HK1209129A1 - 用於治療用途的新的 -脫氮嘌呤核苷 - Google Patents

用於治療用途的新的 -脫氮嘌呤核苷

Info

Publication number
HK1209129A1
HK1209129A1 HK15109842.4A HK15109842A HK1209129A1 HK 1209129 A1 HK1209129 A1 HK 1209129A1 HK 15109842 A HK15109842 A HK 15109842A HK 1209129 A1 HK1209129 A1 HK 1209129A1
Authority
HK
Hong Kong
Prior art keywords
novel
therapeutic uses
deazapurine nucleosides
deazapurine
nucleosides
Prior art date
Application number
HK15109842.4A
Other languages
English (en)
Inventor
‧布爾德里奧克斯
‧霍塞克
‧瑙斯
Original Assignee
Acad Of Science Czech Republic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acad Of Science Czech Republic filed Critical Acad Of Science Czech Republic
Publication of HK1209129A1 publication Critical patent/HK1209129A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/14—Pyrrolo-pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
HK15109842.4A 2009-04-22 2015-10-08 用於治療用途的新的 -脫氮嘌呤核苷 HK1209129A1 (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17165609P 2009-04-22 2009-04-22

Publications (1)

Publication Number Publication Date
HK1209129A1 true HK1209129A1 (zh) 2016-03-24

Family

ID=42768153

Family Applications (2)

Application Number Title Priority Date Filing Date
HK12107027.8A HK1166325A1 (en) 2009-04-22 2012-07-18 Novel 7-deazapurine nucleosides for therapeutic uses
HK15109842.4A HK1209129A1 (zh) 2009-04-22 2015-10-08 用於治療用途的新的 -脫氮嘌呤核苷

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HK12107027.8A HK1166325A1 (en) 2009-04-22 2012-07-18 Novel 7-deazapurine nucleosides for therapeutic uses

Country Status (16)

Country Link
US (3) US9321800B2 (zh)
EP (1) EP2421879B1 (zh)
JP (2) JP5721275B2 (zh)
CN (2) CN102459300B (zh)
AU (3) AU2010238985B2 (zh)
CA (2) CA2966647A1 (zh)
DK (1) DK2421879T3 (zh)
ES (1) ES2437917T3 (zh)
HK (2) HK1166325A1 (zh)
HR (1) HRP20131021T1 (zh)
MX (1) MX2011011160A (zh)
NZ (2) NZ700583A (zh)
PL (1) PL2421879T3 (zh)
PT (1) PT2421879E (zh)
SI (1) SI2421879T1 (zh)
WO (1) WO2010121576A2 (zh)

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NZ700583A (en) * 2009-04-22 2016-04-29 Acad Of Science Czech Republic Novel 7-deazapurine nucleosides for therapeutic uses
EP2513298A4 (en) * 2009-12-18 2013-03-27 Harvard College COMPOUNDS PROMOTING BETA CELL REPLICATION AND METHODS OF USE THEREOF
CN102319254B (zh) * 2011-07-20 2013-06-19 上海交通大学 5-碘代杀菌核素在制备抗肿瘤药物中的应用
CZ305466B6 (cs) * 2013-11-04 2015-10-14 Ústav organické chemie a biochemie Akademie věd České republiky, v. v. i. Substituované 7-deazapurinové ribonukleosidy pro terapeutické použití
JP6421241B2 (ja) 2014-11-14 2018-11-07 ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ タンパク質キナーゼ阻害剤としての６−アミノ−７−ビシクロ−７−デアザ−プリン誘導体
CN109562113A (zh) 2016-05-10 2019-04-02 C4医药公司 用于靶蛋白降解的螺环降解决定子体
CN109641874A (zh) 2016-05-10 2019-04-16 C4医药公司 用于靶蛋白降解的c3-碳连接的戊二酰亚胺降解决定子体
WO2017197055A1 (en) 2016-05-10 2017-11-16 C4 Therapeutics, Inc. Heterocyclic degronimers for target protein degradation
JP6650074B2 (ja) 2016-06-29 2020-02-19 ウスタフ オルガニッケ ヘミエ アー ビオヘミエ アカデミエ ヴェド ツェーエル，ヴェー．ヴェー．イー 治療に使用するための、置換チエノピロロピリミジンリボヌクレオシド
CZ307334B6 (cs) 2016-08-02 2018-06-13 Ăšstav organickĂ© chemie a biochemie AV ÄŚR, v.v.i. Substituované heteropentadieno-pyrrolopyrimidinové ribonukleosidy pro terapeutické použití
CN110267960B (zh) 2017-01-18 2022-04-26 阿雷生物药品公司 作为RET激酶抑制剂的取代的吡唑并[1,5-a]吡嗪化合物
EP3697800A1 (en) 2017-10-19 2020-08-26 Universiteit Gent Nucleoside analogues for the treatment of parasitic infections
CA3087972C (en) * 2018-01-18 2023-01-10 Array Biopharma Inc. Substituted pyrazolyl[4,3-c]pyridinecompounds as ret kinase inhibitors
TW201938169A (zh) 2018-01-18 2019-10-01 美商亞雷生物製藥股份有限公司 作為RET激酶抑制劑之經取代吡唑并[3,4-d]嘧啶化合物
EP3740491A1 (en) * 2018-01-18 2020-11-25 Array Biopharma, Inc. Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors
CZ308104B6 (cs) 2018-03-12 2020-01-08 Ăšstav organickĂ© chemie a biochemie AV ÄŚR, v. v. i. Pyridinopyrrolopyrimidinové ribonukleosidy pro terapeutické použití
MX2021001486A (es) * 2018-08-07 2021-07-15 Merck Sharp & Dohme Llc Inhibidores prmt5.
US11964988B2 (en) 2018-09-10 2024-04-23 Array Biopharma Inc. Fused heterocyclic compounds as RET kinase inhibitors
CA3143911A1 (en) * 2019-06-18 2020-12-24 Taiho Pharmaceutical Co., Ltd. Phosphate ester compound having pyrrolopyrimidine skeleton or pharmaceutically acceptable salt thereof
US20230104311A1 (en) * 2020-02-17 2023-04-06 Katholieke Universiteit Leuven Novel 6-substituted 7-deazapurines and corresponding nucleosides as medicaments
EP4300796A1 (en) 2021-02-26 2024-01-03 Hitachi Industrial Products, Ltd. Dynamo-electric machine
EP4408854A1 (en) 2021-09-28 2024-08-07 Universiteit Antwerpen Nucleoside analogues for the treatment of parasitic infections

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL108523A0 (en) * 1993-02-03 1994-05-30 Gensia Inc Pharmaceutical compositions containing adenosine kinase inhibitors for preventing or treating conditions involving inflammatory responses and pain
ES2532836T3 (es) * 2001-01-22 2015-04-01 Merck Sharp & Dohme Corp. Derivados de nucleósidos como inhibidores de la ARN polimerasa viral dependiente de ARN
AU2002353165A1 (en) * 2001-12-17 2003-06-30 Ribapharm Inc. Deazapurine nucleoside libraries and compounds
WO2003093290A2 (en) * 2002-05-06 2003-11-13 Genelabs Technologies, Inc. Nucleoside derivatives for treating hepatitis c virus infection
US20040157892A1 (en) 2003-02-12 2004-08-12 Crompton Co./Cie Pesticidal fluoroethyl pyrazoles
US7202223B2 (en) * 2003-10-27 2007-04-10 Genelabs Technologies, Inc. Nucleoside compounds for treating viral infections
WO2005044835A1 (en) * 2003-10-27 2005-05-19 Genelabs Technologies, Inc. METHODS FOR PREPARING 7-(2'-SUBSTITUTED-ß-D-RIBOFURANOSYL)-4-(NR2R3)-5-(SUBSTITUTED ETHYN-1-YL)-PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES
MXPA06004680A (es) * 2003-10-27 2007-04-17 Genelabs Tech Inc Compuestos de nucleosido para el tratamiento de infecciones virales.
WO2006033709A2 (en) * 2004-07-29 2006-03-30 Metabasis Therapeutics, Inc. Novel nucleoside derivatives
HUE041598T2 (hu) * 2008-01-18 2019-05-28 Inst Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Újfajta citosztatikus 7-deazapurin nukleozidok
WO2010008761A1 (en) * 2008-06-23 2010-01-21 Janssen Pharmaceutica Nv Piperidyl acrylamide antogonists of ccr2
GB0815968D0 (en) * 2008-09-03 2008-10-08 Angeletti P Ist Richerche Bio Antiviral agents
NZ700583A (en) * 2009-04-22 2016-04-29 Acad Of Science Czech Republic Novel 7-deazapurine nucleosides for therapeutic uses

Also Published As

Publication number Publication date
US10294262B2 (en) 2019-05-21
CA2759131A1 (en) 2010-10-28
AU2010238985A1 (en) 2011-12-01
ES2437917T3 (es) 2014-01-15
MX2011011160A (es) 2012-01-27
AU2017204148B2 (en) 2018-12-06
WO2010121576A2 (en) 2010-10-28
NZ596301A (en) 2014-10-31
AU2017204148A1 (en) 2017-07-06
JP5721275B2 (ja) 2015-05-20
AU2015205885B2 (en) 2017-04-06
CA2759131C (en) 2017-06-20
JP2012524731A (ja) 2012-10-18
CN104497084B (zh) 2018-06-05
US20170240584A1 (en) 2017-08-24
SI2421879T1 (sl) 2014-01-31
CN104497084A (zh) 2015-04-08
CN102459300B (zh) 2014-12-10
CA2966647A1 (en) 2010-10-28
DK2421879T3 (da) 2013-11-25
CN102459300A (zh) 2012-05-16
US20150218201A1 (en) 2015-08-06
AU2015205885A1 (en) 2015-09-03
PT2421879E (pt) 2013-12-09
JP6087889B2 (ja) 2017-03-01
WO2010121576A3 (en) 2011-06-16
EP2421879A2 (en) 2012-02-29
HRP20131021T1 (hr) 2014-01-31
AU2010238985B2 (en) 2015-04-23
NZ700583A (en) 2016-04-29
EP2421879B1 (en) 2013-09-04
HK1166325A1 (en) 2012-12-14
US9321800B2 (en) 2016-04-26
US20160318970A1 (en) 2016-11-03
JP2015013901A (ja) 2015-01-22
PL2421879T3 (pl) 2014-02-28
US9624257B2 (en) 2017-04-18

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