HK1143802A1 - 具有 取代苯基 -丙烯醛部分的化合物、它們的衍生物、生物活性及其用途 - Google Patents

具有 取代苯基 -丙烯醛部分的化合物、它們的衍生物、生物活性及其用途

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Publication number
HK1143802A1
HK1143802A1 HK10110115.7A HK10110115A HK1143802A1 HK 1143802 A1 HK1143802 A1 HK 1143802A1 HK 10110115 A HK10110115 A HK 10110115A HK 1143802 A1 HK1143802 A1 HK 1143802A1
Authority
HK
Hong Kong
Prior art keywords
derivatives
compounds
biological activity
substituted phenyl
propenal moiety
Prior art date
Application number
HK10110115.7A
Other languages
English (en)
Inventor
石秋洋
王慧康
蘇卿淵
史謙
Original Assignee
安德魯科技有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 安德魯科技有限公司 filed Critical 安德魯科技有限公司
Publication of HK1143802A1 publication Critical patent/HK1143802A1/zh

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    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/255—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P17/00—Drugs for dermatological disorders
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07C225/14—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
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    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/30—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation
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    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
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    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
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    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C07C45/73—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with hydrogenation
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    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
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    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
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    • C07C49/24—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups
    • C07C49/245—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups containing six-membered aromatic rings
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    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Reproductive Health (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK10110115.7A 2007-01-08 2010-10-28 具有 取代苯基 -丙烯醛部分的化合物、它們的衍生物、生物活性及其用途 HK1143802A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87945807P 2007-01-08 2007-01-08
PCT/US2008/000285 WO2008085984A1 (en) 2007-01-08 2008-01-08 Compounds with (substituted phenyl)-propenal moiety, their derivatives, biological activity, and uses thereof

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Publication Number Publication Date
HK1143802A1 true HK1143802A1 (zh) 2011-02-25

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HK10110115.7A HK1143802A1 (zh) 2007-01-08 2010-10-28 具有 取代苯基 -丙烯醛部分的化合物、它們的衍生物、生物活性及其用途
HK16110440.7A HK1222168A1 (zh) 2007-01-08 2016-09-01 具有 取代苯基 -丙烯醛部分的化合物、它們的衍生物、生物活性及其用途

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Country Status (12)

Country Link
US (2) US8236852B2 (zh)
EP (2) EP2104659B1 (zh)
JP (3) JP2010515685A (zh)
KR (1) KR101563370B1 (zh)
CN (1) CN101711231B (zh)
AU (1) AU2008205312B2 (zh)
CA (1) CA2674780C (zh)
DK (1) DK2104659T3 (zh)
HK (2) HK1143802A1 (zh)
MX (1) MX2009007345A (zh)
NZ (1) NZ578914A (zh)
WO (1) WO2008085984A1 (zh)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8710272B2 (en) 2007-01-08 2014-04-29 Androscience Corporation Compounds with (1 E, 6E)-1,7-bis-(3,4-dimethoxyphenyl)-4,4-disubstituted-hepta-1,6-diene-3,5-dione structural scaffold, their biological activity, and uses thereof
US9000222B2 (en) 2007-01-08 2015-04-07 Androscience Corporation Compounds with (1E, 6E)-1,7-bis-(3,4-dimethoxyphenyl)-4,4-disubstituted-hepta-1,6-diene-3,5-dione structural scaffold, their biological activity, and uses thereof
EP2104659B1 (en) * 2007-01-08 2015-07-29 AndroScience Corporation Compounds with (substituted phenyl)-propenal moiety, their derivatives, biological activity, and uses thereof
US20110036771A1 (en) 2007-01-09 2011-02-17 Steven Woodard Ballasted anaerobic system and method for treating wastewater
EP2175726A4 (en) * 2007-07-31 2011-01-05 Androscience Corp COMPOSITIONS WITH ANDROGEN RECEPTOR DERIVATIVES AND METHOD FOR THE PROPHYLACTIC OR THERAPEUTIC TREATMENT OF SKIN DISEASES OR HAIR LOSS
JP5643200B2 (ja) * 2008-07-22 2014-12-17 ザ ジェネラル ホスピタル コーポレイション 筋萎縮性側索硬化症および関連する運動ニューロン疾患の診断、処置および予防のための、ｆｕｓ／ｔｌｓベースの化合物および方法
CN101700995B (zh) * 2008-12-30 2013-06-05 中山大学 具有抗肿瘤作用的多芳乙烯取代beta-二酮类化合物
US9187406B2 (en) 2009-05-15 2015-11-17 The Research Foundation Of State University Of New York Curcumin analogues as zinc chelators and their uses
MY187188A (en) * 2009-10-09 2021-09-09 Alexander Macgregor Derivatives of di(phenylpropanoid) glycerol for the treatment of cancer
KR101907631B1 (ko) * 2010-08-20 2018-10-12 알리안츠 파마사이언스 리미티드 1,5-디페닐-펜타-1,4-디엔-3-온 화합물
CN102060795B (zh) * 2011-01-14 2012-01-25 扬州大学 1,3,5-三苯基间三氮杂苯的合成方法
HUP1100532A2 (en) 2011-09-23 2013-04-29 Avidin Kft Substituted curcumin derivatives, process for their preparation, and pharmaceutical compositions containing them
MX2014015936A (es) * 2012-06-18 2016-06-24 Androscience Corp Compuestos con andamio estructural de (1e,6e)-1,7-bis-(3-4-dimetox ifenil)- hepa-1,6-dieno-3,5-diona 4,4-disustituida -, su actividad biologica, y usos de los mismos.
US9220695B2 (en) 2012-06-29 2015-12-29 The Research Foundation For The State University Of New York Polyenolic zinc-binding agents (pezbins) actively promote inactivation of cancer stem cells and potentiate cytotoxic anti-tumor drug substances
US9371263B2 (en) * 2013-09-20 2016-06-21 Augusta University Research Institute, Inc. Protective effects of curcumin against hemorrhagic stroke injury
US10300000B2 (en) 2016-09-12 2019-05-28 The Research Foundation For The State University Of New York Inhibition of melanogenesis by chemically modified curcumins
US11707449B2 (en) * 2017-10-27 2023-07-25 St. Jude Children's Research Hospital, Inc. Methods and formulations for treatment of spinobulbar muscular atrophy
EP3508855A1 (en) * 2018-01-05 2019-07-10 Allianz Pharmascience Ltd Method for the selection of patients and kit
CA3036444C (en) * 2018-03-23 2021-03-23 Merry Life Biomedical Company, Ltd. Uses of curcumin derivative
JP2020117488A (ja) * 2019-01-04 2020-08-06 アリアンツ ファーマサイエンス リミテッド 炎症性疾患の治療方法
CN110183320B (zh) * 2019-04-15 2021-06-11 四川大学 一类多烯二酮类抗肿瘤化合物

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2728242A1 (de) * 1977-06-23 1979-01-11 Henkel Kgaa Kosmetische lichtschutzmittel fuer den uv-a-bereich
AU565915B2 (en) 1982-12-31 1987-10-01 Mortimer, C.H. Pharmaceutical composition of antibiotic and anti- androgen
JPS6032756A (ja) * 1983-08-02 1985-02-19 Nippon Redarii Kk Ν−（ｃｉｓ−３，４−ジメトキシシンナモイル）アントラニル酸の製造方法
US5334481A (en) * 1985-05-02 1994-08-02 Ciba-Geigy Corporation Positive diazo quinone photoresist compositions containing antihalation compound
JPH0623129B2 (ja) * 1986-02-28 1994-03-30 三井東圧化学株式会社 桂皮酸類の製法
US4649157A (en) * 1986-03-28 1987-03-10 G. D. Searle & Co. Pharmaceutical compositions containing 5-phenyl-1,3-dioxoalkenyl compounds
JPH0390021A (ja) * 1989-09-01 1991-04-16 Terumo Corp ジンゲロール誘導体を含有する医薬製剤
US5300294A (en) * 1990-06-27 1994-04-05 Smithkline Beecham Corporation Method of treating prostatic adenocarcinoma
US5605930A (en) * 1991-10-21 1997-02-25 The United States Of America As Represented By The Department Of Health And Human Services Compositions and methods for treating and preventing pathologies including cancer
TW203552B (en) * 1992-02-18 1993-04-11 J Baroody Lloyd Compositions of clindamycin and benzoyl peroxide for acne treatment
IT1255467B (it) * 1992-07-29 1995-11-02 Dompe Farmaceutici Spa Ammidi acriliche farmacologicamente attive
US5637310A (en) * 1993-12-20 1997-06-10 Smithkline Beecham Corporation Method of treating prostatic adenocarcinoma
US5609858A (en) * 1994-11-22 1997-03-11 Buck; Carol J. Method for treatment of androgenic alopecia
IT1274549B (it) * 1995-05-23 1997-07-17 Indena Spa Uso di flavanolignani per la preparazione di medicamenti ad attivita' antiproliferativa nei tumori dell'utero,dell'ovaio e del seno
US5679864A (en) * 1995-11-03 1997-10-21 Gene Print Inc. Process for the synthesis of curcumin-related compounds
AUPN814496A0 (en) * 1996-02-19 1996-03-14 Monash University Dermal penetration enhancer
US5958645A (en) * 1996-08-28 1999-09-28 Japan Synthetic Rubber Co., Ltd. Radiation-sensitive resin composition
US6699714B1 (en) * 1998-07-17 2004-03-02 University Of Rochester Androgen receptor coactivators
JP2000258904A (ja) * 1999-03-04 2000-09-22 Fujifilm Olin Co Ltd ネガ型化学増幅系感光性組成物
JP2000256259A (ja) * 1999-03-11 2000-09-19 Nippon Zoki Pharmaceut Co Ltd メイラード反応阻害剤
FR2799753B1 (fr) * 1999-10-19 2002-01-04 Atofina Procede perfectionne de fabrication d'anhydrides symetriques
TWI290469B (en) * 2000-07-12 2007-12-01 Medical & Pharm Ind Tech & Dev Method for manufacturing product with component capable of efficiently preventing inflammation and platelets agglutination form ginger and medical composition with the efficient component
JP4596441B2 (ja) 2000-08-22 2010-12-08 有限会社吉川塩ビ工業所 混合流体分離装置
US20040248971A1 (en) 2001-07-27 2004-12-09 Shuyuan Yeh Use of vitamin e succinate and antiandrogen combination
JP2003073392A (ja) * 2001-09-04 2003-03-12 Univ Nihon 新規なケイヒ酸誘導体並びにこれを用いた組成物、抗アレルギー剤及び抗炎症剤
US7355081B2 (en) * 2002-04-17 2008-04-08 The University Of North Carolina At Chapel Hill Curcumin analogues and uses thereof
US6790979B2 (en) * 2002-04-17 2004-09-14 University Of North Carolina At Chapel Hill Curcumin analogues and uses thereof
WO2004080396A2 (en) * 2003-03-07 2004-09-23 The University Of Texas Md Anderson Cancer Center Liposomal curcumin for treatment of cancer
TWI287990B (en) * 2004-01-08 2007-10-11 Nat Defense Medical Ct Inhibitors and enhancers of uridine diphosphate-glucuronosyl transferase 2B (UGT2B)
WO2005072462A2 (en) 2004-01-28 2005-08-11 Charles Shih Enhancement of anti-androgenic activity by a combination of inhibitors targeting different steps of a steroid-dependent gene activation pathway and uses thereof
US20060258752A1 (en) * 2004-02-12 2006-11-16 Vander Jagt David L Method and compounds for cancer treatment utilizing NFkB as a direct or ultimate target for small molecule inhibitors
US20080103213A1 (en) * 2004-03-05 2008-05-01 Board Of Regents, The University Of Texas System Liposomal curcumin for treatment of neurofibromatosis
US20060004875A1 (en) * 2004-05-11 2006-01-05 Microsoft Corporation CMDB schema
US20060024385A1 (en) * 2004-07-27 2006-02-02 Pedersen Mark A Metabolic capacity enhancing compositions and methods for use in a mammal
EP1804806A2 (en) 2004-09-02 2007-07-11 AndroScience Corporation Methods and compositions for enhancing degradation of nuclear receptor transcription factors and uses thereof
EP1874801A4 (en) * 2005-03-07 2009-03-25 Univ North Carolina RECA ACTIVITY INHIBITORS TO CONTROL ANTIBIOTIC-RESISTANT BACTERIAL PATHOGENS
US20060275516A1 (en) * 2005-06-02 2006-12-07 Ram A N S Compositions and methods for the treatment of allergic rhinitis
CA2632782A1 (en) 2005-12-29 2007-07-05 Kansas State University Research Foundation Antimicrobial cathelicidin peptides
US7947091B2 (en) * 2006-03-01 2011-05-24 Arkles Barry C Curcumin and its derivatives for use as silicone colorants
EP2104659B1 (en) * 2007-01-08 2015-07-29 AndroScience Corporation Compounds with (substituted phenyl)-propenal moiety, their derivatives, biological activity, and uses thereof

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MX2009007345A (es) 2010-02-22
KR101563370B1 (ko) 2015-10-26
JP5998117B2 (ja) 2016-09-28
US20080188557A1 (en) 2008-08-07
EP2104659A4 (en) 2011-09-07
WO2008085984A1 (en) 2008-07-17
AU2008205312B2 (en) 2013-11-21
EP2104659A1 (en) 2009-09-30
JP2014055134A (ja) 2014-03-27
CA2674780C (en) 2014-03-11
DK2104659T3 (en) 2015-11-02
EP2993165B1 (en) 2018-06-27
US8236852B2 (en) 2012-08-07
JP2016065068A (ja) 2016-04-28
JP2010515685A (ja) 2010-05-13
CN101711231A (zh) 2010-05-19
NZ578914A (en) 2012-11-30
EP2993165A2 (en) 2016-03-09
HK1222168A1 (zh) 2017-06-23
EP2993165A3 (en) 2016-07-06
CA2674780A1 (en) 2008-07-17
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AU2008205312A1 (en) 2008-07-17
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