CY1115680T1 - POLYMER CONJECTION PRODUCTS WITH REDUCED ANTIGENITY, METHODS OF PRESENTATION AND THEIR USES - Google Patents
POLYMER CONJECTION PRODUCTS WITH REDUCED ANTIGENITY, METHODS OF PRESENTATION AND THEIR USESInfo
- Publication number
- CY1115680T1 CY1115680T1 CY20141100764T CY141100764T CY1115680T1 CY 1115680 T1 CY1115680 T1 CY 1115680T1 CY 20141100764 T CY20141100764 T CY 20141100764T CY 141100764 T CY141100764 T CY 141100764T CY 1115680 T1 CY1115680 T1 CY 1115680T1
- Authority
- CY
- Cyprus
- Prior art keywords
- conjugates
- methods
- products
- reduced
- antigenity
- Prior art date
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- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Παρέχονται μέθοδοι για την παρασκευή προϊόντων σύζευξης μιας ποικιλίας βιοδραστικών συστατικών, ειδικώς πρωτεϊνών, με υδατο-διαλυτά πολυμερή (π.χ., πολυ(αιθυλενογλυκόλη) και παράγωγα αυτής), τα οποία προϊόντα σύζευξης έχουν μειωμένη αντιγονικότητα και ανοσογονικότητα εν συγκρίσει προς παρόμοια προϊόντα σύζευξης που παρασκευάζονται χρησιμοποιώντας πολυ(αιθυλενογλυκόλη) που περιέχει μεθοξύλ ή άλλη αλκοξύλ ομάδα. Η εφεύρεση επίσης παρέχει προϊόντα σύζευξης που παρασκευάζονται με τέτοιες μεθόδους, συνθέσεις που περιλαμβάνουν τέτοια προϊόντα σύζευξης, κιτ που περιέχουν τέτοια προϊόντα σύζευξης ή συνθέσεις και μεθόδους χρήσης των προϊόντων σύζευξης και συνθέσεων σε διαγνωστικά και θεραπευτικά πρωτόκολλα.Methods are provided for the preparation of conjugates of a variety of bioactive constituents, especially proteins, with water-soluble polymers (e.g., poly (ethylene glycol) and derivatives thereof), which conjugates have reduced antigenicity and immunogenicity compared to similar products. prepared using poly (ethylene glycol) containing methoxy or other alkoxy group. The invention also provides conjugates prepared by such methods, compositions comprising such conjugates, kits containing such conjugates or compositions, and methods of using the conjugates and compositions in diagnostic and therapeutic protocols.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US41442402A | 2002-09-30 | 2002-09-30 | |
US10/317,092 US20040062748A1 (en) | 2002-09-30 | 2002-12-12 | Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof |
EP03759445.4A EP1572728B1 (en) | 2002-09-30 | 2003-09-25 | Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1115680T1 true CY1115680T1 (en) | 2017-01-25 |
Family
ID=58457035
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20141100764T CY1115680T1 (en) | 2002-09-30 | 2014-09-18 | POLYMER CONJECTION PRODUCTS WITH REDUCED ANTIGENITY, METHODS OF PRESENTATION AND THEIR USES |
Country Status (1)
Country | Link |
---|---|
CY (1) | CY1115680T1 (en) |
-
2014
- 2014-09-18 CY CY20141100764T patent/CY1115680T1/en unknown
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