications (1)

Publication Number Publication Date
HK1166325A1 true HK1166325A1 (en) 2012-12-14

Family

ID=42768153

Family Applications (2)

Application Number Title Priority Date Filing Date
HK12107027.8A HK1166325A1 (en) 2009-04-22 2012-07-18 Novel 7-deazapurine nucleosides for therapeutic uses
HK15109842.4A HK1209129A1 (zh) 2009-04-22 2015-10-08 用於治療用途的新的 -脫氮嘌呤核苷

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK15109842.4A HK1209129A1 (zh) 2009-04-22 2015-10-08 用於治療用途的新的 -脫氮嘌呤核苷

Country Status (16)

Country Link
US (3) US9321800B2 (zh)
EP (1) EP2421879B1 (zh)
JP (2) JP5721275B2 (zh)
CN (2) CN104497084B (zh)
AU (3) AU2010238985B2 (zh)
CA (2) CA2966647A1 (zh)
DK (1) DK2421879T3 (zh)
ES (1) ES2437917T3 (zh)
HK (2) HK1166325A1 (zh)
HR (1) HRP20131021T1 (zh)
MX (1) MX2011011160A (zh)
NZ (2) NZ596301A (zh)
PL (1) PL2421879T3 (zh)
PT (1) PT2421879E (zh)
SI (1) SI2421879T1 (zh)
WO (1) WO2010121576A2 (zh)

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* Cited by examiner, † Cited by third party
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AU2010238985B2 (en) * 2009-04-22 2015-04-23 Institute Of Organic Chemistry And Biochemistry Ascr,V.V.I. Novel 7-deazapurine nucleosides for therapeutic uses
CN102803474A (zh) * 2009-12-18 2012-11-28 哈佛大学校长及研究员协会 促进β细胞复制的化合物及其使用方法
CN102319254B (zh) * 2011-07-20 2013-06-19 上海交通大学 5-碘代杀菌核素在制备抗肿瘤药物中的应用
CZ305466B6 (cs) * 2013-11-04 2015-10-14 Ústav organické chemie a biochemie Akademie věd České republiky, v. v. i. Substituované 7-deazapurinové ribonukleosidy pro terapeutické použití
PL3218378T3 (pl) 2014-11-14 2020-10-19 Nerviano Medical Sciences S.R.L. Pochodne 6-amino-7-bicyklo-7-deazapuryny jako inhibitory kinaz białkowych
WO2017197046A1 (en) 2016-05-10 2017-11-16 C4 Therapeutics, Inc. C3-carbon linked glutarimide degronimers for target protein degradation
EP3454856A4 (en) 2016-05-10 2019-12-25 C4 Therapeutics, Inc. HETEROCYCLIC DEGRONIMERS FOR TARGET PROTEIN REDUCTION
EP3454862A4 (en) 2016-05-10 2020-02-12 C4 Therapeutics, Inc. SPIROCYCLIC DEGRONIMERS FOR TARGET PROTEIN REDUCTION
EP3478701B1 (en) 2016-06-29 2022-08-10 Ustav organicke chemie a biochemie AV CR, v.v.i. Substituted thienopyrrolopyrimidine ribonucleosides for therapeutic use
CZ307334B6 (cs) 2016-08-02 2018-06-13 Ăšstav organickĂ© chemie a biochemie AV ÄŚR, v.v.i. Substituované heteropentadieno-pyrrolopyrimidinové ribonukleosidy pro terapeutické použití
CA3049136C (en) 2017-01-18 2022-06-14 Array Biopharma Inc. Substituted pyrazolo[1,5-a]pyrazine compounds as ret kinase inhibitors
US11072628B2 (en) 2017-10-19 2021-07-27 Universiteit Gent Nucleoside analogues for the treatment of parasitic infections
CA3087972C (en) 2018-01-18 2023-01-10 Array Biopharma Inc. Substituted pyrazolyl[4,3-c]pyridinecompounds as ret kinase inhibitors
CA3087578C (en) 2018-01-18 2023-08-08 Array Biopharma Inc. Substituted pyrazolo[3,4-d]pyrimidine compounds as ret kinase inhibitors
TWI802635B (zh) * 2018-01-18 2023-05-21 美商亞雷生物製藥股份有限公司 作為ｒｅｔ激酶抑制劑之經取代吡咯并[2,3-d]嘧啶化合物
CZ308104B6 (cs) 2018-03-12 2020-01-08 Ăšstav organickĂ© chemie a biochemie AV ÄŚR, v. v. i. Pyridinopyrrolopyrimidinové ribonukleosidy pro terapeutické použití
MA53287A (fr) * 2018-08-07 2022-05-11 Merck Sharp & Dohme Inhibiteurs de prmt5
WO2020055672A1 (en) 2018-09-10 2020-03-19 Array Biopharma Inc. Fused heterocyclic compounds as ret kinase inhibitors
MA56544A (fr) * 2019-06-18 2022-04-27 Taiho Pharmaceutical Co Ltd Nouveau compose ester d'acide phosphorique possedant un squelette pyrolo-pyrimidine ou sel pharmaceutiquement acceptable de celui-ci
US20230104311A1 (en) * 2020-02-17 2023-04-06 Katholieke Universiteit Leuven Novel 6-substituted 7-deazapurines and corresponding nucleosides as medicaments
EP4300796A1 (en) 2021-02-26 2024-01-03 Hitachi Industrial Products, Ltd. Dynamo-electric machine
CA3233416A1 (en) 2021-09-28 2023-04-06 Universiteit Antwerpen Nucleoside analogues for the treatment of parasitic infections

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL108523A0 (en) * 1993-02-03 1994-05-30 Gensia Inc Pharmaceutical compositions containing adenosine kinase inhibitors for preventing or treating conditions involving inflammatory responses and pain
EP2360166A1 (en) * 2001-01-22 2011-08-24 Merck Sharp & Dohme Corp. Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase
AU2002353165A1 (en) * 2001-12-17 2003-06-30 Ribapharm Inc. Deazapurine nucleoside libraries and compounds
NZ536123A (en) * 2002-05-06 2006-09-29 Genelabs Tech Inc Nucleoside derivatives for treating hepatitis C virus infection
US20040157892A1 (en) 2003-02-12 2004-08-12 Crompton Co./Cie Pesticidal fluoroethyl pyrazoles
US7202223B2 (en) * 2003-10-27 2007-04-10 Genelabs Technologies, Inc. Nucleoside compounds for treating viral infections
CA2543116A1 (en) 2003-10-27 2005-05-19 Genelabs Technologies, Inc. Methods for preparing 7-(2'-substituted-.szlig.-d-ribofuranosyl)-4-(nr2r3)-5-(substituted ethyn-1-yl)-pyrrolo[2,3-d]pyrimidine derivatives
AU2004285923A1 (en) * 2003-10-27 2005-05-12 Genelabs Technologies, Inc. Nucleoside compounds for treating viral infections
WO2006033709A2 (en) * 2004-07-29 2006-03-30 Metabasis Therapeutics, Inc. Novel nucleoside derivatives
PL3133080T3 (pl) * 2008-01-18 2018-12-31 Inst Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Nowe cytostatyczne nukleozydy 7-deazapurynowe
KR20110019438A (ko) * 2008-06-23 2011-02-25 얀센 파마슈티카 엔.브이. Ｃｃｒ２의 피페리딜 아크릴아미드 길항제
GB0815968D0 (en) * 2008-09-03 2008-10-08 Angeletti P Ist Richerche Bio Antiviral agents
AU2010238985B2 (en) * 2009-04-22 2015-04-23 Institute Of Organic Chemistry And Biochemistry Ascr,V.V.I. Novel 7-deazapurine nucleosides for therapeutic uses

Also Published As

Publication number Publication date
US10294262B2 (en) 2019-05-21
CN102459300A (zh) 2012-05-16
CN102459300B (zh) 2014-12-10
HRP20131021T1 (hr) 2014-01-31
US20170240584A1 (en) 2017-08-24
AU2015205885B2 (en) 2017-04-06
NZ700583A (en) 2016-04-29
JP6087889B2 (ja) 2017-03-01
HK1209129A1 (zh) 2016-03-24
SI2421879T1 (sl) 2014-01-31
MX2011011160A (es) 2012-01-27
DK2421879T3 (da) 2013-11-25
AU2010238985A1 (en) 2011-12-01
US20150218201A1 (en) 2015-08-06
AU2017204148A1 (en) 2017-07-06
US20160318970A1 (en) 2016-11-03
CN104497084A (zh) 2015-04-08
PT2421879E (pt) 2013-12-09
US9624257B2 (en) 2017-04-18
US9321800B2 (en) 2016-04-26
JP2015013901A (ja) 2015-01-22
WO2010121576A3 (en) 2011-06-16
JP5721275B2 (ja) 2015-05-20
WO2010121576A2 (en) 2010-10-28
CA2759131A1 (en) 2010-10-28
ES2437917T3 (es) 2014-01-15
CA2759131C (en) 2017-06-20
AU2010238985B2 (en) 2015-04-23
AU2015205885A1 (en) 2015-09-03
EP2421879B1 (en) 2013-09-04
CN104497084B (zh) 2018-06-05
CA2966647A1 (en) 2010-10-28
NZ596301A (en) 2014-10-31
EP2421879A2 (en) 2012-02-29
AU2017204148B2 (en) 2018-12-06
JP2012524731A (ja) 2012-10-18
PL2421879T3 (pl) 2014-02-28

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