HK1138850A1 - Quinoline derivatives for the treatment of inflammatory diseases - Google Patents
Quinoline derivatives for the treatment of inflammatory diseasesInfo
- Publication number
- HK1138850A1 HK1138850A1 HK10105772.1A HK10105772A HK1138850A1 HK 1138850 A1 HK1138850 A1 HK 1138850A1 HK 10105772 A HK10105772 A HK 10105772A HK 1138850 A1 HK1138850 A1 HK 1138850A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- treatment
- inflammatory diseases
- quinoline derivatives
- quinoline
- derivatives
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US89629807P | 2007-03-22 | 2007-03-22 | |
PCT/GB2008/000946 WO2008114002A1 (en) | 2007-03-22 | 2008-03-19 | Quinoline derivatives for the treatment of inflammatory diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1138850A1 true HK1138850A1 (en) | 2010-09-03 |
Family
ID=39471999
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK10105772.1A HK1138850A1 (en) | 2007-03-22 | 2010-06-10 | Quinoline derivatives for the treatment of inflammatory diseases |
Country Status (18)
Country | Link |
---|---|
US (1) | US7964616B2 (xx) |
EP (1) | EP2139879B1 (xx) |
JP (1) | JP2010522227A (xx) |
KR (1) | KR20090122396A (xx) |
CN (1) | CN101679350B (xx) |
AR (1) | AR065806A1 (xx) |
AU (1) | AU2008228067B2 (xx) |
BR (1) | BRPI0809106A2 (xx) |
CA (1) | CA2680761A1 (xx) |
CL (1) | CL2008000825A1 (xx) |
ES (1) | ES2388454T3 (xx) |
HK (1) | HK1138850A1 (xx) |
MX (1) | MX2009010059A (xx) |
PE (1) | PE20091225A1 (xx) |
RU (1) | RU2460727C2 (xx) |
TW (1) | TW200904427A (xx) |
UY (1) | UY30976A1 (xx) |
WO (1) | WO2008114002A1 (xx) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2388454T3 (es) | 2007-03-22 | 2012-10-15 | Astrazeneca Ab | Derivados de quinolina para el tratamiento de enfermedades inflamatorias |
PE20091036A1 (es) * | 2007-11-30 | 2009-08-15 | Astrazeneca Ab | Derivado de quinolina como antagonista del receptor p2x7 |
JP5955957B2 (ja) | 2011-07-22 | 2016-07-20 | アクテリオン ファーマシューティカルズ リミテッドActelion Pharmaceuticals Ltd | P2x7受容体アンタゴニストとしての複素環アミド誘導体 |
EA024204B1 (ru) | 2012-01-20 | 2016-08-31 | Актелион Фармасьютиклз Лтд. | Производные гетероциклических амидов в качестве антагонистов p2xрецептора |
CA2890886C (en) | 2012-12-12 | 2020-10-27 | Actelion Pharmaceuticals Ltd | Indole carboxamide derivatives as p2x7 receptor antagonists |
US9556117B2 (en) | 2012-12-18 | 2017-01-31 | Actelion Pharmaceuticals Ltd. | Indole carboxamide derivatives as P2X7 receptor antagonists |
JP6282016B2 (ja) | 2013-01-22 | 2018-02-21 | イドーシア ファーマシューティカルズ リミテッドIdorsia Pharmaceuticals Ltd | P2x7受容体アンタゴニストとしての複素環アミド誘導体 |
CN104918946B (zh) | 2013-01-22 | 2017-03-29 | 埃科特莱茵药品有限公司 | 作为p2x7受体拮抗剂的杂环酰胺衍生物 |
PE20160608A1 (es) | 2013-10-14 | 2016-07-08 | Eisai Randd Man Co Ltd | Compuestos de quinolina selectivamente sustituida |
US9399623B2 (en) * | 2014-06-05 | 2016-07-26 | Merck Patent Gmbh | Quinoline derivatives and their use in neurodegenerative diseases |
ES2928164T3 (es) | 2015-10-19 | 2022-11-15 | Incyte Corp | Compuestos heterocíclicos como inmunomoduladores |
MX2018006207A (es) | 2015-11-19 | 2018-09-05 | Incyte Corp | Compuestos heterociclicos como inmunomoduladores. |
EA201891494A1 (ru) | 2015-12-22 | 2019-01-31 | Инсайт Корпорейшн | Гетероциклические соединения в качестве иммуномодуляторов |
EP3452476B1 (en) | 2016-05-06 | 2021-12-15 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
ES2905980T3 (es) | 2016-05-26 | 2022-04-12 | Incyte Corp | Compuestos heterocíclicos como inmunomoduladores |
HUE060256T2 (hu) | 2016-06-20 | 2023-02-28 | Incyte Corp | Heterociklusos vegyületek mint immunmodulátorok |
US20180016260A1 (en) | 2016-07-14 | 2018-01-18 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
WO2018044783A1 (en) | 2016-08-29 | 2018-03-08 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
EP3558973B1 (en) | 2016-12-22 | 2021-09-15 | Incyte Corporation | Pyridine derivatives as immunomodulators |
KR20190111025A (ko) | 2016-12-22 | 2019-10-01 | 인사이트 코포레이션 | 면역조절제로서의 벤조옥사졸 유도체 |
WO2018119236A1 (en) | 2016-12-22 | 2018-06-28 | Incyte Corporation | Triazolo[1,5-a]pyridine derivatives as immunomodulators |
HRP20230090T1 (hr) | 2018-03-30 | 2023-03-17 | Incyte Corporation | Heterociklički spojevi kao imunomodulatori |
SG11202011165TA (en) | 2018-05-11 | 2020-12-30 | Incyte Corp | Tetrahydro-imidazo[4,5-c]pyridine derivatives as pd-l1 immunomodulators |
MA55805A (fr) | 2019-05-03 | 2022-03-09 | Flagship Pioneering Innovations V Inc | Métodes de modulation de l'activité immunitaire |
MX2022001671A (es) | 2019-08-09 | 2022-05-13 | Incyte Corp | Sales de un inhibidor de pd-1/pd-l1. |
EP4037773A1 (en) | 2019-09-30 | 2022-08-10 | Incyte Corporation | Pyrido[3,2-d]pyrimidine compounds as immunomodulators |
AU2020385113A1 (en) | 2019-11-11 | 2022-05-19 | Incyte Corporation | Salts and crystalline forms of a PD-1/PD-L1 inhibitor |
JP2023548859A (ja) | 2020-11-06 | 2023-11-21 | インサイト・コーポレイション | Pd-1/pd-l1阻害剤ならびにその塩及び結晶形態を作製するためのプロセス |
US11760756B2 (en) | 2020-11-06 | 2023-09-19 | Incyte Corporation | Crystalline form of a PD-1/PD-L1 inhibitor |
WO2022099018A1 (en) | 2020-11-06 | 2022-05-12 | Incyte Corporation | Process of preparing a pd-1/pd-l1 inhibitor |
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SE9704544D0 (sv) * | 1997-12-05 | 1997-12-05 | Astra Pharma Prod | Novel compounds |
RU2254333C2 (ru) | 1999-04-09 | 2005-06-20 | Астразенека Аб | Производные адамантана, способ их получения, фармацевтическая композиция на их основе и способы лечения |
DE60022050C5 (de) | 1999-06-02 | 2007-10-11 | NPS Pharmaceuticals, Inc., Salt Lake City | Metabotrope glutamatrezeptorantagonisten zur behandlung von krankheiten des zentralen nervensystems |
CN1391469B (zh) | 1999-11-26 | 2010-05-26 | 盐野义制药株式会社 | Npy y5拮抗剂 |
SE9904652D0 (sv) * | 1999-12-17 | 1999-12-17 | Astra Pharma Prod | Novel Compounds |
GB0013737D0 (en) | 2000-06-07 | 2000-07-26 | Astrazeneca Ab | Novel compounds |
KR100908468B1 (ko) * | 2001-07-02 | 2009-07-21 | 엔.브이.오가논 | 테트라히드로퀴놀린 유도체 |
WO2003042190A1 (en) | 2001-11-12 | 2003-05-22 | Pfizer Products Inc. | N-alkyl-adamantyl derivatives as p2x7-receptor antagonists |
SE0103836D0 (sv) * | 2001-11-16 | 2001-11-16 | Astrazeneca Ab | Novel compounds |
US7084156B2 (en) | 2001-11-27 | 2006-08-01 | Merck & Co., Inc. | 2-Aminoquinoline compounds |
SE0200920D0 (sv) | 2002-03-25 | 2002-03-25 | Astrazeneca Ab | Novel compounds |
AU2003226149A1 (en) | 2002-04-05 | 2003-10-27 | Merck & Co., Inc. | Substituted aryl amides |
CA2525437C (en) * | 2003-05-12 | 2009-04-28 | Pfizer Products Inc. | Benzamide inhibitors of the p2x7 receptor |
GB0312609D0 (en) * | 2003-06-02 | 2003-07-09 | Astrazeneca Ab | Novel compounds |
SE0302139D0 (sv) * | 2003-07-28 | 2003-07-28 | Astrazeneca Ab | Novel compounds |
SE0402925D0 (sv) | 2004-11-30 | 2004-11-30 | Astrazeneca Ab | Novel Compounds |
US20080058309A1 (en) * | 2006-07-27 | 2008-03-06 | Astrazeneca Ab | Novel Compounds 171 |
ES2388454T3 (es) | 2007-03-22 | 2012-10-15 | Astrazeneca Ab | Derivados de quinolina para el tratamiento de enfermedades inflamatorias |
PE20091036A1 (es) * | 2007-11-30 | 2009-08-15 | Astrazeneca Ab | Derivado de quinolina como antagonista del receptor p2x7 |
-
2008
- 2008-03-19 ES ES08718785T patent/ES2388454T3/es active Active
- 2008-03-19 EP EP08718785A patent/EP2139879B1/en not_active Not-in-force
- 2008-03-19 AU AU2008228067A patent/AU2008228067B2/en not_active Ceased
- 2008-03-19 CN CN200880017135.1A patent/CN101679350B/zh not_active Expired - Fee Related
- 2008-03-19 BR BRPI0809106-4A patent/BRPI0809106A2/pt not_active IP Right Cessation
- 2008-03-19 KR KR1020097021940A patent/KR20090122396A/ko not_active Application Discontinuation
- 2008-03-19 AR ARP080101169A patent/AR065806A1/es unknown
- 2008-03-19 PE PE2008000516A patent/PE20091225A1/es not_active Application Discontinuation
- 2008-03-19 CA CA002680761A patent/CA2680761A1/en not_active Abandoned
- 2008-03-19 RU RU2009135621/04A patent/RU2460727C2/ru not_active IP Right Cessation
- 2008-03-19 MX MX2009010059A patent/MX2009010059A/es active IP Right Grant
- 2008-03-19 WO PCT/GB2008/000946 patent/WO2008114002A1/en active Application Filing
- 2008-03-19 JP JP2010500344A patent/JP2010522227A/ja active Pending
- 2008-03-20 CL CL2008000825A patent/CL2008000825A1/es unknown
- 2008-03-21 US US12/052,908 patent/US7964616B2/en not_active Expired - Fee Related
- 2008-03-21 TW TW097110021A patent/TW200904427A/zh unknown
- 2008-03-24 UY UY30976A patent/UY30976A1/es unknown
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2010
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Also Published As
Publication number | Publication date |
---|---|
JP2010522227A (ja) | 2010-07-01 |
KR20090122396A (ko) | 2009-11-27 |
CL2008000825A1 (es) | 2008-11-03 |
BRPI0809106A2 (pt) | 2014-08-26 |
US7964616B2 (en) | 2011-06-21 |
AU2008228067B2 (en) | 2011-12-08 |
RU2460727C2 (ru) | 2012-09-10 |
UY30976A1 (es) | 2008-10-31 |
RU2009135621A (ru) | 2011-04-27 |
AU2008228067A1 (en) | 2008-09-25 |
EP2139879B1 (en) | 2012-07-11 |
ES2388454T3 (es) | 2012-10-15 |
US20080234319A1 (en) | 2008-09-25 |
CN101679350A (zh) | 2010-03-24 |
MX2009010059A (es) | 2009-10-12 |
AR065806A1 (es) | 2009-07-01 |
EP2139879A1 (en) | 2010-01-06 |
PE20091225A1 (es) | 2009-09-16 |
TW200904427A (en) | 2009-02-01 |
CN101679350B (zh) | 2014-03-12 |
WO2008114002A1 (en) | 2008-09-25 |
CA2680761A1 (en) | 2008-09-25 |
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