HK1152644A1 - Controlled release compositions for interferon based on block polymers - Google Patents

Controlled release compositions for interferon based on block polymers

Info

Publication number
HK1152644A1
HK1152644A1 HK11106616.8A HK11106616A HK1152644A1 HK 1152644 A1 HK1152644 A1 HK 1152644A1 HK 11106616 A HK11106616 A HK 11106616A HK 1152644 A1 HK1152644 A1 HK 1152644A1
Authority
HK
Hong Kong
Prior art keywords
composition
controlled release
block polymers
release compositions
pharmaceutical
Prior art date
Application number
HK11106616.8A
Other languages
English (en)
Inventor
Anne Chantal Bechet
Riemke Van Dijkhuizen-Radersma
Martin Stigter
Jeroen Mattijs Bezemer
Original Assignee
Biolex Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biolex Therapeutics Inc filed Critical Biolex Therapeutics Inc
Publication of HK1152644A1 publication Critical patent/HK1152644A1/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/21Interferons [IFN]
    • A61K38/212IFN-alpha
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/21Interferons [IFN]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1641Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647Polyesters, e.g. poly(lactide-co-glycolide)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Communicable Diseases (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • AIDS & HIV (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK11106616.8A 2005-01-07 2011-06-28 Controlled release compositions for interferon based on block polymers HK1152644A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP05075043A EP1679065A1 (en) 2005-01-07 2005-01-07 Controlled release compositions for interferon based on PEGT/PBT block copolymers

Publications (1)

Publication Number Publication Date
HK1152644A1 true HK1152644A1 (en) 2012-03-09

Family

ID=34937981

Family Applications (1)

Application Number Title Priority Date Filing Date
HK11106616.8A HK1152644A1 (en) 2005-01-07 2011-06-28 Controlled release compositions for interferon based on block polymers

Country Status (24)

Country Link
US (3) US7736674B2 (pl)
EP (4) EP1679065A1 (pl)
JP (2) JP2008526837A (pl)
KR (2) KR20070118225A (pl)
CN (2) CN101137349B (pl)
AT (1) ATE431134T1 (pl)
AU (2) AU2006213168B2 (pl)
BR (1) BRPI0606514A2 (pl)
CA (1) CA2594434A1 (pl)
CY (1) CY1109297T1 (pl)
DE (1) DE602006006797D1 (pl)
DK (1) DK1843749T3 (pl)
ES (1) ES2327267T3 (pl)
HK (1) HK1152644A1 (pl)
HR (1) HRP20090434T1 (pl)
IL (2) IL184431A (pl)
MX (1) MX2007008293A (pl)
PL (1) PL1843749T3 (pl)
PT (1) PT1843749E (pl)
RS (1) RS51129B (pl)
RU (2) RU2409348C2 (pl)
SG (1) SG158856A1 (pl)
SI (1) SI1843749T1 (pl)
WO (1) WO2006085747A1 (pl)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1679065A1 (en) 2005-01-07 2006-07-12 OctoPlus Sciences B.V. Controlled release compositions for interferon based on PEGT/PBT block copolymers
CA2694440A1 (en) * 2007-07-25 2009-01-29 Biolex Therapeutics, Inc. Controlled release interferon drug products and treatment of hcv infection using same
EP2055299A1 (en) 2007-10-23 2009-05-06 Koninklijke Philips Electronics N.V. Methods for preparing polymer microparticles
EP2205221A2 (en) 2007-10-23 2010-07-14 Koninklijke Philips Electronics N.V. Methods for preparing polymer microparticles
US8999945B2 (en) * 2008-06-30 2015-04-07 Silenseed Ltd Methods, compositions and systems for local delivery of drugs
EP2403537A1 (en) 2009-03-05 2012-01-11 Ascendis Pharma A/S Interferon alpha carrier prodrugs
JP6320912B2 (ja) * 2011-03-25 2018-05-09 セレクタ バイオサイエンシーズ インコーポレーテッドSelecta Biosciences,Inc. 浸透圧媒介性放出合成ナノ担体
US8492386B2 (en) 2011-10-21 2013-07-23 Abbvie Inc. Methods for treating HCV
SG2014011670A (en) 2011-10-21 2014-10-30 Abbvie Inc Combination treatment (eg. with abt-072 or abt -333) of daas for use in treating hcv
CN103826627B (zh) 2011-10-21 2016-02-24 艾伯维公司 包含至少两种直接抗病毒剂和利巴韦林的组合物在制备治疗hcv的药物中的用途
US8466159B2 (en) 2011-10-21 2013-06-18 Abbvie Inc. Methods for treating HCV
WO2016046817A1 (en) 2014-09-24 2016-03-31 Vital Beverages Global Inc. Compositions and methods for selective gi tract delivery
EA201892448A1 (ru) 2016-04-28 2019-06-28 Эмори Юниверсити Алкинсодержащие нуклеотидные и нуклеозидные терапевтические композиции и связанные с ними способы применения
CN114096234A (zh) 2019-07-12 2022-02-25 巴斯夫欧洲公司 生产载有挥发性有机活性物的微粒的方法

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL137652C (pl) * 1962-07-11
US5372808A (en) * 1990-10-17 1994-12-13 Amgen Inc. Methods and compositions for the treatment of diseases with consensus interferon while reducing side effect
US5192743A (en) * 1992-01-16 1993-03-09 Genentech, Inc. Reconstitutable lyophilized protein formulation
ATE227963T1 (de) 1992-04-24 2002-12-15 Osteotech Inc Vorrichtung zum vermeiden von gewebeadhäsionen
US5711968A (en) * 1994-07-25 1998-01-27 Alkermes Controlled Therapeutics, Inc. Composition and method for the controlled release of metal cation-stabilized interferon
EP0582459B1 (en) * 1992-08-07 1998-01-07 Takeda Chemical Industries, Ltd. Production of microcapsules of water-soluble drugs
US5643605A (en) 1993-10-25 1997-07-01 Genentech, Inc. Methods and compositions for microencapsulation of adjuvants
US6117455A (en) 1994-09-30 2000-09-12 Takeda Chemical Industries, Ltd. Sustained-release microcapsule of amorphous water-soluble pharmaceutical active agent
US5612052A (en) 1995-04-13 1997-03-18 Poly-Med, Inc. Hydrogel-forming, self-solvating absorbable polyester copolymers, and methods for use thereof
DE19545257A1 (de) 1995-11-24 1997-06-19 Schering Ag Verfahren zur Herstellung von morphologisch einheitlichen Mikrokapseln sowie nach diesem Verfahren hergestellte Mikrokapseln
CA2238829A1 (en) 1995-11-30 1997-06-05 Board Of Regents, The University Of Texas System Methods and compositions for the diagnosis and treatment of cancer
US5792477A (en) 1996-05-07 1998-08-11 Alkermes Controlled Therapeutics, Inc. Ii Preparation of extended shelf-life biodegradable, biocompatible microparticles containing a biologically active agent
US5980948A (en) * 1996-08-16 1999-11-09 Osteotech, Inc. Polyetherester copolymers as drug delivery matrices
DK0990440T3 (da) 1997-02-27 2009-02-23 Novartis Ag Farmaceutisk sammensætning indeholdende 2-amino-2[2-(4-octylphenyl)-ethyl]-propan-1,3-diol, en lecithin og et saccharid
DK0975334T3 (da) * 1997-04-17 2004-01-19 Amgen Inc Biologisk nedbrydelige mikropartikler til langvarig frigivelse af terapeutiske midler
AR012448A1 (es) 1997-04-18 2000-10-18 Ipsen Pharma Biotech Composicion en forma de microcapsulas o de implantes que comprende un excipiente biodegradable, polimero o co-polimero, o una mezcla de talesexcipientes, y una sustancia activa o una mezcla de sustancias activas, procedimiento para la preparacion de una sustancia soluble en agua de elevada
US6531154B1 (en) 1997-06-10 2003-03-11 Brown University Research Foundation Modulated release from biocompatible polymers
KR20010024556A (ko) * 1997-10-24 2001-03-26 피터 지. 스트링거 불용성 인슐린 조성물
US6270802B1 (en) 1998-10-28 2001-08-07 Oakwood Laboratories L.L.C. Method and apparatus for formulating microspheres and microcapsules
US6194006B1 (en) 1998-12-30 2001-02-27 Alkermes Controlled Therapeutics Inc. Ii Preparation of microparticles having a selected release profile
EP1145713A4 (en) * 1999-01-12 2003-08-06 Kyowa Hakko Kogyo Kk Telomerase inhibitors
US6204308B1 (en) 1999-03-01 2001-03-20 Novartis Ag Organic compounds
US20030206928A1 (en) * 1999-04-07 2003-11-06 Pertti Tormala Bioactive, bioabsorbable surgical polyethylene glycol and polybutylene terephtalate copolymer composites and devices
US6291013B1 (en) 1999-05-03 2001-09-18 Southern Biosystems, Inc. Emulsion-based processes for making microparticles
IL147417A0 (en) 1999-07-15 2002-08-14 Takeda Chemical Industries Ltd Sustained release compositions, methods for producing the same and uses thereof
EP1090928B1 (en) 1999-09-30 2004-05-26 Chienna B.V. Polymers loaded with bioactive agents
US6465425B1 (en) 2000-02-10 2002-10-15 Alkermes Controlled Therapeutics, Inc. Microencapsulation and sustained release of biologically active acid-stable or free sulfhydryl-containing proteins
US6495164B1 (en) 2000-05-25 2002-12-17 Alkermes Controlled Therapeutics, Inc. I Preparation of injectable suspensions having improved injectability
US6479065B2 (en) 2000-08-10 2002-11-12 Alkermes Controlled Therapeutics, Inc. Process for the preparation of polymer-based sustained release compositions
US6471995B1 (en) 2000-09-27 2002-10-29 Alkermes Controlled Therapeutics, Inc. Ii Apparatus and method for preparing microparticles using liquid-liquid extraction
JP4557409B2 (ja) * 2000-11-13 2010-10-06 日東電工株式会社 多孔質ポリイミドの製造方法及び多孔質ポリイミド
ATE309788T1 (de) 2000-12-13 2005-12-15 Merckle Gmbh Mikropartikel mit verbessertem freisetzungsprofil und verfahren zu deren herstellung
CA2433037C (en) 2000-12-28 2010-12-21 Takeda Chemical Industries, Ltd. Sustained-release preparation
RU2191012C1 (ru) 2001-06-20 2002-10-20 Научно-исследовательский испытательный центр (медико-биологической защиты) Государственного научно-исследовательского испытательного института военной медицины МО РФ Глазные капли для лечения эндотелиально-эпителиальной дистрофии роговицы
RU2279292C2 (ru) 2001-10-24 2006-07-10 Пари Гмбх Набор для приготовления фармацевтической композиции
EP1443907A1 (en) * 2001-11-12 2004-08-11 Alkermes Controlled Therapeutics, Inc. Biocompatible polymer blends and uses thereof
TWI252111B (en) 2001-12-14 2006-04-01 Solvay Pharm Gmbh Matrix film tablet with controlled release of a natural mixture of conjugated estrogens
WO2003055470A1 (fr) 2001-12-26 2003-07-10 Takeda Chemical Industries, Ltd. Nouvelle microsphere et son procede de production
AU2003244157A1 (en) 2002-06-25 2004-01-06 Takeda Pharmaceutical Company Limited Process for producing sustained-release composition
US8871269B2 (en) 2003-07-15 2014-10-28 Evonik Corporation Method for the preparation of controlled release formulations
KR101040415B1 (ko) 2004-04-15 2011-06-09 알케르메스,인코포레이티드 중합체 기재 지속적 방출 방법
EP1679065A1 (en) 2005-01-07 2006-07-12 OctoPlus Sciences B.V. Controlled release compositions for interferon based on PEGT/PBT block copolymers

Also Published As

Publication number Publication date
PL1843749T3 (pl) 2009-10-30
EP2266535B1 (en) 2013-03-06
ES2327267T3 (es) 2009-10-27
CN101791396A (zh) 2010-08-04
EP1886668A1 (en) 2008-02-13
IL184431A0 (en) 2007-10-31
JP4887542B2 (ja) 2012-02-29
EP1843749A1 (en) 2007-10-17
WO2006085747A1 (en) 2006-08-17
SI1843749T1 (sl) 2009-10-31
DE602006006797D1 (de) 2009-06-25
US7867518B2 (en) 2011-01-11
CY1109297T1 (el) 2014-07-02
PT1843749E (pt) 2009-08-17
KR20070118225A (ko) 2007-12-14
AU2006213168B2 (en) 2011-09-15
EP1843749B1 (en) 2009-05-13
AU2006213168A1 (en) 2006-08-17
JP2011016836A (ja) 2011-01-27
EP2266535A3 (en) 2011-06-15
EP2266535A2 (en) 2010-12-29
RU2409348C2 (ru) 2011-01-20
AU2010224413A1 (en) 2010-10-14
IL184431A (en) 2012-03-29
EP1679065A1 (en) 2006-07-12
CA2594434A1 (en) 2006-08-17
RS51129B (sr) 2010-10-31
US8163307B2 (en) 2012-04-24
AU2010224413B2 (en) 2012-03-22
US20080008733A1 (en) 2008-01-10
US20100074868A1 (en) 2010-03-25
US20090226532A1 (en) 2009-09-10
MX2007008293A (es) 2007-12-07
ATE431134T1 (de) 2009-05-15
RU2010138739A (ru) 2012-03-27
EP1886668B1 (en) 2012-11-14
JP2008526837A (ja) 2008-07-24
HRP20090434T1 (hr) 2009-09-30
DK1843749T3 (da) 2009-09-07
CN101137349A (zh) 2008-03-05
RU2007130090A (ru) 2009-02-20
KR20100109983A (ko) 2010-10-11
CN101137349B (zh) 2013-01-02
BRPI0606514A2 (pt) 2010-01-19
US7736674B2 (en) 2010-06-15
IL208175A0 (en) 2010-12-30
SG158856A1 (en) 2010-02-26
KR101354521B1 (ko) 2014-01-22

Similar Documents

Publication Publication Date Title
HK1152644A1 (en) Controlled release compositions for interferon based on block polymers
WO2007127440A3 (en) Heterofunctional poly(ethylene glycol) containing acid-labile amino protecting groups and uses thereof
GEP20074016B (en) Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
WO2006105172A3 (en) Peg-polyacetal and peg-polyacetal-poe graft copolymers and pharmaceutical compositions
SI3404102T1 (sl) Konjugati za dodajanje kostem in njihova uporaba za ciljanje beljakovin na kosti
HK1146075A1 (en) Polyglutamate-amino acid conjugates and methods
WO2007050387A3 (en) Keratin bioceramic compositions
EP1721625A3 (en) Biodegradable medical devices with enhanced mechanical strength and pharmacological functions
MX2007002189A (es) Sales de dicetopiperazina, sales de dicetomorfolina o sales de dicetodioxano para suministro de farmacos.
MXPA03008886A (es) Composiciones de baja respuesta glicemica.
FR2824329B1 (fr) Compositions de polymeres antistatique
NZ580686A (en) Modified interferon beta polypeptides and their uses
WO2007127473A3 (en) Poly (ethylene glycol) containing chemically disparate endgroups
WO2004063342A3 (en) Cellular delivery and activation polypeptide-nucleic acid complexes
NZ600958A (en) Methods and compositions for live attentuated viruses
EA200700435A1 (ru) Рентгеноконтрастные полимерные стенты
ATE345775T1 (de) Zusammensetzungen zur verabreichung von arzneimittelkombinationen
EP1891143A4 (en) POLYMER-BASED SERUM ALBUMINE REPLACEMENT
WO2007065074A3 (en) Biodegradable implant polymers and composites
DE602004021501D1 (de) Gegenüber ionisierender strahlung stabile polyarylestercarbonatzusammensetzungen
MXPA05010926A (es) Composicion farmaceutica que comprende proteinas y/o polipeptidos y particulas coloidales.
RU2006144370A (ru) Способ профилактики послеоперационного остеомиелита
MXPA02001852A (es) Composiciones de polimeros altos no gelificantes y mezclas termoplsticas derivadas.
UA90805C2 (en) Polyethylene glycol-interferon alpha conjugate
TNSN05095A1 (en) Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20170106