HK1127360A1 - Cationic oligonucleotides, automated methods for preparing same and their uses - Google Patents
Cationic oligonucleotides, automated methods for preparing same and their usesInfo
- Publication number
- HK1127360A1 HK1127360A1 HK09106495.8A HK09106495A HK1127360A1 HK 1127360 A1 HK1127360 A1 HK 1127360A1 HK 09106495 A HK09106495 A HK 09106495A HK 1127360 A1 HK1127360 A1 HK 1127360A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- preparing same
- automated methods
- cationic oligonucleotides
- oligonucleotides
- cationic
- Prior art date
Links
- 108091034117 Oligonucleotide Proteins 0.000 title 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 title 1
- 125000002091 cationic group Chemical group 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
- A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
- A61K48/0041—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being polymeric
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75034605P | 2005-12-15 | 2005-12-15 | |
| PCT/IB2006/004085 WO2007069092A2 (en) | 2005-12-15 | 2006-12-14 | Cationic oligonucleotides, automated methods for preparing same and their uses |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1127360A1 true HK1127360A1 (en) | 2009-09-25 |
Family
ID=38163300
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK09106495.8A HK1127360A1 (en) | 2005-12-15 | 2009-07-16 | Cationic oligonucleotides, automated methods for preparing same and their uses |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US9090648B2 (ru) |
| EP (1) | EP1973927B1 (ru) |
| JP (1) | JP5346585B2 (ru) |
| KR (1) | KR101388320B1 (ru) |
| CN (1) | CN101370817B (ru) |
| AU (1) | AU2006325054B2 (ru) |
| BR (1) | BRPI0619932A2 (ru) |
| CA (1) | CA2633065C (ru) |
| ES (1) | ES2435420T3 (ru) |
| HK (1) | HK1127360A1 (ru) |
| IL (1) | IL192158A0 (ru) |
| NZ (1) | NZ569138A (ru) |
| RU (1) | RU2451022C2 (ru) |
| WO (1) | WO2007069092A2 (ru) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1973927B1 (en) | 2005-12-15 | 2013-08-14 | Centre National de la Recherche Scientifique - CNRS | Cationic oligonucleotides, automated methods for preparing same and their uses |
| EP2075342A1 (en) | 2007-12-27 | 2009-07-01 | PolyPlus Transfection | Method for hybridizing nucleic acids |
| FR2926818B1 (fr) * | 2008-01-30 | 2012-04-06 | Centre Nat Rech Scient | siRNA CATIONIQUES, SYNTHESE ET UTILISATION POUR L'ARN INTERFERENCE |
| WO2010028288A2 (en) | 2008-09-05 | 2010-03-11 | Aueon, Inc. | Methods for stratifying and annotating cancer drug treatment options |
| US20120302737A1 (en) | 2009-09-16 | 2012-11-29 | Genentech, Inc. | Coiled coil and/or tether containing protein complexes and uses thereof |
| CN102140458B (zh) * | 2010-01-29 | 2013-05-22 | 苏州瑞博生物技术有限公司 | 小干扰核酸和药物组合物及其制药应用 |
| CN102140461B (zh) * | 2010-01-29 | 2012-12-05 | 苏州瑞博生物技术有限公司 | 小干扰核酸和药物组合物及其制药应用 |
| CN102140459B (zh) * | 2010-01-29 | 2013-04-03 | 苏州瑞博生物技术有限公司 | 一种小干扰核酸和药物组合物及其制药应用 |
| WO2011108930A1 (en) | 2010-03-04 | 2011-09-09 | Interna Technologies Bv | A MiRNA MOLECULE DEFINED BY ITS SOURCE AND ITS DIAGNOSTIC AND THERAPEUTIC USES IN DISEASES OR CONDITIONS ASSOCIATED WITH EMT |
| TW201138821A (en) | 2010-03-26 | 2011-11-16 | Roche Glycart Ag | Bispecific antibodies |
| CA2804599C (en) | 2010-07-06 | 2023-01-31 | Interna Technologies Bv | Mirna and its diagnostic and therapeutic uses in diseases or conditions associated with melanoma, or in diseases or conditions associated with activated braf pathway |
| WO2012085113A1 (en) | 2010-12-23 | 2012-06-28 | Roche Diagnostics Gmbh | Binding agent |
| SG191153A1 (en) | 2010-12-23 | 2013-07-31 | Hoffmann La Roche | Polypeptide-polynucleotide-complex and its use in targeted effector moiety delivery |
| EP2659269B1 (en) | 2010-12-23 | 2016-10-26 | Roche Diagniostics GmbH | Detection of a posttranslationally modified polypeptide by a bi-valent binding agent |
| EP2474617A1 (en) | 2011-01-11 | 2012-07-11 | InteRNA Technologies BV | Mir for treating neo-angiogenesis |
| WO2012157723A1 (ja) | 2011-05-17 | 2012-11-22 | 味の素株式会社 | オリゴヌクレオチドの製造方法 |
| US10174314B2 (en) | 2011-12-22 | 2019-01-08 | Interna Technologies B.V. | MiRNA for treating head and neck cancer |
| CN104105711B (zh) | 2012-02-10 | 2018-11-30 | 弗·哈夫曼-拉罗切有限公司 | 单链抗体及其他异多聚体 |
| CN104395339A (zh) | 2012-06-27 | 2015-03-04 | 弗·哈夫曼-拉罗切有限公司 | 用于选择并产生含有至少两种不同结合实体的定制高度选择性和多特异性靶向实体的方法及其用途 |
| CA2871882A1 (en) | 2012-06-27 | 2014-01-03 | F. Hoffmann-La Roche Ag | Method for making antibody fc-region conjugates comprising at least one binding entity that specifically binds to a target and uses thereof |
| EP3800256A1 (en) | 2012-11-06 | 2021-04-07 | InteRNA Technologies B.V. | Combination to be used in therapeutic use against diseases or conditions associated with melanoma, or in diseases or conditions associated with activated b-raf pathway |
| JP6609246B2 (ja) | 2013-06-28 | 2019-11-20 | エスリス ゲーエムベーハー | 細胞内へのｒｎａ導入用組成物 |
| US9410172B2 (en) | 2013-09-16 | 2016-08-09 | General Electric Company | Isothermal amplification using oligocation-conjugated primer sequences |
| KR20160121584A (ko) | 2014-02-26 | 2016-10-19 | 에트리스 게엠베하 | Rna의 위장 투여용 조성물 |
| RU2553349C1 (ru) * | 2014-05-07 | 2015-06-10 | Федеральное бюджетное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор" (ФБУН ГНЦ ВБ "Вектор") | Олигодезоксирибонуклеотидный ингибитор днк-метилтрансферазы 1 человека |
| ES2764111T3 (es) | 2014-12-03 | 2020-06-02 | Hoffmann La Roche | Anticuerpos multiespecíficos |
| EP3034539A1 (en) | 2014-12-19 | 2016-06-22 | Ethris GmbH | Compositions for introducing nucleic acid into cells |
| DE102017123919A1 (de) | 2017-10-13 | 2019-04-18 | Gna Biosolutions Gmbh | Verfahren und Vorrichtung zur Lyse von Mikroorganismen |
| US11497762B2 (en) | 2017-11-03 | 2022-11-15 | Interna Technologies B.V. | MiRNA molecule, equivalent, antagomir, or source thereof for treating and/or diagnosing a condition and/or a disease associated with neuronal deficiency or for neuronal (re)generation |
| CA3088321A1 (en) | 2018-02-12 | 2019-08-15 | Interna Technologies B.V. | Anticancer microrna and lipid formulations thereof |
| WO2019207061A1 (en) | 2018-04-25 | 2019-10-31 | Ethris Gmbh | Cryoprotective agents for particulate formulations |
| KR20200045212A (ko) * | 2018-10-22 | 2020-05-04 | (주)바이오니아 | 옥타민 또는 옥타민 유도체가 결합된 프로브 및 이의 용도 |
| US20240156729A1 (en) | 2021-02-26 | 2024-05-16 | Ethris Gmbh | Formulations for aerosol formation and aerosols for the delivery of nucleic acid |
| EP4327829A1 (en) | 2022-08-26 | 2024-02-28 | Ethris GmbH | Stabilization of lipid or lipidoid nanoparticle suspensions |
| WO2024042236A1 (en) | 2022-08-26 | 2024-02-29 | Ethris Gmbh | Stable lipid or lipidoid nanoparticle suspensions |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5656611A (en) * | 1994-11-18 | 1997-08-12 | Supratek Pharma Inc. | Polynucleotide compositions |
| US6071890A (en) | 1994-12-09 | 2000-06-06 | Genzyme Corporation | Organ-specific targeting of cationic amphiphile/DNA complexes for gene therapy |
| EP1003527A4 (en) * | 1997-08-01 | 2003-07-16 | Supratek Pharma Inc | POLYNUCLEOTIDE COMPOSITIONS |
| EP1013770A1 (en) * | 1998-12-23 | 2000-06-28 | Université Louis Pasteur de Strasbourg | Non-viral transfection vector |
| US6147200A (en) * | 1999-08-19 | 2000-11-14 | Isis Pharmaceuticals, Inc. | 2'-O-acetamido modified monomers and oligomers |
| DE10207177A1 (de) | 2002-02-19 | 2003-09-04 | Novosom Ag | Fakultativ kationische Lipide |
| US20040019008A1 (en) | 2002-05-28 | 2004-01-29 | Lewis David L. | Compositions and processes using siRNA, amphipathic compounds and polycations |
| JP2004137143A (ja) | 2002-08-21 | 2004-05-13 | Fuji Photo Film Co Ltd | 有機変性層状珪酸塩及びその組成物 |
| EP1585756B1 (en) | 2002-11-26 | 2010-04-21 | University of Massachusetts | Delivery of sirnas |
| RU2236467C1 (ru) * | 2003-04-14 | 2004-09-20 | Институт химической биологии и фундаментальной медицины СО РАН | Способ получения днк-чипов |
| WO2004110496A1 (en) | 2003-06-18 | 2004-12-23 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Sphingoid polyalkylamine conjugates for vaccination |
| CA2549720C (en) | 2003-12-19 | 2013-10-15 | Chiron Corporation | Cell transfecting formulations of small interfering rna, related compositions and methods of making and use |
| US7642343B2 (en) * | 2004-04-16 | 2010-01-05 | Japan Science And Technology Agency | PEG-functional nucleic acid conjugate |
| AU2005304816A1 (en) | 2004-11-04 | 2006-05-18 | Raul Andino | Syntheses of polyamine conjugates of small interfering RNAs (si-RNAs) and conjugates formed thereby |
| EP1812016A4 (en) | 2004-11-17 | 2010-07-14 | Univ Maryland | HIGHLY BRANCHED HK PEPTIDES AS EFFECTIVE CARRIERS OF SMALL INTERFERING RNA |
| EP1973927B1 (en) | 2005-12-15 | 2013-08-14 | Centre National de la Recherche Scientifique - CNRS | Cationic oligonucleotides, automated methods for preparing same and their uses |
| EP1844772A1 (en) | 2006-04-06 | 2007-10-17 | Polyplus-Transfection SA | Compositions for transfection of oligonucleotides active for gene silencing and their biological and therapeutical applications |
| AU2007241370A1 (en) | 2006-04-20 | 2007-11-01 | Silence Therapeutics Ag. | Lipoplex formulations for specific delivery to vascular endothelium |
| FR2926818B1 (fr) | 2008-01-30 | 2012-04-06 | Centre Nat Rech Scient | siRNA CATIONIQUES, SYNTHESE ET UTILISATION POUR L'ARN INTERFERENCE |
-
2006
- 2006-12-14 EP EP06847298.4A patent/EP1973927B1/en active Active
- 2006-12-14 AU AU2006325054A patent/AU2006325054B2/en active Active
- 2006-12-14 ES ES06847298T patent/ES2435420T3/es active Active
- 2006-12-14 WO PCT/IB2006/004085 patent/WO2007069092A2/en active Application Filing
- 2006-12-14 JP JP2008545144A patent/JP5346585B2/ja active Active
- 2006-12-14 BR BRPI0619932-1A patent/BRPI0619932A2/pt not_active IP Right Cessation
- 2006-12-14 CA CA2633065A patent/CA2633065C/en active Active
- 2006-12-14 NZ NZ569138A patent/NZ569138A/en unknown
- 2006-12-14 KR KR1020087017193A patent/KR101388320B1/ko active IP Right Grant
- 2006-12-14 US US12/086,599 patent/US9090648B2/en active Active
- 2006-12-14 RU RU2008128853/04A patent/RU2451022C2/ru active
- 2006-12-14 CN CN2006800510864A patent/CN101370817B/zh active Active
-
2008
- 2008-06-15 IL IL192158A patent/IL192158A0/en active IP Right Grant
-
2009
- 2009-07-16 HK HK09106495.8A patent/HK1127360A1/xx unknown
-
2015
- 2015-06-22 US US14/745,871 patent/US9676798B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| RU2008128853A (ru) | 2010-01-20 |
| BRPI0619932A2 (pt) | 2011-10-25 |
| JP5346585B2 (ja) | 2013-11-20 |
| ES2435420T3 (es) | 2013-12-19 |
| EP1973927B1 (en) | 2013-08-14 |
| NZ569138A (en) | 2012-06-29 |
| US9676798B2 (en) | 2017-06-13 |
| US20090069262A1 (en) | 2009-03-12 |
| WO2007069092B1 (en) | 2008-06-19 |
| CN101370817A (zh) | 2009-02-18 |
| RU2451022C2 (ru) | 2012-05-20 |
| WO2007069092A2 (en) | 2007-06-21 |
| CA2633065A1 (en) | 2007-06-21 |
| US9090648B2 (en) | 2015-07-28 |
| CN101370817B (zh) | 2012-08-08 |
| CA2633065C (en) | 2016-10-18 |
| AU2006325054A1 (en) | 2007-06-21 |
| US20160280728A1 (en) | 2016-09-29 |
| KR20080087001A (ko) | 2008-09-29 |
| JP2009519317A (ja) | 2009-05-14 |
| AU2006325054B2 (en) | 2013-05-02 |
| KR101388320B1 (ko) | 2014-04-22 |
| WO2007069092A3 (en) | 2008-04-17 |
| EP1973927A2 (en) | 2008-10-01 |
| IL192158A0 (en) | 2009-02-11 |
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