HK1107692A1 - Radicals and their use as paramagnetic agents in a dynamic nuclear polarisation process - Google Patents

Radicals and their use as paramagnetic agents in a dynamic nuclear polarisation process

Info

Publication number
HK1107692A1
HK1107692A1 HK07113303.8A HK07113303A HK1107692A1 HK 1107692 A1 HK1107692 A1 HK 1107692A1 HK 07113303 A HK07113303 A HK 07113303A HK 1107692 A1 HK1107692 A1 HK 1107692A1
Authority
HK
Hong Kong
Prior art keywords
radicals
dynamic nuclear
paramagnetic agents
nuclear polarisation
polarisation process
Prior art date
Application number
HK07113303.8A
Other languages
English (en)
Chinese (zh)
Inventor
Mikkel Thaning
Original Assignee
Ge Healthcare As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ge Healthcare As filed Critical Ge Healthcare As
Publication of HK1107692A1 publication Critical patent/HK1107692A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves  involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/20—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations containing free radicals, e.g. trityl radical for overhauser
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/62—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using double resonance

Landscapes

  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Signal Processing (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
HK07113303.8A 2004-07-30 2007-12-05 Radicals and their use as paramagnetic agents in a dynamic nuclear polarisation process HK1107692A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NO20043227 2004-07-30
PCT/NO2005/000283 WO2006011811A2 (en) 2004-07-30 2005-07-28 Radicals and their use as paramagnetic agents in a dynamic nuclear polarisation process

Publications (1)

Publication Number Publication Date
HK1107692A1 true HK1107692A1 (en) 2008-04-11

Family

ID=35502005

Family Applications (1)

Application Number Title Priority Date Filing Date
HK07113303.8A HK1107692A1 (en) 2004-07-30 2007-12-05 Radicals and their use as paramagnetic agents in a dynamic nuclear polarisation process

Country Status (18)

Country Link
US (1) US8431723B2 (pt)
EP (1) EP1805186B1 (pt)
JP (1) JP5535435B2 (pt)
KR (3) KR20070061805A (pt)
CN (1) CN101027310B (pt)
AU (1) AU2005267670B2 (pt)
BR (1) BRPI0513880A (pt)
CA (1) CA2575473C (pt)
DK (1) DK1805186T3 (pt)
ES (1) ES2545377T3 (pt)
HK (1) HK1107692A1 (pt)
IL (1) IL180895A (pt)
MX (1) MX2007001034A (pt)
NO (1) NO339934B1 (pt)
PL (1) PL1805186T3 (pt)
RU (1) RU2374253C2 (pt)
WO (1) WO2006011811A2 (pt)
ZA (1) ZA200701272B (pt)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2005267668B2 (en) * 2004-07-30 2011-10-20 Ge Healthcare As Method of producing a composition, composition and its use
EP1954321B1 (en) 2005-12-01 2011-11-23 Ge Healthcare As Method of dynamic nuclear polarisation (dnp) using a trityl radical and a paramagnetic metal ion
EP1962912B1 (en) * 2005-12-16 2012-09-26 Ge Healthcare As Method to produce hyperpolarised carboxylates of organic amines
JP5269791B2 (ja) 2006-08-30 2013-08-21 ジーイー・ヘルスケア・アクスイェ・セルスカプ 動的核分極（ｄｎｐ）方法並びに該方法で使用するための化合物及び組成物
JP2008084485A (ja) * 2006-09-28 2008-04-10 Toshiba Corp 不揮発性半導体記憶装置及びデータ読出方法
US20100092391A1 (en) 2007-01-11 2010-04-15 Huntington Medical Research Institutes Imaging agents and methods of use thereof
US9227173B2 (en) 2007-06-22 2016-01-05 General Electric Company Methods for dynamic filtration of pharmaceutical products
EP2902041A1 (en) 2007-12-19 2015-08-05 GE Healthcare Limited Composition and method for generating a metabolic profile using 13C-MR detection
WO2009129265A1 (en) 2008-04-14 2009-10-22 Huntington Medical Research Institutes Methods and apparatus for pasadena hyperpolarization
US8968703B2 (en) 2009-09-10 2015-03-03 Ge Healthcare Limited 13C-MR detection using hyperpolarised 13C-fructose
JP5150822B2 (ja) * 2009-10-29 2013-02-27 国立大学法人九州大学 生体内因性分子の検出方法
FR2967158A1 (fr) 2010-11-08 2012-05-11 Phosphoenix Sarl Nouveaux radicaux triarylmethyle: leur preparation et application
WO2012066542A1 (en) * 2010-11-16 2012-05-24 Aspect Magnet Technologies Ltd. System and method for generating invasively hyperpolarized images
GB2498181A (en) 2011-12-29 2013-07-10 Bruker Biospin Gmbh Device and method for rapid dynamic nuclear polarisation
KR102255333B1 (ko) * 2013-01-31 2021-05-26 브라코 이미징 에스.피.에이. Mr에서 대사 마커로서 사용되는 과분극화된 에스테르
US9874622B2 (en) 2013-09-27 2018-01-23 General Electric Company Hyperpolarized media transport vessel
WO2018158891A1 (ja) * 2017-03-01 2018-09-07 国立大学法人九州大学 生体計測方法
CN108794510B (zh) * 2018-07-25 2021-08-06 天津医科大学 一种由三芳基甲基自由基与氮氧自由基组成的双自由基化合物及其盐、其制备方法和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0515458T3 (da) 1990-02-12 1995-09-25 Nycomed Innovation Ab Triarylmethylradikaler og anvendelse af inerte, frie carbon-radikaler ved MRI
US5728370A (en) * 1993-04-02 1998-03-17 Nycomed Imaging As Free Radicals
GB9704669D0 (en) * 1997-03-06 1997-04-23 Nycomed Imaging As Free radicals
DE69815305T2 (de) * 1997-03-06 2004-04-29 Amersham Health As Triarylmethylfreie radikale als bildverbesserungsmittel
US6278893B1 (en) 1998-01-05 2001-08-21 Nycomed Imaging As Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent

Also Published As

Publication number Publication date
IL180895A (en) 2013-03-24
KR20070061805A (ko) 2007-06-14
JP2008508267A (ja) 2008-03-21
RU2374253C2 (ru) 2009-11-27
NO339934B1 (no) 2017-02-20
NO20071116L (no) 2007-04-30
US20090214432A1 (en) 2009-08-27
IL180895A0 (en) 2007-07-04
AU2005267670A1 (en) 2006-02-02
MX2007001034A (es) 2007-07-25
CN101027310A (zh) 2007-08-29
JP5535435B2 (ja) 2014-07-02
KR101554832B1 (ko) 2015-09-21
KR101413934B1 (ko) 2014-06-30
EP1805186A2 (en) 2007-07-11
AU2005267670B2 (en) 2011-03-03
ZA200701272B (en) 2008-04-30
BRPI0513880A (pt) 2008-05-20
CA2575473A1 (en) 2006-02-02
WO2006011811A2 (en) 2006-02-02
KR20140146042A (ko) 2014-12-24
KR20130045378A (ko) 2013-05-03
EP1805186B1 (en) 2015-05-27
CA2575473C (en) 2013-02-19
RU2007102844A (ru) 2008-09-10
PL1805186T3 (pl) 2015-10-30
WO2006011811A3 (en) 2006-06-01
US8431723B2 (en) 2013-04-30
DK1805186T3 (en) 2015-08-24
ES2545377T3 (es) 2015-09-10
CN101027310B (zh) 2012-08-22

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20190725