HK1128624A1 - Bispecific single chain fv antibody molecules and methods of use thereof fv - Google Patents

Bispecific single chain fv antibody molecules and methods of use thereof fv

Info

Publication number
HK1128624A1
HK1128624A1 HK09106873.0A HK09106873A HK1128624A1 HK 1128624 A1 HK1128624 A1 HK 1128624A1 HK 09106873 A HK09106873 A HK 09106873A HK 1128624 A1 HK1128624 A1 HK 1128624A1
Authority
HK
Hong Kong
Prior art keywords
single chain
antibody molecules
bispecific single
methods
overexpression
Prior art date
Application number
HK09106873.0A
Other languages
English (en)
Chinese (zh)
Inventor
Gregory P Adams
Eva M Horak
Louis M Weiner
James D Marks
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Publication of HK1128624A1 publication Critical patent/HK1128624A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1084—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody the antibody being a hybrid immunoglobulin
    • A61K51/109—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody the antibody being a hybrid immunoglobulin immunoglobulins having two or more different antigen-binding sites or multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/71—Assays involving receptors, cell surface antigens or cell surface determinants for growth factors; for growth regulators

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
HK09106873.0A 2005-06-15 2009-07-24 Bispecific single chain fv antibody molecules and methods of use thereof fv HK1128624A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/154,103 US7332585B2 (en) 2002-04-05 2005-06-15 Bispecific single chain Fv antibody molecules and methods of use thereof
PCT/US2006/023479 WO2007084181A2 (fr) 2005-06-15 2006-06-14 Molécules d'anticorps fv à chaîne unique bispécifiques et procédés d'utilisation de celles-ci

Publications (1)

Publication Number Publication Date
HK1128624A1 true HK1128624A1 (en) 2009-11-06

Family

ID=38288069

Family Applications (1)

Application Number Title Priority Date Filing Date
HK09106873.0A HK1128624A1 (en) 2005-06-15 2009-07-24 Bispecific single chain fv antibody molecules and methods of use thereof fv

Country Status (12)

Country Link
US (3) US7332585B2 (fr)
EP (2) EP2425850B1 (fr)
JP (1) JP4945557B2 (fr)
CN (1) CN101355966B (fr)
AT (1) ATE530195T1 (fr)
AU (1) AU2006336279B2 (fr)
BR (1) BRPI0611829A2 (fr)
CA (1) CA2612467A1 (fr)
DK (1) DK1912674T3 (fr)
ES (1) ES2377098T3 (fr)
HK (1) HK1128624A1 (fr)
WO (1) WO2007084181A2 (fr)

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US8329873B2 (en) 2012-12-11
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ATE530195T1 (de) 2011-11-15
WO2007084181A2 (fr) 2007-07-26
EP2425850A8 (fr) 2012-04-25
US20130202603A1 (en) 2013-08-08
DK1912674T3 (da) 2012-02-13
CN101355966A (zh) 2009-01-28
EP1912674B1 (fr) 2011-10-26
EP1912674A4 (fr) 2009-05-27
CA2612467A1 (fr) 2007-07-26
AU2006336279A1 (en) 2007-07-26
US20090010840A1 (en) 2009-01-08
EP1912674B8 (fr) 2012-04-25
WO2007084181A3 (fr) 2008-08-28
AU2006336279B2 (en) 2012-05-17
US7332585B2 (en) 2008-02-19
EP1912674A2 (fr) 2008-04-23
BRPI0611829A2 (pt) 2010-09-28
CN101355966B (zh) 2014-06-25
EP2425850A3 (fr) 2012-05-23
US20060099205A1 (en) 2006-05-11
EP2425850A2 (fr) 2012-03-07
US8980258B2 (en) 2015-03-17
ES2377098T3 (es) 2012-03-22

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