HK1156660A1 - Focused libraries of genetic packages - Google Patents

Focused libraries of genetic packages

Info

Publication number
HK1156660A1
HK1156660A1 HK11110875.6A HK11110875A HK1156660A1 HK 1156660 A1 HK1156660 A1 HK 1156660A1 HK 11110875 A HK11110875 A HK 11110875A HK 1156660 A1 HK1156660 A1 HK 1156660A1
Authority
HK
Hong Kong
Prior art keywords
display
genetic packages
libraries
focused
focused libraries
Prior art date
Application number
HK11110875.6A
Other languages
English (en)
Inventor
Robert Charles Ladner
Original Assignee
Dyax Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dyax Corp filed Critical Dyax Corp
Publication of HK1156660A1 publication Critical patent/HK1156660A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C40B40/08—Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Luminescent Compositions (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Catalysts (AREA)
HK11110875.6A 2000-12-18 2011-10-13 Focused libraries of genetic packages HK1156660A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25638000P 2000-12-18 2000-12-18

Publications (1)

Publication Number Publication Date
HK1156660A1 true HK1156660A1 (en) 2012-06-15

Family

ID=22972033

Family Applications (1)

Application Number Title Priority Date Filing Date
HK11110875.6A HK1156660A1 (en) 2000-12-18 2011-10-13 Focused libraries of genetic packages

Country Status (12)

Country Link
US (10) US20030119056A1 (fr)
EP (2) EP2316940B1 (fr)
JP (2) JP4860098B2 (fr)
AT (1) ATE498718T1 (fr)
AU (1) AU2002249854B2 (fr)
CA (2) CA2784251A1 (fr)
DE (1) DE60144063D1 (fr)
DK (2) DK2316940T3 (fr)
ES (2) ES2430857T3 (fr)
HK (1) HK1156660A1 (fr)
PT (2) PT1360288E (fr)
WO (1) WO2002061071A2 (fr)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2199393B1 (fr) * 2000-04-17 2012-10-31 Dyax Corp. Nouveaux procédés de construction de bibliothèques de paquets génétiques qui affichent collectivement une famille diverse de peptides, polypeptides ou protéines
US8288322B2 (en) * 2000-04-17 2012-10-16 Dyax Corp. Methods of constructing libraries comprising displayed and/or expressed members of a diverse family of peptides, polypeptides or proteins and the novel libraries
WO2002061071A2 (fr) 2000-12-18 2002-08-08 Dyax Corp. Banques ciblees de capsides genetiques
US20040067532A1 (en) 2002-08-12 2004-04-08 Genetastix Corporation High throughput generation and affinity maturation of humanized antibody
GB0230201D0 (en) * 2002-12-27 2003-02-05 Domantis Ltd Retargeting
GB0230203D0 (en) * 2002-12-27 2003-02-05 Domantis Ltd Fc fusion
US7785903B2 (en) 2004-04-09 2010-08-31 Genentech, Inc. Variable domain library and uses
JP5143551B2 (ja) 2004-07-06 2013-02-13 バイオレン，インク． ユニバーサル抗体のライブラリー
WO2006084050A2 (fr) * 2005-02-01 2006-08-10 Dyax Corp. Banques et methodes permettant d'isoler des anticorps
EP2465870A1 (fr) * 2005-11-07 2012-06-20 Genentech, Inc. Polypeptides de liaison dotés de séquences hypvervariables VH/VL diversifiées et consensuelles
RU2470941C2 (ru) * 2005-12-02 2012-12-27 Дженентек, Инк. Связывающие полипептиды и их применения
CN101370832B (zh) * 2005-12-02 2014-07-02 健泰科生物技术公司 结合多肽及其用途
EP1973951A2 (fr) * 2005-12-02 2008-10-01 Genentech, Inc. Polypeptides de liaison avec des sequences de diversite limitees
NZ569359A (en) * 2005-12-20 2011-11-25 Morphosys Ag Novel collection of HCDR3 regions and uses therefor
EP2024393A2 (fr) * 2006-05-15 2009-02-18 Sea Lane Biotechnologies,llc. Anticorps neutralisants dirigés contre les virus de la grippe
US8148085B2 (en) 2006-05-15 2012-04-03 Sea Lane Biotechnologies, Llc Donor specific antibody libraries
MX2010002661A (es) 2007-09-14 2010-05-20 Adimab Inc Bancos de anticuerpos sinteticos, designados racionalmente y usos para los mismos.
US8877688B2 (en) 2007-09-14 2014-11-04 Adimab, Llc Rationally designed, synthetic antibody libraries and uses therefor
WO2009114815A1 (fr) * 2008-03-13 2009-09-17 Dyax Corp Bibliothèques de boîtiers génétiques comprenant de nouvelles conceptions de hc cdr3
CA2722409C (fr) 2008-04-24 2017-12-12 Dyax Corp. Bibliotheques de materiels genetiques comprenant de nouvelles conceptions cdr1, cdr2 et cdr3 hc et de nouvelles conceptions cdr1, cdr2 et cdr3 lc
WO2011032181A2 (fr) * 2009-09-14 2011-03-17 Dyax Corp. Bibliothèques d'ensembles génétiques comprenant de nouvelles conceptions de hc cdr3
KR20210129278A (ko) 2010-07-16 2021-10-27 아디맵 엘엘씨 항체 라이브러리
ES2696548T3 (es) 2010-11-19 2019-01-16 Morphosys Ag Una colección de secuencias de anticuerpos y su uso
CA2845391C (fr) * 2011-08-18 2021-01-19 Affinity Biosciences Pty Ltd Polypeptides solubles
JP6498600B2 (ja) 2012-06-08 2019-04-10 ストロ バイオファーマ インコーポレーテッド 部位特異的な非天然アミノ酸残基を含む抗体、その調製方法、及びその使用方法
US9764039B2 (en) 2013-07-10 2017-09-19 Sutro Biopharma, Inc. Antibodies comprising multiple site-specific non-natural amino acid residues, methods of their preparation and methods of their use
NZ722807A (en) 2014-02-10 2019-05-31 Philip Morris Products Sa Cartridge with a heater assembly for an aerosol-generating system
EP3126384B1 (fr) 2014-04-01 2020-12-02 Adimab, LLC Analogues d'anticorps multispécifiques comprenant une chaîne légère commune, et leur procédés de préparation et leur utilisation
TWI695011B (zh) 2014-06-18 2020-06-01 美商梅爾莎納醫療公司 抗ｈｅｒ２表位之單株抗體及其使用之方法
ES2753551T3 (es) 2014-07-22 2020-04-13 Sutro Biopharma Inc Anticuerpos anti-cd74, composiciones que comprenden anticuerpos anti-CD74 y procedimientos de uso de los anticuerpos anti-CD74
AU2016245887B2 (en) 2015-04-10 2021-09-23 Adimab, Llc. Methods for purifying heterodimeric multispecific antibodies from parental homodimeric antibody species
PL3821730T3 (pl) 2015-07-09 2023-10-02 Philip Morris Products S.A. Zespół ogrzewacza do układu wytwarzania aerozolu
EP3377533A2 (fr) 2015-11-19 2018-09-26 Sutro Biopharma, Inc. Anticorps anti-lag3, compositions comprenant des anticorps anti-lag3 et méthodes de production et d'utilisation d'anticorps anti-lag3
CA3011455A1 (fr) 2016-01-27 2017-08-03 Sutro Biopharma, Inc. Conjugues d'anticorps anti-cd74, compositions comprenant des conjugues d'anticorps anti-cd74 et methodes d'utilisations desdits conjugues d'anticorps anti-cd74
AU2017234163B2 (en) 2016-03-15 2023-01-19 Mersana Therapeutics, Inc. NaPi2b-targeted antibody-drug conjugates and methods of use thereof
EP3472197A1 (fr) 2016-06-15 2019-04-24 Sutro Biopharma, Inc. Anticorps à domaines ch2 modifiés, compositions les contenant et leurs procédés d'utilisation
EP3293293A1 (fr) 2016-09-08 2018-03-14 Italfarmaco SpA Bibliothèques uniquement de hc-cdr3-avec redondance combinatoire réduite et distribution de longueur de boucle optimisée
EP3526254A1 (fr) 2016-10-12 2019-08-21 Sutro Biopharma, Inc. Anticorps anti-récepteur de folate, compositions comprenant des anticorps anti-récepteur de folate et procédés de fabrication et d'utilisation d'anticorps de récepteur anti-folate
JOP20190100A1 (ar) 2016-11-19 2019-05-01 Potenza Therapeutics Inc بروتينات ربط مولد ضد مضاد لـ gitr وطرق استخدامها
JOP20190134A1 (ar) 2016-12-23 2019-06-02 Potenza Therapeutics Inc بروتينات رابطة لمولد ضد مضادة لنيوروبيلين وطرق استخدامها
WO2018156777A1 (fr) 2017-02-22 2018-08-30 Sutro Biopharma, Inc. Anticorps bispécifiques anti-pd-1/tim -3, compositions de ceux-ci, et procédés de fabrication et d'utilisation de ceux-ci
JOP20190203A1 (ar) 2017-03-30 2019-09-03 Potenza Therapeutics Inc بروتينات رابطة لمولد ضد مضادة لـ tigit وطرق استخدامها
WO2018217944A1 (fr) 2017-05-24 2018-11-29 Sutro Biopharma, Inc. Anticorps bispécifiques anti-pd-1/lag3, compositions de ceux-ci et procédés de fabrication et d'utilisation de ceux-ci
CN111278858A (zh) 2017-07-11 2020-06-12 指南针制药有限责任公司 结合人cd137的激动剂抗体及其用途
SG11202000658PA (en) 2017-07-26 2020-02-27 Forty Seven Inc Anti-sirp-alpha antibodies and related methods
US20200207859A1 (en) 2017-07-26 2020-07-02 Sutro Biopharma, Inc. Methods of using anti-cd74 antibodies and antibody conjugates in treatment of t-cell lymphoma
MA50265A (fr) 2017-09-18 2020-07-29 Sutro Biopharma Inc Conjugués anticorps-récepteur alpha anti-folate et leurs utilisations
US11718679B2 (en) 2017-10-31 2023-08-08 Compass Therapeutics Llc CD137 antibodies and PD-1 antagonists and uses thereof
EP3713961A2 (fr) 2017-11-20 2020-09-30 Compass Therapeutics LLC Anticorps cd137 et anticorps ciblant un antigène tumoral et leurs utilisations
CN111818943A (zh) 2018-01-04 2020-10-23 伊科尼克治疗公司 抗组织因子抗体、抗体-药物缀合物及相关方法
WO2019190969A1 (fr) 2018-03-26 2019-10-03 Sutro Biopharma, Inc. Anticorps anti-récepteur bcma, compositions comprenant des anticorps anti-récepteur bcma et procédés de fabrication et d'utilisation d'anticorps anti-bcma
WO2020060944A1 (fr) 2018-09-17 2020-03-26 Sutro Biopharma, Inc. Polythérapies avec des conjugués d'anticorps anti-récepteur du folate
US20210340259A1 (en) 2018-09-27 2021-11-04 Tizona Therapeutics Anti-hla-g antibodies, compositions comprising anti-hla-g antibodies and methods of using anti-hla-g antibodies
CN113166269A (zh) 2018-11-13 2021-07-23 指南针制药有限责任公司 对抗检查点分子的多特异性结合构建体及其用途
US20230242660A1 (en) 2019-02-21 2023-08-03 Trishula Therapeutics, Inc. Combination therapy involving anti-cd39 antibodies and anti-pd-1 or anti-pd-l1 antibodies
CA3134918A1 (fr) 2019-05-03 2020-11-12 John Lee Conjugue d'anticorps anti-bcma, compositions les comprenant, et procedes de fabrication et d'utilisation de ceux-ci
EP3962951A1 (fr) 2019-05-03 2022-03-09 Sutro Biopharma, Inc. Conjugués d'anticorps anti-bcma
WO2020252043A1 (fr) 2019-06-10 2020-12-17 Sutro Biopharma, Inc. Composés 5h-pyrrolo[3,2-d]pyrimidine-2,4-diamino et conjugués d'anticorps associés
EP3983410A1 (fr) 2019-06-17 2022-04-20 Sutro Biopharma, Inc. Dérivés de 1-(4-(aminométhyl)benzyl)-2-butyl-2h-pyrazolo[3,4-c]quinoléin-4-amine et composés apparentés en tant qu'agonistes du récepteur 7/8 de type toll (tlr), ainsi que des conjugués anticorps-médicament de ceux-ci destinés à être utilisés dans la thérapie et le diagnostic du cancer
US11931420B2 (en) 2021-04-30 2024-03-19 Celgene Corporation Combination therapies using an anti-BCMA antibody drug conjugate (ADC) in combination with a gamma secretase inhibitor (GSI)
EP4340876A1 (fr) 2021-05-19 2024-03-27 Sutro Biopharma, Inc. Polythérapie à conjugué de récepteur anti-folate avec du bévacizumab
WO2023028501A1 (fr) 2021-08-23 2023-03-02 Immunitas Therapeutics, Inc. Anticorps anti-cd161 et leurs utilisations
WO2023102077A1 (fr) 2021-12-01 2023-06-08 Sutro Biopharma, Inc. Thérapie anticancéreuse basée sur un conjugué de récepteur anti-folate
WO2023104904A2 (fr) 2021-12-08 2023-06-15 Genclis Sars-cov-2 et variants utilisant deux récepteurs cellulaires indépendants pour la réplication

Family Cites Families (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5118605A (en) * 1984-10-16 1992-06-02 Chiron Corporation Polynucleotide determination with selectable cleavage sites
DE3546806C2 (fr) * 1985-03-30 1991-03-28 Marc Genf/Geneve Ch Ballivet
US6492107B1 (en) * 1986-11-20 2002-12-10 Stuart Kauffman Process for obtaining DNA, RNA, peptides, polypeptides, or protein, by recombinant DNA technique
US5618920A (en) * 1985-11-01 1997-04-08 Xoma Corporation Modular assembly of antibody genes, antibodies prepared thereby and use
US5223409A (en) * 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5688666A (en) * 1988-10-28 1997-11-18 Genentech, Inc. Growth hormone variants with altered binding properties
US5750373A (en) * 1990-12-03 1998-05-12 Genentech, Inc. Enrichment method for variant proteins having altered binding properties, M13 phagemids, and growth hormone variants
WO1990005144A1 (fr) * 1988-11-11 1990-05-17 Medical Research Council Ligands a domaine unique, recepteurs comprenant lesdits ligands, procedes pour leur production, et emploi desdits ligands et recepteurs
US6969586B1 (en) * 1989-05-16 2005-11-29 Scripps Research Institute Method for tapping the immunological repertoire
US6680192B1 (en) * 1989-05-16 2004-01-20 Scripps Research Institute Method for producing polymers having a preselected activity
US6291161B1 (en) * 1989-05-16 2001-09-18 Scripps Research Institute Method for tapping the immunological repertiore
US6291159B1 (en) * 1989-05-16 2001-09-18 Scripps Research Institute Method for producing polymers having a preselected activity
US6291160B1 (en) * 1989-05-16 2001-09-18 Scripps Research Institute Method for producing polymers having a preselected activity
US6291158B1 (en) * 1989-05-16 2001-09-18 Scripps Research Institute Method for tapping the immunological repertoire
DE4002897A1 (de) * 1990-02-01 1991-08-08 Behringwerke Ag Herstellung und verwendung von genbanken synthetischer menschlicher antikoerper ("synthetische human-antikoerper-bibliotheken")
ATE449853T1 (de) * 1990-02-01 2009-12-15 Siemens Healthcare Diagnostics HERSTELLUNG UND VERWENDUNG VON GENBANKEN MENSCHLICHER ANTIKÖRPER(ßHUMAN-ANTIKÖRPER- BIBLIOTHEKENß)
DE69112207T2 (de) * 1990-04-05 1996-03-28 Roberto Crea "walk-through"-mutagenese.
KR100193802B1 (ko) 1990-04-18 1999-06-15 한스 월터 라벤 돌연변이된 베타-락탐 아실라아제 유전자
US7063943B1 (en) * 1990-07-10 2006-06-20 Cambridge Antibody Technology Methods for producing members of specific binding pairs
US6172197B1 (en) * 1991-07-10 2001-01-09 Medical Research Council Methods for producing members of specific binding pairs
GB9206318D0 (en) * 1992-03-24 1992-05-06 Cambridge Antibody Tech Binding substances
GB9015198D0 (en) * 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
US6916605B1 (en) * 1990-07-10 2005-07-12 Medical Research Council Methods for producing members of specific binding pairs
US5780279A (en) * 1990-12-03 1998-07-14 Genentech, Inc. Method of selection of proteolytic cleavage sites by directed evolution and phagemid display
DK1471142T3 (da) * 1991-04-10 2009-03-09 Scripps Research Inst Heterodimere receptor-biblioteker under anvendelse af fagemider
US5858657A (en) * 1992-05-15 1999-01-12 Medical Research Council Methods for producing members of specific binding pairs
US6492160B1 (en) * 1991-05-15 2002-12-10 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
US5871907A (en) * 1991-05-15 1999-02-16 Medical Research Council Methods for producing members of specific binding pairs
US6225447B1 (en) * 1991-05-15 2001-05-01 Cambridge Antibody Technology Ltd. Methods for producing members of specific binding pairs
US5962255A (en) * 1992-03-24 1999-10-05 Cambridge Antibody Technology Limited Methods for producing recombinant vectors
JPH06509473A (ja) * 1991-08-10 1994-10-27 メディカル・リサーチ・カウンシル 細胞個体群の処理
US5565332A (en) * 1991-09-23 1996-10-15 Medical Research Council Production of chimeric antibodies - a combinatorial approach
US5872215A (en) * 1991-12-02 1999-02-16 Medical Research Council Specific binding members, materials and methods
ES2227512T3 (es) * 1991-12-02 2005-04-01 Medical Research Council Produccion de anticuerpos contra auto-antigenos a partir de repertorios de segmentos de anticuerpos fijados en un fago.
US5733743A (en) * 1992-03-24 1998-03-31 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
ATE233814T1 (de) 1992-09-30 2003-03-15 Scripps Research Inst Humaner neutralisierender monoklonaler antikörper gegen den die immunschwäche beim menschen hervorringenden virus
AU690528B2 (en) * 1992-12-04 1998-04-30 Medical Research Council Multivalent and multispecific binding proteins, their manufacture and use
GB9225453D0 (en) * 1992-12-04 1993-01-27 Medical Res Council Binding proteins
DE69432744T2 (de) * 1993-02-04 2004-03-25 Borean Pharma A/S Verbessertes verfahren zur rückfaltung der proteine
GB9313509D0 (en) * 1993-06-30 1993-08-11 Medical Res Council Chemisynthetic libraries
AU680685B2 (en) * 1993-09-22 1997-08-07 Medical Research Council Retargeting antibodies
DK1143006T3 (da) * 1995-08-18 2008-07-14 Morphosys Ip Gmbh Vektorer/DNA-sekvenser fra humane kombinatoriske antistofbiblioteker
US7264963B1 (en) * 1995-08-18 2007-09-04 Morphosys Ag Protein(poly)peptide libraries
FR2741892B1 (fr) 1995-12-04 1998-02-13 Pasteur Merieux Serums Vacc Procede de preparation d'une banque multicombinatoire de vecteurs d'expression de genes d'anticorps, banque et systemes d'expression d'anticorps "coliclonaux" obtenus
US6747136B2 (en) 1996-04-19 2004-06-08 Karolinska Innovations Ab Human monoclonal antibodies specific for hepatitis C virus (HCV) E2 antigen
US6300065B1 (en) 1996-05-31 2001-10-09 Board Of Trustees Of The University Of Illinois Yeast cell surface display of proteins and uses thereof
DE19624562A1 (de) 1996-06-20 1998-01-02 Thomas Dr Koehler Verfahren zur Bestimmung von Konzentrationsverhältnissen zweier sich um mindestens ein Nucleotid unterscheidender Nucleinsäuren und Testkit zur Durchführung des Verfahrens
NZ333329A (en) 1996-06-24 2000-07-28 Rotkreuzstiftung Zentrallab Polypeptides capable of forming antigen binding structures with specificity for rhesus d antigens
GB9712818D0 (en) * 1996-07-08 1997-08-20 Cambridge Antibody Tech Labelling and selection of specific binding molecules
US5858671A (en) * 1996-11-01 1999-01-12 The University Of Iowa Research Foundation Iterative and regenerative DNA sequencing method
JP2002514919A (ja) * 1997-04-04 2002-05-21 バイオサイト ダイアグノスティックス，インコーポレイテッド 多価ライブラリーおよびポリクローナルライブラリー
US6057098A (en) * 1997-04-04 2000-05-02 Biosite Diagnostics, Inc. Polyvalent display libraries
US20030044772A1 (en) 1997-08-04 2003-03-06 Applied Molecular Evolution [Formerly Ixsys] Methods for identifying ligand specific binding molecules
EP1007967A2 (fr) * 1997-08-04 2000-06-14 Ixsys, Incorporated Procedes permettant d'identifier des molecules de liaison presentant une affinite specifique pour des ligands
GB9722131D0 (en) * 1997-10-20 1997-12-17 Medical Res Council Method
US7244826B1 (en) 1998-04-24 2007-07-17 The Regents Of The University Of California Internalizing ERB2 antibodies
US6794128B2 (en) 1998-04-24 2004-09-21 The Regents Of The University Of California Methods of selecting internalizing antibodies
WO2000018905A1 (fr) 1998-09-25 2000-04-06 G.D. Searle & Co. Procede de production de permuteines par permutagenese d'exploration
US6531580B1 (en) * 1999-06-24 2003-03-11 Ixsys, Inc. Anti-αvβ3 recombinant human antibodies and nucleic acids encoding same
PT1144607E (pt) * 1999-07-20 2009-04-22 Morphosys Ag Novos métodos para apresentar (poli)peptídeos/ proteínas em partículas bacteriofágicas através de ligações dissulfureto
EP2199393B1 (fr) * 2000-04-17 2012-10-31 Dyax Corp. Nouveaux procédés de construction de bibliothèques de paquets génétiques qui affichent collectivement une famille diverse de peptides, polypeptides ou protéines
US8288322B2 (en) * 2000-04-17 2012-10-16 Dyax Corp. Methods of constructing libraries comprising displayed and/or expressed members of a diverse family of peptides, polypeptides or proteins and the novel libraries
ATE494304T1 (de) 2000-06-16 2011-01-15 Human Genome Sciences Inc Immunspezifisch bindende antikörper gegen blys
US20050158838A1 (en) * 2000-06-19 2005-07-21 Dyax Corp., A Delaware Corporation Novel enterokinase cleavage sequences
WO2002061071A2 (fr) 2000-12-18 2002-08-08 Dyax Corp. Banques ciblees de capsides genetiques
DE10230997A1 (de) * 2001-10-26 2003-07-17 Ribopharma Ag Medikament zur Erhöhung der Wirksamkeit eines Rezeptor-vermittelt Apoptose in Tumorzellen auslösenden Arzneimittels
ATE386810T1 (de) 2002-06-14 2008-03-15 Dyax Corp Rekombination von nukleinsäurebibliotheksmitgliedern
MX2010002661A (es) * 2007-09-14 2010-05-20 Adimab Inc Bancos de anticuerpos sinteticos, designados racionalmente y usos para los mismos.

Also Published As

Publication number Publication date
US8895475B2 (en) 2014-11-25
WO2002061071A3 (fr) 2003-09-12
DE60144063D1 (de) 2011-03-31
US20180291368A1 (en) 2018-10-11
US20030119056A1 (en) 2003-06-26
EP2316940A1 (fr) 2011-05-04
PT2316940E (pt) 2013-10-16
US20120021952A1 (en) 2012-01-26
US20140018261A9 (en) 2014-01-16
ATE498718T1 (de) 2011-03-15
ES2360479T3 (es) 2011-06-06
JP4860098B2 (ja) 2012-01-25
US10604753B2 (en) 2020-03-31
US20200325469A1 (en) 2020-10-15
US20120028840A1 (en) 2012-02-02
PT1360288E (pt) 2011-03-07
WO2002061071A2 (fr) 2002-08-08
US20100292103A1 (en) 2010-11-18
DK2316940T3 (da) 2013-11-04
EP1360288A2 (fr) 2003-11-12
US9617536B2 (en) 2017-04-11
JP2004518432A (ja) 2004-06-24
US20060257937A1 (en) 2006-11-16
JP2008183014A (ja) 2008-08-14
EP1360288B1 (fr) 2011-02-16
US8466091B2 (en) 2013-06-18
US9803190B2 (en) 2017-10-31
US20120028841A1 (en) 2012-02-02
DK1360288T3 (da) 2011-06-14
CA2432377C (fr) 2012-10-09
CA2432377A1 (fr) 2002-08-08
ES2430857T3 (es) 2013-11-22
EP2316940B1 (fr) 2013-07-24
US20120302463A1 (en) 2012-11-29
JP4855436B2 (ja) 2012-01-18
CA2784251A1 (fr) 2002-08-08
US8399384B2 (en) 2013-03-19
US20130178396A1 (en) 2013-07-11
AU2002249854B2 (en) 2007-09-20
US8258082B2 (en) 2012-09-04

Similar Documents

Publication Publication Date Title
HK1156660A1 (en) Focused libraries of genetic packages
WO2002099119A3 (fr) Acides nucleiques et polypeptides associes a b7 utiles pour l'immunomodulation
MXPA02012106A (es) Polipeptidos y acidos nucleicos relacionados con b7 empleados para inmunomodulacion.
WO2003102157A3 (fr) Bibliotheques de phages et anticorps synthetiques
GB2346616B (en) Transport vectors
GB9917027D0 (en) In vitro selection and optional identification of polypeptides using solid support carriers
EP1663278A4 (fr) Peptides mimetiques epo et proteines de fusion
AU6063500A (en) Glycoprotein vi and uses thereof
WO2002102828A3 (fr) Vecteurs de flavivirus chimères
WO2005012531A3 (fr) Polypeptides de liaison avec sequences de diversite restreinte
ATE389668T1 (de) Tumorantigen
AU5358901A (en) Novel methods of constructing libraries of genetic packages that collectively display the members of a diverse family of peptides, polypeptides or proteins
WO2003072595A3 (fr) Methodes fondees sur l'oligomerisation de proteines de stress et produits associes
EP2305710A3 (fr) Bibliothèques de phages et anticorps synthétiques
WO2002088315A3 (fr) Vecteurs phagemides
WO2004020588A3 (fr) Banques de proteines de fusion de la transferine
EP1177212A4 (fr) Gene derive de lawsonia et polypeptides, peptides et proteines sodc associes, et leurs utilisations
EP1183268A4 (fr) Gene derive de lawsonia et polypeptides, peptides et proteines omph apparentes, et leurs utilisations
WO2001000673A8 (fr) Proteines associees aux membranes et secretees, et leurs utilisations
EP1892251A3 (fr) Acides nucléiques et polypeptides apparentés à B7 utiles pour effectuer une immunomodulation
EP1181315A4 (fr) Gene derive de lawsonia, polypeptides flge, peptides et proteines et leurs utilisations
EP1177213A4 (fr) Gene derive de lawsonia, polypeptides, peptides et proteines d'hemolysine et leurs utilisations
EP1561817A3 (fr) CEA modifié et ses utilisations
AU8557801A (en) Modified proteins, isolated novel peptides, and uses thereof
WO2003000846A3 (fr) Gave 3, nouveau recepteur couple a une proteine g

Legal Events

Date Code Title Description
PE Patent expired

Effective date: 20211220