HK1165410A1 - Intermediary (aza)indole derivative substituted in position 5 5 () - Google Patents

Intermediary (aza)indole derivative substituted in position 5 5 ()

Info

Publication number
HK1165410A1
HK1165410A1 HK12105916.6A HK12105916A HK1165410A1 HK 1165410 A1 HK1165410 A1 HK 1165410A1 HK 12105916 A HK12105916 A HK 12105916A HK 1165410 A1 HK1165410 A1 HK 1165410A1
Authority
HK
Hong Kong
Prior art keywords
aza
intermediary
indole derivative
derivative substituted
substituted
Prior art date
Application number
HK12105916.6A
Other languages
English (en)
Chinese (zh)
Inventor
Maria Alessandra Alisi
Guido Furlotti
Nicola Cazzolla
Caterina Maugeri
Patrizia Dragone
Barbara Garofalo
Isabella Coletta
Giorgina Mangano
Beatrice Garrone
Original Assignee
Acraf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acraf filed Critical Acraf
Publication of HK1165410A1 publication Critical patent/HK1165410A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
HK12105916.6A 2007-12-28 2010-12-07 Intermediary (aza)indole derivative substituted in position 5 5 () HK1165410A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07425830A EP2078711A1 (fr) 2007-12-28 2007-12-28 Dérivés (aza)indole substitués en position 5, compositions pharmaceutiques, composés intermédiaires et procédé de préparation

Publications (1)

Publication Number Publication Date
HK1165410A1 true HK1165410A1 (en) 2012-10-05

Family

ID=39167787

Family Applications (2)

Application Number Title Priority Date Filing Date
HK12105916.6A HK1165410A1 (en) 2007-12-28 2010-12-07 Intermediary (aza)indole derivative substituted in position 5 5 ()
HK10111381.2A HK1145172A1 (en) 2007-12-28 2010-12-07 (aza)indole derivative substituted in position 5, pharmaceutical composition comprising it, intermediate compounds and preparation process therefor

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK10111381.2A HK1145172A1 (en) 2007-12-28 2010-12-07 (aza)indole derivative substituted in position 5, pharmaceutical composition comprising it, intermediate compounds and preparation process therefor

Country Status (21)

Country Link
US (2) US8399477B2 (fr)
EP (3) EP2078711A1 (fr)
JP (1) JP5698985B2 (fr)
KR (2) KR20160029861A (fr)
CN (1) CN101910127B (fr)
AR (1) AR069961A1 (fr)
AU (1) AU2008342705B2 (fr)
BR (1) BRPI0821450A2 (fr)
CA (1) CA2707339C (fr)
DK (2) DK2234968T3 (fr)
EA (1) EA020373B1 (fr)
ES (2) ES2523167T3 (fr)
GE (1) GEP20125547B (fr)
HK (2) HK1165410A1 (fr)
IL (1) IL206062A (fr)
PL (2) PL2234968T3 (fr)
PT (2) PT2234968E (fr)
SG (1) SG187400A1 (fr)
SI (2) SI2444392T1 (fr)
UA (1) UA100867C2 (fr)
WO (1) WO2009083436A1 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101365824B1 (ko) 2010-10-22 2014-02-20 엘지디스플레이 주식회사 유기전계발광소자
SG11201606080SA (en) 2014-02-03 2016-08-30 Vitae Pharmaceuticals Inc Dihydropyrrolopyridine inhibitors of ror-gamma
BR112016023679A2 (pt) * 2014-04-14 2017-08-15 Jiangsu Hengrui Medicine Co derivados de amida e sais farmaceuticamente aceitáveis dos mesmos, método de preparação dos mesmos e aplicação medicinal dos mesmos
US9663515B2 (en) 2014-11-05 2017-05-30 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
ES2856931T3 (es) 2015-08-05 2021-09-28 Vitae Pharmaceuticals Llc Moduladores de ROR-gamma
US11008340B2 (en) 2015-11-20 2021-05-18 Vitae Pharmaceuticals, Llc Modulators of ROR-gamma
TW202220968A (zh) 2016-01-29 2022-06-01 美商維它藥物有限責任公司 ＲＯＲ－γ調節劑
CN107033026A (zh) * 2017-06-07 2017-08-11 李博强 一种对硝基苯肼盐酸盐的制备方法
WO2019023207A1 (fr) 2017-07-24 2019-01-31 Vitae Pharmaceuticals, Inc. Inhibiteurs de rorƴ
WO2019018975A1 (fr) 2017-07-24 2019-01-31 Vitae Pharmaceuticals, Inc. Inhibiteurs de ror gamma
US20230000821A1 (en) * 2019-08-26 2023-01-05 Kukje Pharma Co., Ltd. Indole carboxamide derivative and pharmaceutical composition containing same
CN114605303A (zh) * 2022-03-14 2022-06-10 武汉工程大学 一种地拉韦啶及其中间体的合成方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2354766A1 (fr) * 1976-06-17 1978-01-13 Labaz Derives n-aminoalkyles d'indole et procedes pour les preparer
US6114532A (en) * 1998-02-03 2000-09-05 Boehringer Ingelheim Pharma Kg Bicyclic heterocycles, the preparation thereof, and their use as pharmaceuticals
AU2720199A (en) * 1998-02-03 1999-08-23 Boehringer Ingelheim Pharma Kg Five-membered, benzo-condensed heterocycles used as antithrombotic agents
DE19834751A1 (de) * 1998-08-01 2000-02-03 Boehringer Ingelheim Pharma Disubstituierte bicyclische Heterocyclen, ihre Herstellung und ihre Verwendung als Arzneimittel
WO2001070743A1 (fr) * 2000-03-20 2001-09-27 Axys Pharmaceuticals, Inc. Inhibiteurs de la protease exempte d'amidine
US20020052373A1 (en) * 2000-10-26 2002-05-02 Zorn Stevin H. Combination treatment for dementia or cognitive deficits associated with alzheimer's disease and parkinson's disease
IL140096A0 (en) * 2000-12-05 2002-02-10 Internat Specialty Products Is Process for preparation of zafirlukast
DE10147672A1 (de) * 2001-09-27 2003-04-10 Bayer Ag Substituierte 2,5-Diamidoindole und ihre Verwendung
EP1578418A2 (fr) * 2002-12-20 2005-09-28 Bayer HealthCare AG Utilisation de 2,5-diamidoindoles substitues pour le traitement de maladies urologiques
SE0300908D0 (sv) * 2003-03-31 2003-03-31 Astrazeneca Ab Azaindole derivatives, preparations thereof, uses thereof and compositions containing them
WO2006066913A2 (fr) * 2004-12-23 2006-06-29 F. Hoffmann-La Roche Ag Derives benzamides, leur fabrication et leur utilisation comme agents pharmaceutiques
CA2620899A1 (fr) * 2005-10-12 2007-04-19 Biolipox Ab Benzoxazoles convenant pour le traitement d'une inflammation
DK2007756T3 (en) * 2006-04-07 2015-10-05 Vertex Pharma MODULATORS OF ATP BINDING CASSETTE TRANSPORT
JP2008006663A (ja) * 2006-06-28 2008-01-17 Pilot Ink Co Ltd 出没式筆記具
ITMI20061368A1 (it) * 2006-07-14 2008-01-15 Acraf Composto 2-arilindolico sostituito in posizione 5, composizione farmaceutica che lo comprende nonche' composti intermedi e procedimento per prepararlo

Also Published As

Publication number Publication date
DK2234968T3 (da) 2013-06-17
IL206062A0 (en) 2010-11-30
ES2523167T3 (es) 2014-11-21
AU2008342705A1 (en) 2009-07-09
GEP20125547B (en) 2012-05-25
EP2078711A1 (fr) 2009-07-15
US8399477B2 (en) 2013-03-19
JP2011507929A (ja) 2011-03-10
BRPI0821450A2 (pt) 2015-06-16
PL2444392T3 (pl) 2015-03-31
CA2707339A1 (fr) 2009-07-09
US20100286189A1 (en) 2010-11-11
AR069961A1 (es) 2010-03-03
JP5698985B2 (ja) 2015-04-08
EA201070804A1 (ru) 2010-12-30
PT2234968E (pt) 2013-06-03
EA020373B1 (ru) 2014-10-30
SI2234968T1 (sl) 2013-06-28
AU2008342705B2 (en) 2013-11-14
IL206062A (en) 2015-08-31
US8871948B2 (en) 2014-10-28
CN101910127A (zh) 2010-12-08
WO2009083436A1 (fr) 2009-07-09
CN101910127B (zh) 2013-01-23
DK2444392T3 (en) 2014-12-08
HK1145172A1 (en) 2011-04-08
EP2444392A1 (fr) 2012-04-25
EP2444392B1 (fr) 2014-09-24
ES2408955T3 (es) 2013-06-24
CA2707339C (fr) 2018-05-01
KR101671874B1 (ko) 2016-11-03
US20130158269A1 (en) 2013-06-20
EP2234968B1 (fr) 2013-03-27
EP2234968A1 (fr) 2010-10-06
KR20100103569A (ko) 2010-09-27
PT2444392E (pt) 2014-11-19
SG187400A1 (en) 2013-02-28
KR20160029861A (ko) 2016-03-15
UA100867C2 (uk) 2013-02-11
PL2234968T3 (pl) 2013-08-30
SI2444392T1 (sl) 2014-12-31

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20181220