CY1115680T1 - POLYMER CONJECTION PRODUCTS WITH REDUCED ANTIGENITY, METHODS OF PRESENTATION AND THEIR USES - Google Patents

POLYMER CONJECTION PRODUCTS WITH REDUCED ANTIGENITY, METHODS OF PRESENTATION AND THEIR USES

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Publication number
CY1115680T1
CY1115680T1 CY20141100764T CY141100764T CY1115680T1 CY 1115680 T1 CY1115680 T1 CY 1115680T1 CY 20141100764 T CY20141100764 T CY 20141100764T CY 141100764 T CY141100764 T CY 141100764T CY 1115680 T1 CY1115680 T1 CY 1115680T1
Authority
CY
Cyprus
Prior art keywords
conjugates
methods
products
reduced
antigenity
Prior art date
Application number
CY20141100764T
Other languages
Greek (el)
Inventor
Alexa L Martinez
Merry R Sherman
Mark G P Saifer
L David Williams
Original Assignee
Mountain View Pharmaceuticals Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/317,092 external-priority patent/US20040062748A1/en
Application filed by Mountain View Pharmaceuticals Inc. filed Critical Mountain View Pharmaceuticals Inc.
Publication of CY1115680T1 publication Critical patent/CY1115680T1/en

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  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Παρέχονται μέθοδοι για την παρασκευή προϊόντων σύζευξης μιας ποικιλίας βιοδραστικών συστατικών, ειδικώς πρωτεϊνών, με υδατο-διαλυτά πολυμερή (π.χ., πολυ(αιθυλενογλυκόλη) και παράγωγα αυτής), τα οποία προϊόντα σύζευξης έχουν μειωμένη αντιγονικότητα και ανοσογονικότητα εν συγκρίσει προς παρόμοια προϊόντα σύζευξης που παρασκευάζονται χρησιμοποιώντας πολυ(αιθυλενογλυκόλη) που περιέχει μεθοξύλ ή άλλη αλκοξύλ ομάδα. Η εφεύρεση επίσης παρέχει προϊόντα σύζευξης που παρασκευάζονται με τέτοιες μεθόδους, συνθέσεις που περιλαμβάνουν τέτοια προϊόντα σύζευξης, κιτ που περιέχουν τέτοια προϊόντα σύζευξης ή συνθέσεις και μεθόδους χρήσης των προϊόντων σύζευξης και συνθέσεων σε διαγνωστικά και θεραπευτικά πρωτόκολλα.Methods are provided for the preparation of conjugates of a variety of bioactive constituents, especially proteins, with water-soluble polymers (e.g., poly (ethylene glycol) and derivatives thereof), which conjugates have reduced antigenicity and immunogenicity compared to similar products. prepared using poly (ethylene glycol) containing methoxy or other alkoxy group. The invention also provides conjugates prepared by such methods, compositions comprising such conjugates, kits containing such conjugates or compositions, and methods of using the conjugates and compositions in diagnostic and therapeutic protocols.

CY20141100764T 2002-09-30 2014-09-18 POLYMER CONJECTION PRODUCTS WITH REDUCED ANTIGENITY, METHODS OF PRESENTATION AND THEIR USES CY1115680T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41442402A 2002-09-30 2002-09-30
US10/317,092 US20040062748A1 (en) 2002-09-30 2002-12-12 Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
EP03759445.4A EP1572728B1 (en) 2002-09-30 2003-09-25 Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof

Publications (1)

Publication Number Publication Date
CY1115680T1 true CY1115680T1 (en) 2017-01-25

Family

ID=58457035

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20141100764T CY1115680T1 (en) 2002-09-30 2014-09-18 POLYMER CONJECTION PRODUCTS WITH REDUCED ANTIGENITY, METHODS OF PRESENTATION AND THEIR USES

Country Status (1)

Country Link
CY (1) CY1115680T1 (en)

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