HK1139563A1 - 溶瘤牛痘病毒癌症療法 - Google Patents
溶瘤牛痘病毒癌症療法Info
- Publication number
- HK1139563A1 HK1139563A1 HK10106289.5A HK10106289A HK1139563A1 HK 1139563 A1 HK1139563 A1 HK 1139563A1 HK 10106289 A HK10106289 A HK 10106289A HK 1139563 A1 HK1139563 A1 HK 1139563A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- cancer therapy
- vaccinia virus
- oncolytic vaccinia
- virus cancer
- oncolytic
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
- A61K35/768—Oncolytic viruses not provided for in groups A61K35/761 - A61K35/766
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/193—Colony stimulating factors [CSF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24132—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24141—Use of virus, viral particle or viral elements as a vector
- C12N2710/24143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24171—Demonstrated in vivo effect
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US89493207P | 2007-03-15 | 2007-03-15 | |
PCT/US2008/057257 WO2008113078A1 (en) | 2007-03-15 | 2008-03-17 | Oncolytic vaccinia virus cancer therapy |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1139563A1 true HK1139563A1 (zh) | 2010-09-24 |
Family
ID=39760123
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK10106289.5A HK1139563A1 (zh) | 2007-03-15 | 2010-06-25 | 溶瘤牛痘病毒癌症療法 |
Country Status (18)
Country | Link |
---|---|
US (1) | US20100303714A1 (zh) |
EP (1) | EP2136633B1 (zh) |
JP (2) | JP5879024B2 (zh) |
KR (3) | KR20080084528A (zh) |
CN (2) | CN101790310A (zh) |
AU (1) | AU2008224811B2 (zh) |
BR (1) | BRPI0808736A2 (zh) |
CA (1) | CA2681096C (zh) |
CY (1) | CY1117107T1 (zh) |
DK (1) | DK2136633T3 (zh) |
ES (1) | ES2559684T3 (zh) |
HK (1) | HK1139563A1 (zh) |
HR (1) | HRP20160041T1 (zh) |
HU (1) | HUE028362T2 (zh) |
PL (1) | PL2136633T3 (zh) |
PT (1) | PT2136633E (zh) |
SI (1) | SI2136633T1 (zh) |
WO (1) | WO2008113078A1 (zh) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
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EP2269618A1 (en) | 2002-08-12 | 2011-01-05 | Jennerex Biotherapeutics ULC | An oncolytic vaccinia virus for use in combination with a chemotherapy for treating cancer. |
US8980246B2 (en) | 2005-09-07 | 2015-03-17 | Sillajen Biotherapeutics, Inc. | Oncolytic vaccinia virus cancer therapy |
KR20090004839A (ko) | 2005-09-07 | 2009-01-12 | 제네렉스, 인코포레이티드 | Gm-csf를 발현하는 폭스바이러스를 사용한 전이성및/또는 전신 파종성 암의 전신 치료법 |
WO2009139921A2 (en) * | 2008-05-16 | 2009-11-19 | Genelux Corporation | Microorganisms for preventing and treating neoplasms accompanying cellular therapy |
DK2477499T3 (en) | 2009-09-14 | 2018-06-06 | Sillajen Biotherapeutics Inc | COMBINATION CANCER THERAPY WITH ONCOLYTIC VACCINIA VIRUS |
JP6121910B2 (ja) * | 2011-01-04 | 2017-04-26 | シラジェン バイオセラピューティクス インコーポレイテッド | 腫瘍溶解性ワクシニアウイルスの投与による腫瘍抗原に対する抗体の生成および腫瘍特異的補体依存性細胞傷害の生成 |
EP2697368B1 (en) | 2011-04-15 | 2019-06-05 | Genelux Corporation | Clonal strains of attenuated vaccinia viruses and methods of use thereof |
CN103732236B (zh) * | 2011-08-05 | 2017-09-15 | 新罗杰公司 | 用于生产痘苗病毒的方法和组合物 |
US10140420B2 (en) * | 2011-10-12 | 2018-11-27 | Merge Healthcare Incorporation | Systems and methods for independent assessment of image data |
TWI690322B (zh) | 2012-10-02 | 2020-04-11 | 法商傳斯堅公司 | 含病毒的調配物及其使用 |
KR101632897B1 (ko) * | 2013-04-10 | 2016-06-23 | 신라젠(주) | 백시니아 바이러스로부터 유래한 신규한 항암 바이러스 hbb301 |
LT3778897T (lt) | 2013-08-22 | 2024-02-12 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Imunoonkolitinės terapijos |
ES2768715T3 (es) * | 2014-04-10 | 2020-06-23 | Transgene | Vectores oncolíticos poxvíricos |
KR102504758B1 (ko) | 2014-07-16 | 2023-02-28 | 트랜스진 | 종양 세포 붕괴성 바이러스와 면역 체크포인트 조절제의 배합물 |
KR101949849B1 (ko) * | 2014-07-17 | 2019-05-30 | 더 보드 오브 트러스티즈 오브 웨스턴 미시간 유니버시티 | 암세포를 치료하기 위한 조성물 및 그 방법 |
EP3186738A1 (en) | 2014-08-29 | 2017-07-05 | Koninklijke Philips N.V. | Handling undetermined quantifiable lesions |
AU2015357225B2 (en) | 2014-12-01 | 2020-04-09 | Transgene Sa | Stable liquid vaccinia virus formulations |
WO2016144564A2 (en) | 2015-02-25 | 2016-09-15 | Memorial Sloan-Kettering Cancer Center | Use of inactivated nonreplicating modified vaccinia virus ankara (mva)as monoimmunotherapy or in combination with immune checkpoint blocking agents for solid tumors |
US10548930B2 (en) | 2015-04-17 | 2020-02-04 | Memorial Sloan Kettering Cancer Center | Use of MVA or MVAΔE3L as immunotherapeutic agents against solid tumors |
CA2990133A1 (en) * | 2015-06-19 | 2017-03-09 | Sillajen, Inc. | Compositions and methods for viral embolization |
CN107921096A (zh) * | 2015-07-30 | 2018-04-17 | 恩多技术公司 | 用于胰腺癌或结肠癌治疗的集落刺激因子 |
MX2018010231A (es) | 2016-02-25 | 2019-06-06 | Memorial Sloan Kettering Cancer Center | Mva recombinante o mvadele3l que expresa el flt3l humano y uso de los mismos como agentes inmunoterapéuticos contra tumores sólidos. |
CN116440176A (zh) * | 2016-02-25 | 2023-07-18 | 纪念斯隆凯特琳癌症中心 | 具有胸苷激酶缺失和具有或不具有人flt3l或gm-csf表达的复制型减毒痘苗病毒 |
WO2017205674A1 (en) * | 2016-05-25 | 2017-11-30 | Arizona Board Of Regents On Behalf Of Arizona State University | Oncolytic vaccinia virus mutants and using same for cancer treatment |
CA3052463A1 (en) * | 2017-02-03 | 2018-08-09 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Oncolytic virus therapy |
US10575774B2 (en) | 2017-02-27 | 2020-03-03 | Case Western Reserve University | Predicting immunotherapy response in non-small cell lung cancer with serial radiomics |
ES2971065T3 (es) * | 2017-04-21 | 2024-06-03 | Sillajen Inc | Terapia de combinación de virus vaccinia oncolítica y un inhibidor de punto de control |
CN111107872A (zh) | 2017-05-12 | 2020-05-05 | 纪念斯隆-凯特林癌症中心 | 有用于癌症免疫疗法的牛痘病毒突变体 |
KR20190059421A (ko) * | 2017-11-23 | 2019-05-31 | 주식회사 바이오녹스 | 항암바이러스의 간동맥 투여를 이용한 간암 치료방법 |
JP2021503965A (ja) | 2017-12-01 | 2021-02-15 | スッター,ゲルド | 複製効率の高い免疫調節ワクシニアウイルス株 |
SG11202006457YA (en) | 2018-01-05 | 2020-08-28 | Ottawa Hospital Res Inst | Modified orthopoxvirus vectors |
WO2019168346A1 (ko) * | 2018-02-28 | 2019-09-06 | 주식회사 바이오녹스 | 항암바이러스 및 히드록시유레아를 유효성분으로 포함하는 암 예방 또는 치료용 약학 조성물 |
MX2021003013A (es) | 2018-09-15 | 2021-08-11 | Memorial Sloan Kettering Cancer Center | Poxvirus recombinantes para inmunoterapia contra cáncer. |
KR102661908B1 (ko) * | 2019-08-29 | 2024-04-29 | 주식회사 바이오녹스 | 백시니아 바이러스 및 과립백혈구 형성 억제제를 유효성분으로 포함하는 암 치료용 약학 조성물 |
EP4268837A1 (en) | 2020-12-22 | 2023-11-01 | Virocure, Inc. | Novel modified reovirus and use thereof |
KR20220122551A (ko) * | 2021-02-26 | 2022-09-02 | 신라젠(주) | 항암 바이러스 및 이의 용도 |
WO2024054040A1 (ko) * | 2022-09-07 | 2024-03-14 | 신라젠(주) | 항암 바이러스의 신규 용도 |
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US6177076B1 (en) * | 1997-12-09 | 2001-01-23 | Thomas Jefferson University | Method of treating bladder cancer with wild type vaccinia virus |
EP2325321A1 (en) * | 1999-05-28 | 2011-05-25 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | A combined growth factor-deleted and thymidine kinase-deleted vaccinia virus vector |
US20040091995A1 (en) * | 2001-06-15 | 2004-05-13 | Jeffrey Schlom | Recombinant non-replicating virus expressing gm-csf and uses thereof to enhance immune responses |
DE10134955C1 (de) * | 2001-07-23 | 2003-03-06 | Infineon Technologies Ag | Anordnung von Gräben in einem Halbleitersubstrat, insbesondere für Grabenkondensatoren |
EP2269618A1 (en) * | 2002-08-12 | 2011-01-05 | Jennerex Biotherapeutics ULC | An oncolytic vaccinia virus for use in combination with a chemotherapy for treating cancer. |
MXPA05013879A (es) * | 2003-06-18 | 2006-06-27 | Genelux Corp | Virus de la vaccinia recombinantes modificados y otros microorganismos, y usos de los mismos. |
KR20090004839A (ko) * | 2005-09-07 | 2009-01-12 | 제네렉스, 인코포레이티드 | Gm-csf를 발현하는 폭스바이러스를 사용한 전이성및/또는 전신 파종성 암의 전신 치료법 |
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2007
- 2007-07-11 KR KR1020070069583A patent/KR20080084528A/ko not_active Application Discontinuation
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2008
- 2008-03-17 WO PCT/US2008/057257 patent/WO2008113078A1/en active Application Filing
- 2008-03-17 JP JP2009553840A patent/JP5879024B2/ja active Active
- 2008-03-17 AU AU2008224811A patent/AU2008224811B2/en active Active
- 2008-03-17 DK DK08732358.0T patent/DK2136633T3/en active
- 2008-03-17 PT PT87323580T patent/PT2136633E/pt unknown
- 2008-03-17 CN CN200880014543A patent/CN101790310A/zh active Pending
- 2008-03-17 SI SI200831556T patent/SI2136633T1/sl unknown
- 2008-03-17 CA CA2681096A patent/CA2681096C/en active Active
- 2008-03-17 US US12/531,353 patent/US20100303714A1/en not_active Abandoned
- 2008-03-17 ES ES08732358.0T patent/ES2559684T3/es active Active
- 2008-03-17 HU HUE08732358A patent/HUE028362T2/en unknown
- 2008-03-17 BR BRPI0808736-9A2A patent/BRPI0808736A2/pt not_active Application Discontinuation
- 2008-03-17 CN CN201610872804.XA patent/CN106265765A/zh active Pending
- 2008-03-17 KR KR1020097021555A patent/KR20090122293A/ko active Search and Examination
- 2008-03-17 EP EP08732358.0A patent/EP2136633B1/en active Active
- 2008-03-17 KR KR1020157008176A patent/KR101869235B1/ko active IP Right Grant
- 2008-03-17 PL PL08732358T patent/PL2136633T3/pl unknown
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2010
- 2010-06-25 HK HK10106289.5A patent/HK1139563A1/zh unknown
-
2014
- 2014-05-07 JP JP2014095947A patent/JP6147696B2/ja active Active
-
2016
- 2016-01-08 CY CY20161100008T patent/CY1117107T1/el unknown
- 2016-01-13 HR HRP20160041TT patent/HRP20160041T1/hr unknown
Also Published As
Publication number | Publication date |
---|---|
BRPI0808736A2 (pt) | 2014-08-19 |
AU2008224811A1 (en) | 2008-09-18 |
CA2681096C (en) | 2015-09-01 |
PL2136633T3 (pl) | 2016-04-29 |
US20100303714A1 (en) | 2010-12-02 |
KR20090122293A (ko) | 2009-11-26 |
PT2136633E (pt) | 2016-02-22 |
CY1117107T1 (el) | 2017-04-05 |
CA2681096A1 (en) | 2008-09-18 |
JP2014193882A (ja) | 2014-10-09 |
CN101790310A (zh) | 2010-07-28 |
KR20150041181A (ko) | 2015-04-15 |
EP2136633A4 (en) | 2012-01-18 |
KR20080084528A (ko) | 2008-09-19 |
DK2136633T3 (en) | 2016-01-25 |
KR101869235B1 (ko) | 2018-07-11 |
EP2136633B1 (en) | 2015-10-28 |
AU2008224811B2 (en) | 2013-09-26 |
HUE028362T2 (en) | 2016-12-28 |
JP2010521497A (ja) | 2010-06-24 |
HRP20160041T1 (hr) | 2016-02-12 |
SI2136633T1 (sl) | 2016-03-31 |
WO2008113078A1 (en) | 2008-09-18 |
EP2136633A1 (en) | 2009-12-30 |
JP5879024B2 (ja) | 2016-03-08 |
JP6147696B2 (ja) | 2017-06-14 |
ES2559684T3 (es) | 2016-02-15 |
CN106265765A (zh) | 2017-01-04 |
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