HK1143802A1 - Compounds with (substituted phenyl)-propenal moiety, their derivatives, biological activity, and uses thereof ()- - Google Patents
Compounds with (substituted phenyl)-propenal moiety, their derivatives, biological activity, and uses thereof ()-Info
- Publication number
- HK1143802A1 HK1143802A1 HK10110115.7A HK10110115A HK1143802A1 HK 1143802 A1 HK1143802 A1 HK 1143802A1 HK 10110115 A HK10110115 A HK 10110115A HK 1143802 A1 HK1143802 A1 HK 1143802A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- derivatives
- compounds
- biological activity
- substituted phenyl
- propenal moiety
- Prior art date
Links
- -1 (substituted phenyl)-propenal moiety Chemical group 0.000 title 1
- 230000004071 biological effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
- C07C49/255—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A61P13/08—Drugs for disorders of the urinary system of the prostate
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
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- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
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- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
- C07C225/14—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
- C07C225/16—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
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- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
- C07C45/30—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation
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- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
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- C—CHEMISTRY; METALLURGY
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- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
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- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
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- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
- C07C45/73—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with hydrogenation
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- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
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- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
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- C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
- C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
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- C07C47/00—Compounds having —CHO groups
- C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
- C07C49/24—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups
- C07C49/245—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups containing six-membered aromatic rings
- C07C49/248—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups containing six-membered aromatic rings having unsaturation outside the aromatic rings
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- C—CHEMISTRY; METALLURGY
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
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- C07C69/007—Esters of unsaturated alcohols having the esterified hydroxy group bound to an acyclic carbon atom
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- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
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- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Reproductive Health (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US87945807P | 2007-01-08 | 2007-01-08 | |
PCT/US2008/000285 WO2008085984A1 (fr) | 2007-01-08 | 2008-01-08 | Composés comprenant un groupe caractéristique de propénal (substitué par du phényle), leurs dérivés, leur activité biologique et leurs utilisations |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1143802A1 true HK1143802A1 (en) | 2011-02-25 |
Family
ID=39609007
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK10110115.7A HK1143802A1 (en) | 2007-01-08 | 2010-10-28 | Compounds with (substituted phenyl)-propenal moiety, their derivatives, biological activity, and uses thereof ()- |
HK16110440.7A HK1222168A1 (zh) | 2007-01-08 | 2016-09-01 | 具有 取代苯基 -丙烯醛部分的化合物、它們的衍生物、生物活性及其用途 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK16110440.7A HK1222168A1 (zh) | 2007-01-08 | 2016-09-01 | 具有 取代苯基 -丙烯醛部分的化合物、它們的衍生物、生物活性及其用途 |
Country Status (12)
Country | Link |
---|---|
US (2) | US8236852B2 (fr) |
EP (2) | EP2993165B1 (fr) |
JP (3) | JP2010515685A (fr) |
KR (1) | KR101563370B1 (fr) |
CN (1) | CN101711231B (fr) |
AU (1) | AU2008205312B2 (fr) |
CA (1) | CA2674780C (fr) |
DK (1) | DK2104659T3 (fr) |
HK (2) | HK1143802A1 (fr) |
MX (1) | MX2009007345A (fr) |
NZ (1) | NZ578914A (fr) |
WO (1) | WO2008085984A1 (fr) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8236852B2 (en) * | 2007-01-08 | 2012-08-07 | Androscience Corporation | Compounds with (substituted phenyl)-propenal moiety, their derivatives, biological activity, and use thereof |
US9000222B2 (en) | 2007-01-08 | 2015-04-07 | Androscience Corporation | Compounds with (1E, 6E)-1,7-bis-(3,4-dimethoxyphenyl)-4,4-disubstituted-hepta-1,6-diene-3,5-dione structural scaffold, their biological activity, and uses thereof |
US8710272B2 (en) | 2007-01-08 | 2014-04-29 | Androscience Corporation | Compounds with (1 E, 6E)-1,7-bis-(3,4-dimethoxyphenyl)-4,4-disubstituted-hepta-1,6-diene-3,5-dione structural scaffold, their biological activity, and uses thereof |
US20110036771A1 (en) | 2007-01-09 | 2011-02-17 | Steven Woodard | Ballasted anaerobic system and method for treating wastewater |
US9446127B2 (en) * | 2007-07-31 | 2016-09-20 | Androscience Corporation | Compositions including androgen receptor degradation (ARD) enhancers and methods of prophylactic or therapeutic treatment of skin disorders and hair loss |
CA2731643C (fr) | 2008-07-22 | 2020-05-05 | The General Hospital Corporation | Composes a base de fus/tls et methodes de diagnostic, traitement et prevention d'une sclerose laterale amyotrophique et de maladies des motoneurones apparentees |
CN101700995B (zh) * | 2008-12-30 | 2013-06-05 | 中山大学 | 具有抗肿瘤作用的多芳乙烯取代beta-二酮类化合物 |
EP3206488B1 (fr) | 2009-05-15 | 2019-08-21 | The Research Foundation for The State University of New York | Analogues de curcumine utilisés en tant que chélateurs du zinc et leurs utilisations |
MX360417B (es) * | 2009-10-09 | 2018-10-25 | Macgregor Alexander | Fenilpropanoides digliceridos para el tratamiento del cancer. |
JP5998139B2 (ja) * | 2010-08-20 | 2016-09-28 | アリアンズ ファーマサイエンス リミテッド | 1,5−ジフェニル−ペンタ−1,4−ジエン−3−オン化合物 |
CN102060795B (zh) * | 2011-01-14 | 2012-01-25 | 扬州大学 | 1,3,5-三苯基间三氮杂苯的合成方法 |
HUP1100532A2 (en) | 2011-09-23 | 2013-04-29 | Avidin Kft | Substituted curcumin derivatives, process for their preparation, and pharmaceutical compositions containing them |
CN104755076A (zh) * | 2012-06-18 | 2015-07-01 | 安德鲁科技有限公司 | 具有(1e,6e)-1,7-双-(3,4-二甲氧基苯基)-4,4-二取代的庚-1,6-二烯-3,5-二酮结构骨架的化合物、它们的生物活性及其用途 |
US9220695B2 (en) | 2012-06-29 | 2015-12-29 | The Research Foundation For The State University Of New York | Polyenolic zinc-binding agents (pezbins) actively promote inactivation of cancer stem cells and potentiate cytotoxic anti-tumor drug substances |
US9371263B2 (en) * | 2013-09-20 | 2016-06-21 | Augusta University Research Institute, Inc. | Protective effects of curcumin against hemorrhagic stroke injury |
US10300000B2 (en) | 2016-09-12 | 2019-05-28 | The Research Foundation For The State University Of New York | Inhibition of melanogenesis by chemically modified curcumins |
US11707449B2 (en) * | 2017-10-27 | 2023-07-25 | St. Jude Children's Research Hospital, Inc. | Methods and formulations for treatment of spinobulbar muscular atrophy |
EP3508855A1 (fr) * | 2018-01-05 | 2019-07-10 | Allianz Pharmascience Ltd | Procédé de sélection de patients et kit |
FR3079141B1 (fr) * | 2018-03-23 | 2022-05-20 | Merry Life Biomedical Company Ltd | Utilisations de derives de curcumine |
JP2020117488A (ja) * | 2019-01-04 | 2020-08-06 | アリアンツ ファーマサイエンス リミテッド | 炎症性疾患の治療方法 |
CN110183320B (zh) * | 2019-04-15 | 2021-06-11 | 四川大学 | 一类多烯二酮类抗肿瘤化合物 |
CN116120182A (zh) * | 2023-02-16 | 2023-05-16 | 常州大学 | 姜黄素衍生物及其合成方法和在抗雄激素受体中的应用 |
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DE2728242A1 (de) * | 1977-06-23 | 1979-01-11 | Henkel Kgaa | Kosmetische lichtschutzmittel fuer den uv-a-bereich |
AU565915B2 (en) | 1982-12-31 | 1987-10-01 | Mortimer, C.H. | Pharmaceutical composition of antibiotic and anti- androgen |
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-
2008
- 2008-01-08 US US12/008,124 patent/US8236852B2/en active Active
- 2008-01-08 EP EP15178708.2A patent/EP2993165B1/fr not_active Not-in-force
- 2008-01-08 KR KR1020097016216A patent/KR101563370B1/ko active IP Right Grant
- 2008-01-08 WO PCT/US2008/000285 patent/WO2008085984A1/fr active Application Filing
- 2008-01-08 EP EP08713067.0A patent/EP2104659B1/fr active Active
- 2008-01-08 CN CN200880005067.7A patent/CN101711231B/zh active Active
- 2008-01-08 AU AU2008205312A patent/AU2008205312B2/en active Active
- 2008-01-08 JP JP2009544955A patent/JP2010515685A/ja active Pending
- 2008-01-08 DK DK08713067.0T patent/DK2104659T3/en active
- 2008-01-08 NZ NZ578914A patent/NZ578914A/xx unknown
- 2008-01-08 MX MX2009007345A patent/MX2009007345A/es unknown
- 2008-01-08 CA CA2674780A patent/CA2674780C/fr active Active
-
2010
- 2010-05-11 US US12/800,251 patent/US8202905B2/en active Active
- 2010-10-28 HK HK10110115.7A patent/HK1143802A1/xx unknown
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2013
- 2013-09-19 JP JP2013194113A patent/JP5998117B2/ja active Active
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2015
- 2015-10-29 JP JP2015212420A patent/JP2016065068A/ja active Pending
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Also Published As
Publication number | Publication date |
---|---|
AU2008205312A1 (en) | 2008-07-17 |
CA2674780C (fr) | 2014-03-11 |
KR20090114387A (ko) | 2009-11-03 |
NZ578914A (en) | 2012-11-30 |
JP2016065068A (ja) | 2016-04-28 |
EP2993165B1 (fr) | 2018-06-27 |
US8236852B2 (en) | 2012-08-07 |
JP5998117B2 (ja) | 2016-09-28 |
US20100292342A1 (en) | 2010-11-18 |
CN101711231B (zh) | 2014-03-12 |
WO2008085984A1 (fr) | 2008-07-17 |
DK2104659T3 (en) | 2015-11-02 |
JP2014055134A (ja) | 2014-03-27 |
US20080188557A1 (en) | 2008-08-07 |
EP2104659A1 (fr) | 2009-09-30 |
JP2010515685A (ja) | 2010-05-13 |
AU2008205312B2 (en) | 2013-11-21 |
US8202905B2 (en) | 2012-06-19 |
HK1222168A1 (zh) | 2017-06-23 |
EP2993165A3 (fr) | 2016-07-06 |
KR101563370B1 (ko) | 2015-10-26 |
CA2674780A1 (fr) | 2008-07-17 |
EP2104659A4 (fr) | 2011-09-07 |
MX2009007345A (es) | 2010-02-22 |
EP2104659B1 (fr) | 2015-07-29 |
EP2993165A2 (fr) | 2016-03-09 |
CN101711231A (zh) | 2010-05-19 |
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