HK1209129A1 - 用於治療用途的新的 -脫氮嘌呤核苷 - Google Patents

用於治療用途的新的 -脫氮嘌呤核苷

Info

Publication number
HK1209129A1
HK1209129A1 HK15109842.4A HK15109842A HK1209129A1 HK 1209129 A1 HK1209129 A1 HK 1209129A1 HK 15109842 A HK15109842 A HK 15109842A HK 1209129 A1 HK1209129 A1 HK 1209129A1
Authority
HK
Hong Kong
Prior art keywords
novel
therapeutic uses
deazapurine nucleosides
deazapurine
nucleosides
Prior art date
Application number
HK15109842.4A
Other languages
English (en)
Inventor
‧布爾德里奧克斯
‧霍塞克
‧瑙斯
Original Assignee
Acad Of Science Czech Republic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acad Of Science Czech Republic filed Critical Acad Of Science Czech Republic
Publication of HK1209129A1 publication Critical patent/HK1209129A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/14—Pyrrolo-pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK15109842.4A 2009-04-22 2015-10-08 用於治療用途的新的 -脫氮嘌呤核苷 HK1209129A1 (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17165609P 2009-04-22 2009-04-22

Publications (1)

Publication Number Publication Date
HK1209129A1 true HK1209129A1 (zh) 2016-03-24

Family

ID=42768153

Family Applications (2)

Application Number Title Priority Date Filing Date
HK12107027.8A HK1166325A1 (en) 2009-04-22 2012-07-18 Novel 7-deazapurine nucleosides for therapeutic uses
HK15109842.4A HK1209129A1 (zh) 2009-04-22 2015-10-08 用於治療用途的新的 -脫氮嘌呤核苷

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HK12107027.8A HK1166325A1 (en) 2009-04-22 2012-07-18 Novel 7-deazapurine nucleosides for therapeutic uses

Country Status (16)

Country Link
US (3) US9321800B2 (zh)
EP (1) EP2421879B1 (zh)
JP (2) JP5721275B2 (zh)
CN (2) CN102459300B (zh)
AU (3) AU2010238985B2 (zh)
CA (2) CA2759131C (zh)
DK (1) DK2421879T3 (zh)
ES (1) ES2437917T3 (zh)
HK (2) HK1166325A1 (zh)
HR (1) HRP20131021T1 (zh)
MX (1) MX2011011160A (zh)
NZ (2) NZ596301A (zh)
PL (1) PL2421879T3 (zh)
PT (1) PT2421879E (zh)
SI (1) SI2421879T1 (zh)
WO (1) WO2010121576A2 (zh)

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US9321800B2 (en) * 2009-04-22 2016-04-26 Gilead Sciences, Inc. 7-deazapurine nucleosides for therapeutic uses
KR20120113228A (ko) * 2009-12-18 2012-10-12 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 베타 세포 복제 촉진 화합물 및 그 사용 방법
CN102319254B (zh) * 2011-07-20 2013-06-19 上海交通大学 5-碘代杀菌核素在制备抗肿瘤药物中的应用
CZ305466B6 (cs) * 2013-11-04 2015-10-14 Ústav organické chemie a biochemie Akademie věd České republiky, v. v. i. Substituované 7-deazapurinové ribonukleosidy pro terapeutické použití
US10221181B2 (en) 2014-11-14 2019-03-05 Nerviano Medical Sciences S.R.L. 6-amino-7-bicyclo-7-deaza-purine derivatives as protein kinase inhibitors
CN109562107A (zh) 2016-05-10 2019-04-02 C4医药公司 用于靶蛋白降解的杂环降解决定子体
CN109641874A (zh) 2016-05-10 2019-04-16 C4医药公司 用于靶蛋白降解的c3-碳连接的戊二酰亚胺降解决定子体
WO2017197036A1 (en) 2016-05-10 2017-11-16 C4 Therapeutics, Inc. Spirocyclic degronimers for target protein degradation
WO2018001393A1 (en) 2016-06-29 2018-01-04 Ustav Organicke Chemie A Biochemie Av Cr, V.V.I. Substituted thienopyrrolopyrimidine ribonucleosides for therapeutic use
CZ307334B6 (cs) 2016-08-02 2018-06-13 Ăšstav organickĂ© chemie a biochemie AV ÄŚR, v.v.i. Substituované heteropentadieno-pyrrolopyrimidinové ribonukleosidy pro terapeutické použití
CA3049136C (en) 2017-01-18 2022-06-14 Array Biopharma Inc. Substituted pyrazolo[1,5-a]pyrazine compounds as ret kinase inhibitors
EP3697800A1 (en) 2017-10-19 2020-08-26 Universiteit Gent Nucleoside analogues for the treatment of parasitic infections
JP7061195B2 (ja) * 2018-01-18 2022-04-27 アレイ バイオファーマ インコーポレイテッド ＲＥＴキナーゼ阻害剤としての置換ピラゾロ［３，４－ｄ］ピリミジン化合物
CA3087354C (en) * 2018-01-18 2023-01-03 Array Biopharma Inc. Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors
US11472802B2 (en) 2018-01-18 2022-10-18 Array Biopharma Inc. Substituted pyrazolyl[4,3-c]pyridine compounds as RET kinase inhibitors
CZ308104B6 (cs) 2018-03-12 2020-01-08 Ăšstav organickĂ© chemie a biochemie AV ÄŚR, v. v. i. Pyridinopyrrolopyrimidinové ribonukleosidy pro terapeutické použití
US20220363707A1 (en) * 2018-08-07 2022-11-17 Merck Sharp & Dohme Corp. Prmt5 inhibitors
EP3849986B1 (en) 2018-09-10 2022-06-08 Array Biopharma, Inc. Fused heterocyclic compounds as ret kinase inhibitors
AU2020298440B2 (en) * 2019-06-18 2023-10-05 Taiho Pharmaceutical Co., Ltd. Novel phosphate ester compound having pyrrolopyrimidine skeleton or pharmaceutically acceptable salt thereof
CN115515593A (zh) * 2020-02-17 2022-12-23 勒芬天主教大学 作为药物的新的6-取代的7-脱氮嘌呤和相应的核苷
WO2022180784A1 (ja) 2021-02-26 2022-09-01 株式会社日立インダストリアルプロダクツ 回転電機
CA3233416A1 (en) 2021-09-28 2023-04-06 Universiteit Antwerpen Nucleoside analogues for the treatment of parasitic infections

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL108523A0 (en) * 1993-02-03 1994-05-30 Gensia Inc Pharmaceutical compositions containing adenosine kinase inhibitors for preventing or treating conditions involving inflammatory responses and pain
MY134070A (en) * 2001-01-22 2007-11-30 Isis Pharmaceuticals Inc Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
AU2002353165A1 (en) * 2001-12-17 2003-06-30 Ribapharm Inc. Deazapurine nucleoside libraries and compounds
KR20050006221A (ko) * 2002-05-06 2005-01-15 제네랩스 테크놀로지스, 인코포레이티드 Ｃ형 간염 바이러스 감염 치료용의 뉴클레오시드 유도체
US20040157892A1 (en) 2003-02-12 2004-08-12 Crompton Co./Cie Pesticidal fluoroethyl pyrazoles
US7202223B2 (en) * 2003-10-27 2007-04-10 Genelabs Technologies, Inc. Nucleoside compounds for treating viral infections
US7169918B2 (en) * 2003-10-27 2007-01-30 Genelabs Technologies, Inc. Methods for preparing 7-(2′-substituted-β-D-ribofuranosyl)-4-(NR2R3)-5-(substituted ethyn-1-yl)-pyrrolo[2,3-d]pyrimidine derivatives
KR20060096487A (ko) * 2003-10-27 2006-09-11 진랩스 테크놀러지스, 인크. 바이러스 감염증들을 치료하기 위한 뉴클레오시드 화합물
EP1781101A2 (en) * 2004-07-29 2007-05-09 Metabasis Therapeutics, Inc. Novel nucleoside derivatives
PL2231689T3 (pl) * 2008-01-18 2017-01-31 Inst Of Organic Chemistry And Biochemistry Of The Acad Of Sciences Of The Czech Republic Nowe 7-deazapurynowe nukleozydy o właściwościach cytostatycznych
WO2010008761A1 (en) * 2008-06-23 2010-01-21 Janssen Pharmaceutica Nv Piperidyl acrylamide antogonists of ccr2
GB0815968D0 (en) * 2008-09-03 2008-10-08 Angeletti P Ist Richerche Bio Antiviral agents
US9321800B2 (en) * 2009-04-22 2016-04-26 Gilead Sciences, Inc. 7-deazapurine nucleosides for therapeutic uses

Also Published As

Publication number Publication date
JP6087889B2 (ja) 2017-03-01
JP2012524731A (ja) 2012-10-18
ES2437917T3 (es) 2014-01-15
CA2759131C (en) 2017-06-20
AU2010238985A1 (en) 2011-12-01
CN102459300B (zh) 2014-12-10
US20170240584A1 (en) 2017-08-24
AU2010238985B2 (en) 2015-04-23
CA2759131A1 (en) 2010-10-28
US10294262B2 (en) 2019-05-21
HRP20131021T1 (hr) 2014-01-31
PT2421879E (pt) 2013-12-09
CN104497084B (zh) 2018-06-05
WO2010121576A2 (en) 2010-10-28
AU2015205885B2 (en) 2017-04-06
AU2017204148A1 (en) 2017-07-06
CA2966647A1 (en) 2010-10-28
AU2015205885A1 (en) 2015-09-03
US9321800B2 (en) 2016-04-26
US20150218201A1 (en) 2015-08-06
SI2421879T1 (sl) 2014-01-31
EP2421879A2 (en) 2012-02-29
PL2421879T3 (pl) 2014-02-28
NZ700583A (en) 2016-04-29
US9624257B2 (en) 2017-04-18
CN102459300A (zh) 2012-05-16
US20160318970A1 (en) 2016-11-03
HK1166325A1 (en) 2012-12-14
AU2017204148B2 (en) 2018-12-06
WO2010121576A3 (en) 2011-06-16
NZ596301A (en) 2014-10-31
CN104497084A (zh) 2015-04-08
MX2011011160A (es) 2012-01-27
JP2015013901A (ja) 2015-01-22
EP2421879B1 (en) 2013-09-04
JP5721275B2 (ja) 2015-05-20
DK2421879T3 (da) 2013-11-25

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