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Priority claimed from PCT/US2003/029989external-prioritypatent/WO2004030617A2/en
Application filed by Mountain View Pharmaceuticals IncfiledCriticalMountain View Pharmaceuticals Inc
Publication of TNSN05095A1publicationCriticalpatent/TNSN05095A1/en
Methods are provided for the preparation of conjugates of a viariety of bioactive components, especially proteins, with water-soluble polymers (e.g., poly ( ethylene glycol) and derivatives thereof), with conjugates have reduced antigenicity and immunogenicity compared to similar conjugates prepared using poly (ethylene glycol) containing a methoxyl or another alkoxyl group. The invention also provides conjugates prepared by such methods, compositions comprising such conjugates, kits containing such conjugates or compositions and methods of use of the conjugates and compositions in diagnostic and therapeutic protocols.
TNP2005000095A2002-09-302005-03-28Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
TNSN05095A1
(en)